Incidental Mutation 'R7351:Gpr26'
ID 570575
Institutional Source Beutler Lab
Gene Symbol Gpr26
Ensembl Gene ENSMUSG00000040125
Gene Name G protein-coupled receptor 26
Synonyms 9630036A11Rik
MMRRC Submission 045437-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # R7351 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 131567891-131587362 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 131576094 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Arginine at position 253 (C253R)
Ref Sequence ENSEMBL: ENSMUSP00000041664 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045840] [ENSMUST00000124096]
AlphaFold Q8BZA7
Predicted Effect probably damaging
Transcript: ENSMUST00000045840
AA Change: C253R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000041664
Gene: ENSMUSG00000040125
AA Change: C253R

Pfam:7TM_GPCR_Srsx 15 309 1.9e-7 PFAM
Pfam:7tm_1 22 294 1.4e-33 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000124096
SMART Domains Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849

Pfam:Pkinase 1 118 4.8e-19 PFAM
Pfam:Pkinase_Tyr 1 118 1.7e-50 PFAM
low complexity region 146 160 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 98.9%
Validation Efficiency 98% (56/57)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
PHENOTYPE: Mice homozygous for one null allele exhibit increased anxiety- and depression-related behaviors and alcohol preference. Female mice homozygous for another allele display increased susceptibility to diet-induced obesity with increased food intake. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700006A11Rik C A 3: 124,206,159 (GRCm39) G343V probably damaging Het
Adamts6 G A 13: 104,526,620 (GRCm39) S516N possibly damaging Het
Ahi1 A G 10: 20,841,832 (GRCm39) D301G probably damaging Het
Arhgef37 T A 18: 61,631,286 (GRCm39) L566F possibly damaging Het
AU040320 A G 4: 126,710,237 (GRCm39) N328D probably damaging Het
Bicc1 G T 10: 70,783,730 (GRCm39) T469K probably benign Het
Brk1 T C 6: 113,592,742 (GRCm39) S42P probably benign Het
Ccdc180 A G 4: 45,903,887 (GRCm39) E351G possibly damaging Het
Cenpo A T 12: 4,266,581 (GRCm39) F176I probably damaging Het
Cfap97d1 A G 11: 101,882,331 (GRCm39) E163G probably benign Het
Clec12b A G 6: 129,356,874 (GRCm39) probably null Het
Ddx42 A G 11: 106,138,508 (GRCm39) N769S probably benign Het
Drc7 A G 8: 95,785,135 (GRCm39) D165G probably benign Het
Dync2h1 A T 9: 7,167,145 (GRCm39) I486N probably damaging Het
Gmip A G 8: 70,270,034 (GRCm39) D679G probably benign Het
Gml2 T C 15: 74,693,225 (GRCm39) V76A possibly damaging Het
H2-Q4 A G 17: 35,601,854 (GRCm39) T239A possibly damaging Het
Hmcn1 T A 1: 150,543,640 (GRCm39) Y2845F probably damaging Het
Ift172 A G 5: 31,433,240 (GRCm39) Y550H probably damaging Het
Irgm2 G A 11: 58,110,431 (GRCm39) V41M possibly damaging Het
Lrp2 C T 2: 69,278,486 (GRCm39) G3956R probably damaging Het
Matn2 G A 15: 34,345,482 (GRCm39) R163H probably damaging Het
Mxd1 A G 6: 86,628,448 (GRCm39) S151P probably damaging Het
Or10ak16 T C 4: 118,751,033 (GRCm39) V251A probably benign Het
Or4a73 C T 2: 89,420,857 (GRCm39) G201S probably benign Het
Or5m10b G T 2: 85,694,415 (GRCm39) probably benign Het
Or8b3 C T 9: 38,314,739 (GRCm39) L190F probably damaging Het
Plcg2 A G 8: 118,317,049 (GRCm39) E642G possibly damaging Het
Pramel6 T A 2: 87,340,672 (GRCm39) F335I probably benign Het
Psd G T 19: 46,310,869 (GRCm39) S393R probably benign Het
Pwwp2a A G 11: 43,573,107 (GRCm39) D63G probably benign Het
Rbm28 T C 6: 29,158,879 (GRCm39) T139A probably benign Het
Ripk2 T G 4: 16,155,048 (GRCm39) E157A probably damaging Het
Rnf145 G A 11: 44,439,623 (GRCm39) V140I possibly damaging Het
Rnf38 T C 4: 44,149,102 (GRCm39) N114D probably benign Het
Samd9l G A 6: 3,374,157 (GRCm39) R1035C probably benign Het
Sec14l3 A G 11: 4,024,785 (GRCm39) T245A probably benign Het
Serpina10 A T 12: 103,595,194 (GRCm39) F8L probably benign Het
Slc16a8 T A 15: 79,137,841 (GRCm39) D56V probably damaging Het
Spag9 A T 11: 93,983,802 (GRCm39) E726D probably benign Het
Spg11 A G 2: 121,900,412 (GRCm39) F1547L possibly damaging Het
Sspo T C 6: 48,441,855 (GRCm39) I1955T possibly damaging Het
Stx18 T A 5: 38,196,755 (GRCm39) V27E probably benign Het
Taf1c A G 8: 120,325,739 (GRCm39) S708P probably damaging Het
Tas2r126 T C 6: 42,412,240 (GRCm39) F258L probably benign Het
Tdpoz2 C T 3: 93,559,900 (GRCm39) W24* probably null Het
Tmc8 T C 11: 117,674,654 (GRCm39) L123P probably damaging Het
Trmo A T 4: 46,387,716 (GRCm39) Y35N possibly damaging Het
Ttn C T 2: 76,598,030 (GRCm39) V19628I possibly damaging Het
Ttn G A 2: 76,770,274 (GRCm39) A2685V unknown Het
Usp15 A T 10: 122,968,904 (GRCm39) M349K probably damaging Het
Vmn2r89 A G 14: 51,693,739 (GRCm39) N363S probably benign Het
Vwa3a T A 7: 120,375,559 (GRCm39) I423N probably damaging Het
Zfp592 T C 7: 80,691,439 (GRCm39) V1206A probably benign Het
Zfp866 A T 8: 70,218,547 (GRCm39) Y358N probably damaging Het
Other mutations in Gpr26
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01065:Gpr26 APN 7 131,569,230 (GRCm39) missense probably damaging 1.00
IGL01345:Gpr26 APN 7 131,569,161 (GRCm39) missense possibly damaging 0.90
IGL01658:Gpr26 APN 7 131,585,834 (GRCm39) missense probably benign
IGL02724:Gpr26 APN 7 131,576,121 (GRCm39) critical splice donor site probably null
R0408:Gpr26 UTSW 7 131,576,001 (GRCm39) splice site probably null
R0408:Gpr26 UTSW 7 131,569,249 (GRCm39) missense possibly damaging 0.81
R0547:Gpr26 UTSW 7 131,586,026 (GRCm39) missense probably benign 0.01
R2508:Gpr26 UTSW 7 131,568,823 (GRCm39) missense probably damaging 0.98
R4088:Gpr26 UTSW 7 131,568,805 (GRCm39) missense probably benign 0.00
R4630:Gpr26 UTSW 7 131,568,709 (GRCm39) missense probably damaging 1.00
R4680:Gpr26 UTSW 7 131,576,082 (GRCm39) missense probably benign 0.34
R4756:Gpr26 UTSW 7 131,569,230 (GRCm39) missense probably damaging 1.00
R5229:Gpr26 UTSW 7 131,585,976 (GRCm39) missense probably damaging 1.00
R5610:Gpr26 UTSW 7 131,568,694 (GRCm39) missense possibly damaging 0.94
R6605:Gpr26 UTSW 7 131,585,893 (GRCm39) missense possibly damaging 0.91
R6653:Gpr26 UTSW 7 131,585,830 (GRCm39) missense probably benign 0.00
R7213:Gpr26 UTSW 7 131,569,219 (GRCm39) missense probably damaging 1.00
R7768:Gpr26 UTSW 7 131,576,077 (GRCm39) missense probably damaging 0.99
R7887:Gpr26 UTSW 7 131,568,702 (GRCm39) missense probably benign
R8822:Gpr26 UTSW 7 131,568,997 (GRCm39) missense probably damaging 0.98
R9382:Gpr26 UTSW 7 131,568,963 (GRCm39) missense probably damaging 1.00
R9508:Gpr26 UTSW 7 131,585,830 (GRCm39) missense probably benign 0.00
Z1088:Gpr26 UTSW 7 131,585,823 (GRCm39) frame shift probably null
Z1176:Gpr26 UTSW 7 131,568,954 (GRCm39) missense probably damaging 1.00
Z1176:Gpr26 UTSW 7 131,568,777 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2019-09-13