Incidental Mutation 'R7348:Lrp6'
| ID |
570347 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp6
|
| Ensembl Gene |
ENSMUSG00000030201 |
| Gene Name |
low density lipoprotein receptor-related protein 6 |
| Synonyms |
ska, Cd, skax26, ska26 |
| MMRRC Submission |
045380-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.965)
|
| Stock # |
R7348 (G1)
|
| Quality Score |
158.009 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
134423439-134543876 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to T
at 134427781 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Proline to Threonine
at position 1604
(P1604T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032322]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032322
AA Change: P1604T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000032322
Gene: ENSMUSG00000030201
AA Change: P1604T
| Domain | Start | End | E-Value | Type |
|---|
|
LY
|
43 |
85 |
1.55e-2 |
SMART |
|
LY
|
87 |
129 |
1.91e-11 |
SMART |
|
LY
|
130 |
173 |
5.19e-13 |
SMART |
|
LY
|
174 |
216 |
1.39e-13 |
SMART |
|
LY
|
217 |
258 |
2.87e-6 |
SMART |
|
EGF
|
285 |
324 |
2.16e-1 |
SMART |
|
low complexity region
|
330 |
341 |
N/A |
INTRINSIC |
|
LY
|
352 |
394 |
1.29e-8 |
SMART |
|
LY
|
395 |
437 |
5.73e-15 |
SMART |
|
LY
|
438 |
481 |
1.07e-14 |
SMART |
|
LY
|
482 |
524 |
3.07e-15 |
SMART |
|
LY
|
525 |
565 |
4.66e-6 |
SMART |
|
EGF
|
591 |
628 |
1.47e-3 |
SMART |
|
LY
|
654 |
696 |
2.06e-7 |
SMART |
|
LY
|
697 |
739 |
3.73e-14 |
SMART |
|
LY
|
740 |
783 |
3.37e-12 |
SMART |
|
LY
|
784 |
825 |
1.17e-6 |
SMART |
|
LY
|
827 |
865 |
1.91e-2 |
SMART |
|
EGF
|
892 |
930 |
7.35e-4 |
SMART |
|
LY
|
957 |
999 |
1.41e-5 |
SMART |
|
LY
|
1005 |
1048 |
5.32e-1 |
SMART |
|
LY
|
1049 |
1093 |
5e-6 |
SMART |
|
LY
|
1094 |
1136 |
4.25e-9 |
SMART |
|
LY
|
1137 |
1177 |
1.91e-2 |
SMART |
|
EGF
|
1206 |
1250 |
1.23e1 |
SMART |
|
LDLa
|
1248 |
1287 |
2.42e-12 |
SMART |
|
LDLa
|
1288 |
1324 |
4.37e-10 |
SMART |
|
LDLa
|
1325 |
1362 |
1.66e-10 |
SMART |
|
transmembrane domain
|
1371 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1429 |
1438 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1457 |
N/A |
INTRINSIC |
|
low complexity region
|
1508 |
1524 |
N/A |
INTRINSIC |
|
low complexity region
|
1566 |
1573 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1608 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1468 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 98.8%
|
| Validation Efficiency |
99% (80/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
PHENOTYPE: Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 79 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abra |
G |
A |
15: 41,729,555 (GRCm39) |
R282C |
probably damaging |
Het |
| Adcy2 |
T |
A |
13: 68,882,794 (GRCm39) |
E314D |
possibly damaging |
Het |
| Adgrl2 |
A |
T |
3: 148,523,402 (GRCm39) |
I274N |
|
Het |
| Adpgk |
A |
G |
9: 59,221,069 (GRCm39) |
I292V |
probably benign |
Het |
| Agtrap |
G |
T |
4: 148,165,054 (GRCm39) |
F124L |
probably benign |
Het |
| Ankrd26 |
A |
G |
6: 118,485,525 (GRCm39) |
Y1450H |
probably damaging |
Het |
| Ap4e1 |
A |
T |
2: 126,903,896 (GRCm39) |
S933C |
probably damaging |
Het |
| Ap4e1 |
G |
T |
2: 126,903,897 (GRCm39) |
S933I |
possibly damaging |
Het |
| Ap5s1 |
A |
T |
2: 131,054,572 (GRCm39) |
T128S |
possibly damaging |
Het |
| Arih1 |
T |
C |
9: 59,393,341 (GRCm39) |
Y97C |
probably damaging |
Het |
| Atp1a3 |
A |
G |
7: 24,678,251 (GRCm39) |
F1034S |
unknown |
Het |
| Bmp6 |
T |
C |
13: 38,669,879 (GRCm39) |
S388P |
probably benign |
Het |
| Ccdc39 |
A |
G |
3: 33,886,825 (GRCm39) |
V261A |
possibly damaging |
Het |
| Ccdc66 |
C |
T |
14: 27,222,293 (GRCm39) |
C150Y |
probably damaging |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Cln6 |
A |
G |
9: 62,756,458 (GRCm39) |
S201G |
probably benign |
Het |
| Cntnap4 |
T |
C |
8: 113,391,909 (GRCm39) |
Y125H |
probably damaging |
Het |
| Copa |
A |
G |
1: 171,929,790 (GRCm39) |
T286A |
possibly damaging |
Het |
| Cul9 |
A |
T |
17: 46,821,919 (GRCm39) |
I1852K |
possibly damaging |
Het |
| Cyp2j8 |
C |
A |
4: 96,332,877 (GRCm39) |
A490S |
probably benign |
Het |
| Cyp2t4 |
A |
G |
7: 26,856,676 (GRCm39) |
I239V |
probably benign |
Het |
| Dpcd |
A |
G |
19: 45,560,905 (GRCm39) |
Y111C |
probably damaging |
Het |
| E2f7 |
C |
T |
10: 110,616,836 (GRCm39) |
T692I |
probably damaging |
Het |
| Fastkd5 |
A |
G |
2: 130,457,055 (GRCm39) |
Y512H |
probably damaging |
Het |
| Fastkd5 |
A |
C |
2: 130,458,359 (GRCm39) |
M77R |
probably benign |
Het |
| Fhod3 |
A |
G |
18: 25,223,524 (GRCm39) |
R957G |
possibly damaging |
Het |
| H6pd |
C |
A |
4: 150,068,359 (GRCm39) |
|
probably null |
Het |
| Haus5 |
G |
T |
7: 30,356,391 (GRCm39) |
P544Q |
possibly damaging |
Het |
| Ifi207 |
CTGTTGATGAAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGTTGTTGATAGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGTTGTTGATAGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATACAGTTGCTTGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATAGAGTTGCATATGGAGCCAGGAGGATGCTATATGTTGTTGATGAAGTTGCATGTGGAGCCAGGAG |
CTGTTGATAGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGTTGTTGATAGAGTTGCATGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATACAGTTGCTTGTGGAGCCAGGAGGTTGCTAGATGCTGTTGATAGAGTTGCATATGGAGCCAGGAGGATGCTATATGTTGTTGATGAAGTTGCATGTGGAGCCAGGAG |
1: 173,556,762 (GRCm39) |
|
probably benign |
Het |
| Igf2r |
A |
G |
17: 12,922,371 (GRCm39) |
Y1248H |
probably damaging |
Het |
| Izumo3 |
T |
C |
4: 92,035,455 (GRCm39) |
N6S |
possibly damaging |
Het |
| Map3k8 |
T |
A |
18: 4,340,561 (GRCm39) |
H251L |
probably damaging |
Het |
| Mapre3 |
T |
C |
5: 31,019,173 (GRCm39) |
Y6H |
probably benign |
Het |
| Mlh3 |
G |
T |
12: 85,314,215 (GRCm39) |
P657Q |
probably damaging |
Het |
| Mrgpra1 |
T |
C |
7: 46,985,157 (GRCm39) |
Y174C |
probably benign |
Het |
| Ms4a6d |
G |
A |
19: 11,567,437 (GRCm39) |
Q155* |
probably null |
Het |
| Myh1 |
C |
A |
11: 67,093,365 (GRCm39) |
P152Q |
probably damaging |
Het |
| Myh6 |
A |
T |
14: 55,189,716 (GRCm39) |
L1110Q |
probably damaging |
Het |
| Nf1 |
T |
A |
11: 79,427,676 (GRCm39) |
S1778T |
probably benign |
Het |
| Nkpd1 |
G |
A |
7: 19,258,341 (GRCm39) |
E707K |
probably damaging |
Het |
| Nlrp4a |
A |
G |
7: 26,143,698 (GRCm39) |
E21G |
probably damaging |
Het |
| Nr4a3 |
T |
G |
4: 48,051,290 (GRCm39) |
S15A |
possibly damaging |
Het |
| Or2f1 |
T |
C |
6: 42,721,790 (GRCm39) |
L273S |
possibly damaging |
Het |
| Or5p1 |
T |
C |
7: 107,916,920 (GRCm39) |
V273A |
possibly damaging |
Het |
| Or5p64 |
T |
C |
7: 107,855,330 (GRCm39) |
D5G |
probably benign |
Het |
| Or7a38 |
A |
G |
10: 78,753,396 (GRCm39) |
T241A |
probably damaging |
Het |
| Parg |
G |
A |
14: 31,972,036 (GRCm39) |
R677Q |
possibly damaging |
Het |
| Pcsk5 |
A |
T |
19: 17,434,182 (GRCm39) |
C1395* |
probably null |
Het |
| Psd2 |
G |
A |
18: 36,113,389 (GRCm39) |
S287N |
possibly damaging |
Het |
| Psd3 |
T |
C |
8: 68,243,583 (GRCm39) |
N685S |
possibly damaging |
Het |
| Pygb |
C |
T |
2: 150,628,903 (GRCm39) |
T39M |
probably benign |
Het |
| Rbfox1 |
C |
A |
16: 7,225,888 (GRCm39) |
Y351* |
probably null |
Het |
| Rftn1 |
A |
G |
17: 50,311,351 (GRCm39) |
L396P |
probably damaging |
Het |
| S1pr1 |
A |
G |
3: 115,505,710 (GRCm39) |
Y295H |
probably damaging |
Het |
| Scn5a |
T |
C |
9: 119,364,899 (GRCm39) |
M440V |
probably benign |
Het |
| Sel1l2 |
T |
C |
2: 140,107,644 (GRCm39) |
N240S |
probably benign |
Het |
| Skic3 |
T |
C |
13: 76,331,003 (GRCm39) |
F1478L |
possibly damaging |
Het |
| Skint1 |
T |
C |
4: 111,878,770 (GRCm39) |
L234P |
probably damaging |
Het |
| Skint11 |
T |
A |
4: 114,101,919 (GRCm39) |
Y311N |
probably benign |
Het |
| Slc6a5 |
A |
T |
7: 49,559,915 (GRCm39) |
|
probably benign |
Het |
| Tas2r134 |
T |
C |
2: 51,518,414 (GRCm39) |
S298P |
possibly damaging |
Het |
| Tbcd |
C |
A |
11: 121,485,137 (GRCm39) |
A773D |
probably benign |
Het |
| Tgoln1 |
G |
C |
6: 72,593,261 (GRCm39) |
T73R |
probably benign |
Het |
| Tmem184a |
T |
C |
5: 139,799,809 (GRCm39) |
E24G |
probably null |
Het |
| Tmem207 |
C |
A |
16: 26,335,577 (GRCm39) |
W53C |
possibly damaging |
Het |
| Tns1 |
T |
A |
1: 73,956,076 (GRCm39) |
H549L |
possibly damaging |
Het |
| Ttc41 |
G |
T |
10: 86,586,212 (GRCm39) |
E839* |
probably null |
Het |
| Ufd1 |
T |
G |
16: 18,634,635 (GRCm39) |
|
probably benign |
Het |
| Usp28 |
A |
G |
9: 48,942,177 (GRCm39) |
E713G |
probably benign |
Het |
| Utrn |
A |
G |
10: 12,623,762 (GRCm39) |
W159R |
probably damaging |
Het |
| Vcl |
C |
T |
14: 21,053,218 (GRCm39) |
A411V |
probably benign |
Het |
| Vcl |
T |
A |
14: 21,059,020 (GRCm39) |
C545* |
probably null |
Het |
| Vmn1r120 |
A |
T |
7: 20,787,377 (GRCm39) |
S111R |
probably damaging |
Het |
| Wwox |
T |
A |
8: 115,199,392 (GRCm39) |
C146S |
probably benign |
Het |
| Zbtb2 |
T |
C |
10: 4,324,574 (GRCm39) |
T57A |
possibly damaging |
Het |
| Zfp362 |
T |
C |
4: 128,671,010 (GRCm39) |
D336G |
possibly damaging |
Het |
| Zfp628 |
G |
A |
7: 4,924,817 (GRCm39) |
G1013E |
probably damaging |
Het |
| Zfp704 |
A |
G |
3: 9,539,658 (GRCm39) |
S231P |
probably damaging |
Het |
| Zhx3 |
G |
T |
2: 160,624,038 (GRCm39) |
S43* |
probably null |
Het |
|
| Other mutations in Lrp6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Lrp6
|
APN |
6 |
134,433,053 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL00765:Lrp6
|
APN |
6 |
134,518,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00898:Lrp6
|
APN |
6 |
134,456,702 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00916:Lrp6
|
APN |
6 |
134,461,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Lrp6
|
APN |
6 |
134,484,609 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01620:Lrp6
|
APN |
6 |
134,488,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01765:Lrp6
|
APN |
6 |
134,433,108 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02066:Lrp6
|
APN |
6 |
134,427,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL02067:Lrp6
|
APN |
6 |
134,457,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02169:Lrp6
|
APN |
6 |
134,490,290 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02281:Lrp6
|
APN |
6 |
134,434,697 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02484:Lrp6
|
APN |
6 |
134,518,886 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02724:Lrp6
|
APN |
6 |
134,461,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Lrp6
|
APN |
6 |
134,433,077 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03011:Lrp6
|
APN |
6 |
134,497,380 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03352:Lrp6
|
APN |
6 |
134,456,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Aileron
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Cielo
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
Coiled
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
flap
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
soar
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Swoop
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Upswing
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Wingman
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4494001:Lrp6
|
UTSW |
6 |
134,456,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0201:Lrp6
|
UTSW |
6 |
134,427,860 (GRCm39) |
nonsense |
probably null |
|
|
R0295:Lrp6
|
UTSW |
6 |
134,434,656 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0370:Lrp6
|
UTSW |
6 |
134,456,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0382:Lrp6
|
UTSW |
6 |
134,444,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0413:Lrp6
|
UTSW |
6 |
134,484,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0468:Lrp6
|
UTSW |
6 |
134,462,624 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0492:Lrp6
|
UTSW |
6 |
134,457,481 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0584:Lrp6
|
UTSW |
6 |
134,433,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0631:Lrp6
|
UTSW |
6 |
134,456,738 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0738:Lrp6
|
UTSW |
6 |
134,519,008 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0907:Lrp6
|
UTSW |
6 |
134,484,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1273:Lrp6
|
UTSW |
6 |
134,444,470 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1548:Lrp6
|
UTSW |
6 |
134,436,392 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1639:Lrp6
|
UTSW |
6 |
134,430,529 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1650:Lrp6
|
UTSW |
6 |
134,445,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1696:Lrp6
|
UTSW |
6 |
134,445,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Lrp6
|
UTSW |
6 |
134,441,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2013:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2015:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2165:Lrp6
|
UTSW |
6 |
134,436,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Lrp6
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2336:Lrp6
|
UTSW |
6 |
134,484,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2964:Lrp6
|
UTSW |
6 |
134,444,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Lrp6
|
UTSW |
6 |
134,484,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4370:Lrp6
|
UTSW |
6 |
134,483,321 (GRCm39) |
nonsense |
probably null |
|
|
R4521:Lrp6
|
UTSW |
6 |
134,462,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Lrp6
|
UTSW |
6 |
134,447,693 (GRCm39) |
nonsense |
probably null |
|
|
R4645:Lrp6
|
UTSW |
6 |
134,461,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Lrp6
|
UTSW |
6 |
134,488,230 (GRCm39) |
missense |
probably benign |
|
|
R4688:Lrp6
|
UTSW |
6 |
134,456,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4784:Lrp6
|
UTSW |
6 |
134,456,502 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5236:Lrp6
|
UTSW |
6 |
134,488,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5506:Lrp6
|
UTSW |
6 |
134,436,259 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5508:Lrp6
|
UTSW |
6 |
134,441,479 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6001:Lrp6
|
UTSW |
6 |
134,441,481 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6319:Lrp6
|
UTSW |
6 |
134,518,798 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6537:Lrp6
|
UTSW |
6 |
134,457,458 (GRCm39) |
missense |
probably benign |
|
|
R6552:Lrp6
|
UTSW |
6 |
134,431,692 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6559:Lrp6
|
UTSW |
6 |
134,490,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Lrp6
|
UTSW |
6 |
134,518,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6585:Lrp6
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
R6700:Lrp6
|
UTSW |
6 |
134,456,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6724:Lrp6
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7159:Lrp6
|
UTSW |
6 |
134,484,514 (GRCm39) |
missense |
probably benign |
|
|
R7266:Lrp6
|
UTSW |
6 |
134,484,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7341:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7359:Lrp6
|
UTSW |
6 |
134,427,923 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7501:Lrp6
|
UTSW |
6 |
134,463,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Lrp6
|
UTSW |
6 |
134,484,471 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7652:Lrp6
|
UTSW |
6 |
134,488,208 (GRCm39) |
nonsense |
probably null |
|
|
R7771:Lrp6
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8717:Lrp6
|
UTSW |
6 |
134,434,711 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8726:Lrp6
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
R8792:Lrp6
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8812:Lrp6
|
UTSW |
6 |
134,433,141 (GRCm39) |
missense |
probably benign |
|
|
R8855:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8866:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8994:Lrp6
|
UTSW |
6 |
134,518,656 (GRCm39) |
missense |
probably benign |
|
|
R9021:Lrp6
|
UTSW |
6 |
134,518,930 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9089:Lrp6
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9154:Lrp6
|
UTSW |
6 |
134,518,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Lrp6
|
UTSW |
6 |
134,457,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Lrp6
|
UTSW |
6 |
134,483,259 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9545:Lrp6
|
UTSW |
6 |
134,483,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9574:Lrp6
|
UTSW |
6 |
134,447,662 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9640:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lrp6
|
UTSW |
6 |
134,433,120 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1177:Lrp6
|
UTSW |
6 |
134,439,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTGTACAAATATCTCCAGCACCC -3'
(R):5'- AGCACTGATGTCTGTGACAG -3'
Sequencing Primer
(F):5'- ACCCACCCACTTTATAATGTTAACTG -3'
(R):5'- GTGACAGTGACTATGCTCCTAGC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation