Incidental Mutation 'R7341:Lmo7'
| ID |
569888 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lmo7
|
| Ensembl Gene |
ENSMUSG00000033060 |
| Gene Name |
LIM domain only 7 |
| Synonyms |
FBXO20, LOC380928 |
| MMRRC Submission |
045431-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.133)
|
| Stock # |
R7341 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
14 |
| Chromosomal Location |
101967393-102172146 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 102122948 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 379
(N379S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000097910
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000100337]
[ENSMUST00000159026]
[ENSMUST00000159258]
[ENSMUST00000159314]
[ENSMUST00000159597]
|
| AlphaFold |
E9PYF4 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000100337
AA Change: N379S
PolyPhen 2
Score 0.297 (Sensitivity: 0.91; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000097910
Gene: ENSMUSG00000033060
AA Change: N379S
| Domain | Start | End | E-Value | Type |
|---|
|
CH
|
14 |
124 |
2.57e-13 |
SMART |
|
low complexity region
|
200 |
211 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
242 |
348 |
2.2e-14 |
PFAM |
|
low complexity region
|
448 |
462 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
568 |
735 |
1.8e-46 |
PFAM |
|
low complexity region
|
861 |
879 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
991 |
N/A |
INTRINSIC |
|
low complexity region
|
1003 |
1015 |
N/A |
INTRINSIC |
|
PDZ
|
1047 |
1119 |
1.05e-8 |
SMART |
|
coiled coil region
|
1222 |
1275 |
N/A |
INTRINSIC |
|
coiled coil region
|
1319 |
1411 |
N/A |
INTRINSIC |
|
low complexity region
|
1585 |
1596 |
N/A |
INTRINSIC |
|
low complexity region
|
1599 |
1617 |
N/A |
INTRINSIC |
|
LIM
|
1629 |
1687 |
6.54e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159026
AA Change: N146S
PolyPhen 2
Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000124605
Gene: ENSMUSG00000033060
AA Change: N146S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
471 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159258
AA Change: N146S
PolyPhen 2
Score 0.095 (Sensitivity: 0.93; Specificity: 0.85)
|
| SMART Domains |
Protein: ENSMUSP00000125465
Gene: ENSMUSG00000033060
AA Change: N146S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159314
AA Change: N146S
PolyPhen 2
Score 0.919 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000124349
Gene: ENSMUSG00000033060
AA Change: N146S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
215 |
229 |
N/A |
INTRINSIC |
|
coiled coil region
|
435 |
492 |
N/A |
INTRINSIC |
|
low complexity region
|
628 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
770 |
782 |
N/A |
INTRINSIC |
|
PDZ
|
814 |
886 |
1.05e-8 |
SMART |
|
coiled coil region
|
989 |
1042 |
N/A |
INTRINSIC |
|
coiled coil region
|
1086 |
1178 |
N/A |
INTRINSIC |
|
low complexity region
|
1352 |
1363 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1384 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000159597
AA Change: N257S
PolyPhen 2
Score 0.869 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000123706
Gene: ENSMUSG00000033060
AA Change: N257S
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
78 |
89 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
111 |
141 |
6.96e-5 |
PROSPERO |
|
internal_repeat_1
|
218 |
248 |
6.96e-5 |
PROSPERO |
|
low complexity region
|
326 |
340 |
N/A |
INTRINSIC |
|
coiled coil region
|
546 |
603 |
N/A |
INTRINSIC |
|
low complexity region
|
739 |
757 |
N/A |
INTRINSIC |
|
low complexity region
|
857 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
881 |
893 |
N/A |
INTRINSIC |
|
PDZ
|
925 |
997 |
1.05e-8 |
SMART |
|
coiled coil region
|
1127 |
1180 |
N/A |
INTRINSIC |
|
coiled coil region
|
1224 |
1316 |
N/A |
INTRINSIC |
|
low complexity region
|
1490 |
1501 |
N/A |
INTRINSIC |
|
low complexity region
|
1504 |
1522 |
N/A |
INTRINSIC |
|
LIM
|
1534 |
1592 |
6.54e-10 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159806
|
| SMART Domains |
Protein: ENSMUSP00000124300
Gene: ENSMUSG00000033060
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
45 |
N/A |
INTRINSIC |
|
Pfam:DUF4757
|
76 |
225 |
4.5e-53 |
PFAM |
|
low complexity region
|
351 |
369 |
N/A |
INTRINSIC |
|
low complexity region
|
469 |
481 |
N/A |
INTRINSIC |
|
low complexity region
|
493 |
505 |
N/A |
INTRINSIC |
|
PDZ
|
537 |
609 |
1.05e-8 |
SMART |
|
internal_repeat_1
|
620 |
691 |
9.31e-5 |
PROSPERO |
|
coiled coil region
|
711 |
764 |
N/A |
INTRINSIC |
|
coiled coil region
|
808 |
900 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
921 |
976 |
9.31e-5 |
PROSPERO |
|
low complexity region
|
1075 |
1086 |
N/A |
INTRINSIC |
|
low complexity region
|
1089 |
1107 |
N/A |
INTRINSIC |
|
LIM
|
1119 |
1177 |
6.54e-10 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (92/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]
PHENOTYPE: Targeted mutations in this gene result in postnatal lethality, growth defects, skeletal muscle abnormalities and retinal defects reflective of retinal degeneration. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
C |
T |
2: 69,130,211 (GRCm39) |
D282N |
probably damaging |
Het |
| Adam3 |
T |
A |
8: 25,177,996 (GRCm39) |
N639I |
possibly damaging |
Het |
| Adamtsl3 |
T |
A |
7: 82,206,082 (GRCm39) |
C756S |
probably damaging |
Het |
| Arhgap31 |
C |
T |
16: 38,532,876 (GRCm39) |
|
probably null |
Het |
| Ascl4 |
G |
A |
10: 85,764,529 (GRCm39) |
A59T |
possibly damaging |
Het |
| Ash1l |
T |
A |
3: 88,889,066 (GRCm39) |
I315N |
possibly damaging |
Het |
| Atp6v0d2 |
T |
C |
4: 19,887,330 (GRCm39) |
D206G |
possibly damaging |
Het |
| Baz1b |
T |
A |
5: 135,251,970 (GRCm39) |
L923I |
probably damaging |
Het |
| Birc6 |
T |
A |
17: 74,919,069 (GRCm39) |
N1966K |
probably damaging |
Het |
| Bod1l |
T |
C |
5: 41,946,200 (GRCm39) |
N3025S |
probably benign |
Het |
| Bub1b |
C |
A |
2: 118,467,267 (GRCm39) |
H863Q |
possibly damaging |
Het |
| C1rb |
T |
A |
6: 124,554,411 (GRCm39) |
Y397* |
probably null |
Het |
| Ccdc180 |
A |
G |
4: 45,898,644 (GRCm39) |
E164G |
possibly damaging |
Het |
| Ccdc9 |
C |
T |
7: 16,014,552 (GRCm39) |
V230M |
probably damaging |
Het |
| Cchcr1 |
C |
A |
17: 35,837,610 (GRCm39) |
N437K |
probably benign |
Het |
| Cdhr2 |
T |
A |
13: 54,867,305 (GRCm39) |
L408Q |
probably damaging |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Chd1 |
T |
C |
17: 15,990,499 (GRCm39) |
S1684P |
probably damaging |
Het |
| CN725425 |
A |
G |
15: 91,126,873 (GRCm39) |
Y221C |
possibly damaging |
Het |
| Col4a2 |
T |
C |
8: 11,448,678 (GRCm39) |
V66A |
probably damaging |
Het |
| Cpd |
C |
A |
11: 76,737,779 (GRCm39) |
R5L |
unknown |
Het |
| Cpeb4 |
C |
T |
11: 31,868,807 (GRCm39) |
T422I |
possibly damaging |
Het |
| Cspg4b |
G |
T |
13: 113,454,706 (GRCm39) |
G251C |
|
Het |
| Cyp1a1 |
G |
T |
9: 57,608,107 (GRCm39) |
R245L |
probably damaging |
Het |
| Cyp4f39 |
A |
G |
17: 32,705,928 (GRCm39) |
T340A |
probably damaging |
Het |
| Cyp4v3 |
A |
T |
8: 45,774,787 (GRCm39) |
F122L |
probably benign |
Het |
| Drc1 |
T |
A |
5: 30,521,812 (GRCm39) |
L728Q |
probably damaging |
Het |
| Dsel |
C |
T |
1: 111,789,303 (GRCm39) |
G411S |
probably damaging |
Het |
| Ecpas |
A |
T |
4: 58,809,415 (GRCm39) |
V1653D |
possibly damaging |
Het |
| Ermp1 |
T |
A |
19: 29,623,654 (GRCm39) |
H112L |
probably benign |
Het |
| Exoc8 |
T |
C |
8: 125,623,320 (GRCm39) |
D349G |
probably damaging |
Het |
| Fam151a |
T |
A |
4: 106,592,707 (GRCm39) |
M63K |
probably benign |
Het |
| Fmo9 |
C |
A |
1: 166,504,115 (GRCm39) |
G149V |
probably damaging |
Het |
| Fndc8 |
A |
G |
11: 82,789,603 (GRCm39) |
T254A |
possibly damaging |
Het |
| Foxi3 |
G |
A |
6: 70,937,862 (GRCm39) |
V365I |
probably benign |
Het |
| Frem2 |
C |
T |
3: 53,561,916 (GRCm39) |
G864S |
probably damaging |
Het |
| Fstl5 |
T |
A |
3: 76,389,704 (GRCm39) |
|
probably null |
Het |
| Garnl3 |
T |
A |
2: 32,924,141 (GRCm39) |
E247V |
probably damaging |
Het |
| Gdi1 |
G |
A |
X: 73,350,461 (GRCm39) |
R55H |
probably benign |
Het |
| Gorasp1 |
T |
A |
9: 119,766,600 (GRCm39) |
|
probably benign |
Het |
| Hcar2 |
T |
C |
5: 124,002,541 (GRCm39) |
N321D |
possibly damaging |
Het |
| Hoxb6 |
G |
T |
11: 96,190,395 (GRCm39) |
M131I |
probably damaging |
Het |
| Kif13a |
A |
G |
13: 46,980,221 (GRCm39) |
V177A |
probably damaging |
Het |
| Limch1 |
C |
T |
5: 67,191,545 (GRCm39) |
T794I |
probably benign |
Het |
| Lmbrd2 |
A |
G |
15: 9,165,906 (GRCm39) |
Y260C |
possibly damaging |
Het |
| Lrp6 |
G |
T |
6: 134,427,781 (GRCm39) |
P1604T |
probably damaging |
Het |
| Lrrc14 |
A |
T |
15: 76,598,711 (GRCm39) |
E449V |
probably damaging |
Het |
| Lrrc8c |
T |
C |
5: 105,755,133 (GRCm39) |
Y303H |
probably damaging |
Het |
| Mecr |
T |
G |
4: 131,570,986 (GRCm39) |
V58G |
probably null |
Het |
| Med12l |
T |
A |
3: 58,949,824 (GRCm39) |
D193E |
possibly damaging |
Het |
| Moap1 |
T |
C |
12: 102,709,438 (GRCm39) |
E37G |
probably damaging |
Het |
| Mrgprb2 |
T |
A |
7: 48,202,644 (GRCm39) |
Y27F |
probably benign |
Het |
| Ms4a6d |
G |
A |
19: 11,567,437 (GRCm39) |
Q155* |
probably null |
Het |
| Ndufs5 |
A |
T |
4: 123,609,744 (GRCm39) |
C43* |
probably null |
Het |
| Oaz2 |
A |
T |
9: 65,596,183 (GRCm39) |
D83V |
|
Het |
| Or2t29 |
A |
T |
11: 58,433,533 (GRCm39) |
Y269* |
probably null |
Het |
| Or5ac22 |
T |
A |
16: 59,135,512 (GRCm39) |
N86I |
possibly damaging |
Het |
| Palm |
A |
G |
10: 79,652,697 (GRCm39) |
T191A |
probably damaging |
Het |
| Pclo |
C |
A |
5: 14,725,850 (GRCm39) |
D1569E |
unknown |
Het |
| Ppid |
T |
A |
3: 79,507,604 (GRCm39) |
D264E |
probably benign |
Het |
| Ppp1r3a |
A |
G |
6: 14,718,749 (GRCm39) |
S722P |
probably damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,321,619 (GRCm39) |
S2639G |
possibly damaging |
Het |
| Rbak |
T |
C |
5: 143,161,827 (GRCm39) |
T68A |
probably benign |
Het |
| Rbm15b |
C |
T |
9: 106,762,246 (GRCm39) |
G641R |
probably benign |
Het |
| Rgsl1 |
A |
G |
1: 153,669,591 (GRCm39) |
I265T |
probably benign |
Het |
| Rmdn1 |
T |
A |
4: 19,586,837 (GRCm39) |
Y98* |
probably null |
Het |
| Sfxn3 |
T |
G |
19: 45,037,701 (GRCm39) |
N52K |
probably benign |
Het |
| Slc17a3 |
G |
T |
13: 24,030,867 (GRCm39) |
G182* |
probably null |
Het |
| Slc29a3 |
A |
T |
10: 60,586,437 (GRCm39) |
Y10N |
probably benign |
Het |
| Slc43a1 |
T |
C |
2: 84,693,278 (GRCm39) |
Y577H |
probably damaging |
Het |
| Smarcd3 |
T |
A |
5: 24,800,435 (GRCm39) |
I210F |
possibly damaging |
Het |
| Snapc4 |
A |
T |
2: 26,259,273 (GRCm39) |
S626T |
probably benign |
Het |
| Sp5 |
T |
A |
2: 70,307,041 (GRCm39) |
L242* |
probably null |
Het |
| Spata25 |
C |
G |
2: 164,669,582 (GRCm39) |
G143A |
probably damaging |
Het |
| Spata6 |
T |
A |
4: 111,625,935 (GRCm39) |
Y101* |
probably null |
Het |
| Tdp2 |
T |
G |
13: 25,016,059 (GRCm39) |
S89A |
probably benign |
Het |
| Tlr6 |
T |
C |
5: 65,110,972 (GRCm39) |
E645G |
probably benign |
Het |
| Tmem209 |
T |
C |
6: 30,494,794 (GRCm39) |
I355V |
probably benign |
Het |
| Trappc8 |
A |
T |
18: 20,985,704 (GRCm39) |
Y646N |
probably damaging |
Het |
| Tspoap1 |
A |
G |
11: 87,657,205 (GRCm39) |
N399S |
probably damaging |
Het |
| Ube4b |
A |
G |
4: 149,427,458 (GRCm39) |
Y897H |
probably damaging |
Het |
| Urb1 |
CACTTAC |
CAC |
16: 90,569,461 (GRCm39) |
|
probably benign |
Het |
| Usp9y |
A |
T |
Y: 1,315,759 (GRCm39) |
|
probably null |
Het |
| Vmn2r1 |
T |
C |
3: 64,012,877 (GRCm39) |
*913Q |
probably null |
Het |
| Vmn2r12 |
T |
A |
5: 109,234,113 (GRCm39) |
T700S |
possibly damaging |
Het |
| Vmn2r12 |
C |
T |
5: 109,239,811 (GRCm39) |
A251T |
possibly damaging |
Het |
| Wdr70 |
A |
C |
15: 7,953,725 (GRCm39) |
F389V |
possibly damaging |
Het |
| Wdr91 |
A |
T |
6: 34,868,395 (GRCm39) |
M442K |
possibly damaging |
Het |
| Ydjc |
T |
C |
16: 16,968,762 (GRCm39) |
C234R |
probably benign |
Het |
| Zfp87 |
A |
G |
13: 74,520,467 (GRCm39) |
Y204H |
possibly damaging |
Het |
|
| Other mutations in Lmo7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00569:Lmo7
|
APN |
14 |
102,124,487 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00733:Lmo7
|
APN |
14 |
102,153,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00778:Lmo7
|
APN |
14 |
102,148,321 (GRCm39) |
splice site |
probably benign |
|
|
IGL01014:Lmo7
|
APN |
14 |
102,157,993 (GRCm39) |
splice site |
probably benign |
|
|
IGL01401:Lmo7
|
APN |
14 |
102,031,713 (GRCm39) |
nonsense |
probably null |
|
|
IGL01550:Lmo7
|
APN |
14 |
102,163,576 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL01570:Lmo7
|
APN |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01602:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL01605:Lmo7
|
APN |
14 |
102,148,192 (GRCm39) |
splice site |
probably benign |
|
|
IGL02012:Lmo7
|
APN |
14 |
102,126,152 (GRCm39) |
intron |
probably benign |
|
|
IGL02145:Lmo7
|
APN |
14 |
102,139,659 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02236:Lmo7
|
APN |
14 |
102,163,524 (GRCm39) |
splice site |
probably benign |
|
|
IGL02318:Lmo7
|
APN |
14 |
102,137,502 (GRCm39) |
splice site |
probably benign |
|
|
IGL02345:Lmo7
|
APN |
14 |
102,124,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02498:Lmo7
|
APN |
14 |
102,044,918 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02583:Lmo7
|
APN |
14 |
102,171,360 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL02670:Lmo7
|
APN |
14 |
102,118,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02694:Lmo7
|
APN |
14 |
102,124,606 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03026:Lmo7
|
APN |
14 |
102,166,769 (GRCm39) |
utr 3 prime |
probably benign |
|
|
IGL03062:Lmo7
|
APN |
14 |
102,149,515 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
IGL03068:Lmo7
|
APN |
14 |
102,112,928 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03178:Lmo7
|
APN |
14 |
102,166,696 (GRCm39) |
nonsense |
probably null |
|
|
IGL03279:Lmo7
|
APN |
14 |
102,137,944 (GRCm39) |
missense |
probably benign |
0.30 |
|
PIT4458001:Lmo7
|
UTSW |
14 |
102,124,923 (GRCm39) |
nonsense |
probably null |
|
|
R0029:Lmo7
|
UTSW |
14 |
102,171,357 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R0112:Lmo7
|
UTSW |
14 |
102,124,629 (GRCm39) |
nonsense |
probably null |
|
|
R0345:Lmo7
|
UTSW |
14 |
102,114,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0372:Lmo7
|
UTSW |
14 |
102,155,489 (GRCm39) |
splice site |
probably benign |
|
|
R0393:Lmo7
|
UTSW |
14 |
102,137,892 (GRCm39) |
missense |
probably benign |
|
|
R0514:Lmo7
|
UTSW |
14 |
102,133,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0514:Lmo7
|
UTSW |
14 |
102,124,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0526:Lmo7
|
UTSW |
14 |
102,137,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0615:Lmo7
|
UTSW |
14 |
102,114,295 (GRCm39) |
nonsense |
probably null |
|
|
R0900:Lmo7
|
UTSW |
14 |
102,124,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0961:Lmo7
|
UTSW |
14 |
102,031,705 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0964:Lmo7
|
UTSW |
14 |
102,158,003 (GRCm39) |
splice site |
probably benign |
|
|
R1078:Lmo7
|
UTSW |
14 |
102,157,910 (GRCm39) |
splice site |
probably benign |
|
|
R1252:Lmo7
|
UTSW |
14 |
102,138,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1527:Lmo7
|
UTSW |
14 |
102,114,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1537:Lmo7
|
UTSW |
14 |
102,166,700 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R1565:Lmo7
|
UTSW |
14 |
102,124,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1637:Lmo7
|
UTSW |
14 |
102,118,268 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1943:Lmo7
|
UTSW |
14 |
102,139,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Lmo7
|
UTSW |
14 |
102,137,651 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2002:Lmo7
|
UTSW |
14 |
102,124,497 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2057:Lmo7
|
UTSW |
14 |
102,124,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Lmo7
|
UTSW |
14 |
102,137,674 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2153:Lmo7
|
UTSW |
14 |
102,157,951 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R2257:Lmo7
|
UTSW |
14 |
102,137,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2355:Lmo7
|
UTSW |
14 |
102,126,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2356:Lmo7
|
UTSW |
14 |
102,124,381 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2898:Lmo7
|
UTSW |
14 |
102,114,350 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3847:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3848:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3849:Lmo7
|
UTSW |
14 |
102,159,531 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R3916:Lmo7
|
UTSW |
14 |
102,166,778 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R4050:Lmo7
|
UTSW |
14 |
102,139,713 (GRCm39) |
nonsense |
probably null |
|
|
R4326:Lmo7
|
UTSW |
14 |
102,137,510 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4357:Lmo7
|
UTSW |
14 |
102,125,091 (GRCm39) |
missense |
probably null |
1.00 |
|
R4571:Lmo7
|
UTSW |
14 |
102,125,030 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4658:Lmo7
|
UTSW |
14 |
102,124,393 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4857:Lmo7
|
UTSW |
14 |
102,124,784 (GRCm39) |
splice site |
probably null |
|
|
R5006:Lmo7
|
UTSW |
14 |
102,163,673 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5528:Lmo7
|
UTSW |
14 |
102,139,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5588:Lmo7
|
UTSW |
14 |
102,134,026 (GRCm39) |
splice site |
probably null |
|
|
R5643:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5644:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R5650:Lmo7
|
UTSW |
14 |
102,136,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5737:Lmo7
|
UTSW |
14 |
102,124,672 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5832:Lmo7
|
UTSW |
14 |
102,121,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5966:Lmo7
|
UTSW |
14 |
102,137,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6026:Lmo7
|
UTSW |
14 |
102,118,426 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6072:Lmo7
|
UTSW |
14 |
102,166,772 (GRCm39) |
utr 3 prime |
probably benign |
|
|
R6158:Lmo7
|
UTSW |
14 |
102,137,573 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6246:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6335:Lmo7
|
UTSW |
14 |
102,138,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6620:Lmo7
|
UTSW |
14 |
102,112,888 (GRCm39) |
missense |
probably benign |
0.29 |
|
R6658:Lmo7
|
UTSW |
14 |
102,148,281 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6917:Lmo7
|
UTSW |
14 |
102,155,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7064:Lmo7
|
UTSW |
14 |
102,121,615 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7072:Lmo7
|
UTSW |
14 |
102,136,136 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7121:Lmo7
|
UTSW |
14 |
102,124,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7136:Lmo7
|
UTSW |
14 |
102,157,975 (GRCm39) |
missense |
unknown |
|
|
R7196:Lmo7
|
UTSW |
14 |
102,133,936 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R7228:Lmo7
|
UTSW |
14 |
102,133,971 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7337:Lmo7
|
UTSW |
14 |
102,121,640 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7408:Lmo7
|
UTSW |
14 |
102,118,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Lmo7
|
UTSW |
14 |
102,139,551 (GRCm39) |
missense |
probably benign |
0.42 |
|
R7470:Lmo7
|
UTSW |
14 |
102,138,040 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7506:Lmo7
|
UTSW |
14 |
102,157,045 (GRCm39) |
missense |
unknown |
|
|
R7559:Lmo7
|
UTSW |
14 |
102,124,662 (GRCm39) |
nonsense |
probably null |
|
|
R7565:Lmo7
|
UTSW |
14 |
102,122,737 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7788:Lmo7
|
UTSW |
14 |
102,136,012 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8095:Lmo7
|
UTSW |
14 |
102,124,855 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8100:Lmo7
|
UTSW |
14 |
102,137,899 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8121:Lmo7
|
UTSW |
14 |
102,163,736 (GRCm39) |
missense |
unknown |
|
|
R8308:Lmo7
|
UTSW |
14 |
102,139,807 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8371:Lmo7
|
UTSW |
14 |
102,124,444 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8403:Lmo7
|
UTSW |
14 |
102,139,800 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8690:Lmo7
|
UTSW |
14 |
102,168,644 (GRCm39) |
missense |
unknown |
|
|
R8778:Lmo7
|
UTSW |
14 |
102,156,655 (GRCm39) |
missense |
probably benign |
0.24 |
|
R8778:Lmo7
|
UTSW |
14 |
102,149,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8822:Lmo7
|
UTSW |
14 |
102,121,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Lmo7
|
UTSW |
14 |
102,163,543 (GRCm39) |
missense |
unknown |
|
|
R8923:Lmo7
|
UTSW |
14 |
102,137,679 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9006:Lmo7
|
UTSW |
14 |
102,155,072 (GRCm39) |
small deletion |
probably benign |
|
|
R9135:Lmo7
|
UTSW |
14 |
102,118,297 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9154:Lmo7
|
UTSW |
14 |
102,122,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9178:Lmo7
|
UTSW |
14 |
102,044,906 (GRCm39) |
nonsense |
probably null |
|
|
R9375:Lmo7
|
UTSW |
14 |
102,136,123 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9428:Lmo7
|
UTSW |
14 |
102,155,076 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9488:Lmo7
|
UTSW |
14 |
102,122,783 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9493:Lmo7
|
UTSW |
14 |
102,137,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9594:Lmo7
|
UTSW |
14 |
102,156,136 (GRCm39) |
missense |
probably null |
0.98 |
|
R9674:Lmo7
|
UTSW |
14 |
102,078,340 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9736:Lmo7
|
UTSW |
14 |
102,157,929 (GRCm39) |
missense |
unknown |
|
|
X0066:Lmo7
|
UTSW |
14 |
102,124,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0067:Lmo7
|
UTSW |
14 |
102,124,369 (GRCm39) |
splice site |
probably null |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,717 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,121,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lmo7
|
UTSW |
14 |
102,166,664 (GRCm39) |
missense |
unknown |
|
|
Z1176:Lmo7
|
UTSW |
14 |
102,156,879 (GRCm39) |
missense |
unknown |
|
|
Z1177:Lmo7
|
UTSW |
14 |
102,135,993 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Lmo7
|
UTSW |
14 |
102,133,954 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTTGAACAGTACCCAGAGGAG -3'
(R):5'- TCTACAGATGTTAGAGGGCAAATC -3'
Sequencing Primer
(F):5'- ATGGAGACCTGGCACACAGTC -3'
(R):5'- GGCAAATCAAGCTTTCTGGC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation