Incidental Mutation 'R7344:Slfn3'
ID 570104
Institutional Source Beutler Lab
Gene Symbol Slfn3
Ensembl Gene ENSMUSG00000018986
Gene Name schlafen 3
Synonyms
MMRRC Submission 045434-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7344 (G1)
Quality Score 225.009
Status Validated
Chromosome 11
Chromosomal Location 83082156-83105980 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 83103648 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 173 (V173A)
Ref Sequence ENSEMBL: ENSMUSP00000150425 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019130] [ENSMUST00000214041]
AlphaFold A0A1L1STQ7
Predicted Effect probably benign
Transcript: ENSMUST00000019130
AA Change: V50A

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000019130
Gene: ENSMUSG00000018986
AA Change: V50A

DomainStartEndE-ValueType
Pfam:AlbA_2 165 303 5.5e-11 PFAM
low complexity region 394 412 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214041
AA Change: V173A

PolyPhen 2 Score 0.276 (Sensitivity: 0.91; Specificity: 0.88)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (58/58)
MGI Phenotype PHENOTYPE: Mice homozygous for a targeted allele exhibit normal immune cell populations. [provided by MGI curators]
Allele List at MGI

All alleles(3) : Targeted(3)

Other mutations in this stock
Total: 58 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930438A08Rik A C 11: 58,182,273 (GRCm39) Y216S Het
Anpep G T 7: 79,488,398 (GRCm39) S477R possibly damaging Het
Atp7b T C 8: 22,487,515 (GRCm39) D1293G probably damaging Het
Caprin2 A G 6: 148,774,565 (GRCm39) V249A probably benign Het
Cep41 C T 6: 30,693,655 (GRCm39) R5K probably benign Het
Cyp2c23 A T 19: 44,010,176 (GRCm39) probably null Het
Dazap2 T A 15: 100,514,824 (GRCm39) V15E possibly damaging Het
Ecpas A T 4: 58,824,770 (GRCm39) D1070E probably benign Het
Epha8 T A 4: 136,661,849 (GRCm39) H582L probably benign Het
Fam193a A G 5: 34,643,074 (GRCm39) T1513A possibly damaging Het
Fancd2 T C 6: 113,545,670 (GRCm39) V901A probably benign Het
Fbl T A 7: 27,878,360 (GRCm39) V284E probably damaging Het
Fbln2 A G 6: 91,246,955 (GRCm39) E1065G probably damaging Het
Fbxw16 A G 9: 109,278,103 (GRCm39) V25A probably benign Het
Fcgbpl1 C T 7: 27,852,185 (GRCm39) T1236I possibly damaging Het
Fcgbpl1 T C 7: 27,839,704 (GRCm39) S506P possibly damaging Het
Gm11562 T G 11: 99,511,195 (GRCm39) T2P unknown Het
Gm17728 G T 17: 9,640,955 (GRCm39) G22W probably damaging Het
Gm30083 A G 14: 33,721,537 (GRCm39) Y190H probably benign Het
Gm6793 T A 8: 112,741,561 (GRCm39) D27V probably damaging Het
Gm7324 A G 14: 43,952,134 (GRCm39) D259G probably benign Het
Gtf2a1l G A 17: 89,001,531 (GRCm39) G129D probably damaging Het
Ildr2 T A 1: 166,122,166 (GRCm39) V203E probably damaging Het
Ipo4 C T 14: 55,872,988 (GRCm39) R23Q probably benign Het
Irx5 A G 8: 93,086,183 (GRCm39) T89A probably benign Het
Itga7 A G 10: 128,776,798 (GRCm39) N221S possibly damaging Het
Lpcat2 T C 8: 93,602,195 (GRCm39) W259R probably damaging Het
Lrrc8e C T 8: 4,284,815 (GRCm39) R347C probably damaging Het
Lyst T A 13: 13,881,140 (GRCm39) D2790E probably benign Het
Magi2 G A 5: 20,755,238 (GRCm39) R604Q probably benign Het
Mertk C A 2: 128,613,417 (GRCm39) H478N probably benign Het
Mical3 T A 6: 121,013,505 (GRCm39) K293* probably null Het
Nod2 T C 8: 89,387,210 (GRCm39) L168P probably damaging Het
Npnt T C 3: 132,614,100 (GRCm39) probably null Het
Or1x6 T G 11: 50,939,122 (GRCm39) F63V probably damaging Het
Or5af1 A T 11: 58,722,308 (GRCm39) E109D probably damaging Het
Or8b37 T C 9: 37,959,253 (GRCm39) M245T probably benign Het
Or9g4 A T 2: 85,505,275 (GRCm39) Y73* probably null Het
Plcd4 A T 1: 74,593,811 (GRCm39) D312V probably damaging Het
Prss58 A G 6: 40,872,399 (GRCm39) I208T probably damaging Het
Pus7l A G 15: 94,438,498 (GRCm39) S116P probably benign Het
Rcc1l A T 5: 134,205,276 (GRCm39) I93N probably benign Het
Rftn2 A C 1: 55,265,311 (GRCm39) Y36* probably null Het
Rp1l1 G A 14: 64,267,069 (GRCm39) R885Q probably benign Het
Rpgrip1 A T 14: 52,378,116 (GRCm39) D488V probably damaging Het
Sacs A G 14: 61,444,893 (GRCm39) Y2313C possibly damaging Het
Scrib T C 15: 75,921,107 (GRCm39) Y1332C probably damaging Het
Serpinb10 T C 1: 107,468,672 (GRCm39) V105A probably damaging Het
Slc35d1 A T 4: 103,070,243 (GRCm39) probably null Het
Smpd3 C T 8: 106,991,825 (GRCm39) V243M probably damaging Het
Stard9 A T 2: 120,535,167 (GRCm39) D3808V possibly damaging Het
Supt16 A T 14: 52,411,028 (GRCm39) V692D probably damaging Het
Tapt1 A T 5: 44,345,999 (GRCm39) V317E probably damaging Het
Vmn2r101 T C 17: 19,832,059 (GRCm39) I685T probably benign Het
Vmn2r92 A G 17: 18,387,513 (GRCm39) I173V probably benign Het
Vps54 T C 11: 21,224,999 (GRCm39) I165T probably damaging Het
Zswim4 G A 8: 84,950,327 (GRCm39) R628* probably null Het
Zzz3 T C 3: 152,157,736 (GRCm39) S770P probably damaging Het
Other mutations in Slfn3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00843:Slfn3 APN 11 83,104,257 (GRCm39) missense probably damaging 1.00
IGL01405:Slfn3 APN 11 83,105,542 (GRCm39) missense possibly damaging 0.90
IGL01631:Slfn3 APN 11 83,104,361 (GRCm39) missense probably damaging 0.99
IGL01944:Slfn3 APN 11 83,103,974 (GRCm39) missense possibly damaging 0.59
IGL02354:Slfn3 APN 11 83,104,068 (GRCm39) missense possibly damaging 0.95
IGL02361:Slfn3 APN 11 83,104,068 (GRCm39) missense possibly damaging 0.95
IGL02512:Slfn3 APN 11 83,103,851 (GRCm39) missense possibly damaging 0.55
IGL02875:Slfn3 APN 11 83,104,253 (GRCm39) missense probably damaging 0.98
IGL02944:Slfn3 APN 11 83,103,837 (GRCm39) missense probably damaging 0.99
IGL03402:Slfn3 APN 11 83,104,257 (GRCm39) missense probably damaging 1.00
R0452:Slfn3 UTSW 11 83,103,954 (GRCm39) missense possibly damaging 0.87
R0506:Slfn3 UTSW 11 83,103,986 (GRCm39) missense probably damaging 0.99
R0560:Slfn3 UTSW 11 83,103,978 (GRCm39) missense probably damaging 0.99
R0788:Slfn3 UTSW 11 83,103,662 (GRCm39) missense possibly damaging 0.47
R1602:Slfn3 UTSW 11 83,103,541 (GRCm39) missense probably damaging 1.00
R1713:Slfn3 UTSW 11 83,104,140 (GRCm39) missense probably damaging 0.98
R1881:Slfn3 UTSW 11 83,104,202 (GRCm39) missense possibly damaging 0.80
R2264:Slfn3 UTSW 11 83,103,798 (GRCm39) missense probably benign 0.00
R2441:Slfn3 UTSW 11 83,103,509 (GRCm39) missense probably benign 0.00
R2921:Slfn3 UTSW 11 83,105,871 (GRCm39) missense probably benign 0.01
R4163:Slfn3 UTSW 11 83,103,596 (GRCm39) missense probably damaging 1.00
R5099:Slfn3 UTSW 11 83,105,764 (GRCm39) missense probably damaging 0.98
R5448:Slfn3 UTSW 11 83,105,431 (GRCm39) missense probably damaging 0.99
R6441:Slfn3 UTSW 11 83,105,740 (GRCm39) missense probably benign 0.00
R6527:Slfn3 UTSW 11 83,103,932 (GRCm39) missense probably benign 0.01
R6785:Slfn3 UTSW 11 83,105,427 (GRCm39) missense possibly damaging 0.73
R7128:Slfn3 UTSW 11 83,105,721 (GRCm39) missense probably benign 0.00
R7528:Slfn3 UTSW 11 83,105,731 (GRCm39) missense probably benign 0.01
R7763:Slfn3 UTSW 11 83,105,614 (GRCm39) missense possibly damaging 0.95
R8155:Slfn3 UTSW 11 83,103,611 (GRCm39) missense probably damaging 1.00
R8178:Slfn3 UTSW 11 83,105,505 (GRCm39) missense probably benign 0.33
R8210:Slfn3 UTSW 11 83,105,332 (GRCm39) missense possibly damaging 0.48
R8347:Slfn3 UTSW 11 83,104,415 (GRCm39) missense possibly damaging 0.95
R8671:Slfn3 UTSW 11 83,103,825 (GRCm39) missense probably benign 0.00
R9093:Slfn3 UTSW 11 83,103,948 (GRCm39) missense probably damaging 0.99
R9106:Slfn3 UTSW 11 83,103,458 (GRCm39) missense probably benign 0.00
R9293:Slfn3 UTSW 11 83,105,616 (GRCm39) missense possibly damaging 0.85
R9362:Slfn3 UTSW 11 83,103,807 (GRCm39) missense probably benign
R9521:Slfn3 UTSW 11 83,103,825 (GRCm39) missense probably benign
R9522:Slfn3 UTSW 11 83,103,825 (GRCm39) missense probably benign
R9644:Slfn3 UTSW 11 83,105,728 (GRCm39) missense probably damaging 1.00
Z1176:Slfn3 UTSW 11 83,104,235 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CAGACTATGCTGAACTGGTTCTG -3'
(R):5'- AGCTGCACTGCATTCGCTAC -3'

Sequencing Primer
(F):5'- TTATTGGAGAAATCACACTTGGAGAG -3'
(R):5'- CTTTCACTTCATCTGAGATTGAGTTG -3'
Posted On 2019-09-13