Incidental Mutation 'R0645:Hivep3'
| ID |
57054 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Hivep3
|
| Ensembl Gene |
ENSMUSG00000028634 |
| Gene Name |
human immunodeficiency virus type I enhancer binding protein 3 |
| Synonyms |
Krc, E030045D18Rik, Schnurri-3, Shn3, 2900056N03Rik |
| MMRRC Submission |
038830-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0645 (G1)
|
| Quality Score |
189 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
119590982-119992608 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 119954531 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Histidine
at position 949
(R949H)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000130249
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106307]
[ENSMUST00000166542]
[ENSMUST00000226560]
|
| AlphaFold |
A2A884 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000106307
AA Change: R949H
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000101914
Gene: ENSMUSG00000028634
AA Change: R949H
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
185 |
207 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
213 |
235 |
8.34e-3 |
SMART |
|
low complexity region
|
257 |
285 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
323 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
438 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
527 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
612 |
N/A |
INTRINSIC |
|
low complexity region
|
622 |
633 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
636 |
656 |
2.06e1 |
SMART |
|
low complexity region
|
736 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
806 |
817 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
894 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
1010 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1136 |
N/A |
INTRINSIC |
|
low complexity region
|
1143 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1183 |
N/A |
INTRINSIC |
|
low complexity region
|
1259 |
1284 |
N/A |
INTRINSIC |
|
low complexity region
|
1376 |
1390 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1547 |
N/A |
INTRINSIC |
|
low complexity region
|
1673 |
1684 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1720 |
1742 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
1748 |
1772 |
1.69e-3 |
SMART |
|
low complexity region
|
1778 |
1791 |
N/A |
INTRINSIC |
|
low complexity region
|
1814 |
1843 |
N/A |
INTRINSIC |
|
low complexity region
|
2203 |
2216 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000166542
AA Change: R949H
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000130249
Gene: ENSMUSG00000028634
AA Change: R949H
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_C2H2
|
185 |
207 |
1.67e-2 |
SMART |
|
ZnF_C2H2
|
213 |
235 |
8.34e-3 |
SMART |
|
low complexity region
|
257 |
285 |
N/A |
INTRINSIC |
|
low complexity region
|
292 |
323 |
N/A |
INTRINSIC |
|
low complexity region
|
425 |
438 |
N/A |
INTRINSIC |
|
low complexity region
|
513 |
527 |
N/A |
INTRINSIC |
|
low complexity region
|
589 |
612 |
N/A |
INTRINSIC |
|
low complexity region
|
622 |
633 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
636 |
656 |
2.06e1 |
SMART |
|
low complexity region
|
736 |
749 |
N/A |
INTRINSIC |
|
low complexity region
|
806 |
817 |
N/A |
INTRINSIC |
|
low complexity region
|
844 |
865 |
N/A |
INTRINSIC |
|
low complexity region
|
878 |
894 |
N/A |
INTRINSIC |
|
low complexity region
|
896 |
931 |
N/A |
INTRINSIC |
|
low complexity region
|
1010 |
1020 |
N/A |
INTRINSIC |
|
low complexity region
|
1050 |
1061 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1136 |
N/A |
INTRINSIC |
|
low complexity region
|
1143 |
1167 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1183 |
N/A |
INTRINSIC |
|
low complexity region
|
1259 |
1284 |
N/A |
INTRINSIC |
|
low complexity region
|
1376 |
1390 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1547 |
N/A |
INTRINSIC |
|
low complexity region
|
1673 |
1684 |
N/A |
INTRINSIC |
|
ZnF_C2H2
|
1720 |
1742 |
1.82e-3 |
SMART |
|
ZnF_C2H2
|
1748 |
1772 |
1.69e-3 |
SMART |
|
low complexity region
|
1778 |
1791 |
N/A |
INTRINSIC |
|
low complexity region
|
1814 |
1843 |
N/A |
INTRINSIC |
|
low complexity region
|
2203 |
2216 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226560
|
| Meta Mutation Damage Score |
0.0883 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
99% (94/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the human immunodeficiency virus type 1 enhancer-binding protein family. Members of this protein family contain multiple zinc finger and acid-rich (ZAS) domains and serine-threonine rich regions. This protein acts as a transcription factor and is able to regulate nuclear factor kappaB-mediated transcription by binding the kappaB motif in target genes. This protein also binds the recombination signal sequence that flanks the V, D, and J regions of immunoglobulin and T-cell receptors. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Sep 2011]
PHENOTYPE: Homozygous mutation of this gene results in diminished IL-2 production by stimulated CD4 cells. Mice homozygous for a knock-out allele exhibit increased bone volume. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam18 |
G |
T |
8: 25,162,136 (GRCm39) |
Y46* |
probably null |
Het |
| Adam26b |
A |
C |
8: 43,973,524 (GRCm39) |
C493G |
probably damaging |
Het |
| Ak5 |
A |
T |
3: 152,359,252 (GRCm39) |
L182Q |
probably damaging |
Het |
| Akt1s1 |
T |
C |
7: 44,498,645 (GRCm39) |
|
probably benign |
Het |
| Amhr2 |
G |
T |
15: 102,354,863 (GRCm39) |
G133C |
probably damaging |
Het |
| Btbd9 |
A |
T |
17: 30,743,941 (GRCm39) |
L187Q |
probably damaging |
Het |
| Ccdc117 |
A |
T |
11: 5,484,385 (GRCm39) |
|
probably benign |
Het |
| Ccdc138 |
A |
T |
10: 58,411,542 (GRCm39) |
I637F |
probably damaging |
Het |
| Ccdc162 |
A |
G |
10: 41,462,407 (GRCm39) |
|
probably benign |
Het |
| Cdc25b |
C |
A |
2: 131,033,533 (GRCm39) |
H157Q |
probably benign |
Het |
| Cdon |
A |
G |
9: 35,388,379 (GRCm39) |
|
probably null |
Het |
| Cdt1 |
G |
A |
8: 123,298,884 (GRCm39) |
|
probably benign |
Het |
| Cep350 |
C |
T |
1: 155,816,458 (GRCm39) |
|
probably null |
Het |
| Cfb |
T |
C |
17: 35,078,992 (GRCm39) |
K831R |
probably benign |
Het |
| Cldn4 |
C |
A |
5: 134,975,645 (GRCm39) |
|
probably benign |
Het |
| Cntnap5b |
T |
C |
1: 99,999,767 (GRCm39) |
|
probably benign |
Het |
| Cyp27b1 |
T |
G |
10: 126,884,967 (GRCm39) |
S77A |
probably benign |
Het |
| Dlc1 |
T |
C |
8: 37,041,203 (GRCm39) |
D1342G |
possibly damaging |
Het |
| Dlgap4 |
A |
G |
2: 156,603,799 (GRCm39) |
H887R |
probably damaging |
Het |
| Duox2 |
A |
G |
2: 122,123,139 (GRCm39) |
I503T |
probably damaging |
Het |
| Eml4 |
T |
C |
17: 83,770,922 (GRCm39) |
|
probably benign |
Het |
| Ermap |
A |
G |
4: 119,042,888 (GRCm39) |
S212P |
probably benign |
Het |
| Esrrg |
T |
A |
1: 187,775,538 (GRCm39) |
C22S |
probably benign |
Het |
| Evx2 |
T |
A |
2: 74,488,238 (GRCm39) |
Y194F |
possibly damaging |
Het |
| Fbn2 |
T |
G |
18: 58,191,461 (GRCm39) |
D1554A |
probably damaging |
Het |
| Flrt1 |
G |
A |
19: 7,074,508 (GRCm39) |
|
probably benign |
Het |
| Fndc5 |
A |
G |
4: 129,033,630 (GRCm39) |
|
probably benign |
Het |
| Frem1 |
A |
T |
4: 82,907,403 (GRCm39) |
I837N |
probably damaging |
Het |
| Fzd10 |
G |
T |
5: 128,679,662 (GRCm39) |
A461S |
possibly damaging |
Het |
| Ganab |
T |
A |
19: 8,888,477 (GRCm39) |
Y511N |
probably damaging |
Het |
| Gbp7 |
A |
G |
3: 142,243,926 (GRCm39) |
|
probably null |
Het |
| Gm5919 |
T |
A |
9: 83,765,436 (GRCm39) |
C91S |
unknown |
Het |
| Gpr31b |
A |
T |
17: 13,271,093 (GRCm39) |
C25* |
probably null |
Het |
| Grb10 |
A |
G |
11: 11,886,755 (GRCm39) |
S505P |
probably damaging |
Het |
| Grm4 |
A |
T |
17: 27,654,183 (GRCm39) |
V542E |
probably damaging |
Het |
| Gsta5 |
T |
C |
9: 78,206,303 (GRCm39) |
I75T |
possibly damaging |
Het |
| Hycc1 |
C |
T |
5: 24,184,506 (GRCm39) |
G242D |
probably damaging |
Het |
| Invs |
A |
T |
4: 48,407,653 (GRCm39) |
M543L |
probably benign |
Het |
| Kcnk2 |
T |
C |
1: 188,988,927 (GRCm39) |
|
probably null |
Het |
| Kdm6b |
A |
T |
11: 69,295,844 (GRCm39) |
S808T |
unknown |
Het |
| Klhl30 |
C |
T |
1: 91,283,228 (GRCm39) |
R277W |
probably damaging |
Het |
| Lama1 |
A |
G |
17: 68,080,707 (GRCm39) |
Q1245R |
probably benign |
Het |
| Lingo3 |
G |
T |
10: 80,671,169 (GRCm39) |
H254N |
probably benign |
Het |
| Lzts1 |
A |
T |
8: 69,588,392 (GRCm39) |
H521Q |
possibly damaging |
Het |
| Map3k19 |
A |
C |
1: 127,749,919 (GRCm39) |
I1144S |
possibly damaging |
Het |
| Mast2 |
T |
C |
4: 116,170,043 (GRCm39) |
|
probably benign |
Het |
| Mast2 |
A |
G |
4: 116,165,184 (GRCm39) |
S1411P |
probably damaging |
Het |
| Mesp1 |
G |
T |
7: 79,442,328 (GRCm39) |
S225R |
possibly damaging |
Het |
| Micu1 |
A |
G |
10: 59,675,503 (GRCm39) |
T366A |
possibly damaging |
Het |
| Mideas |
G |
T |
12: 84,205,077 (GRCm39) |
N834K |
possibly damaging |
Het |
| Mknk2 |
T |
C |
10: 80,507,742 (GRCm39) |
|
probably null |
Het |
| Msh5 |
A |
G |
17: 35,258,199 (GRCm39) |
L309P |
probably damaging |
Het |
| Myo7b |
T |
C |
18: 32,127,962 (GRCm39) |
I577V |
probably benign |
Het |
| Myom2 |
T |
A |
8: 15,167,698 (GRCm39) |
D1094E |
probably damaging |
Het |
| Nedd1 |
T |
C |
10: 92,527,693 (GRCm39) |
|
probably null |
Het |
| Neu4 |
T |
C |
1: 93,950,191 (GRCm39) |
L50S |
probably damaging |
Het |
| Noa1 |
T |
C |
5: 77,457,722 (GRCm39) |
Y61C |
probably benign |
Het |
| Nr1h4 |
A |
T |
10: 89,342,390 (GRCm39) |
M30K |
probably benign |
Het |
| Nsd3 |
A |
G |
8: 26,199,096 (GRCm39) |
I1219V |
probably benign |
Het |
| Nup188 |
T |
A |
2: 30,233,478 (GRCm39) |
|
probably null |
Het |
| Or10ag2 |
T |
A |
2: 87,248,612 (GRCm39) |
Y71* |
probably null |
Het |
| Or5al5 |
A |
G |
2: 85,961,378 (GRCm39) |
S210P |
probably damaging |
Het |
| Or6c208 |
T |
A |
10: 129,224,162 (GRCm39) |
I220N |
possibly damaging |
Het |
| Or6k2 |
A |
T |
1: 173,986,920 (GRCm39) |
T194S |
probably benign |
Het |
| Pbk |
G |
A |
14: 66,051,245 (GRCm39) |
|
probably benign |
Het |
| Pcnx2 |
G |
A |
8: 126,487,459 (GRCm39) |
T1848M |
possibly damaging |
Het |
| Pdzd7 |
C |
T |
19: 45,033,914 (GRCm39) |
G57R |
possibly damaging |
Het |
| Pik3r4 |
C |
A |
9: 105,546,386 (GRCm39) |
|
probably benign |
Het |
| Plce1 |
A |
G |
19: 38,766,433 (GRCm39) |
S2153G |
probably damaging |
Het |
| Potefam1 |
C |
T |
2: 111,044,928 (GRCm39) |
|
probably null |
Het |
| Pphln1 |
G |
A |
15: 93,318,192 (GRCm39) |
V34M |
possibly damaging |
Het |
| Prrc2a |
T |
C |
17: 35,375,308 (GRCm39) |
D1114G |
probably damaging |
Het |
| Prss16 |
T |
C |
13: 22,193,546 (GRCm39) |
|
probably benign |
Het |
| Rtp3 |
T |
C |
9: 110,816,168 (GRCm39) |
K128E |
probably damaging |
Het |
| Scn3a |
T |
A |
2: 65,355,194 (GRCm39) |
I241F |
possibly damaging |
Het |
| Setd1a |
G |
A |
7: 127,386,382 (GRCm39) |
V336I |
probably damaging |
Het |
| Sfpq |
A |
G |
4: 126,916,762 (GRCm39) |
I320V |
possibly damaging |
Het |
| Skint5 |
A |
T |
4: 113,620,679 (GRCm39) |
D678E |
unknown |
Het |
| Slc12a9 |
G |
A |
5: 137,313,638 (GRCm39) |
P774S |
probably benign |
Het |
| Slc25a54 |
C |
G |
3: 109,019,481 (GRCm39) |
L362V |
possibly damaging |
Het |
| Smarcd1 |
A |
G |
15: 99,605,267 (GRCm39) |
|
probably null |
Het |
| Spata31e5 |
T |
A |
1: 28,816,011 (GRCm39) |
N674Y |
probably damaging |
Het |
| Suco |
A |
T |
1: 161,661,683 (GRCm39) |
M916K |
probably damaging |
Het |
| Tiam2 |
T |
C |
17: 3,564,973 (GRCm39) |
S1404P |
possibly damaging |
Het |
| Topors |
T |
C |
4: 40,260,333 (GRCm39) |
T984A |
unknown |
Het |
| Trabd2b |
A |
T |
4: 114,443,767 (GRCm39) |
K308M |
probably damaging |
Het |
| Trmo |
A |
T |
4: 46,377,083 (GRCm39) |
|
probably benign |
Het |
| Trpc3 |
A |
T |
3: 36,725,654 (GRCm39) |
D107E |
probably benign |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Uggt2 |
A |
C |
14: 119,295,010 (GRCm39) |
Y539D |
probably benign |
Het |
| Wwc2 |
T |
G |
8: 48,353,674 (GRCm39) |
|
probably benign |
Het |
| Zdbf2 |
T |
A |
1: 63,344,109 (GRCm39) |
D829E |
possibly damaging |
Het |
|
| Other mutations in Hivep3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00953:Hivep3
|
APN |
4 |
119,955,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01017:Hivep3
|
APN |
4 |
119,956,443 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01837:Hivep3
|
APN |
4 |
119,951,759 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01878:Hivep3
|
APN |
4 |
119,952,424 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02134:Hivep3
|
APN |
4 |
119,990,771 (GRCm39) |
splice site |
probably benign |
|
|
IGL02183:Hivep3
|
APN |
4 |
119,989,221 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02350:Hivep3
|
APN |
4 |
119,980,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02451:Hivep3
|
APN |
4 |
119,991,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02567:Hivep3
|
APN |
4 |
119,991,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02617:Hivep3
|
APN |
4 |
119,952,641 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02725:Hivep3
|
APN |
4 |
119,953,019 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
IGL02828:Hivep3
|
APN |
4 |
119,954,929 (GRCm39) |
nonsense |
probably null |
|
|
IGL02954:Hivep3
|
APN |
4 |
119,990,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02966:Hivep3
|
APN |
4 |
119,989,383 (GRCm39) |
missense |
probably benign |
0.04 |
|
Branchial
|
UTSW |
4 |
119,953,772 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Deceit
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
Mandible
|
UTSW |
4 |
119,954,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Sclerotic
|
UTSW |
4 |
119,952,296 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
Stealth
|
UTSW |
4 |
119,980,073 (GRCm39) |
nonsense |
probably null |
|
|
Yellowjacket
|
UTSW |
4 |
119,989,554 (GRCm39) |
missense |
probably benign |
0.01 |
|
PIT4260001:Hivep3
|
UTSW |
4 |
119,956,379 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0321:Hivep3
|
UTSW |
4 |
119,952,788 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0336:Hivep3
|
UTSW |
4 |
119,961,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0558:Hivep3
|
UTSW |
4 |
119,953,763 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0562:Hivep3
|
UTSW |
4 |
119,953,751 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0637:Hivep3
|
UTSW |
4 |
119,989,738 (GRCm39) |
nonsense |
probably null |
|
|
R1186:Hivep3
|
UTSW |
4 |
119,671,920 (GRCm39) |
start gained |
probably benign |
|
|
R1254:Hivep3
|
UTSW |
4 |
119,956,490 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1428:Hivep3
|
UTSW |
4 |
119,953,772 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1623:Hivep3
|
UTSW |
4 |
119,952,901 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1739:Hivep3
|
UTSW |
4 |
119,952,371 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1766:Hivep3
|
UTSW |
4 |
119,953,868 (GRCm39) |
missense |
probably benign |
|
|
R1769:Hivep3
|
UTSW |
4 |
119,954,768 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1773:Hivep3
|
UTSW |
4 |
119,956,034 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1968:Hivep3
|
UTSW |
4 |
119,953,435 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R2220:Hivep3
|
UTSW |
4 |
119,591,235 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R2428:Hivep3
|
UTSW |
4 |
119,955,705 (GRCm39) |
nonsense |
probably null |
|
|
R3789:Hivep3
|
UTSW |
4 |
119,955,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3917:Hivep3
|
UTSW |
4 |
119,956,624 (GRCm39) |
missense |
probably benign |
0.27 |
|
R4366:Hivep3
|
UTSW |
4 |
119,953,286 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R4436:Hivep3
|
UTSW |
4 |
119,953,120 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4504:Hivep3
|
UTSW |
4 |
119,590,990 (GRCm39) |
unclassified |
probably benign |
|
|
R4705:Hivep3
|
UTSW |
4 |
119,729,247 (GRCm39) |
intron |
probably benign |
|
|
R4713:Hivep3
|
UTSW |
4 |
119,989,000 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4756:Hivep3
|
UTSW |
4 |
119,955,020 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4887:Hivep3
|
UTSW |
4 |
119,980,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4888:Hivep3
|
UTSW |
4 |
119,980,131 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5008:Hivep3
|
UTSW |
4 |
119,956,114 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5204:Hivep3
|
UTSW |
4 |
119,961,053 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5594:Hivep3
|
UTSW |
4 |
119,980,245 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5697:Hivep3
|
UTSW |
4 |
119,954,152 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5715:Hivep3
|
UTSW |
4 |
119,953,570 (GRCm39) |
missense |
probably benign |
|
|
R5740:Hivep3
|
UTSW |
4 |
119,953,220 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5760:Hivep3
|
UTSW |
4 |
119,952,208 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R5923:Hivep3
|
UTSW |
4 |
119,953,490 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R5927:Hivep3
|
UTSW |
4 |
119,954,305 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6042:Hivep3
|
UTSW |
4 |
119,955,061 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6074:Hivep3
|
UTSW |
4 |
119,954,891 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6150:Hivep3
|
UTSW |
4 |
119,591,274 (GRCm39) |
nonsense |
probably null |
|
|
R6211:Hivep3
|
UTSW |
4 |
119,955,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6251:Hivep3
|
UTSW |
4 |
119,952,137 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6451:Hivep3
|
UTSW |
4 |
119,956,105 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6531:Hivep3
|
UTSW |
4 |
119,980,073 (GRCm39) |
nonsense |
probably null |
|
|
R6651:Hivep3
|
UTSW |
4 |
119,980,146 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6701:Hivep3
|
UTSW |
4 |
119,951,737 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6721:Hivep3
|
UTSW |
4 |
119,952,296 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6796:Hivep3
|
UTSW |
4 |
119,953,558 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R6864:Hivep3
|
UTSW |
4 |
119,952,085 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6902:Hivep3
|
UTSW |
4 |
119,953,192 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7111:Hivep3
|
UTSW |
4 |
119,952,431 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R7113:Hivep3
|
UTSW |
4 |
119,955,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7140:Hivep3
|
UTSW |
4 |
119,954,318 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7189:Hivep3
|
UTSW |
4 |
119,989,416 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7218:Hivep3
|
UTSW |
4 |
119,952,649 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7366:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7368:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7491:Hivep3
|
UTSW |
4 |
119,956,027 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7496:Hivep3
|
UTSW |
4 |
119,989,599 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7514:Hivep3
|
UTSW |
4 |
119,954,052 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7604:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7605:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7607:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7610:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7611:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7613:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7626:Hivep3
|
UTSW |
4 |
119,955,108 (GRCm39) |
frame shift |
probably null |
|
|
R7707:Hivep3
|
UTSW |
4 |
119,591,156 (GRCm39) |
missense |
|
|
|
R7736:Hivep3
|
UTSW |
4 |
119,952,740 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7915:Hivep3
|
UTSW |
4 |
119,954,962 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7943:Hivep3
|
UTSW |
4 |
119,989,554 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7972:Hivep3
|
UTSW |
4 |
119,954,711 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R8093:Hivep3
|
UTSW |
4 |
119,952,632 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8111:Hivep3
|
UTSW |
4 |
119,955,583 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8215:Hivep3
|
UTSW |
4 |
119,980,098 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8364:Hivep3
|
UTSW |
4 |
119,956,639 (GRCm39) |
missense |
probably benign |
0.10 |
|
R8467:Hivep3
|
UTSW |
4 |
119,952,238 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8768:Hivep3
|
UTSW |
4 |
119,989,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8890:Hivep3
|
UTSW |
4 |
119,953,657 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8902:Hivep3
|
UTSW |
4 |
119,953,937 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9022:Hivep3
|
UTSW |
4 |
119,955,304 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9336:Hivep3
|
UTSW |
4 |
119,952,400 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R9606:Hivep3
|
UTSW |
4 |
119,989,786 (GRCm39) |
missense |
probably damaging |
0.98 |
|
RF019:Hivep3
|
UTSW |
4 |
119,955,467 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0062:Hivep3
|
UTSW |
4 |
119,955,895 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0067:Hivep3
|
UTSW |
4 |
119,988,984 (GRCm39) |
missense |
probably damaging |
0.96 |
|
Z1176:Hivep3
|
UTSW |
4 |
119,990,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Hivep3
|
UTSW |
4 |
119,988,975 (GRCm39) |
nonsense |
probably null |
|
|
Z1177:Hivep3
|
UTSW |
4 |
119,953,143 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGAAGAATTCCAGTGGCCCCAG -3'
(R):5'- TGCCGTAGTCAAAGGATTTGCTTCG -3'
Sequencing Primer
(F):5'- GGAGAAGCTGCCACCCAAG -3'
(R):5'- CAAAGGATTTGCTTCGGGTCTC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation