Incidental Mutation 'R7341:Chd1'
| ID |
569896 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Chd1
|
| Ensembl Gene |
ENSMUSG00000023852 |
| Gene Name |
chromodomain helicase DNA binding protein 1 |
| Synonyms |
4930525N21Rik |
| MMRRC Submission |
045431-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7341 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
15704967-15772610 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 15770237 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1684
(S1684P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000024627
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000024627]
|
| AlphaFold |
P40201 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000024627
AA Change: S1684P
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000024627
Gene: ENSMUSG00000023852
AA Change: S1684P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
17 |
67 |
N/A |
INTRINSIC |
|
low complexity region
|
105 |
115 |
N/A |
INTRINSIC |
|
low complexity region
|
116 |
136 |
N/A |
INTRINSIC |
|
low complexity region
|
151 |
175 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
230 |
N/A |
INTRINSIC |
|
CHROMO
|
268 |
355 |
6.43e-20 |
SMART |
|
CHROMO
|
385 |
443 |
1.19e-14 |
SMART |
|
DEXDc
|
475 |
672 |
3.44e-34 |
SMART |
|
Blast:DEXDc
|
692 |
786 |
2e-54 |
BLAST |
|
low complexity region
|
787 |
799 |
N/A |
INTRINSIC |
|
HELICc
|
816 |
900 |
8.48e-25 |
SMART |
|
Blast:DEXDc
|
955 |
1234 |
1e-112 |
BLAST |
|
PDB:4B4C|A
|
1119 |
1320 |
1e-132 |
PDB |
|
low complexity region
|
1325 |
1348 |
N/A |
INTRINSIC |
|
low complexity region
|
1377 |
1388 |
N/A |
INTRINSIC |
|
DUF4208
|
1396 |
1500 |
5.54e-51 |
SMART |
|
low complexity region
|
1507 |
1516 |
N/A |
INTRINSIC |
|
low complexity region
|
1538 |
1549 |
N/A |
INTRINSIC |
|
low complexity region
|
1626 |
1650 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
100% (92/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The CHD family of proteins is characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. CHD genes alter gene expression possibly by modification of chromatin structure thus altering access of the transcriptional apparatus to its chromosomal DNA template. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit complete embryonic lethality associated with arrest of epiblast development due to increased apoptosis and cell cycle defects, abnormal rostral-caudal axis patterning, and failure to gastrulate. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 90 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
C |
T |
2: 69,299,867 (GRCm38) |
D282N |
probably damaging |
Het |
| Adam3 |
T |
A |
8: 24,687,980 (GRCm38) |
N639I |
possibly damaging |
Het |
| Adamtsl3 |
T |
A |
7: 82,556,874 (GRCm38) |
C756S |
probably damaging |
Het |
| AI314180 |
A |
T |
4: 58,809,415 (GRCm38) |
V1653D |
possibly damaging |
Het |
| Arhgap31 |
C |
T |
16: 38,712,514 (GRCm38) |
|
probably null |
Het |
| Ascl4 |
G |
A |
10: 85,928,665 (GRCm38) |
A59T |
possibly damaging |
Het |
| Ash1l |
T |
A |
3: 88,981,759 (GRCm38) |
I315N |
possibly damaging |
Het |
| Atp6v0d2 |
T |
C |
4: 19,887,330 (GRCm38) |
D206G |
possibly damaging |
Het |
| Baz1b |
T |
A |
5: 135,223,116 (GRCm38) |
L923I |
probably damaging |
Het |
| BC067074 |
G |
T |
13: 113,318,172 (GRCm38) |
G251C |
|
Het |
| Birc6 |
T |
A |
17: 74,612,074 (GRCm38) |
N1966K |
probably damaging |
Het |
| Bod1l |
T |
C |
5: 41,788,857 (GRCm38) |
N3025S |
probably benign |
Het |
| Bub1b |
C |
A |
2: 118,636,786 (GRCm38) |
H863Q |
possibly damaging |
Het |
| C1rb |
T |
A |
6: 124,577,452 (GRCm38) |
Y397* |
probably null |
Het |
| Ccdc180 |
A |
G |
4: 45,898,644 (GRCm38) |
E164G |
possibly damaging |
Het |
| Ccdc9 |
C |
T |
7: 16,280,627 (GRCm38) |
V230M |
probably damaging |
Het |
| Cchcr1 |
C |
A |
17: 35,526,713 (GRCm38) |
N437K |
probably benign |
Het |
| Cdhr2 |
T |
A |
13: 54,719,492 (GRCm38) |
L408Q |
probably damaging |
Het |
| Cep89 |
G |
A |
7: 35,429,928 (GRCm38) |
R630H |
probably damaging |
Het |
| CN725425 |
A |
G |
15: 91,242,670 (GRCm38) |
Y221C |
possibly damaging |
Het |
| Col4a2 |
T |
C |
8: 11,398,678 (GRCm38) |
V66A |
probably damaging |
Het |
| Cpd |
C |
A |
11: 76,846,953 (GRCm38) |
R5L |
unknown |
Het |
| Cpeb4 |
C |
T |
11: 31,918,807 (GRCm38) |
T422I |
possibly damaging |
Het |
| Cyp1a1 |
G |
T |
9: 57,700,824 (GRCm38) |
R245L |
probably damaging |
Het |
| Cyp4f39 |
A |
G |
17: 32,486,954 (GRCm38) |
T340A |
probably damaging |
Het |
| Cyp4v3 |
A |
T |
8: 45,321,750 (GRCm38) |
F122L |
probably benign |
Het |
| Drc1 |
T |
A |
5: 30,364,468 (GRCm38) |
L728Q |
probably damaging |
Het |
| Dsel |
C |
T |
1: 111,861,573 (GRCm38) |
G411S |
probably damaging |
Het |
| Ermp1 |
T |
A |
19: 29,646,254 (GRCm38) |
H112L |
probably benign |
Het |
| Exoc8 |
T |
C |
8: 124,896,581 (GRCm38) |
D349G |
probably damaging |
Het |
| Fam151a |
T |
A |
4: 106,735,510 (GRCm38) |
M63K |
probably benign |
Het |
| Fmo9 |
C |
A |
1: 166,676,546 (GRCm38) |
G149V |
probably damaging |
Het |
| Fndc8 |
A |
G |
11: 82,898,777 (GRCm38) |
T254A |
possibly damaging |
Het |
| Foxi3 |
G |
A |
6: 70,960,878 (GRCm38) |
V365I |
probably benign |
Het |
| Frem2 |
C |
T |
3: 53,654,495 (GRCm38) |
G864S |
probably damaging |
Het |
| Fstl5 |
T |
A |
3: 76,482,397 (GRCm38) |
|
probably null |
Het |
| Garnl3 |
T |
A |
2: 33,034,129 (GRCm38) |
E247V |
probably damaging |
Het |
| Gdi1 |
G |
A |
X: 74,306,855 (GRCm38) |
R55H |
probably benign |
Het |
| Gorasp1 |
T |
A |
9: 119,937,534 (GRCm38) |
|
probably benign |
Het |
| Hcar2 |
T |
C |
5: 123,864,478 (GRCm38) |
N321D |
possibly damaging |
Het |
| Hoxb6 |
G |
T |
11: 96,299,569 (GRCm38) |
M131I |
probably damaging |
Het |
| Kif13a |
A |
G |
13: 46,826,745 (GRCm38) |
V177A |
probably damaging |
Het |
| Limch1 |
C |
T |
5: 67,034,202 (GRCm38) |
T794I |
probably benign |
Het |
| Lmbrd2 |
A |
G |
15: 9,165,819 (GRCm38) |
Y260C |
possibly damaging |
Het |
| Lmo7 |
A |
G |
14: 101,885,512 (GRCm38) |
N379S |
probably benign |
Het |
| Lrp6 |
G |
T |
6: 134,450,818 (GRCm38) |
P1604T |
probably damaging |
Het |
| Lrrc14 |
A |
T |
15: 76,714,511 (GRCm38) |
E449V |
probably damaging |
Het |
| Lrrc8c |
T |
C |
5: 105,607,267 (GRCm38) |
Y303H |
probably damaging |
Het |
| Mecr |
T |
G |
4: 131,843,675 (GRCm38) |
V58G |
probably null |
Het |
| Med12l |
T |
A |
3: 59,042,403 (GRCm38) |
D193E |
possibly damaging |
Het |
| Moap1 |
T |
C |
12: 102,743,179 (GRCm38) |
E37G |
probably damaging |
Het |
| Mrgprb2 |
T |
A |
7: 48,552,896 (GRCm38) |
Y27F |
probably benign |
Het |
| Ms4a6d |
G |
A |
19: 11,590,073 (GRCm38) |
Q155* |
probably null |
Het |
| Ndufs5 |
A |
T |
4: 123,715,951 (GRCm38) |
C43* |
probably null |
Het |
| Oaz2 |
A |
T |
9: 65,688,901 (GRCm38) |
D83V |
|
Het |
| Olfr204 |
T |
A |
16: 59,315,149 (GRCm38) |
N86I |
possibly damaging |
Het |
| Olfr329-ps |
A |
T |
11: 58,542,707 (GRCm38) |
Y269* |
probably null |
Het |
| Palm |
A |
G |
10: 79,816,863 (GRCm38) |
T191A |
probably damaging |
Het |
| Pclo |
C |
A |
5: 14,675,836 (GRCm38) |
D1569E |
unknown |
Het |
| Ppid |
T |
A |
3: 79,600,297 (GRCm38) |
D264E |
probably benign |
Het |
| Ppp1r3a |
A |
G |
6: 14,718,750 (GRCm38) |
S722P |
probably damaging |
Het |
| Ranbp2 |
A |
G |
10: 58,485,797 (GRCm38) |
S2639G |
possibly damaging |
Het |
| Rbak |
T |
C |
5: 143,176,072 (GRCm38) |
T68A |
probably benign |
Het |
| Rbm15b |
C |
T |
9: 106,885,047 (GRCm38) |
G641R |
probably benign |
Het |
| Rgsl1 |
A |
G |
1: 153,793,845 (GRCm38) |
I265T |
probably benign |
Het |
| Rmdn1 |
T |
A |
4: 19,586,837 (GRCm38) |
Y98* |
probably null |
Het |
| Sfxn3 |
T |
G |
19: 45,049,262 (GRCm38) |
N52K |
probably benign |
Het |
| Slc17a3 |
G |
T |
13: 23,846,884 (GRCm38) |
G182* |
probably null |
Het |
| Slc29a3 |
A |
T |
10: 60,750,658 (GRCm38) |
Y10N |
probably benign |
Het |
| Slc43a1 |
T |
C |
2: 84,862,934 (GRCm38) |
Y577H |
probably damaging |
Het |
| Smarcd3 |
T |
A |
5: 24,595,437 (GRCm38) |
I210F |
possibly damaging |
Het |
| Snapc4 |
A |
T |
2: 26,369,261 (GRCm38) |
S626T |
probably benign |
Het |
| Sp5 |
T |
A |
2: 70,476,697 (GRCm38) |
L242* |
probably null |
Het |
| Spata25 |
C |
G |
2: 164,827,662 (GRCm38) |
G143A |
probably damaging |
Het |
| Spata6 |
T |
A |
4: 111,768,738 (GRCm38) |
Y101* |
probably null |
Het |
| Tdp2 |
T |
G |
13: 24,832,076 (GRCm38) |
S89A |
probably benign |
Het |
| Tlr6 |
T |
C |
5: 64,953,629 (GRCm38) |
E645G |
probably benign |
Het |
| Tmem209 |
T |
C |
6: 30,494,795 (GRCm38) |
I355V |
probably benign |
Het |
| Trappc8 |
A |
T |
18: 20,852,647 (GRCm38) |
Y646N |
probably damaging |
Het |
| Tspoap1 |
A |
G |
11: 87,766,379 (GRCm38) |
N399S |
probably damaging |
Het |
| Ube4b |
A |
G |
4: 149,343,001 (GRCm38) |
Y897H |
probably damaging |
Het |
| Urb1 |
CACTTAC |
CAC |
16: 90,772,573 (GRCm38) |
|
probably benign |
Het |
| Usp9y |
A |
T |
Y: 1,315,759 (GRCm38) |
|
probably null |
Het |
| Vmn2r1 |
T |
C |
3: 64,105,456 (GRCm38) |
*913Q |
probably null |
Het |
| Vmn2r12 |
C |
T |
5: 109,091,945 (GRCm38) |
A251T |
possibly damaging |
Het |
| Vmn2r12 |
T |
A |
5: 109,086,247 (GRCm38) |
T700S |
possibly damaging |
Het |
| Wdr70 |
A |
C |
15: 7,924,244 (GRCm38) |
F389V |
possibly damaging |
Het |
| Wdr91 |
A |
T |
6: 34,891,460 (GRCm38) |
M442K |
possibly damaging |
Het |
| Ydjc |
T |
C |
16: 17,150,898 (GRCm38) |
C234R |
probably benign |
Het |
| Zfp72 |
A |
G |
13: 74,372,348 (GRCm38) |
Y204H |
possibly damaging |
Het |
|
| Other mutations in Chd1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00704:Chd1
|
APN |
17 |
15,732,565 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL01356:Chd1
|
APN |
17 |
15,749,865 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01369:Chd1
|
APN |
17 |
15,754,997 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL01519:Chd1
|
APN |
17 |
17,378,569 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01604:Chd1
|
APN |
17 |
15,770,097 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL01635:Chd1
|
APN |
17 |
17,378,596 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01721:Chd1
|
APN |
17 |
15,770,168 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01959:Chd1
|
APN |
17 |
15,742,173 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02367:Chd1
|
APN |
17 |
17,390,053 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL02476:Chd1
|
APN |
17 |
15,734,273 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02756:Chd1
|
APN |
17 |
15,730,807 (GRCm38) |
missense |
probably damaging |
0.97 |
|
IGL02817:Chd1
|
APN |
17 |
15,749,500 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL03084:Chd1
|
APN |
17 |
15,770,298 (GRCm38) |
missense |
probably benign |
0.22 |
|
IGL03108:Chd1
|
APN |
17 |
15,725,281 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
Holly
|
UTSW |
17 |
15,726,283 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R0053:Chd1
|
UTSW |
17 |
15,747,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0053:Chd1
|
UTSW |
17 |
15,747,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0128:Chd1
|
UTSW |
17 |
17,393,567 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0197:Chd1
|
UTSW |
17 |
15,725,431 (GRCm38) |
missense |
probably benign |
|
|
R0285:Chd1
|
UTSW |
17 |
17,374,680 (GRCm38) |
splice site |
probably benign |
|
|
R0326:Chd1
|
UTSW |
17 |
15,768,568 (GRCm38) |
missense |
probably benign |
|
|
R0326:Chd1
|
UTSW |
17 |
15,768,566 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0372:Chd1
|
UTSW |
17 |
17,387,290 (GRCm38) |
missense |
probably benign |
0.14 |
|
R0391:Chd1
|
UTSW |
17 |
15,749,894 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0486:Chd1
|
UTSW |
17 |
15,734,342 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0637:Chd1
|
UTSW |
17 |
15,742,288 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R0675:Chd1
|
UTSW |
17 |
15,758,261 (GRCm38) |
unclassified |
probably benign |
|
|
R0701:Chd1
|
UTSW |
17 |
15,725,431 (GRCm38) |
missense |
probably benign |
|
|
R0788:Chd1
|
UTSW |
17 |
15,707,114 (GRCm38) |
missense |
possibly damaging |
0.86 |
|
R0848:Chd1
|
UTSW |
17 |
15,770,241 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0883:Chd1
|
UTSW |
17 |
15,725,431 (GRCm38) |
missense |
probably benign |
|
|
R1169:Chd1
|
UTSW |
17 |
15,735,732 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1218:Chd1
|
UTSW |
17 |
15,725,312 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1370:Chd1
|
UTSW |
17 |
17,387,480 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1470:Chd1
|
UTSW |
17 |
15,726,283 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R1470:Chd1
|
UTSW |
17 |
15,726,283 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R1478:Chd1
|
UTSW |
17 |
15,739,507 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1752:Chd1
|
UTSW |
17 |
15,743,232 (GRCm38) |
critical splice donor site |
probably null |
|
|
R1759:Chd1
|
UTSW |
17 |
17,387,271 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1767:Chd1
|
UTSW |
17 |
15,770,303 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1938:Chd1
|
UTSW |
17 |
15,762,486 (GRCm38) |
missense |
probably benign |
0.39 |
|
R2007:Chd1
|
UTSW |
17 |
15,731,006 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2069:Chd1
|
UTSW |
17 |
15,742,294 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3771:Chd1
|
UTSW |
17 |
17,374,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3773:Chd1
|
UTSW |
17 |
17,374,651 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3849:Chd1
|
UTSW |
17 |
15,731,871 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4241:Chd1
|
UTSW |
17 |
15,770,027 (GRCm38) |
nonsense |
probably null |
|
|
R4242:Chd1
|
UTSW |
17 |
15,770,027 (GRCm38) |
nonsense |
probably null |
|
|
R4354:Chd1
|
UTSW |
17 |
17,390,001 (GRCm38) |
missense |
probably benign |
0.23 |
|
R4468:Chd1
|
UTSW |
17 |
15,760,395 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4469:Chd1
|
UTSW |
17 |
15,760,395 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R4731:Chd1
|
UTSW |
17 |
17,377,817 (GRCm38) |
missense |
probably benign |
0.36 |
|
R4824:Chd1
|
UTSW |
17 |
15,733,124 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4840:Chd1
|
UTSW |
17 |
15,768,754 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4840:Chd1
|
UTSW |
17 |
15,768,753 (GRCm38) |
nonsense |
probably null |
|
|
R4880:Chd1
|
UTSW |
17 |
17,374,654 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4960:Chd1
|
UTSW |
17 |
15,742,231 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R5071:Chd1
|
UTSW |
17 |
15,762,405 (GRCm38) |
missense |
probably benign |
|
|
R5078:Chd1
|
UTSW |
17 |
15,726,354 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R5114:Chd1
|
UTSW |
17 |
15,728,198 (GRCm38) |
missense |
probably benign |
0.25 |
|
R5268:Chd1
|
UTSW |
17 |
15,735,743 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5304:Chd1
|
UTSW |
17 |
15,770,268 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R5304:Chd1
|
UTSW |
17 |
15,754,951 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5307:Chd1
|
UTSW |
17 |
15,732,570 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5458:Chd1
|
UTSW |
17 |
15,738,549 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5553:Chd1
|
UTSW |
17 |
17,385,613 (GRCm38) |
missense |
probably benign |
0.17 |
|
R5623:Chd1
|
UTSW |
17 |
15,754,932 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6022:Chd1
|
UTSW |
17 |
17,377,773 (GRCm38) |
missense |
probably benign |
0.39 |
|
R6137:Chd1
|
UTSW |
17 |
15,758,688 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6257:Chd1
|
UTSW |
17 |
15,730,203 (GRCm38) |
splice site |
probably null |
|
|
R6373:Chd1
|
UTSW |
17 |
15,738,636 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6458:Chd1
|
UTSW |
17 |
15,730,602 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6476:Chd1
|
UTSW |
17 |
17,380,988 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6508:Chd1
|
UTSW |
17 |
15,738,633 (GRCm38) |
missense |
probably benign |
0.31 |
|
R6553:Chd1
|
UTSW |
17 |
15,725,430 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6745:Chd1
|
UTSW |
17 |
17,387,167 (GRCm38) |
missense |
probably benign |
0.08 |
|
R7107:Chd1
|
UTSW |
17 |
15,761,366 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R7230:Chd1
|
UTSW |
17 |
15,706,937 (GRCm38) |
splice site |
probably null |
|
|
R7317:Chd1
|
UTSW |
17 |
15,742,274 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R7421:Chd1
|
UTSW |
17 |
15,749,398 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7704:Chd1
|
UTSW |
17 |
15,767,475 (GRCm38) |
missense |
probably benign |
|
|
R7763:Chd1
|
UTSW |
17 |
15,733,041 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8156:Chd1
|
UTSW |
17 |
15,761,404 (GRCm38) |
missense |
probably benign |
|
|
R8194:Chd1
|
UTSW |
17 |
17,374,475 (GRCm38) |
start gained |
probably benign |
|
|
R8261:Chd1
|
UTSW |
17 |
17,387,542 (GRCm38) |
missense |
probably benign |
0.02 |
|
R8338:Chd1
|
UTSW |
17 |
15,769,980 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8401:Chd1
|
UTSW |
17 |
15,743,211 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8411:Chd1
|
UTSW |
17 |
15,762,449 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R9067:Chd1
|
UTSW |
17 |
15,730,845 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R9184:Chd1
|
UTSW |
17 |
15,742,289 (GRCm38) |
missense |
possibly damaging |
0.71 |
|
R9210:Chd1
|
UTSW |
17 |
15,730,505 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9212:Chd1
|
UTSW |
17 |
15,730,505 (GRCm38) |
missense |
possibly damaging |
0.70 |
|
R9666:Chd1
|
UTSW |
17 |
15,735,714 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9673:Chd1
|
UTSW |
17 |
15,768,761 (GRCm38) |
missense |
probably benign |
0.24 |
|
Z1176:Chd1
|
UTSW |
17 |
15,768,733 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1176:Chd1
|
UTSW |
17 |
15,766,347 (GRCm38) |
missense |
probably damaging |
0.98 |
|
Z1177:Chd1
|
UTSW |
17 |
15,747,801 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCACTCTGACCACCGATC -3'
(R):5'- ATAGACCTTGCGTCCTGGAGAG -3'
Sequencing Primer
(F):5'- GATCTCACTCGGACCATCGAATG -3'
(R):5'- CCTTGCGTCCTGGAGAGAAGTAAC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation