Incidental Mutation 'IGL00485:Arhgef37'
ID 5707
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Arhgef37
Ensembl Gene ENSMUSG00000045094
Gene Name Rho guanine nucleotide exchange factor 37
Synonyms 4933429F08Rik
Accession Numbers
Essential gene? Probably non essential (E-score: 0.149) question?
Stock # IGL00485
Quality Score
Status
Chromosome 18
Chromosomal Location 61624728-61669665 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 61656942 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 41 (T41I)
Ref Sequence ENSEMBL: ENSMUSP00000130560 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171629]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000171629
AA Change: T41I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000130560
Gene: ENSMUSG00000045094
AA Change: T41I

DomainStartEndE-ValueType
RhoGEF 34 212 2.62e-35 SMART
Pfam:BAR 311 444 5.6e-10 PFAM
SH3 509 568 8.06e-1 SMART
SH3 606 665 2.56e-14 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 26 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap23 G A 11: 97,383,497 (GRCm39) probably benign Het
Brms1 A C 19: 5,099,070 (GRCm39) probably benign Het
Cdkn1a C A 17: 29,317,494 (GRCm39) A38E possibly damaging Het
Col4a2 A G 8: 11,489,012 (GRCm39) M1133V probably benign Het
Ctps1 T C 4: 120,410,141 (GRCm39) Y314C probably damaging Het
Defa30 T A 8: 21,625,467 (GRCm39) M77K probably benign Het
Eif3a T C 19: 60,758,328 (GRCm39) R817G unknown Het
Entrep1 G A 19: 23,962,086 (GRCm39) R306W probably damaging Het
Ftdc2 A G 16: 58,455,854 (GRCm39) Y140H probably damaging Het
Greb1l A G 18: 10,555,962 (GRCm39) S1725G possibly damaging Het
Hmgxb4 T C 8: 75,756,131 (GRCm39) S545P probably damaging Het
Hrob C T 11: 102,146,783 (GRCm39) S353F possibly damaging Het
Kif13b A G 14: 65,002,522 (GRCm39) E1049G possibly damaging Het
Mug1 T C 6: 121,864,375 (GRCm39) V1424A probably benign Het
Nlrp2 A G 7: 5,340,547 (GRCm39) V89A probably benign Het
Osbpl11 T G 16: 33,062,115 (GRCm39) W741G probably damaging Het
Pam A G 1: 97,750,678 (GRCm39) V914A possibly damaging Het
Phldb2 T A 16: 45,577,551 (GRCm39) I1117F possibly damaging Het
Pign A T 1: 105,525,448 (GRCm39) L460* probably null Het
Pramel31 G A 4: 144,090,012 (GRCm39) V351I probably damaging Het
Prdm10 A T 9: 31,238,842 (GRCm39) I196F possibly damaging Het
Stk36 T C 1: 74,673,244 (GRCm39) S1044P probably benign Het
Trim43b T C 9: 88,973,695 (GRCm39) T13A probably benign Het
Unc5b T C 10: 60,618,995 (GRCm39) Y49C possibly damaging Het
Urb2 T C 8: 124,755,433 (GRCm39) I380T probably damaging Het
Zfyve27 T A 19: 42,171,872 (GRCm39) C229S probably benign Het
Other mutations in Arhgef37
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00801:Arhgef37 APN 18 61,632,905 (GRCm39) missense probably damaging 1.00
IGL01146:Arhgef37 APN 18 61,651,081 (GRCm39) missense possibly damaging 0.93
IGL02052:Arhgef37 APN 18 61,632,839 (GRCm39) missense probably damaging 1.00
IGL02489:Arhgef37 APN 18 61,639,540 (GRCm39) missense possibly damaging 0.91
IGL03236:Arhgef37 APN 18 61,656,897 (GRCm39) missense probably damaging 1.00
R0715:Arhgef37 UTSW 18 61,641,860 (GRCm39) missense probably damaging 0.98
R0746:Arhgef37 UTSW 18 61,651,064 (GRCm39) critical splice donor site probably null
R1843:Arhgef37 UTSW 18 61,651,121 (GRCm39) missense probably damaging 0.99
R1934:Arhgef37 UTSW 18 61,657,014 (GRCm39) missense probably benign 0.00
R1980:Arhgef37 UTSW 18 61,641,767 (GRCm39) missense probably damaging 0.98
R2012:Arhgef37 UTSW 18 61,637,427 (GRCm39) missense possibly damaging 0.56
R2237:Arhgef37 UTSW 18 61,637,477 (GRCm39) missense probably damaging 1.00
R3024:Arhgef37 UTSW 18 61,634,959 (GRCm39) missense probably damaging 0.96
R4864:Arhgef37 UTSW 18 61,627,996 (GRCm39) missense probably benign
R4876:Arhgef37 UTSW 18 61,631,310 (GRCm39) nonsense probably null
R5024:Arhgef37 UTSW 18 61,639,511 (GRCm39) missense probably damaging 0.99
R5050:Arhgef37 UTSW 18 61,637,402 (GRCm39) missense probably benign 0.43
R5512:Arhgef37 UTSW 18 61,632,845 (GRCm39) nonsense probably null
R5611:Arhgef37 UTSW 18 61,640,334 (GRCm39) missense probably benign 0.03
R6051:Arhgef37 UTSW 18 61,640,345 (GRCm39) missense probably damaging 0.97
R6488:Arhgef37 UTSW 18 61,651,123 (GRCm39) missense probably benign 0.43
R6612:Arhgef37 UTSW 18 61,627,952 (GRCm39) missense probably benign
R7117:Arhgef37 UTSW 18 61,637,481 (GRCm39) missense probably benign 0.00
R7351:Arhgef37 UTSW 18 61,631,286 (GRCm39) missense possibly damaging 0.93
R7426:Arhgef37 UTSW 18 61,637,456 (GRCm39) missense probably damaging 1.00
R7571:Arhgef37 UTSW 18 61,637,403 (GRCm39) missense probably damaging 0.97
R7992:Arhgef37 UTSW 18 61,638,827 (GRCm39) missense probably benign 0.03
R8493:Arhgef37 UTSW 18 61,640,277 (GRCm39) missense probably benign 0.03
R8936:Arhgef37 UTSW 18 61,656,948 (GRCm39) missense probably damaging 0.98
R9000:Arhgef37 UTSW 18 61,637,333 (GRCm39) missense possibly damaging 0.81
R9053:Arhgef37 UTSW 18 61,641,760 (GRCm39) missense probably damaging 1.00
R9298:Arhgef37 UTSW 18 61,651,072 (GRCm39) missense probably damaging 0.98
R9490:Arhgef37 UTSW 18 61,641,907 (GRCm39) missense probably damaging 1.00
R9559:Arhgef37 UTSW 18 61,640,267 (GRCm39) critical splice donor site probably null
Posted On 2012-04-20