Incidental Mutation 'R7340:Cdcp3'
ID |
569774 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cdcp3
|
Ensembl Gene |
ENSMUSG00000006204 |
Gene Name |
CUB domain containing protein 3 |
Synonyms |
5430419D17Rik |
MMRRC Submission |
045430-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R7340 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
130776131-130908180 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 130879344 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 1788
(T1788A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000150784
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000124096]
[ENSMUST00000208921]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
SMART Domains |
Protein: ENSMUSP00000130971 Gene: ENSMUSG00000030849
Domain | Start | End | E-Value | Type |
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
Predicted Effect |
unknown
Transcript: ENSMUST00000208921
AA Change: T1788A
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.1%
|
Validation Efficiency |
99% (83/84) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 83 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abcb11 |
C |
T |
2: 69,130,211 (GRCm39) |
D282N |
probably damaging |
Het |
Adam30 |
A |
T |
3: 98,069,637 (GRCm39) |
N490I |
probably benign |
Het |
Ankrd55 |
A |
T |
13: 112,492,497 (GRCm39) |
I223F |
probably damaging |
Het |
Ano8 |
T |
A |
8: 71,935,655 (GRCm39) |
E321V |
probably damaging |
Het |
Apc2 |
A |
G |
10: 80,149,316 (GRCm39) |
K1457E |
probably benign |
Het |
Asb15 |
T |
A |
6: 24,558,513 (GRCm39) |
V38E |
probably benign |
Het |
Atp4a |
T |
C |
7: 30,416,155 (GRCm39) |
S417P |
possibly damaging |
Het |
AY358078 |
A |
G |
14: 52,063,716 (GRCm39) |
N454S |
probably damaging |
Het |
Cables2 |
A |
G |
2: 179,903,450 (GRCm39) |
Y245H |
|
Het |
Cactin |
CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG |
CCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAGTCGGAG |
10: 81,157,152 (GRCm39) |
|
probably benign |
Het |
Camsap3 |
G |
A |
8: 3,637,960 (GRCm39) |
|
probably null |
Het |
Ccdc178 |
A |
T |
18: 22,150,518 (GRCm39) |
V705E |
probably benign |
Het |
Ccdc47 |
T |
C |
11: 106,091,799 (GRCm39) |
Q472R |
possibly damaging |
Het |
Ccdc62 |
A |
G |
5: 124,089,283 (GRCm39) |
D307G |
probably damaging |
Het |
Cdh23 |
A |
G |
10: 60,366,775 (GRCm39) |
I235T |
probably benign |
Het |
Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
Cfap65 |
T |
C |
1: 74,960,742 (GRCm39) |
N743D |
probably benign |
Het |
Cimap1b |
T |
A |
15: 89,262,610 (GRCm39) |
T116S |
probably benign |
Het |
Clec16a |
A |
G |
16: 10,398,827 (GRCm39) |
N329S |
probably null |
Het |
Col25a1 |
A |
G |
3: 130,340,006 (GRCm39) |
|
probably null |
Het |
Daam1 |
T |
G |
12: 72,035,713 (GRCm39) |
D969E |
probably benign |
Het |
Dntt |
A |
C |
19: 41,047,004 (GRCm39) |
|
probably null |
Het |
Dsel |
C |
T |
1: 111,789,303 (GRCm39) |
G411S |
probably damaging |
Het |
Dst |
T |
A |
1: 34,229,810 (GRCm39) |
Y2468N |
probably benign |
Het |
Exosc9 |
A |
G |
3: 36,615,297 (GRCm39) |
T262A |
possibly damaging |
Het |
Exph5 |
G |
A |
9: 53,288,309 (GRCm39) |
A1797T |
probably damaging |
Het |
Fbp2 |
A |
T |
13: 62,985,061 (GRCm39) |
Y287N |
probably damaging |
Het |
Fmn2 |
CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC |
CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC |
1: 174,436,769 (GRCm39) |
|
probably benign |
Het |
Fus |
T |
A |
7: 127,581,123 (GRCm39) |
|
probably null |
Het |
Galnt9 |
T |
A |
5: 110,762,054 (GRCm39) |
N397K |
probably damaging |
Het |
Gdi1 |
G |
A |
X: 73,350,461 (GRCm39) |
R55H |
probably benign |
Het |
Gga1 |
A |
G |
15: 78,775,651 (GRCm39) |
T369A |
probably benign |
Het |
Gp1ba |
T |
C |
11: 70,531,119 (GRCm39) |
I295T |
unknown |
Het |
Hk2 |
T |
C |
6: 82,705,873 (GRCm39) |
E810G |
probably benign |
Het |
Igsf10 |
A |
G |
3: 59,233,189 (GRCm39) |
V1848A |
probably damaging |
Het |
Insrr |
G |
A |
3: 87,721,623 (GRCm39) |
|
probably null |
Het |
Ip6k3 |
T |
A |
17: 27,367,504 (GRCm39) |
M231L |
probably benign |
Het |
Itgb8 |
T |
C |
12: 119,155,939 (GRCm39) |
N171S |
probably benign |
Het |
Ldlrad3 |
T |
C |
2: 101,897,184 (GRCm39) |
|
probably null |
Het |
Ltbp1 |
T |
A |
17: 75,634,223 (GRCm39) |
C886* |
probably null |
Het |
Mettl13 |
T |
C |
1: 162,366,547 (GRCm39) |
D444G |
probably benign |
Het |
Mns1 |
A |
G |
9: 72,356,025 (GRCm39) |
Y224C |
probably damaging |
Het |
Mri1 |
C |
T |
8: 84,983,525 (GRCm39) |
R122Q |
probably benign |
Het |
Ms4a6d |
G |
A |
19: 11,567,437 (GRCm39) |
Q155* |
probably null |
Het |
Myo5c |
A |
C |
9: 75,196,423 (GRCm39) |
K1290Q |
probably benign |
Het |
Nlrp12 |
T |
G |
7: 3,281,755 (GRCm39) |
Q842H |
possibly damaging |
Het |
Oga |
G |
A |
19: 45,755,895 (GRCm39) |
Q583* |
probably null |
Het |
Or14c44 |
T |
C |
7: 86,061,957 (GRCm39) |
L129P |
possibly damaging |
Het |
Or14j8 |
T |
A |
17: 38,263,413 (GRCm39) |
R167S |
probably benign |
Het |
Or2t1 |
A |
T |
14: 14,328,401 (GRCm38) |
T97S |
possibly damaging |
Het |
Or5d39 |
T |
C |
2: 87,979,620 (GRCm39) |
T248A |
possibly damaging |
Het |
Otoa |
A |
G |
7: 120,729,288 (GRCm39) |
T554A |
probably benign |
Het |
Per1 |
A |
G |
11: 68,994,008 (GRCm39) |
D438G |
probably damaging |
Het |
Phactr3 |
G |
A |
2: 177,975,854 (GRCm39) |
R533H |
probably damaging |
Het |
Phykpl |
T |
C |
11: 51,490,370 (GRCm39) |
F417S |
probably damaging |
Het |
Pole |
A |
T |
5: 110,482,330 (GRCm39) |
T2057S |
probably benign |
Het |
Polq |
A |
G |
16: 36,881,288 (GRCm39) |
T1151A |
probably benign |
Het |
Polr1g |
T |
C |
7: 19,093,073 (GRCm39) |
T36A |
probably benign |
Het |
Rbm26 |
A |
T |
14: 105,389,976 (GRCm39) |
V216E |
possibly damaging |
Het |
Ryk |
T |
C |
9: 102,775,737 (GRCm39) |
I449T |
probably damaging |
Het |
Sap25 |
A |
G |
5: 137,640,935 (GRCm39) |
T225A |
probably benign |
Het |
Sart3 |
A |
G |
5: 113,882,728 (GRCm39) |
M864T |
probably benign |
Het |
Sec31b |
T |
C |
19: 44,517,161 (GRCm39) |
S280G |
probably benign |
Het |
Sema4d |
A |
T |
13: 51,877,598 (GRCm39) |
I78N |
probably damaging |
Het |
Sgip1 |
G |
C |
4: 102,778,661 (GRCm39) |
R419S |
unknown |
Het |
Slc13a3 |
T |
C |
2: 165,272,210 (GRCm39) |
I278V |
probably benign |
Het |
Slc2a5 |
A |
G |
4: 150,224,439 (GRCm39) |
D312G |
probably benign |
Het |
Slc39a2 |
A |
T |
14: 52,131,660 (GRCm39) |
Q77L |
possibly damaging |
Het |
Srbd1 |
A |
T |
17: 86,443,782 (GRCm39) |
V148E |
probably benign |
Het |
Syngr2 |
A |
G |
11: 117,703,322 (GRCm39) |
E46G |
probably damaging |
Het |
Taok1 |
A |
G |
11: 77,470,643 (GRCm39) |
V54A |
possibly damaging |
Het |
Tas2r106 |
T |
A |
6: 131,655,185 (GRCm39) |
H222L |
probably damaging |
Het |
Tcaf3 |
A |
G |
6: 42,566,848 (GRCm39) |
I747T |
probably benign |
Het |
Tmem151b |
G |
T |
17: 45,856,195 (GRCm39) |
P415Q |
probably benign |
Het |
Tmf1 |
T |
C |
6: 97,145,061 (GRCm39) |
D659G |
possibly damaging |
Het |
Tnn |
G |
T |
1: 159,973,592 (GRCm39) |
D258E |
probably damaging |
Het |
Traj33 |
A |
G |
14: 54,422,862 (GRCm39) |
I16V |
unknown |
Het |
Ttll13 |
G |
T |
7: 79,906,772 (GRCm39) |
C480F |
probably damaging |
Het |
Ttn |
T |
C |
2: 76,714,415 (GRCm39) |
N8137S |
unknown |
Het |
Vmn1r85 |
T |
C |
7: 12,819,073 (GRCm39) |
N24D |
probably damaging |
Het |
Wdr81 |
T |
C |
11: 75,335,525 (GRCm39) |
Q649R |
probably null |
Het |
Zan |
T |
C |
5: 137,382,092 (GRCm39) |
T5152A |
unknown |
Het |
Zc3h6 |
A |
G |
2: 128,835,110 (GRCm39) |
D82G |
possibly damaging |
Het |
|
Other mutations in Cdcp3 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00226:Cdcp3
|
APN |
7 |
130,839,823 (GRCm39) |
splice site |
probably null |
|
IGL00848:Cdcp3
|
APN |
7 |
130,848,453 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL00966:Cdcp3
|
APN |
7 |
130,844,836 (GRCm39) |
nonsense |
probably null |
|
IGL01286:Cdcp3
|
APN |
7 |
130,848,432 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01303:Cdcp3
|
APN |
7 |
130,796,060 (GRCm39) |
missense |
possibly damaging |
0.53 |
IGL01585:Cdcp3
|
APN |
7 |
130,846,487 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL01665:Cdcp3
|
APN |
7 |
130,848,386 (GRCm39) |
nonsense |
probably null |
|
IGL01953:Cdcp3
|
APN |
7 |
130,826,709 (GRCm39) |
missense |
probably benign |
0.04 |
IGL02427:Cdcp3
|
APN |
7 |
130,846,517 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02508:Cdcp3
|
APN |
7 |
130,824,559 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02678:Cdcp3
|
APN |
7 |
130,830,646 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03092:Cdcp3
|
APN |
7 |
130,803,527 (GRCm39) |
critical splice donor site |
probably null |
|
IGL03122:Cdcp3
|
APN |
7 |
130,798,243 (GRCm39) |
missense |
possibly damaging |
0.68 |
IGL03343:Cdcp3
|
APN |
7 |
130,848,420 (GRCm39) |
missense |
probably damaging |
1.00 |
R0011:Cdcp3
|
UTSW |
7 |
130,831,722 (GRCm39) |
missense |
probably damaging |
0.99 |
R0011:Cdcp3
|
UTSW |
7 |
130,831,722 (GRCm39) |
missense |
probably damaging |
0.99 |
R0234:Cdcp3
|
UTSW |
7 |
130,796,032 (GRCm39) |
splice site |
probably null |
|
R0234:Cdcp3
|
UTSW |
7 |
130,796,032 (GRCm39) |
splice site |
probably null |
|
R0268:Cdcp3
|
UTSW |
7 |
130,839,905 (GRCm39) |
missense |
probably damaging |
1.00 |
R0383:Cdcp3
|
UTSW |
7 |
130,841,268 (GRCm39) |
missense |
probably benign |
0.05 |
R0973:Cdcp3
|
UTSW |
7 |
130,839,911 (GRCm39) |
missense |
probably damaging |
1.00 |
R0973:Cdcp3
|
UTSW |
7 |
130,839,911 (GRCm39) |
missense |
probably damaging |
1.00 |
R0974:Cdcp3
|
UTSW |
7 |
130,839,911 (GRCm39) |
missense |
probably damaging |
1.00 |
R1572:Cdcp3
|
UTSW |
7 |
130,846,560 (GRCm39) |
nonsense |
probably null |
|
R1911:Cdcp3
|
UTSW |
7 |
130,839,818 (GRCm39) |
missense |
probably damaging |
1.00 |
R2032:Cdcp3
|
UTSW |
7 |
130,844,781 (GRCm39) |
missense |
probably damaging |
1.00 |
R2097:Cdcp3
|
UTSW |
7 |
130,783,693 (GRCm39) |
nonsense |
probably null |
|
R2221:Cdcp3
|
UTSW |
7 |
130,849,186 (GRCm39) |
critical splice acceptor site |
probably null |
|
R2223:Cdcp3
|
UTSW |
7 |
130,849,186 (GRCm39) |
critical splice acceptor site |
probably null |
|
R2254:Cdcp3
|
UTSW |
7 |
130,824,634 (GRCm39) |
missense |
probably damaging |
1.00 |
R2913:Cdcp3
|
UTSW |
7 |
130,783,753 (GRCm39) |
missense |
possibly damaging |
0.90 |
R2991:Cdcp3
|
UTSW |
7 |
130,848,429 (GRCm39) |
missense |
probably damaging |
1.00 |
R3439:Cdcp3
|
UTSW |
7 |
130,790,508 (GRCm39) |
critical splice donor site |
probably null |
|
R4418:Cdcp3
|
UTSW |
7 |
130,849,194 (GRCm39) |
missense |
possibly damaging |
0.86 |
R4916:Cdcp3
|
UTSW |
7 |
130,776,206 (GRCm39) |
splice site |
probably null |
|
R5488:Cdcp3
|
UTSW |
7 |
130,848,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R5594:Cdcp3
|
UTSW |
7 |
130,841,252 (GRCm39) |
missense |
probably benign |
0.12 |
R5897:Cdcp3
|
UTSW |
7 |
130,798,280 (GRCm39) |
splice site |
probably null |
|
R5898:Cdcp3
|
UTSW |
7 |
130,843,696 (GRCm39) |
splice site |
probably null |
|
R5940:Cdcp3
|
UTSW |
7 |
130,839,992 (GRCm39) |
missense |
probably damaging |
1.00 |
R6170:Cdcp3
|
UTSW |
7 |
130,776,216 (GRCm39) |
splice site |
probably null |
|
R6187:Cdcp3
|
UTSW |
7 |
130,872,328 (GRCm39) |
intron |
probably benign |
|
R6321:Cdcp3
|
UTSW |
7 |
130,858,735 (GRCm39) |
critical splice donor site |
probably null |
|
R6409:Cdcp3
|
UTSW |
7 |
130,863,800 (GRCm39) |
intron |
probably benign |
|
R6432:Cdcp3
|
UTSW |
7 |
130,846,601 (GRCm39) |
critical splice donor site |
probably null |
|
R6481:Cdcp3
|
UTSW |
7 |
130,858,530 (GRCm39) |
missense |
probably benign |
0.05 |
R6750:Cdcp3
|
UTSW |
7 |
130,889,974 (GRCm39) |
intron |
probably benign |
|
R6783:Cdcp3
|
UTSW |
7 |
130,828,493 (GRCm39) |
missense |
probably damaging |
0.99 |
R6836:Cdcp3
|
UTSW |
7 |
130,798,233 (GRCm39) |
missense |
possibly damaging |
0.84 |
R6925:Cdcp3
|
UTSW |
7 |
130,824,436 (GRCm39) |
missense |
possibly damaging |
0.92 |
R6995:Cdcp3
|
UTSW |
7 |
130,824,400 (GRCm39) |
missense |
probably damaging |
1.00 |
R7199:Cdcp3
|
UTSW |
7 |
130,837,641 (GRCm39) |
nonsense |
probably null |
|
R7205:Cdcp3
|
UTSW |
7 |
130,879,352 (GRCm39) |
critical splice donor site |
probably null |
|
R7354:Cdcp3
|
UTSW |
7 |
130,873,762 (GRCm39) |
missense |
unknown |
|
R7354:Cdcp3
|
UTSW |
7 |
130,858,458 (GRCm39) |
missense |
possibly damaging |
0.84 |
R7434:Cdcp3
|
UTSW |
7 |
130,881,212 (GRCm39) |
missense |
unknown |
|
R7485:Cdcp3
|
UTSW |
7 |
130,830,562 (GRCm39) |
missense |
probably damaging |
0.99 |
R7513:Cdcp3
|
UTSW |
7 |
130,873,800 (GRCm39) |
missense |
unknown |
|
R7562:Cdcp3
|
UTSW |
7 |
130,904,426 (GRCm39) |
missense |
unknown |
|
R7623:Cdcp3
|
UTSW |
7 |
130,879,295 (GRCm39) |
splice site |
probably null |
|
R7782:Cdcp3
|
UTSW |
7 |
130,904,466 (GRCm39) |
splice site |
probably null |
|
R7879:Cdcp3
|
UTSW |
7 |
130,844,871 (GRCm39) |
missense |
probably damaging |
0.98 |
R7935:Cdcp3
|
UTSW |
7 |
130,852,205 (GRCm39) |
missense |
probably damaging |
0.96 |
R7949:Cdcp3
|
UTSW |
7 |
130,895,324 (GRCm39) |
splice site |
probably null |
|
R7964:Cdcp3
|
UTSW |
7 |
130,899,963 (GRCm39) |
missense |
unknown |
|
R7980:Cdcp3
|
UTSW |
7 |
130,836,506 (GRCm39) |
missense |
probably damaging |
0.98 |
R8145:Cdcp3
|
UTSW |
7 |
130,898,045 (GRCm39) |
missense |
unknown |
|
R8673:Cdcp3
|
UTSW |
7 |
130,844,846 (GRCm39) |
missense |
probably damaging |
0.99 |
R8684:Cdcp3
|
UTSW |
7 |
130,837,688 (GRCm39) |
nonsense |
probably null |
|
R8721:Cdcp3
|
UTSW |
7 |
130,879,335 (GRCm39) |
missense |
unknown |
|
R8725:Cdcp3
|
UTSW |
7 |
130,875,485 (GRCm39) |
missense |
unknown |
|
R8727:Cdcp3
|
UTSW |
7 |
130,875,485 (GRCm39) |
missense |
unknown |
|
R8742:Cdcp3
|
UTSW |
7 |
130,783,741 (GRCm39) |
missense |
unknown |
|
R8807:Cdcp3
|
UTSW |
7 |
130,846,507 (GRCm39) |
missense |
probably damaging |
0.97 |
R8822:Cdcp3
|
UTSW |
7 |
130,843,706 (GRCm39) |
critical splice acceptor site |
probably null |
|
R8861:Cdcp3
|
UTSW |
7 |
130,861,690 (GRCm39) |
nonsense |
probably null |
|
R8897:Cdcp3
|
UTSW |
7 |
130,867,566 (GRCm39) |
missense |
unknown |
|
R8900:Cdcp3
|
UTSW |
7 |
130,904,197 (GRCm39) |
intron |
probably benign |
|
R9214:Cdcp3
|
UTSW |
7 |
130,824,481 (GRCm39) |
missense |
possibly damaging |
0.89 |
R9218:Cdcp3
|
UTSW |
7 |
130,863,728 (GRCm39) |
missense |
unknown |
|
R9311:Cdcp3
|
UTSW |
7 |
130,859,490 (GRCm39) |
missense |
unknown |
|
R9323:Cdcp3
|
UTSW |
7 |
130,828,401 (GRCm39) |
missense |
probably damaging |
0.96 |
R9384:Cdcp3
|
UTSW |
7 |
130,904,404 (GRCm39) |
missense |
unknown |
|
R9387:Cdcp3
|
UTSW |
7 |
130,863,620 (GRCm39) |
missense |
unknown |
|
R9417:Cdcp3
|
UTSW |
7 |
130,852,218 (GRCm39) |
missense |
possibly damaging |
0.60 |
R9502:Cdcp3
|
UTSW |
7 |
130,836,815 (GRCm39) |
missense |
possibly damaging |
0.61 |
R9603:Cdcp3
|
UTSW |
7 |
130,830,643 (GRCm39) |
missense |
probably damaging |
0.98 |
R9642:Cdcp3
|
UTSW |
7 |
130,848,257 (GRCm39) |
missense |
probably benign |
0.01 |
Z1088:Cdcp3
|
UTSW |
7 |
130,848,362 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Cdcp3
|
UTSW |
7 |
130,867,595 (GRCm39) |
missense |
unknown |
|
|
Predicted Primers |
PCR Primer
(F):5'- CAGTGCCTTGCTACGCTAAC -3'
(R):5'- TTGAACTTGAGCCTGGGGTC -3'
Sequencing Primer
(F):5'- GCTACGCTAACTCCTTTTAATTTTAC -3'
(R):5'- CTTGACTCGGCTGCGTAAAG -3'
|
Posted On |
2019-09-13 |