Incidental Mutation 'R7349:Trappc9'
ID 570457
Institutional Source Beutler Lab
Gene Symbol Trappc9
Ensembl Gene ENSMUSG00000047921
Gene Name trafficking protein particle complex 9
Synonyms TRS130, Nibp, 2900005P22Rik, 4632408O18Rik, 1810044A24Rik
MMRRC Submission 045435-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7349 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 72461469-72933053 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) A to T at 72608718 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 897 (L897*)
Ref Sequence ENSEMBL: ENSMUSP00000087202 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023276] [ENSMUST00000089770]
AlphaFold no structure available at present
Predicted Effect probably null
Transcript: ENSMUST00000023276
AA Change: L718*
SMART Domains Protein: ENSMUSP00000023276
Gene: ENSMUSG00000047921
AA Change: L718*

DomainStartEndE-ValueType
Pfam:TRAPPC9-Trs120 2 920 3.6e-239 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000089770
AA Change: L897*
SMART Domains Protein: ENSMUSP00000087202
Gene: ENSMUSG00000047921
AA Change: L897*

DomainStartEndE-ValueType
Pfam:TRAPPC9-Trs120 182 350 4.1e-20 PFAM
Pfam:TRAPPC9-Trs120 434 664 2.2e-16 PFAM
low complexity region 993 1004 N/A INTRINSIC
Meta Mutation Damage Score 0.9755 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 100% (70/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein that likely plays a role in NF-kappa-B signaling. Mutations in this gene have been associated with autosomal-recessive mental retardation. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930486L24Rik T A 13: 60,990,717 (GRCm39) T326S possibly damaging Het
Acly A T 11: 100,412,817 (GRCm39) H91Q probably benign Het
Acp3 T A 9: 104,168,657 (GRCm39) I403F probably benign Het
Angpt2 T A 8: 18,742,090 (GRCm39) M489L probably damaging Het
Arap1 T C 7: 101,039,435 (GRCm39) I565T possibly damaging Het
Atg16l2 T C 7: 100,939,473 (GRCm39) D563G probably damaging Het
Atp6v0a2 T A 5: 124,789,392 (GRCm39) Y386* probably null Het
Atp8b4 A G 2: 126,167,265 (GRCm39) V1078A probably benign Het
Bsn T C 9: 107,987,982 (GRCm39) D2590G unknown Het
Casp12 T C 9: 5,345,527 (GRCm39) probably null Het
Ccdc87 T C 19: 4,891,868 (GRCm39) S787P probably damaging Het
Cdh13 A G 8: 119,969,097 (GRCm39) T485A probably damaging Het
Cstdc5 A G 16: 36,184,674 (GRCm39) V23A probably damaging Het
Dip2a T C 10: 76,121,426 (GRCm39) H810R probably damaging Het
Dmbt1 A T 7: 130,642,854 (GRCm39) Y120F unknown Het
Dmgdh C T 13: 93,888,741 (GRCm39) T793I possibly damaging Het
Dnhd1 A G 7: 105,359,330 (GRCm39) D3555G probably damaging Het
Eif4e1b T C 13: 54,932,006 (GRCm39) V30A probably benign Het
Ercc5 T G 1: 44,220,068 (GRCm39) D1113E possibly damaging Het
Fbn1 T C 2: 125,157,321 (GRCm39) N2321D possibly damaging Het
Fbrs T C 7: 127,081,971 (GRCm39) L237P probably damaging Het
Flg2 T A 3: 93,127,513 (GRCm39) S2142T unknown Het
Ftsj3 G A 11: 106,140,572 (GRCm39) T761I probably damaging Het
Gdi2 C A 13: 3,606,395 (GRCm39) T157N probably benign Het
Gm8122 C A 14: 43,088,058 (GRCm39) probably null Het
Gtpbp10 T C 5: 5,605,379 (GRCm39) E108G possibly damaging Het
Hectd4 T C 5: 121,448,726 (GRCm39) L358P probably damaging Het
Herc3 T C 6: 58,835,971 (GRCm39) C271R probably benign Het
Hspb1 C T 5: 135,918,187 (GRCm39) T178M possibly damaging Het
Htr3b C T 9: 48,847,319 (GRCm39) V399M probably benign Het
Hydin A G 8: 111,124,803 (GRCm39) probably null Het
Itpr3 T A 17: 27,326,786 (GRCm39) probably null Het
Iyd G T 10: 3,495,638 (GRCm39) V99F possibly damaging Het
Lrrc36 G A 8: 106,178,900 (GRCm39) G365D probably damaging Het
Map1b T A 13: 99,570,148 (GRCm39) I858F unknown Het
Med12l A T 3: 59,165,746 (GRCm39) D1488V probably damaging Het
Ms4a6c T A 19: 11,455,555 (GRCm39) N121K probably damaging Het
Nlrp1b T G 11: 71,072,943 (GRCm39) Q300P probably benign Het
Nlrp3 G A 11: 59,438,912 (GRCm39) R163H probably damaging Het
Nr4a3 T G 4: 48,051,290 (GRCm39) S15A possibly damaging Het
Optc T G 1: 133,825,617 (GRCm39) D356A probably damaging Het
Or52h7 A G 7: 104,213,857 (GRCm39) H143R probably benign Het
Or9s15 T C 1: 92,524,904 (GRCm39) V221A possibly damaging Het
Pdzd2 C G 15: 12,399,291 (GRCm39) V812L probably damaging Het
Phlpp2 T C 8: 110,655,278 (GRCm39) F691S probably damaging Het
Pigk T C 3: 152,453,238 (GRCm39) F319L probably benign Het
Pkhd1l1 A G 15: 44,378,350 (GRCm39) T1035A probably damaging Het
Plekhg3 A G 12: 76,611,339 (GRCm39) T261A probably benign Het
Plekhm1 A G 11: 103,278,160 (GRCm39) F312S probably damaging Het
Pms2 T A 5: 143,862,654 (GRCm39) I587N probably benign Het
Ppl T A 16: 4,922,593 (GRCm39) H272L probably damaging Het
Prkce G A 17: 86,800,783 (GRCm39) A400T probably benign Het
Ptpn9 T C 9: 56,951,660 (GRCm39) S324P probably benign Het
Ptprk A T 10: 28,468,834 (GRCm39) N1432I possibly damaging Het
R3hdm2 T C 10: 127,328,515 (GRCm39) S746P probably benign Het
Rnf220 G A 4: 117,135,015 (GRCm39) A412V probably damaging Het
Scel G A 14: 103,781,315 (GRCm39) A154T probably benign Het
Sirpb1a A T 3: 15,475,664 (GRCm39) N290K probably damaging Het
Sirpb1c A T 3: 15,886,310 (GRCm39) probably null Het
Sorbs2 A T 8: 46,248,860 (GRCm39) R704* probably null Het
Spast T C 17: 74,680,319 (GRCm39) V427A probably damaging Het
Stxbp4 A T 11: 90,482,937 (GRCm39) probably null Het
Thsd7a C A 6: 12,352,067 (GRCm39) G1043C Het
Tmem205 C T 9: 21,832,410 (GRCm39) C167Y probably damaging Het
Trim36 A G 18: 46,302,495 (GRCm39) F518L probably benign Het
Ttc12 T G 9: 49,359,267 (GRCm39) T402P possibly damaging Het
Twnk T C 19: 44,998,600 (GRCm39) V506A possibly damaging Het
Vmn2r18 A T 5: 151,485,682 (GRCm39) L604* probably null Het
Wdr83 T C 8: 85,806,460 (GRCm39) N113D possibly damaging Het
Zfp628 G A 7: 4,924,817 (GRCm39) G1013E probably damaging Het
Other mutations in Trappc9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Trappc9 APN 15 72,897,875 (GRCm39) missense possibly damaging 0.79
IGL01348:Trappc9 APN 15 72,808,858 (GRCm39) missense possibly damaging 0.64
IGL01367:Trappc9 APN 15 72,462,002 (GRCm39) missense probably benign 0.31
IGL01521:Trappc9 APN 15 72,924,016 (GRCm39) missense probably damaging 1.00
IGL01726:Trappc9 APN 15 72,817,971 (GRCm39) missense probably damaging 0.98
IGL01881:Trappc9 APN 15 72,871,841 (GRCm39) missense probably damaging 1.00
IGL02214:Trappc9 APN 15 72,884,731 (GRCm39) nonsense probably null
IGL02693:Trappc9 APN 15 72,835,542 (GRCm39) splice site probably benign
IGL03229:Trappc9 APN 15 72,930,305 (GRCm39) missense probably damaging 1.00
basilio UTSW 15 72,930,242 (GRCm39) missense probably damaging 1.00
Boomboom UTSW 15 72,608,718 (GRCm39) nonsense probably null
bronto UTSW 15 72,930,087 (GRCm39) nonsense probably null
Earl UTSW 15 72,608,626 (GRCm39) nonsense probably null
Sotto_aceto UTSW 15 72,557,188 (GRCm39) missense probably damaging 0.99
P0026:Trappc9 UTSW 15 72,824,931 (GRCm39) missense probably damaging 1.00
PIT4453001:Trappc9 UTSW 15 72,903,447 (GRCm39) frame shift probably null
PIT4519001:Trappc9 UTSW 15 72,824,943 (GRCm39) missense probably benign
R0001:Trappc9 UTSW 15 72,835,511 (GRCm39) missense probably damaging 1.00
R0094:Trappc9 UTSW 15 72,894,929 (GRCm38) intron probably benign
R0745:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R0747:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R0800:Trappc9 UTSW 15 72,824,981 (GRCm39) splice site probably benign
R0816:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R0819:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R0820:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R0893:Trappc9 UTSW 15 72,461,956 (GRCm39) missense probably damaging 1.00
R0976:Trappc9 UTSW 15 72,871,823 (GRCm39) missense probably damaging 0.99
R1119:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1266:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1453:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1454:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1531:Trappc9 UTSW 15 72,565,397 (GRCm39) nonsense probably null
R1543:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1563:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1565:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1600:Trappc9 UTSW 15 72,808,958 (GRCm39) nonsense probably null
R1712:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1756:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1789:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R1978:Trappc9 UTSW 15 72,871,874 (GRCm39) missense probably damaging 1.00
R2001:Trappc9 UTSW 15 72,929,885 (GRCm39) missense probably damaging 0.99
R2312:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R2334:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R2926:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R3123:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R3124:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R3125:Trappc9 UTSW 15 72,897,816 (GRCm39) missense probably damaging 1.00
R3813:Trappc9 UTSW 15 72,930,242 (GRCm39) missense probably damaging 1.00
R4012:Trappc9 UTSW 15 72,903,472 (GRCm39) missense possibly damaging 0.95
R4080:Trappc9 UTSW 15 72,813,796 (GRCm39) missense probably damaging 1.00
R4282:Trappc9 UTSW 15 72,462,641 (GRCm39) missense probably damaging 1.00
R4572:Trappc9 UTSW 15 72,808,916 (GRCm39) missense possibly damaging 0.61
R4739:Trappc9 UTSW 15 72,808,909 (GRCm39) missense probably damaging 0.97
R4959:Trappc9 UTSW 15 72,808,905 (GRCm39) missense probably damaging 1.00
R4973:Trappc9 UTSW 15 72,808,905 (GRCm39) missense probably damaging 1.00
R5123:Trappc9 UTSW 15 72,785,215 (GRCm39) intron probably benign
R5128:Trappc9 UTSW 15 72,930,242 (GRCm39) missense probably damaging 1.00
R5228:Trappc9 UTSW 15 72,929,844 (GRCm39) missense probably damaging 1.00
R5362:Trappc9 UTSW 15 72,930,066 (GRCm39) missense possibly damaging 0.68
R5802:Trappc9 UTSW 15 72,557,188 (GRCm39) missense probably damaging 0.99
R6032:Trappc9 UTSW 15 72,797,379 (GRCm39) missense probably benign 0.43
R6032:Trappc9 UTSW 15 72,797,379 (GRCm39) missense probably benign 0.43
R6154:Trappc9 UTSW 15 72,929,930 (GRCm39) missense probably benign 0.03
R6372:Trappc9 UTSW 15 72,461,923 (GRCm39) missense possibly damaging 0.75
R6661:Trappc9 UTSW 15 72,461,993 (GRCm39) missense possibly damaging 0.55
R6864:Trappc9 UTSW 15 72,809,011 (GRCm39) splice site probably null
R6893:Trappc9 UTSW 15 72,797,499 (GRCm39) missense possibly damaging 0.93
R7099:Trappc9 UTSW 15 72,565,468 (GRCm39) missense probably benign 0.00
R7276:Trappc9 UTSW 15 72,924,119 (GRCm39) missense probably damaging 0.99
R8260:Trappc9 UTSW 15 72,813,758 (GRCm39) nonsense probably null
R8399:Trappc9 UTSW 15 72,924,131 (GRCm39) missense probably damaging 1.00
R8683:Trappc9 UTSW 15 72,884,664 (GRCm39) missense probably benign 0.26
R8839:Trappc9 UTSW 15 72,930,087 (GRCm39) nonsense probably null
R8945:Trappc9 UTSW 15 72,929,945 (GRCm39) missense probably benign
R9083:Trappc9 UTSW 15 72,608,626 (GRCm39) nonsense probably null
R9323:Trappc9 UTSW 15 72,565,431 (GRCm39) missense probably benign 0.41
R9329:Trappc9 UTSW 15 72,673,202 (GRCm39) missense unknown
R9366:Trappc9 UTSW 15 72,808,937 (GRCm39) missense probably benign
R9723:Trappc9 UTSW 15 72,461,963 (GRCm39) missense possibly damaging 0.87
RF008:Trappc9 UTSW 15 72,673,138 (GRCm39) small insertion probably benign
RF009:Trappc9 UTSW 15 72,673,136 (GRCm39) small insertion probably benign
RF014:Trappc9 UTSW 15 72,673,132 (GRCm39) small insertion probably benign
RF016:Trappc9 UTSW 15 72,673,138 (GRCm39) small insertion probably benign
RF023:Trappc9 UTSW 15 72,673,180 (GRCm39) small insertion probably benign
RF023:Trappc9 UTSW 15 72,673,173 (GRCm39) small insertion probably benign
RF028:Trappc9 UTSW 15 72,673,139 (GRCm39) small insertion probably benign
RF029:Trappc9 UTSW 15 72,673,172 (GRCm39) small insertion probably benign
RF030:Trappc9 UTSW 15 72,673,174 (GRCm39) small insertion probably benign
RF034:Trappc9 UTSW 15 72,673,147 (GRCm39) small insertion probably benign
RF036:Trappc9 UTSW 15 72,673,169 (GRCm39) small insertion probably benign
RF038:Trappc9 UTSW 15 72,673,172 (GRCm39) small insertion probably benign
RF040:Trappc9 UTSW 15 72,673,141 (GRCm39) small insertion probably benign
RF042:Trappc9 UTSW 15 72,673,132 (GRCm39) small insertion probably benign
RF043:Trappc9 UTSW 15 72,673,154 (GRCm39) small insertion probably benign
RF049:Trappc9 UTSW 15 72,673,155 (GRCm39) small insertion probably benign
RF049:Trappc9 UTSW 15 72,673,150 (GRCm39) small insertion probably benign
RF053:Trappc9 UTSW 15 72,673,177 (GRCm39) small insertion probably benign
RF057:Trappc9 UTSW 15 72,673,144 (GRCm39) small insertion probably benign
RF063:Trappc9 UTSW 15 72,673,173 (GRCm39) small insertion probably benign
RF063:Trappc9 UTSW 15 72,673,169 (GRCm39) small insertion probably benign
Z1177:Trappc9 UTSW 15 72,924,011 (GRCm39) missense probably null 0.51
Predicted Primers PCR Primer
(F):5'- TACACGCTGGACTTGAAGGGAG -3'
(R):5'- ATGCCATACCTCTGCACATC -3'

Sequencing Primer
(F):5'- ACTTGAAGGGAGGGGCTCTC -3'
(R):5'- ACCTCTGCACATCTTCAAATAGTGGG -3'
Posted On 2019-09-13