Incidental Mutation 'R0639:Lrrk2'
ID 56961
Institutional Source Beutler Lab
Gene Symbol Lrrk2
Ensembl Gene ENSMUSG00000036273
Gene Name leucine-rich repeat kinase 2
Synonyms 9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik
MMRRC Submission 038828-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.351) question?
Stock # R0639 (G1)
Quality Score 225
Status Not validated
Chromosome 15
Chromosomal Location 91673175-91816120 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 91772996 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 1831 (M1831K)
Ref Sequence ENSEMBL: ENSMUSP00000052584 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000060642]
AlphaFold Q5S006
Predicted Effect probably benign
Transcript: ENSMUST00000060642
AA Change: M1831K

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
SMART Domains Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: M1831K

DomainStartEndE-ValueType
low complexity region 138 156 N/A INTRINSIC
low complexity region 332 347 N/A INTRINSIC
ANK 708 737 3.95e1 SMART
ANK 770 800 4.58e2 SMART
low complexity region 890 901 N/A INTRINSIC
low complexity region 953 966 N/A INTRINSIC
low complexity region 971 979 N/A INTRINSIC
LRR 1010 1033 9.96e-1 SMART
LRR 1034 1057 8.01e0 SMART
LRR 1082 1105 2.45e0 SMART
LRR 1128 1151 9.3e-1 SMART
LRR 1195 1219 3.24e0 SMART
LRR 1244 1266 3.87e1 SMART
LRR 1267 1291 4.98e1 SMART
Pfam:Roc 1336 1456 4.9e-32 PFAM
Pfam:Ras 1336 1489 3.3e-17 PFAM
Pfam:COR 1524 1740 4e-28 PFAM
Pfam:Pkinase 1881 2132 4.7e-40 PFAM
Pfam:Pkinase_Tyr 1882 2132 6.8e-39 PFAM
WD40 2231 2276 3.09e-1 SMART
WD40 2401 2438 1.37e2 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140734
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156900
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.9%
  • 10x: 97.7%
  • 20x: 95.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]
Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock
Total: 104 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600014C23Rik C T 17: 45,733,073 (GRCm38) W86* probably null Het
Acadl T C 1: 66,857,408 (GRCm38) H75R probably benign Het
Adamtsl1 T C 4: 86,277,143 (GRCm38) F599S probably damaging Het
Adrb3 T C 8: 27,228,265 (GRCm38) N52S probably damaging Het
Agbl3 T A 6: 34,799,705 (GRCm38) L377Q probably damaging Het
Akap9 T C 5: 4,060,318 (GRCm38) L3007P probably damaging Het
Amer3 T A 1: 34,587,821 (GRCm38) Y380* probably null Het
Ankrd13d A T 19: 4,273,019 (GRCm38) probably null Het
Ap4m1 T A 5: 138,176,239 (GRCm38) C235S probably benign Het
Arhgap29 T C 3: 122,007,641 (GRCm38) F675S probably damaging Het
Asah2 C A 19: 32,008,639 (GRCm38) V544F probably damaging Het
Ash2l A G 8: 25,823,291 (GRCm38) I389T possibly damaging Het
Bend5 T C 4: 111,433,298 (GRCm38) S164P probably benign Het
Cacna1d A G 14: 30,171,294 (GRCm38) probably null Het
Cdc25b A G 2: 131,197,262 (GRCm38) N516D probably benign Het
Cdc27 A G 11: 104,531,734 (GRCm38) Y125H probably damaging Het
Cdk5r2 C T 1: 74,855,836 (GRCm38) L247F probably damaging Het
Cenpf C A 1: 189,658,062 (GRCm38) G1191V probably benign Het
Cops4 C T 5: 100,537,460 (GRCm38) T293I possibly damaging Het
Csmd3 A G 15: 47,913,940 (GRCm38) L1294P probably damaging Het
Dclre1a T C 19: 56,538,440 (GRCm38) Y848C probably damaging Het
Disp2 A T 2: 118,790,844 (GRCm38) I686F possibly damaging Het
Dnah6 T A 6: 73,022,412 (GRCm38) Y4012F probably benign Het
Dnajc11 C G 4: 151,969,936 (GRCm38) R200G probably damaging Het
Dnhd1 A T 7: 105,696,464 (GRCm38) D2272V possibly damaging Het
Elane A C 10: 79,886,349 (GRCm38) R5S possibly damaging Het
Entpd7 G A 19: 43,691,094 (GRCm38) V29M probably benign Het
Fanca A G 8: 123,289,359 (GRCm38) probably null Het
Fgl1 G T 8: 41,191,624 (GRCm38) T281K probably benign Het
Flii T C 11: 60,722,997 (GRCm38) probably null Het
Foxn1 T C 11: 78,371,144 (GRCm38) D133G possibly damaging Het
Fzd7 T A 1: 59,484,560 (GRCm38) M534K probably damaging Het
Galnt5 A G 2: 57,999,395 (GRCm38) T336A probably benign Het
Gli3 G A 13: 15,724,715 (GRCm38) D896N probably damaging Het
Gsx1 G T 5: 147,189,946 (GRCm38) W193L probably damaging Het
Gtpbp3 A T 8: 71,492,735 (GRCm38) I485F probably damaging Het
H2-M11 A G 17: 36,547,391 (GRCm38) T26A probably benign Het
Igfbp7 T C 5: 77,351,980 (GRCm38) D243G probably damaging Het
Il31ra A T 13: 112,525,843 (GRCm38) D477E possibly damaging Het
Inmt A C 6: 55,171,227 (GRCm38) V139G probably damaging Het
Inpp5j T A 11: 3,501,147 (GRCm38) M501L probably benign Het
Itsn2 T C 12: 4,712,556 (GRCm38) F1579L probably damaging Het
Kat2b C A 17: 53,567,538 (GRCm38) A70E probably benign Het
Klhl20 T C 1: 161,093,711 (GRCm38) E58G probably damaging Het
Krt79 A T 15: 101,931,548 (GRCm38) Y337* probably null Het
Krt81 C A 15: 101,463,627 (GRCm38) R24L possibly damaging Het
Letm1 T C 5: 33,769,426 (GRCm38) I176V possibly damaging Het
Lingo3 C A 10: 80,835,784 (GRCm38) R104L probably benign Het
Lrig3 T G 10: 126,010,221 (GRCm38) C840G probably damaging Het
Lrrc9 A G 12: 72,486,288 (GRCm38) N977S probably damaging Het
Mn1 A T 5: 111,419,316 (GRCm38) D384V probably damaging Het
Morc3 C A 16: 93,853,850 (GRCm38) H319Q probably damaging Het
Morn1 T C 4: 155,089,503 (GRCm38) F56L possibly damaging Het
Mrpl53 G T 6: 83,109,411 (GRCm38) V64L probably damaging Het
Myo15a T A 11: 60,479,336 (GRCm38) V974D probably benign Het
Neb A G 2: 52,256,124 (GRCm38) V2947A possibly damaging Het
Nfasc A C 1: 132,603,816 (GRCm38) N737K probably damaging Het
Nlk T C 11: 78,572,277 (GRCm38) D464G possibly damaging Het
Nlrc4 C T 17: 74,426,963 (GRCm38) R985K probably benign Het
Nsun6 T C 2: 14,996,336 (GRCm38) K470E probably benign Het
Nup85 T G 11: 115,564,531 (GRCm38) M1R probably null Het
Or8b39 G A 9: 38,085,370 (GRCm38) C178Y probably damaging Het
Otop1 T C 5: 38,287,948 (GRCm38) V150A possibly damaging Het
Pclo C T 5: 14,681,749 (GRCm38) R296* probably null Het
Pdzd2 A T 15: 12,458,058 (GRCm38) C240S possibly damaging Het
Plekhg5 A G 4: 152,114,120 (GRCm38) T922A probably benign Het
Plekhm2 A C 4: 141,642,070 (GRCm38) L101R probably damaging Het
Plscr3 T A 11: 69,847,994 (GRCm38) C161S probably benign Het
Prr14l C T 5: 32,828,915 (GRCm38) D1079N probably benign Het
Ptpru A T 4: 131,771,179 (GRCm38) V1377E possibly damaging Het
Rab37 C A 11: 115,158,702 (GRCm38) D112E probably benign Het
Raet1e T A 10: 22,174,375 (GRCm38) I19N probably damaging Het
Rassf5 T C 1: 131,245,066 (GRCm38) Y22C probably damaging Het
Rp1 T C 1: 4,346,498 (GRCm38) T1464A probably benign Het
Safb T A 17: 56,601,092 (GRCm38) probably benign Het
Scarf2 A G 16: 17,806,505 (GRCm38) probably null Het
Scart2 A G 7: 140,247,959 (GRCm38) N27D probably benign Het
Sh3d19 T C 3: 86,106,973 (GRCm38) S415P probably benign Het
Slc26a9 T A 1: 131,763,804 (GRCm38) L595Q probably damaging Het
Slc4a8 T C 15: 100,796,550 (GRCm38) Y470H probably damaging Het
Slitrk3 T C 3: 73,049,649 (GRCm38) N597D probably benign Het
Spata31 T A 13: 64,922,213 (GRCm38) V725E probably benign Het
Spink12 T A 18: 44,107,764 (GRCm38) C72* probably null Het
Spink5 T A 18: 44,012,975 (GRCm38) probably null Het
Stk40 C A 4: 126,118,332 (GRCm38) S9* probably null Het
Sypl1 A T 12: 32,965,421 (GRCm38) T40S probably damaging Het
Tbc1d8 C T 1: 39,391,209 (GRCm38) E438K probably benign Het
Tdrd7 A G 4: 45,989,102 (GRCm38) T111A probably benign Het
Tg A T 15: 66,741,484 (GRCm38) probably null Het
Tlr5 T A 1: 182,973,889 (GRCm38) W253R probably damaging Het
Tmprss11c C T 5: 86,235,469 (GRCm38) C353Y probably damaging Het
Tnfrsf8 T A 4: 145,288,027 (GRCm38) M271L probably benign Het
Toe1 T C 4: 116,806,750 (GRCm38) N21S probably benign Het
Tpp2 T C 1: 43,975,447 (GRCm38) F649L probably benign Het
Ttll1 G A 15: 83,502,225 (GRCm38) Q60* probably null Het
Vcp C T 4: 42,982,565 (GRCm38) R709Q probably benign Het
Vmn1r119 T A 7: 21,011,668 (GRCm38) H263L possibly damaging Het
Vmn1r195 C A 13: 22,278,941 (GRCm38) Q194K probably damaging Het
Vmn1r33 T C 6: 66,611,799 (GRCm38) Y257C probably damaging Het
Vmn2r15 A G 5: 109,293,015 (GRCm38) F326L probably benign Het
Wbp11 A T 6: 136,816,110 (GRCm38) probably benign Het
Wwp2 T G 8: 107,517,946 (GRCm38) V250G probably benign Het
Xpnpep3 T C 15: 81,430,837 (GRCm38) V246A probably benign Het
Zcchc14 G A 8: 121,605,449 (GRCm38) R419* probably null Het
Other mutations in Lrrk2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00159:Lrrk2 APN 15 91,747,799 (GRCm38) missense possibly damaging 0.90
IGL00542:Lrrk2 APN 15 91,699,943 (GRCm38) missense probably benign
IGL00770:Lrrk2 APN 15 91,801,833 (GRCm38) splice site probably benign
IGL00774:Lrrk2 APN 15 91,801,833 (GRCm38) splice site probably benign
IGL00791:Lrrk2 APN 15 91,779,841 (GRCm38) missense probably damaging 1.00
IGL00827:Lrrk2 APN 15 91,755,790 (GRCm38) missense probably damaging 1.00
IGL00843:Lrrk2 APN 15 91,757,058 (GRCm38) missense possibly damaging 0.58
IGL01109:Lrrk2 APN 15 91,738,832 (GRCm38) missense probably damaging 1.00
IGL01293:Lrrk2 APN 15 91,726,137 (GRCm38) missense probably benign 0.21
IGL01296:Lrrk2 APN 15 91,683,142 (GRCm38) missense probably benign
IGL01301:Lrrk2 APN 15 91,767,339 (GRCm38) missense probably damaging 1.00
IGL01360:Lrrk2 APN 15 91,700,569 (GRCm38) splice site probably null
IGL01465:Lrrk2 APN 15 91,728,925 (GRCm38) missense probably benign 0.21
IGL01529:Lrrk2 APN 15 91,812,313 (GRCm38) missense possibly damaging 0.92
IGL01557:Lrrk2 APN 15 91,699,989 (GRCm38) missense probably damaging 1.00
IGL01560:Lrrk2 APN 15 91,774,988 (GRCm38) missense probably benign 0.33
IGL01991:Lrrk2 APN 15 91,779,946 (GRCm38) missense probably damaging 0.99
IGL02003:Lrrk2 APN 15 91,731,491 (GRCm38) missense probably damaging 0.99
IGL02325:Lrrk2 APN 15 91,726,308 (GRCm38) critical splice donor site probably null
IGL02711:Lrrk2 APN 15 91,685,822 (GRCm38) missense possibly damaging 0.71
IGL02869:Lrrk2 APN 15 91,750,277 (GRCm38) missense probably damaging 1.00
IGL03104:Lrrk2 APN 15 91,747,755 (GRCm38) missense possibly damaging 0.68
IGL03179:Lrrk2 APN 15 91,700,578 (GRCm38) missense probably damaging 1.00
IGL03395:Lrrk2 APN 15 91,797,414 (GRCm38) splice site probably null
horned UTSW 15 91,772,858 (GRCm38) missense probably damaging 1.00
R1312_Lrrk2_980 UTSW 15 91,699,895 (GRCm38) missense probably damaging 1.00
R4710_lrrk2_232 UTSW 15 91,699,927 (GRCm38) missense possibly damaging 0.88
R5245_Lrrk2_127 UTSW 15 91,796,089 (GRCm38) missense probably damaging 1.00
spree UTSW 15 91,702,247 (GRCm38) missense probably benign 0.00
Spur UTSW 15 91,774,995 (GRCm38) nonsense probably null
3-1:Lrrk2 UTSW 15 91,801,934 (GRCm38) missense probably benign 0.01
ANU18:Lrrk2 UTSW 15 91,767,339 (GRCm38) missense probably damaging 1.00
H8562:Lrrk2 UTSW 15 91,673,358 (GRCm38) missense probably benign
H8786:Lrrk2 UTSW 15 91,673,358 (GRCm38) missense probably benign
IGL02835:Lrrk2 UTSW 15 91,814,660 (GRCm38) critical splice acceptor site probably null
R0014:Lrrk2 UTSW 15 91,802,045 (GRCm38) splice site probably benign
R0014:Lrrk2 UTSW 15 91,802,045 (GRCm38) splice site probably benign
R0078:Lrrk2 UTSW 15 91,734,009 (GRCm38) missense probably benign 0.01
R0100:Lrrk2 UTSW 15 91,745,796 (GRCm38) missense probably damaging 1.00
R0282:Lrrk2 UTSW 15 91,778,414 (GRCm38) splice site probably benign
R0448:Lrrk2 UTSW 15 91,709,305 (GRCm38) missense probably damaging 0.99
R0449:Lrrk2 UTSW 15 91,750,275 (GRCm38) missense probably damaging 1.00
R0610:Lrrk2 UTSW 15 91,815,416 (GRCm38) missense probably benign
R0617:Lrrk2 UTSW 15 91,752,278 (GRCm38) missense probably benign 0.00
R0632:Lrrk2 UTSW 15 91,796,028 (GRCm38) missense probably damaging 0.98
R0661:Lrrk2 UTSW 15 91,787,016 (GRCm38) missense probably damaging 1.00
R0666:Lrrk2 UTSW 15 91,757,070 (GRCm38) critical splice donor site probably null
R0764:Lrrk2 UTSW 15 91,775,046 (GRCm38) splice site probably null
R0766:Lrrk2 UTSW 15 91,699,895 (GRCm38) missense probably damaging 1.00
R0845:Lrrk2 UTSW 15 91,755,962 (GRCm38) missense probably benign 0.22
R0940:Lrrk2 UTSW 15 91,729,081 (GRCm38) missense possibly damaging 0.83
R0970:Lrrk2 UTSW 15 91,729,169 (GRCm38) missense probably benign 0.22
R1080:Lrrk2 UTSW 15 91,673,689 (GRCm38) missense probably benign 0.01
R1114:Lrrk2 UTSW 15 91,700,468 (GRCm38) nonsense probably null
R1223:Lrrk2 UTSW 15 91,673,635 (GRCm38) missense probably benign 0.00
R1289:Lrrk2 UTSW 15 91,812,360 (GRCm38) missense probably benign 0.00
R1296:Lrrk2 UTSW 15 91,728,920 (GRCm38) missense probably damaging 1.00
R1312:Lrrk2 UTSW 15 91,699,895 (GRCm38) missense probably damaging 1.00
R1637:Lrrk2 UTSW 15 91,734,058 (GRCm38) missense probably benign
R1773:Lrrk2 UTSW 15 91,779,981 (GRCm38) missense possibly damaging 0.96
R1809:Lrrk2 UTSW 15 91,699,892 (GRCm38) missense possibly damaging 0.86
R1839:Lrrk2 UTSW 15 91,683,134 (GRCm38) missense probably benign 0.00
R1946:Lrrk2 UTSW 15 91,736,661 (GRCm38) splice site probably null
R2160:Lrrk2 UTSW 15 91,796,060 (GRCm38) missense probably damaging 1.00
R2232:Lrrk2 UTSW 15 91,764,716 (GRCm38) missense probably benign 0.05
R2419:Lrrk2 UTSW 15 91,797,526 (GRCm38) splice site probably benign
R2516:Lrrk2 UTSW 15 91,755,927 (GRCm38) missense probably benign
R3110:Lrrk2 UTSW 15 91,814,695 (GRCm38) missense probably benign 0.02
R3112:Lrrk2 UTSW 15 91,814,695 (GRCm38) missense probably benign 0.02
R3801:Lrrk2 UTSW 15 91,737,111 (GRCm38) missense probably benign
R3842:Lrrk2 UTSW 15 91,755,916 (GRCm38) missense probably benign 0.01
R3903:Lrrk2 UTSW 15 91,747,701 (GRCm38) missense probably damaging 1.00
R3903:Lrrk2 UTSW 15 91,747,700 (GRCm38) missense probably damaging 1.00
R3930:Lrrk2 UTSW 15 91,767,461 (GRCm38) critical splice donor site probably null
R3937:Lrrk2 UTSW 15 91,778,504 (GRCm38) missense probably damaging 0.98
R3938:Lrrk2 UTSW 15 91,778,504 (GRCm38) missense probably damaging 0.98
R3938:Lrrk2 UTSW 15 91,712,780 (GRCm38) missense possibly damaging 0.69
R3982:Lrrk2 UTSW 15 91,709,284 (GRCm38) missense probably benign 0.22
R4125:Lrrk2 UTSW 15 91,815,483 (GRCm38) missense probably benign 0.01
R4130:Lrrk2 UTSW 15 91,755,794 (GRCm38) missense probably benign 0.19
R4296:Lrrk2 UTSW 15 91,699,895 (GRCm38) missense probably damaging 1.00
R4465:Lrrk2 UTSW 15 91,747,820 (GRCm38) missense probably damaging 0.96
R4478:Lrrk2 UTSW 15 91,723,188 (GRCm38) missense probably damaging 1.00
R4517:Lrrk2 UTSW 15 91,705,120 (GRCm38) missense probably benign
R4539:Lrrk2 UTSW 15 91,729,142 (GRCm38) missense possibly damaging 0.86
R4654:Lrrk2 UTSW 15 91,765,681 (GRCm38) missense probably damaging 0.96
R4710:Lrrk2 UTSW 15 91,699,927 (GRCm38) missense possibly damaging 0.88
R4722:Lrrk2 UTSW 15 91,688,901 (GRCm38) missense probably damaging 1.00
R4723:Lrrk2 UTSW 15 91,764,759 (GRCm38) missense probably damaging 1.00
R4732:Lrrk2 UTSW 15 91,765,747 (GRCm38) missense probably damaging 1.00
R4732:Lrrk2 UTSW 15 91,688,849 (GRCm38) missense probably damaging 1.00
R4733:Lrrk2 UTSW 15 91,765,747 (GRCm38) missense probably damaging 1.00
R4733:Lrrk2 UTSW 15 91,688,849 (GRCm38) missense probably damaging 1.00
R4787:Lrrk2 UTSW 15 91,712,828 (GRCm38) missense probably benign
R4945:Lrrk2 UTSW 15 91,804,920 (GRCm38) missense probably benign 0.02
R4948:Lrrk2 UTSW 15 91,803,389 (GRCm38) missense probably benign 0.20
R5000:Lrrk2 UTSW 15 91,749,878 (GRCm38) missense probably damaging 1.00
R5031:Lrrk2 UTSW 15 91,700,619 (GRCm38) missense possibly damaging 0.50
R5067:Lrrk2 UTSW 15 91,765,790 (GRCm38) missense probably benign 0.01
R5245:Lrrk2 UTSW 15 91,796,089 (GRCm38) missense probably damaging 1.00
R5341:Lrrk2 UTSW 15 91,772,858 (GRCm38) missense probably damaging 1.00
R5460:Lrrk2 UTSW 15 91,814,644 (GRCm38) splice site probably null
R5551:Lrrk2 UTSW 15 91,812,350 (GRCm38) missense probably benign
R5574:Lrrk2 UTSW 15 91,787,016 (GRCm38) missense probably damaging 1.00
R5577:Lrrk2 UTSW 15 91,765,745 (GRCm38) missense probably damaging 1.00
R5685:Lrrk2 UTSW 15 91,803,301 (GRCm38) nonsense probably null
R5712:Lrrk2 UTSW 15 91,702,222 (GRCm38) nonsense probably null
R5728:Lrrk2 UTSW 15 91,774,974 (GRCm38) missense probably benign 0.36
R5782:Lrrk2 UTSW 15 91,702,183 (GRCm38) missense probably damaging 1.00
R5788:Lrrk2 UTSW 15 91,764,648 (GRCm38) missense possibly damaging 0.55
R5821:Lrrk2 UTSW 15 91,709,390 (GRCm38) critical splice donor site probably null
R5852:Lrrk2 UTSW 15 91,755,949 (GRCm38) missense probably damaging 1.00
R5934:Lrrk2 UTSW 15 91,734,046 (GRCm38) missense probably benign 0.00
R5935:Lrrk2 UTSW 15 91,745,831 (GRCm38) missense probably benign 0.14
R5979:Lrrk2 UTSW 15 91,772,945 (GRCm38) missense possibly damaging 0.47
R6101:Lrrk2 UTSW 15 91,723,135 (GRCm38) missense probably benign 0.10
R6114:Lrrk2 UTSW 15 91,747,826 (GRCm38) missense probably benign 0.33
R6259:Lrrk2 UTSW 15 91,702,247 (GRCm38) missense probably benign 0.00
R6376:Lrrk2 UTSW 15 91,742,266 (GRCm38) missense possibly damaging 0.89
R6417:Lrrk2 UTSW 15 91,812,346 (GRCm38) missense probably benign 0.03
R6420:Lrrk2 UTSW 15 91,812,346 (GRCm38) missense probably benign 0.03
R6737:Lrrk2 UTSW 15 91,723,218 (GRCm38) missense possibly damaging 0.50
R7056:Lrrk2 UTSW 15 91,774,995 (GRCm38) nonsense probably null
R7072:Lrrk2 UTSW 15 91,801,920 (GRCm38) missense probably benign 0.03
R7109:Lrrk2 UTSW 15 91,764,782 (GRCm38) missense probably damaging 1.00
R7128:Lrrk2 UTSW 15 91,801,885 (GRCm38) missense probably benign
R7144:Lrrk2 UTSW 15 91,734,055 (GRCm38) missense possibly damaging 0.54
R7187:Lrrk2 UTSW 15 91,757,001 (GRCm38) missense possibly damaging 0.92
R7270:Lrrk2 UTSW 15 91,700,441 (GRCm38) missense probably benign 0.01
R7356:Lrrk2 UTSW 15 91,738,744 (GRCm38) missense probably benign 0.07
R7360:Lrrk2 UTSW 15 91,731,655 (GRCm38) critical splice donor site probably null
R7373:Lrrk2 UTSW 15 91,700,004 (GRCm38) critical splice donor site probably null
R7465:Lrrk2 UTSW 15 91,767,340 (GRCm38) missense probably damaging 1.00
R7477:Lrrk2 UTSW 15 91,812,325 (GRCm38) missense probably damaging 0.98
R7614:Lrrk2 UTSW 15 91,772,858 (GRCm38) missense probably damaging 1.00
R7622:Lrrk2 UTSW 15 91,812,323 (GRCm38) missense probably damaging 1.00
R7658:Lrrk2 UTSW 15 91,700,358 (GRCm38) missense possibly damaging 0.91
R7679:Lrrk2 UTSW 15 91,726,186 (GRCm38) missense possibly damaging 0.58
R7737:Lrrk2 UTSW 15 91,815,446 (GRCm38) missense probably damaging 0.98
R7739:Lrrk2 UTSW 15 91,700,613 (GRCm38) missense probably damaging 1.00
R7740:Lrrk2 UTSW 15 91,767,324 (GRCm38) missense probably damaging 1.00
R7908:Lrrk2 UTSW 15 91,726,152 (GRCm38) missense probably damaging 1.00
R8299:Lrrk2 UTSW 15 91,673,240 (GRCm38) start gained probably benign
R8389:Lrrk2 UTSW 15 91,699,991 (GRCm38) missense probably damaging 1.00
R8462:Lrrk2 UTSW 15 91,731,477 (GRCm38) missense probably benign
R8698:Lrrk2 UTSW 15 91,752,197 (GRCm38) missense probably benign 0.38
R8947:Lrrk2 UTSW 15 91,702,270 (GRCm38) nonsense probably null
R9084:Lrrk2 UTSW 15 91,750,266 (GRCm38) missense
R9086:Lrrk2 UTSW 15 91,755,848 (GRCm38) missense probably benign 0.01
R9096:Lrrk2 UTSW 15 91,673,256 (GRCm38) start gained probably benign
R9097:Lrrk2 UTSW 15 91,673,256 (GRCm38) start gained probably benign
R9267:Lrrk2 UTSW 15 91,700,426 (GRCm38) missense probably damaging 0.99
R9285:Lrrk2 UTSW 15 91,778,483 (GRCm38) missense probably damaging 1.00
R9341:Lrrk2 UTSW 15 91,700,415 (GRCm38) missense probably benign 0.18
R9343:Lrrk2 UTSW 15 91,700,415 (GRCm38) missense probably benign 0.18
R9371:Lrrk2 UTSW 15 91,723,204 (GRCm38) missense probably damaging 1.00
R9424:Lrrk2 UTSW 15 91,752,185 (GRCm38) nonsense probably null
R9489:Lrrk2 UTSW 15 91,737,217 (GRCm38) missense probably benign 0.37
R9502:Lrrk2 UTSW 15 91,723,162 (GRCm38) missense probably damaging 0.98
R9563:Lrrk2 UTSW 15 91,749,840 (GRCm38) missense possibly damaging 0.90
R9576:Lrrk2 UTSW 15 91,752,185 (GRCm38) nonsense probably null
R9605:Lrrk2 UTSW 15 91,737,217 (GRCm38) missense probably benign 0.37
R9635:Lrrk2 UTSW 15 91,812,324 (GRCm38) missense probably benign 0.21
R9641:Lrrk2 UTSW 15 91,787,048 (GRCm38) missense possibly damaging 0.94
R9660:Lrrk2 UTSW 15 91,734,025 (GRCm38) missense probably benign 0.00
R9673:Lrrk2 UTSW 15 91,765,681 (GRCm38) missense probably damaging 1.00
R9708:Lrrk2 UTSW 15 91,750,279 (GRCm38) nonsense probably null
R9728:Lrrk2 UTSW 15 91,734,025 (GRCm38) missense probably benign 0.00
R9757:Lrrk2 UTSW 15 91,811,026 (GRCm38) missense probably benign 0.03
RF001:Lrrk2 UTSW 15 91,736,633 (GRCm38) missense probably benign 0.11
X0028:Lrrk2 UTSW 15 91,738,851 (GRCm38) missense probably benign 0.00
Z1088:Lrrk2 UTSW 15 91,726,240 (GRCm38) missense probably benign 0.12
Predicted Primers
Posted On 2013-07-11