Incidental Mutation 'R7345:Nek10'
ID 570161
Institutional Source Beutler Lab
Gene Symbol Nek10
Ensembl Gene ENSMUSG00000042567
Gene Name NIMA (never in mitosis gene a)- related kinase 10
Synonyms LOC238944
MMRRC Submission 045379-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7345 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 7457704-7666183 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 14955503 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Leucine at position 838 (F838L)
Ref Sequence ENSEMBL: ENSMUSP00000108249 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000112630] [ENSMUST00000112631] [ENSMUST00000224491]
AlphaFold Q3UGM2
Predicted Effect probably benign
Transcript: ENSMUST00000112630
AA Change: F838L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000108249
Gene: ENSMUSG00000042567
AA Change: F838L

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000112631
AA Change: F838L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000108250
Gene: ENSMUSG00000042567
AA Change: F838L

DomainStartEndE-ValueType
ARM 197 238 8.23e1 SMART
ARM 278 320 5.18e0 SMART
low complexity region 387 400 N/A INTRINSIC
ARM 401 448 7.09e1 SMART
S_TKc 519 791 2.36e-75 SMART
low complexity region 799 811 N/A INTRINSIC
low complexity region 839 863 N/A INTRINSIC
low complexity region 908 926 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000123151
Gene: ENSMUSG00000042567
AA Change: F141L

DomainStartEndE-ValueType
Pfam:Pkinase 1 87 5.1e-13 PFAM
Pfam:Pkinase_Tyr 1 87 4.2e-8 PFAM
low complexity region 103 115 N/A INTRINSIC
low complexity region 143 167 N/A INTRINSIC
low complexity region 212 230 N/A INTRINSIC
low complexity region 257 268 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000224491
AA Change: F838L

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Meta Mutation Damage Score 0.0688 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (55/55)
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anks3 A G 16: 4,773,774 (GRCm39) M174T possibly damaging Het
Arhgap23 G A 11: 97,357,304 (GRCm39) R934Q possibly damaging Het
Atad5 T C 11: 79,986,832 (GRCm39) S640P probably damaging Het
B3galnt2 C T 13: 14,155,065 (GRCm39) probably null Het
B430305J03Rik T C 3: 61,271,539 (GRCm39) S69G unknown Het
Cd163 A T 6: 124,295,897 (GRCm39) N747I possibly damaging Het
Cep126 A G 9: 8,099,817 (GRCm39) S906P probably damaging Het
Cimip2b T C 4: 43,428,022 (GRCm39) D145G possibly damaging Het
Cyp4f39 G A 17: 32,705,753 (GRCm39) G318R probably damaging Het
D630003M21Rik C T 2: 158,059,129 (GRCm39) G257D probably damaging Het
Dcaf10 T C 4: 45,342,583 (GRCm39) L139P probably damaging Het
Dcc A G 18: 71,511,895 (GRCm39) V840A probably benign Het
Dnhd1 A T 7: 105,353,174 (GRCm39) I2776L probably benign Het
Fbxo24 G T 5: 137,619,523 (GRCm39) F234L probably damaging Het
Gm21190 T C 5: 15,732,902 (GRCm39) probably null Het
Grhl3 C T 4: 135,273,557 (GRCm39) R565Q probably damaging Het
Gtf3c1 A T 7: 125,244,842 (GRCm39) Y1731N probably damaging Het
Il1a C A 2: 129,146,693 (GRCm39) R133S probably benign Het
Ipo4 C T 14: 55,872,988 (GRCm39) R23Q probably benign Het
Klc3 G A 7: 19,128,814 (GRCm39) T481M probably benign Het
Map2k6 A T 11: 110,383,734 (GRCm39) I127F Het
Mapk8 A T 14: 33,130,068 (GRCm39) N63K probably damaging Het
Med13l T C 5: 118,880,825 (GRCm39) W1306R probably damaging Het
Megf6 C A 4: 154,351,772 (GRCm39) Q1162K probably benign Het
Myo5b A G 18: 74,841,095 (GRCm39) E992G possibly damaging Het
Ndst4 C T 3: 125,508,308 (GRCm39) T291M probably benign Het
Nrm A G 17: 36,175,476 (GRCm39) H194R probably damaging Het
Nup188 T C 2: 30,230,613 (GRCm39) S1384P probably benign Het
Olfml2a C A 2: 38,850,139 (GRCm39) D618E probably damaging Het
Or5p78 C T 7: 108,212,270 (GRCm39) T252I probably benign Het
Or8g23 A G 9: 38,971,875 (GRCm39) L29P probably damaging Het
Or8g24 G A 9: 38,989,630 (GRCm39) S137F probably damaging Het
Or9s18 A C 13: 65,300,557 (GRCm39) N173T possibly damaging Het
P2ry1 T C 3: 60,911,095 (GRCm39) F78S possibly damaging Het
Pcdhb18 T C 18: 37,624,976 (GRCm39) F769L probably benign Het
Poc5 A G 13: 96,533,304 (GRCm39) E144G probably damaging Het
Pole T A 5: 110,451,769 (GRCm39) N870K possibly damaging Het
Polr2b T C 5: 77,496,966 (GRCm39) F1159L possibly damaging Het
Pramel32 T C 4: 88,546,416 (GRCm39) K309E possibly damaging Het
Rubcnl A G 14: 75,279,793 (GRCm39) Y392C probably benign Het
Sec31a T C 5: 100,533,129 (GRCm39) T539A probably damaging Het
Serpinh1 A C 7: 98,995,563 (GRCm39) S340A probably damaging Het
Slc1a5 T A 7: 16,530,085 (GRCm39) probably null Het
Soat2 A G 15: 102,071,013 (GRCm39) D469G probably benign Het
Speg T C 1: 75,361,479 (GRCm39) L70P probably damaging Het
Spred2 T C 11: 19,874,958 (GRCm39) probably null Het
Stac2 A C 11: 97,933,439 (GRCm39) S168A probably damaging Het
Stx1a T A 5: 135,066,042 (GRCm39) D31E probably benign Het
Timeless C T 10: 128,085,623 (GRCm39) T885M probably damaging Het
Tmem94 G T 11: 115,677,082 (GRCm39) R118L possibly damaging Het
Tsen34 T C 7: 3,698,614 (GRCm39) Y253H probably damaging Het
Unc13b T C 4: 43,173,966 (GRCm39) V1598A unknown Het
Zfat A T 15: 67,976,892 (GRCm39) Y1086N probably damaging Het
Zfp551 G A 7: 12,150,522 (GRCm39) H296Y probably benign Het
Other mutations in Nek10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01361:Nek10 APN 14 14,850,957 (GRCm38) missense probably damaging 0.99
IGL02067:Nek10 APN 14 14,861,639 (GRCm38) missense probably benign 0.12
IGL02361:Nek10 APN 14 14,843,856 (GRCm38) missense probably damaging 1.00
IGL02687:Nek10 APN 14 14,840,570 (GRCm38) missense probably damaging 1.00
IGL02929:Nek10 APN 14 14,821,119 (GRCm38) missense possibly damaging 0.82
IGL03229:Nek10 APN 14 14,986,686 (GRCm38) missense probably benign 0.10
P0041:Nek10 UTSW 14 14,861,603 (GRCm38) missense probably benign 0.01
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0007:Nek10 UTSW 14 14,840,574 (GRCm38) missense probably benign 0.10
R0142:Nek10 UTSW 14 14,861,560 (GRCm38) missense possibly damaging 0.96
R0433:Nek10 UTSW 14 14,860,927 (GRCm38) missense probably benign 0.32
R0633:Nek10 UTSW 14 14,857,782 (GRCm38) critical splice acceptor site probably null
R1087:Nek10 UTSW 14 14,827,059 (GRCm38) missense possibly damaging 0.59
R1184:Nek10 UTSW 14 14,931,325 (GRCm38) splice site probably benign
R1250:Nek10 UTSW 14 14,853,887 (GRCm38) missense probably damaging 1.00
R1371:Nek10 UTSW 14 14,850,983 (GRCm38) missense probably damaging 0.98
R1506:Nek10 UTSW 14 14,999,078 (GRCm38) splice site probably benign
R1829:Nek10 UTSW 14 14,863,454 (GRCm38) critical splice acceptor site probably null
R1831:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1833:Nek10 UTSW 14 14,842,789 (GRCm38) missense probably benign
R1990:Nek10 UTSW 14 14,860,764 (GRCm38) missense probably benign
R1997:Nek10 UTSW 14 14,827,003 (GRCm38) missense probably benign 0.09
R2011:Nek10 UTSW 14 14,885,122 (GRCm38) missense probably damaging 1.00
R2158:Nek10 UTSW 14 14,885,047 (GRCm38) splice site probably null
R2288:Nek10 UTSW 14 14,853,956 (GRCm38) nonsense probably null
R2568:Nek10 UTSW 14 14,999,112 (GRCm38) missense possibly damaging 0.89
R2907:Nek10 UTSW 14 14,980,613 (GRCm38) missense possibly damaging 0.81
R2965:Nek10 UTSW 14 14,836,202 (GRCm38) missense probably damaging 1.00
R3922:Nek10 UTSW 14 14,861,585 (GRCm38) missense possibly damaging 0.88
R4032:Nek10 UTSW 14 14,853,877 (GRCm38) splice site probably null
R4700:Nek10 UTSW 14 14,842,841 (GRCm38) missense possibly damaging 0.69
R4742:Nek10 UTSW 14 14,861,624 (GRCm38) missense probably null 0.03
R4785:Nek10 UTSW 14 14,855,714 (GRCm38) missense probably benign
R4890:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4891:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4920:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4924:Nek10 UTSW 14 14,846,594 (GRCm38) splice site probably null
R4928:Nek10 UTSW 14 14,930,577 (GRCm38) missense probably damaging 1.00
R4948:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4952:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R4953:Nek10 UTSW 14 14,860,986 (GRCm38) missense possibly damaging 0.47
R5092:Nek10 UTSW 14 14,820,851 (GRCm38) missense possibly damaging 0.81
R5097:Nek10 UTSW 14 14,857,851 (GRCm38) missense probably benign 0.00
R5593:Nek10 UTSW 14 14,980,544 (GRCm38) nonsense probably null
R5696:Nek10 UTSW 14 14,860,736 (GRCm38) splice site probably null
R5813:Nek10 UTSW 14 14,986,704 (GRCm38) missense probably benign 0.01
R5829:Nek10 UTSW 14 14,865,404 (GRCm38) missense probably damaging 1.00
R5872:Nek10 UTSW 14 14,850,896 (GRCm38) missense probably benign 0.06
R5939:Nek10 UTSW 14 14,931,290 (GRCm38) missense possibly damaging 0.58
R6025:Nek10 UTSW 14 14,865,633 (GRCm38) missense probably benign 0.41
R6235:Nek10 UTSW 14 14,821,113 (GRCm38) nonsense probably null
R6539:Nek10 UTSW 14 14,860,789 (GRCm38) missense possibly damaging 0.94
R6542:Nek10 UTSW 14 14,999,108 (GRCm38) missense probably benign 0.44
R6561:Nek10 UTSW 14 14,828,448 (GRCm38) missense possibly damaging 0.48
R6659:Nek10 UTSW 14 14,861,684 (GRCm38) missense probably benign 0.29
R7039:Nek10 UTSW 14 14,986,700 (GRCm38) missense probably damaging 0.99
R7039:Nek10 UTSW 14 14,826,946 (GRCm38) missense possibly damaging 0.63
R7102:Nek10 UTSW 14 14,828,517 (GRCm38) missense probably damaging 1.00
R7185:Nek10 UTSW 14 14,846,621 (GRCm38) missense probably benign 0.03
R7198:Nek10 UTSW 14 14,850,947 (GRCm38) missense probably damaging 0.99
R7202:Nek10 UTSW 14 14,836,171 (GRCm38) missense probably benign 0.01
R7251:Nek10 UTSW 14 14,853,965 (GRCm38) missense probably benign
R7590:Nek10 UTSW 14 15,006,693 (GRCm38) makesense probably null
R7593:Nek10 UTSW 14 14,826,955 (GRCm38) missense probably benign 0.04
R7616:Nek10 UTSW 14 14,937,759 (GRCm38) missense probably benign 0.27
R7635:Nek10 UTSW 14 14,850,932 (GRCm38) missense probably benign 0.01
R7817:Nek10 UTSW 14 15,001,017 (GRCm38) missense probably benign 0.00
R7826:Nek10 UTSW 14 14,860,846 (GRCm38) splice site probably null
R7986:Nek10 UTSW 14 15,001,020 (GRCm38) missense probably benign 0.17
R8765:Nek10 UTSW 14 14,999,104 (GRCm38) missense probably damaging 0.97
R8856:Nek10 UTSW 14 14,937,610 (GRCm38) missense probably damaging 0.96
R8973:Nek10 UTSW 14 14,931,321 (GRCm38) critical splice donor site probably null
R9002:Nek10 UTSW 14 14,980,590 (GRCm38) missense probably damaging 1.00
R9088:Nek10 UTSW 14 14,931,314 (GRCm38) missense probably damaging 1.00
R9195:Nek10 UTSW 14 14,821,139 (GRCm38) missense probably benign 0.03
R9464:Nek10 UTSW 14 14,937,766 (GRCm38) missense probably benign
R9511:Nek10 UTSW 14 14,828,511 (GRCm38) missense probably benign 0.05
R9529:Nek10 UTSW 14 14,850,833 (GRCm38) missense probably benign
R9590:Nek10 UTSW 14 14,853,888 (GRCm38) missense probably damaging 1.00
Z1177:Nek10 UTSW 14 15,001,157 (GRCm38) nonsense probably null
Z1177:Nek10 UTSW 14 14,853,948 (GRCm38) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- TCTTACAGGCCTCTGGTGTG -3'
(R):5'- CACACTCTCCAGCTGGAAGTTG -3'

Sequencing Primer
(F):5'- CTCTGGTGTGGGCGTCC -3'
(R):5'- CCAGCTGGAAGTTGTCTTCTGAC -3'
Posted On 2019-09-13