|Institutional Source||Beutler Lab|
|Gene Name||mitogen-activated protein kinase kinase 6|
|Synonyms||MAP kinase kinase 6, SAPKK3, Prkmk6, MKK6|
|Is this an essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7345 (G1)|
|Chromosomal Location||110399122-110525522 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to T at 110492908 bp|
|Amino Acid Change||Isoleucine to Phenylalanine at position 127 (I127F)|
|Ref Sequence||ENSEMBL: ENSMUSP00000020949 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000020949] [ENSMUST00000100260]|
AA Change: I127F
AA Change: I127F
|Meta Mutation Damage Score||0.2094|
|Coding Region Coverage||
|Validation Efficiency||100% (55/55)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for null targeted mutations of this gene are viable, grow normally and have no gross physical or histologic abnormalities. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Map2k6||
(F):5'- TAAGAGCCTCTGGTCGCATAG -3'
(R):5'- AGACACGAAGCCTGGACTTC -3'
(F):5'- GGTCGCATAGCCTCACTAC -3'
(R):5'- CTCCCATTCTCCTTAAGTAGGTGG -3'