Incidental Mutation 'R0645:Myom2'
| ID |
57064 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myom2
|
| Ensembl Gene |
ENSMUSG00000031461 |
| Gene Name |
myomesin 2 |
| Synonyms |
|
| MMRRC Submission |
038830-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.148)
|
| Stock # |
R0645 (G1)
|
| Quality Score |
158 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
15057653-15133541 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 15117698 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 1094
(D1094E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000033842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000033842]
|
| AlphaFold |
Q14BI5 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000033842
AA Change: D1094E
PolyPhen 2
Score 0.963 (Sensitivity: 0.78; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000033842
Gene: ENSMUSG00000031461
AA Change: D1094E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
34 |
63 |
N/A |
INTRINSIC |
|
low complexity region
|
79 |
87 |
N/A |
INTRINSIC |
|
coiled coil region
|
97 |
129 |
N/A |
INTRINSIC |
|
IG
|
160 |
247 |
7.7e-5 |
SMART |
|
IG
|
284 |
373 |
8.01e-3 |
SMART |
|
FN3
|
383 |
466 |
1.5e-14 |
SMART |
|
FN3
|
511 |
594 |
1.79e-12 |
SMART |
|
FN3
|
612 |
693 |
1.95e-13 |
SMART |
|
FN3
|
711 |
794 |
8.69e-11 |
SMART |
|
FN3
|
813 |
896 |
1.86e-10 |
SMART |
|
IG_like
|
913 |
999 |
1.58e2 |
SMART |
|
Blast:IG_like
|
1021 |
1106 |
1e-44 |
BLAST |
|
IG_like
|
1135 |
1215 |
2.27e1 |
SMART |
|
Blast:IG_like
|
1227 |
1321 |
9e-51 |
BLAST |
|
IGc2
|
1357 |
1425 |
4.96e-8 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000140033
|
| Meta Mutation Damage Score |
0.4002 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
99% (94/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The giant protein titin, together with its associated proteins, interconnects the major structure of sarcomeres, the M bands and Z discs. The C-terminal end of the titin string extends into the M line, where it binds tightly to M-band constituents of apparent molecular masses of 190 kD and 165 kD. The predicted MYOM2 protein contains 1,465 amino acids. Like MYOM1, MYOM2 has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Protein sequence comparisons suggested that the MYOM2 protein and bovine M protein are identical. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930430A15Rik |
C |
T |
2: 111,214,583 (GRCm38) |
|
probably null |
Het |
| Adam18 |
G |
T |
8: 24,672,120 (GRCm38) |
Y46* |
probably null |
Het |
| Adam26b |
A |
C |
8: 43,520,487 (GRCm38) |
C493G |
probably damaging |
Het |
| Ak5 |
A |
T |
3: 152,653,615 (GRCm38) |
L182Q |
probably damaging |
Het |
| Akt1s1 |
T |
C |
7: 44,849,221 (GRCm38) |
|
probably benign |
Het |
| Amhr2 |
G |
T |
15: 102,446,428 (GRCm38) |
G133C |
probably damaging |
Het |
| Btbd9 |
A |
T |
17: 30,524,967 (GRCm38) |
L187Q |
probably damaging |
Het |
| Ccdc117 |
A |
T |
11: 5,534,385 (GRCm38) |
|
probably benign |
Het |
| Ccdc138 |
A |
T |
10: 58,575,720 (GRCm38) |
I637F |
probably damaging |
Het |
| Ccdc162 |
A |
G |
10: 41,586,411 (GRCm38) |
|
probably benign |
Het |
| Cdc25b |
C |
A |
2: 131,191,613 (GRCm38) |
H157Q |
probably benign |
Het |
| Cdon |
A |
G |
9: 35,477,083 (GRCm38) |
|
probably null |
Het |
| Cdt1 |
G |
A |
8: 122,572,145 (GRCm38) |
|
probably benign |
Het |
| Cep350 |
C |
T |
1: 155,940,712 (GRCm38) |
|
probably null |
Het |
| Cfb |
T |
C |
17: 34,860,016 (GRCm38) |
K831R |
probably benign |
Het |
| Cldn4 |
C |
A |
5: 134,946,791 (GRCm38) |
|
probably benign |
Het |
| Cntnap5b |
T |
C |
1: 100,072,042 (GRCm38) |
|
probably benign |
Het |
| Cyp27b1 |
T |
G |
10: 127,049,098 (GRCm38) |
S77A |
probably benign |
Het |
| Dlc1 |
T |
C |
8: 36,574,049 (GRCm38) |
D1342G |
possibly damaging |
Het |
| Dlgap4 |
A |
G |
2: 156,761,879 (GRCm38) |
H887R |
probably damaging |
Het |
| Duox2 |
A |
G |
2: 122,292,658 (GRCm38) |
I503T |
probably damaging |
Het |
| Eml4 |
T |
C |
17: 83,463,493 (GRCm38) |
|
probably benign |
Het |
| Ermap |
A |
G |
4: 119,185,691 (GRCm38) |
S212P |
probably benign |
Het |
| Esrrg |
T |
A |
1: 188,043,341 (GRCm38) |
C22S |
probably benign |
Het |
| Evx2 |
T |
A |
2: 74,657,894 (GRCm38) |
Y194F |
possibly damaging |
Het |
| Fbn2 |
T |
G |
18: 58,058,389 (GRCm38) |
D1554A |
probably damaging |
Het |
| Flrt1 |
G |
A |
19: 7,097,143 (GRCm38) |
|
probably benign |
Het |
| Fndc5 |
A |
G |
4: 129,139,837 (GRCm38) |
|
probably benign |
Het |
| Frem1 |
A |
T |
4: 82,989,166 (GRCm38) |
I837N |
probably damaging |
Het |
| Fzd10 |
G |
T |
5: 128,602,598 (GRCm38) |
A461S |
possibly damaging |
Het |
| Ganab |
T |
A |
19: 8,911,113 (GRCm38) |
Y511N |
probably damaging |
Het |
| Gbp7 |
A |
G |
3: 142,538,165 (GRCm38) |
|
probably null |
Het |
| Gm5919 |
T |
A |
9: 83,883,383 (GRCm38) |
C91S |
unknown |
Het |
| Gpr31b |
A |
T |
17: 13,052,206 (GRCm38) |
C25* |
probably null |
Het |
| Grb10 |
A |
G |
11: 11,936,755 (GRCm38) |
S505P |
probably damaging |
Het |
| Grm4 |
A |
T |
17: 27,435,209 (GRCm38) |
V542E |
probably damaging |
Het |
| Gsta5 |
T |
C |
9: 78,299,021 (GRCm38) |
I75T |
possibly damaging |
Het |
| Hivep3 |
G |
A |
4: 120,097,334 (GRCm38) |
R949H |
possibly damaging |
Het |
| Hycc1 |
C |
T |
5: 23,979,508 (GRCm38) |
G242D |
probably damaging |
Het |
| Invs |
A |
T |
4: 48,407,653 (GRCm38) |
M543L |
probably benign |
Het |
| Kcnk2 |
T |
C |
1: 189,256,730 (GRCm38) |
|
probably null |
Het |
| Kdm6b |
A |
T |
11: 69,405,018 (GRCm38) |
S808T |
unknown |
Het |
| Klhl30 |
C |
T |
1: 91,355,506 (GRCm38) |
R277W |
probably damaging |
Het |
| Lama1 |
A |
G |
17: 67,773,712 (GRCm38) |
Q1245R |
probably benign |
Het |
| Lingo3 |
G |
T |
10: 80,835,335 (GRCm38) |
H254N |
probably benign |
Het |
| Lzts1 |
A |
T |
8: 69,135,740 (GRCm38) |
H521Q |
possibly damaging |
Het |
| Map3k19 |
A |
C |
1: 127,822,182 (GRCm38) |
I1144S |
possibly damaging |
Het |
| Mast2 |
A |
G |
4: 116,307,987 (GRCm38) |
S1411P |
probably damaging |
Het |
| Mast2 |
T |
C |
4: 116,312,846 (GRCm38) |
|
probably benign |
Het |
| Mesp1 |
G |
T |
7: 79,792,580 (GRCm38) |
S225R |
possibly damaging |
Het |
| Micu1 |
A |
G |
10: 59,839,681 (GRCm38) |
T366A |
possibly damaging |
Het |
| Mideas |
G |
T |
12: 84,158,303 (GRCm38) |
N834K |
possibly damaging |
Het |
| Mknk2 |
T |
C |
10: 80,671,908 (GRCm38) |
|
probably null |
Het |
| Msh5 |
A |
G |
17: 35,039,223 (GRCm38) |
L309P |
probably damaging |
Het |
| Myo7b |
T |
C |
18: 31,994,909 (GRCm38) |
I577V |
probably benign |
Het |
| Nedd1 |
T |
C |
10: 92,691,831 (GRCm38) |
|
probably null |
Het |
| Neu4 |
T |
C |
1: 94,022,469 (GRCm38) |
L50S |
probably damaging |
Het |
| Noa1 |
T |
C |
5: 77,309,875 (GRCm38) |
Y61C |
probably benign |
Het |
| Nr1h4 |
A |
T |
10: 89,506,528 (GRCm38) |
M30K |
probably benign |
Het |
| Nsd3 |
A |
G |
8: 25,709,069 (GRCm38) |
I1219V |
probably benign |
Het |
| Nup188 |
T |
A |
2: 30,343,466 (GRCm38) |
|
probably null |
Het |
| Or10ag2 |
T |
A |
2: 87,418,268 (GRCm38) |
Y71* |
probably null |
Het |
| Or5al5 |
A |
G |
2: 86,131,034 (GRCm38) |
S210P |
probably damaging |
Het |
| Or6c208 |
T |
A |
10: 129,388,293 (GRCm38) |
I220N |
possibly damaging |
Het |
| Or6k2 |
A |
T |
1: 174,159,354 (GRCm38) |
T194S |
probably benign |
Het |
| Pbk |
G |
A |
14: 65,813,796 (GRCm38) |
|
probably benign |
Het |
| Pcnx2 |
G |
A |
8: 125,760,720 (GRCm38) |
T1848M |
possibly damaging |
Het |
| Pdzd7 |
C |
T |
19: 45,045,475 (GRCm38) |
G57R |
possibly damaging |
Het |
| Pik3r4 |
C |
A |
9: 105,669,187 (GRCm38) |
|
probably benign |
Het |
| Plce1 |
A |
G |
19: 38,777,989 (GRCm38) |
S2153G |
probably damaging |
Het |
| Pphln1 |
G |
A |
15: 93,420,311 (GRCm38) |
V34M |
possibly damaging |
Het |
| Prrc2a |
T |
C |
17: 35,156,332 (GRCm38) |
D1114G |
probably damaging |
Het |
| Prss16 |
T |
C |
13: 22,009,376 (GRCm38) |
|
probably benign |
Het |
| Rtp3 |
T |
C |
9: 110,987,100 (GRCm38) |
K128E |
probably damaging |
Het |
| Scn3a |
T |
A |
2: 65,524,850 (GRCm38) |
I241F |
possibly damaging |
Het |
| Setd1a |
G |
A |
7: 127,787,210 (GRCm38) |
V336I |
probably damaging |
Het |
| Sfpq |
A |
G |
4: 127,022,969 (GRCm38) |
I320V |
possibly damaging |
Het |
| Skint5 |
A |
T |
4: 113,763,482 (GRCm38) |
D678E |
unknown |
Het |
| Slc12a9 |
G |
A |
5: 137,315,376 (GRCm38) |
P774S |
probably benign |
Het |
| Slc25a54 |
C |
G |
3: 109,112,165 (GRCm38) |
L362V |
possibly damaging |
Het |
| Smarcd1 |
A |
G |
15: 99,707,386 (GRCm38) |
|
probably null |
Het |
| Spata31e5 |
T |
A |
1: 28,776,930 (GRCm38) |
N674Y |
probably damaging |
Het |
| Suco |
A |
T |
1: 161,834,114 (GRCm38) |
M916K |
probably damaging |
Het |
| Tiam2 |
T |
C |
17: 3,514,698 (GRCm38) |
S1404P |
possibly damaging |
Het |
| Topors |
T |
C |
4: 40,260,333 (GRCm38) |
T984A |
unknown |
Het |
| Trabd2b |
A |
T |
4: 114,586,570 (GRCm38) |
K308M |
probably damaging |
Het |
| Trmo |
A |
T |
4: 46,377,083 (GRCm38) |
|
probably benign |
Het |
| Trpc3 |
A |
T |
3: 36,671,505 (GRCm38) |
D107E |
probably benign |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm38) |
P46S |
probably benign |
Het |
| Uggt2 |
A |
C |
14: 119,057,598 (GRCm38) |
Y539D |
probably benign |
Het |
| Wwc2 |
T |
G |
8: 47,900,639 (GRCm38) |
|
probably benign |
Het |
| Zdbf2 |
T |
A |
1: 63,304,950 (GRCm38) |
D829E |
possibly damaging |
Het |
|
| Other mutations in Myom2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00422:Myom2
|
APN |
8 |
15,069,490 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00426:Myom2
|
APN |
8 |
15,069,502 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00503:Myom2
|
APN |
8 |
15,114,289 (GRCm38) |
splice site |
probably null |
|
|
IGL01515:Myom2
|
APN |
8 |
15,122,655 (GRCm38) |
missense |
probably benign |
0.15 |
|
IGL01649:Myom2
|
APN |
8 |
15,113,755 (GRCm38) |
missense |
probably benign |
0.24 |
|
IGL01658:Myom2
|
APN |
8 |
15,077,880 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01786:Myom2
|
APN |
8 |
15,106,330 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL01924:Myom2
|
APN |
8 |
15,069,685 (GRCm38) |
missense |
probably benign |
0.37 |
|
IGL01929:Myom2
|
APN |
8 |
15,117,698 (GRCm38) |
missense |
probably damaging |
0.96 |
|
IGL02016:Myom2
|
APN |
8 |
15,125,195 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02511:Myom2
|
APN |
8 |
15,065,743 (GRCm38) |
missense |
probably benign |
|
|
IGL02558:Myom2
|
APN |
8 |
15,114,237 (GRCm38) |
missense |
probably benign |
0.31 |
|
IGL02944:Myom2
|
APN |
8 |
15,104,065 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
IGL03052:Myom2
|
APN |
8 |
15,123,442 (GRCm38) |
splice site |
probably benign |
|
|
IGL03195:Myom2
|
APN |
8 |
15,111,844 (GRCm38) |
nonsense |
probably null |
|
|
IGL03288:Myom2
|
APN |
8 |
15,122,679 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL03402:Myom2
|
APN |
8 |
15,065,731 (GRCm38) |
missense |
probably benign |
|
|
yomama
|
UTSW |
8 |
15,132,895 (GRCm38) |
missense |
probably benign |
0.10 |
|
yoyoma
|
UTSW |
8 |
15,132,667 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0069:Myom2
|
UTSW |
8 |
15,117,624 (GRCm38) |
missense |
probably benign |
|
|
R0116:Myom2
|
UTSW |
8 |
15,117,633 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0131:Myom2
|
UTSW |
8 |
15,083,329 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0373:Myom2
|
UTSW |
8 |
15,098,419 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R0463:Myom2
|
UTSW |
8 |
15,104,123 (GRCm38) |
missense |
probably benign |
0.09 |
|
R0544:Myom2
|
UTSW |
8 |
15,069,796 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0629:Myom2
|
UTSW |
8 |
15,069,783 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0634:Myom2
|
UTSW |
8 |
15,119,216 (GRCm38) |
splice site |
probably benign |
|
|
R0730:Myom2
|
UTSW |
8 |
15,099,326 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0744:Myom2
|
UTSW |
8 |
15,132,924 (GRCm38) |
nonsense |
probably null |
|
|
R0836:Myom2
|
UTSW |
8 |
15,132,924 (GRCm38) |
nonsense |
probably null |
|
|
R1033:Myom2
|
UTSW |
8 |
15,108,934 (GRCm38) |
missense |
probably benign |
0.04 |
|
R1103:Myom2
|
UTSW |
8 |
15,110,827 (GRCm38) |
missense |
probably benign |
0.22 |
|
R1110:Myom2
|
UTSW |
8 |
15,122,413 (GRCm38) |
missense |
probably benign |
0.44 |
|
R1208:Myom2
|
UTSW |
8 |
15,084,631 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1208:Myom2
|
UTSW |
8 |
15,084,631 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1353:Myom2
|
UTSW |
8 |
15,106,424 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1530:Myom2
|
UTSW |
8 |
15,122,384 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1544:Myom2
|
UTSW |
8 |
15,104,059 (GRCm38) |
splice site |
probably benign |
|
|
R1576:Myom2
|
UTSW |
8 |
15,084,556 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1758:Myom2
|
UTSW |
8 |
15,065,795 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1884:Myom2
|
UTSW |
8 |
15,114,278 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1908:Myom2
|
UTSW |
8 |
15,081,023 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1962:Myom2
|
UTSW |
8 |
15,132,599 (GRCm38) |
splice site |
probably null |
|
|
R1977:Myom2
|
UTSW |
8 |
15,085,263 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R2018:Myom2
|
UTSW |
8 |
15,131,151 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2049:Myom2
|
UTSW |
8 |
15,106,379 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R2155:Myom2
|
UTSW |
8 |
15,084,555 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R2314:Myom2
|
UTSW |
8 |
15,063,927 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2350:Myom2
|
UTSW |
8 |
15,108,835 (GRCm38) |
missense |
probably benign |
0.09 |
|
R2358:Myom2
|
UTSW |
8 |
15,112,018 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R2904:Myom2
|
UTSW |
8 |
15,098,348 (GRCm38) |
missense |
probably benign |
0.00 |
|
R3418:Myom2
|
UTSW |
8 |
15,085,294 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3606:Myom2
|
UTSW |
8 |
15,069,775 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3607:Myom2
|
UTSW |
8 |
15,069,775 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3735:Myom2
|
UTSW |
8 |
15,069,676 (GRCm38) |
missense |
probably benign |
0.01 |
|
R3756:Myom2
|
UTSW |
8 |
15,102,650 (GRCm38) |
missense |
probably benign |
0.11 |
|
R3902:Myom2
|
UTSW |
8 |
15,104,165 (GRCm38) |
missense |
probably benign |
|
|
R3951:Myom2
|
UTSW |
8 |
15,084,556 (GRCm38) |
missense |
probably benign |
0.35 |
|
R4240:Myom2
|
UTSW |
8 |
15,132,895 (GRCm38) |
missense |
probably benign |
0.10 |
|
R4361:Myom2
|
UTSW |
8 |
15,112,018 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R4581:Myom2
|
UTSW |
8 |
15,106,459 (GRCm38) |
missense |
probably benign |
0.02 |
|
R4736:Myom2
|
UTSW |
8 |
15,081,271 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5010:Myom2
|
UTSW |
8 |
15,083,310 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R5108:Myom2
|
UTSW |
8 |
15,132,667 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5370:Myom2
|
UTSW |
8 |
15,099,343 (GRCm38) |
missense |
probably benign |
0.10 |
|
R5427:Myom2
|
UTSW |
8 |
15,113,764 (GRCm38) |
missense |
probably benign |
0.03 |
|
R5498:Myom2
|
UTSW |
8 |
15,129,142 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5504:Myom2
|
UTSW |
8 |
15,128,879 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5567:Myom2
|
UTSW |
8 |
15,102,546 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5743:Myom2
|
UTSW |
8 |
15,080,914 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R5745:Myom2
|
UTSW |
8 |
15,122,705 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5844:Myom2
|
UTSW |
8 |
15,131,182 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5854:Myom2
|
UTSW |
8 |
15,108,478 (GRCm38) |
missense |
probably benign |
|
|
R6141:Myom2
|
UTSW |
8 |
15,063,903 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6209:Myom2
|
UTSW |
8 |
15,104,173 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
R6248:Myom2
|
UTSW |
8 |
15,098,472 (GRCm38) |
splice site |
probably null |
|
|
R6378:Myom2
|
UTSW |
8 |
15,099,356 (GRCm38) |
missense |
probably benign |
0.11 |
|
R6829:Myom2
|
UTSW |
8 |
15,122,643 (GRCm38) |
nonsense |
probably null |
|
|
R6913:Myom2
|
UTSW |
8 |
15,065,710 (GRCm38) |
missense |
probably benign |
|
|
R6957:Myom2
|
UTSW |
8 |
15,117,741 (GRCm38) |
missense |
probably null |
0.42 |
|
R6958:Myom2
|
UTSW |
8 |
15,117,741 (GRCm38) |
missense |
probably null |
0.42 |
|
R6960:Myom2
|
UTSW |
8 |
15,117,741 (GRCm38) |
missense |
probably null |
0.42 |
|
R6961:Myom2
|
UTSW |
8 |
15,117,741 (GRCm38) |
missense |
probably null |
0.42 |
|
R6962:Myom2
|
UTSW |
8 |
15,117,741 (GRCm38) |
missense |
probably null |
0.42 |
|
R6999:Myom2
|
UTSW |
8 |
15,084,531 (GRCm38) |
missense |
probably benign |
0.22 |
|
R7148:Myom2
|
UTSW |
8 |
15,084,577 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
R7210:Myom2
|
UTSW |
8 |
15,104,114 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7298:Myom2
|
UTSW |
8 |
15,098,411 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7463:Myom2
|
UTSW |
8 |
15,117,679 (GRCm38) |
missense |
probably null |
0.94 |
|
R7535:Myom2
|
UTSW |
8 |
15,117,679 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7573:Myom2
|
UTSW |
8 |
15,122,450 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7590:Myom2
|
UTSW |
8 |
15,117,679 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7690:Myom2
|
UTSW |
8 |
15,111,717 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R7794:Myom2
|
UTSW |
8 |
15,083,259 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7822:Myom2
|
UTSW |
8 |
15,108,454 (GRCm38) |
missense |
probably benign |
|
|
R7948:Myom2
|
UTSW |
8 |
15,085,306 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8094:Myom2
|
UTSW |
8 |
15,069,418 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R8268:Myom2
|
UTSW |
8 |
15,129,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8292:Myom2
|
UTSW |
8 |
15,132,888 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8514:Myom2
|
UTSW |
8 |
15,125,153 (GRCm38) |
missense |
possibly damaging |
0.65 |
|
R8539:Myom2
|
UTSW |
8 |
15,114,254 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8790:Myom2
|
UTSW |
8 |
15,119,242 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8824:Myom2
|
UTSW |
8 |
15,114,169 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8895:Myom2
|
UTSW |
8 |
15,102,589 (GRCm38) |
nonsense |
probably null |
|
|
R9024:Myom2
|
UTSW |
8 |
15,063,936 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9129:Myom2
|
UTSW |
8 |
15,104,068 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9224:Myom2
|
UTSW |
8 |
15,128,804 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R9237:Myom2
|
UTSW |
8 |
15,102,591 (GRCm38) |
missense |
possibly damaging |
0.85 |
|
R9321:Myom2
|
UTSW |
8 |
15,122,464 (GRCm38) |
missense |
possibly damaging |
0.91 |
|
R9341:Myom2
|
UTSW |
8 |
15,084,633 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9343:Myom2
|
UTSW |
8 |
15,084,633 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R9375:Myom2
|
UTSW |
8 |
15,099,210 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9455:Myom2
|
UTSW |
8 |
15,106,293 (GRCm38) |
missense |
probably benign |
0.31 |
|
R9563:Myom2
|
UTSW |
8 |
15,108,399 (GRCm38) |
nonsense |
probably null |
|
|
R9565:Myom2
|
UTSW |
8 |
15,108,399 (GRCm38) |
nonsense |
probably null |
|
|
RF001:Myom2
|
UTSW |
8 |
15,081,418 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGACACAGAGTTTCATCATGTCAGTC -3'
(R):5'- AAGCCACCACTTACCTTGTTTCCGTAG -3'
Sequencing Primer
(F):5'- AGAGTTTCATCATGTCAGTCTCTGTG -3'
(R):5'- TCTAGGACAGCCTTGAATGC -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation