|Institutional Source||Beutler Lab|
|Gene Name||H1 histone family, member 0|
|Essential gene?||Non essential (E-score: 0.000)|
|Stock #||R7350 (G1)|
|Chromosomal Location||79028450-79030504 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||G to A at 79028903 bp (GRCm38)|
|Amino Acid Change||Glycine to Aspartic acid at position 61 (G61D)|
|Ref Sequence||ENSEMBL: ENSMUSP00000137309 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000006544] [ENSMUST00000171999] [ENSMUST00000180086]|
AA Change: G61D
PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
AA Change: G61D
|Coding Region Coverage||
FUNCTION: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-independent histone that is a member of the histone H1 family. [provided by RefSeq, Oct 2015]
PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and overtly normal with no apparent anatomic or histologic abnormalities or defects in cell division patterns. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in H1f0||
(F):5'- TCCTTGAACAGTGGGAGCAG -3'
(R):5'- CTTTGGAGGCAGCCTTCTTG -3'
(F):5'- GGCCACCATGACCGAGAAC -3'
(R):5'- CTGCCTTCTTTGGAGTGGCC -3'