Incidental Mutation 'R0645:Tiam2'
| ID |
57095 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tiam2
|
| Ensembl Gene |
ENSMUSG00000023800 |
| Gene Name |
T cell lymphoma invasion and metastasis 2 |
| Synonyms |
STEF, 3000002F19Rik |
| MMRRC Submission |
038830-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0645 (G1)
|
| Quality Score |
177 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
3376675-3569672 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 3564973 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 1404
(S1404P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000125842
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000041003]
[ENSMUST00000072156]
[ENSMUST00000169838]
[ENSMUST00000227405]
|
| AlphaFold |
Q6ZPF3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000041003
|
| SMART Domains |
Protein: ENSMUSP00000035291
Gene: ENSMUSG00000036983
| Domain | Start | End | E-Value | Type |
|---|
|
rADc
|
43 |
234 |
5.56e-69 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000072156
AA Change: S1404P
PolyPhen 2
Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000072020
Gene: ENSMUSG00000023800
AA Change: S1404P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000169838
AA Change: S1404P
PolyPhen 2
Score 0.916 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000125842
Gene: ENSMUSG00000023800
AA Change: S1404P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
230 |
245 |
N/A |
INTRINSIC |
|
low complexity region
|
267 |
281 |
N/A |
INTRINSIC |
|
low complexity region
|
471 |
492 |
N/A |
INTRINSIC |
|
PH
|
505 |
620 |
7.82e-16 |
SMART |
|
RBD
|
831 |
902 |
1.32e-26 |
SMART |
|
PDZ
|
921 |
995 |
2.38e-7 |
SMART |
|
RhoGEF
|
1124 |
1313 |
2.23e-61 |
SMART |
|
PH
|
1347 |
1478 |
2.86e0 |
SMART |
|
low complexity region
|
1522 |
1532 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226434
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226913
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000226997
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000227405
|
| Meta Mutation Damage Score |
0.1137 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.5%
|
| Validation Efficiency |
99% (94/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam18 |
G |
T |
8: 25,162,136 (GRCm39) |
Y46* |
probably null |
Het |
| Adam26b |
A |
C |
8: 43,973,524 (GRCm39) |
C493G |
probably damaging |
Het |
| Ak5 |
A |
T |
3: 152,359,252 (GRCm39) |
L182Q |
probably damaging |
Het |
| Akt1s1 |
T |
C |
7: 44,498,645 (GRCm39) |
|
probably benign |
Het |
| Amhr2 |
G |
T |
15: 102,354,863 (GRCm39) |
G133C |
probably damaging |
Het |
| Btbd9 |
A |
T |
17: 30,743,941 (GRCm39) |
L187Q |
probably damaging |
Het |
| Ccdc117 |
A |
T |
11: 5,484,385 (GRCm39) |
|
probably benign |
Het |
| Ccdc138 |
A |
T |
10: 58,411,542 (GRCm39) |
I637F |
probably damaging |
Het |
| Ccdc162 |
A |
G |
10: 41,462,407 (GRCm39) |
|
probably benign |
Het |
| Cdc25b |
C |
A |
2: 131,033,533 (GRCm39) |
H157Q |
probably benign |
Het |
| Cdon |
A |
G |
9: 35,388,379 (GRCm39) |
|
probably null |
Het |
| Cdt1 |
G |
A |
8: 123,298,884 (GRCm39) |
|
probably benign |
Het |
| Cep350 |
C |
T |
1: 155,816,458 (GRCm39) |
|
probably null |
Het |
| Cfb |
T |
C |
17: 35,078,992 (GRCm39) |
K831R |
probably benign |
Het |
| Cldn4 |
C |
A |
5: 134,975,645 (GRCm39) |
|
probably benign |
Het |
| Cntnap5b |
T |
C |
1: 99,999,767 (GRCm39) |
|
probably benign |
Het |
| Cyp27b1 |
T |
G |
10: 126,884,967 (GRCm39) |
S77A |
probably benign |
Het |
| Dlc1 |
T |
C |
8: 37,041,203 (GRCm39) |
D1342G |
possibly damaging |
Het |
| Dlgap4 |
A |
G |
2: 156,603,799 (GRCm39) |
H887R |
probably damaging |
Het |
| Duox2 |
A |
G |
2: 122,123,139 (GRCm39) |
I503T |
probably damaging |
Het |
| Eml4 |
T |
C |
17: 83,770,922 (GRCm39) |
|
probably benign |
Het |
| Ermap |
A |
G |
4: 119,042,888 (GRCm39) |
S212P |
probably benign |
Het |
| Esrrg |
T |
A |
1: 187,775,538 (GRCm39) |
C22S |
probably benign |
Het |
| Evx2 |
T |
A |
2: 74,488,238 (GRCm39) |
Y194F |
possibly damaging |
Het |
| Fbn2 |
T |
G |
18: 58,191,461 (GRCm39) |
D1554A |
probably damaging |
Het |
| Flrt1 |
G |
A |
19: 7,074,508 (GRCm39) |
|
probably benign |
Het |
| Fndc5 |
A |
G |
4: 129,033,630 (GRCm39) |
|
probably benign |
Het |
| Frem1 |
A |
T |
4: 82,907,403 (GRCm39) |
I837N |
probably damaging |
Het |
| Fzd10 |
G |
T |
5: 128,679,662 (GRCm39) |
A461S |
possibly damaging |
Het |
| Ganab |
T |
A |
19: 8,888,477 (GRCm39) |
Y511N |
probably damaging |
Het |
| Gbp7 |
A |
G |
3: 142,243,926 (GRCm39) |
|
probably null |
Het |
| Gm5919 |
T |
A |
9: 83,765,436 (GRCm39) |
C91S |
unknown |
Het |
| Gpr31b |
A |
T |
17: 13,271,093 (GRCm39) |
C25* |
probably null |
Het |
| Grb10 |
A |
G |
11: 11,886,755 (GRCm39) |
S505P |
probably damaging |
Het |
| Grm4 |
A |
T |
17: 27,654,183 (GRCm39) |
V542E |
probably damaging |
Het |
| Gsta5 |
T |
C |
9: 78,206,303 (GRCm39) |
I75T |
possibly damaging |
Het |
| Hivep3 |
G |
A |
4: 119,954,531 (GRCm39) |
R949H |
possibly damaging |
Het |
| Hycc1 |
C |
T |
5: 24,184,506 (GRCm39) |
G242D |
probably damaging |
Het |
| Invs |
A |
T |
4: 48,407,653 (GRCm39) |
M543L |
probably benign |
Het |
| Kcnk2 |
T |
C |
1: 188,988,927 (GRCm39) |
|
probably null |
Het |
| Kdm6b |
A |
T |
11: 69,295,844 (GRCm39) |
S808T |
unknown |
Het |
| Klhl30 |
C |
T |
1: 91,283,228 (GRCm39) |
R277W |
probably damaging |
Het |
| Lama1 |
A |
G |
17: 68,080,707 (GRCm39) |
Q1245R |
probably benign |
Het |
| Lingo3 |
G |
T |
10: 80,671,169 (GRCm39) |
H254N |
probably benign |
Het |
| Lzts1 |
A |
T |
8: 69,588,392 (GRCm39) |
H521Q |
possibly damaging |
Het |
| Map3k19 |
A |
C |
1: 127,749,919 (GRCm39) |
I1144S |
possibly damaging |
Het |
| Mast2 |
A |
G |
4: 116,165,184 (GRCm39) |
S1411P |
probably damaging |
Het |
| Mast2 |
T |
C |
4: 116,170,043 (GRCm39) |
|
probably benign |
Het |
| Mesp1 |
G |
T |
7: 79,442,328 (GRCm39) |
S225R |
possibly damaging |
Het |
| Micu1 |
A |
G |
10: 59,675,503 (GRCm39) |
T366A |
possibly damaging |
Het |
| Mideas |
G |
T |
12: 84,205,077 (GRCm39) |
N834K |
possibly damaging |
Het |
| Mknk2 |
T |
C |
10: 80,507,742 (GRCm39) |
|
probably null |
Het |
| Msh5 |
A |
G |
17: 35,258,199 (GRCm39) |
L309P |
probably damaging |
Het |
| Myo7b |
T |
C |
18: 32,127,962 (GRCm39) |
I577V |
probably benign |
Het |
| Myom2 |
T |
A |
8: 15,167,698 (GRCm39) |
D1094E |
probably damaging |
Het |
| Nedd1 |
T |
C |
10: 92,527,693 (GRCm39) |
|
probably null |
Het |
| Neu4 |
T |
C |
1: 93,950,191 (GRCm39) |
L50S |
probably damaging |
Het |
| Noa1 |
T |
C |
5: 77,457,722 (GRCm39) |
Y61C |
probably benign |
Het |
| Nr1h4 |
A |
T |
10: 89,342,390 (GRCm39) |
M30K |
probably benign |
Het |
| Nsd3 |
A |
G |
8: 26,199,096 (GRCm39) |
I1219V |
probably benign |
Het |
| Nup188 |
T |
A |
2: 30,233,478 (GRCm39) |
|
probably null |
Het |
| Or10ag2 |
T |
A |
2: 87,248,612 (GRCm39) |
Y71* |
probably null |
Het |
| Or5al5 |
A |
G |
2: 85,961,378 (GRCm39) |
S210P |
probably damaging |
Het |
| Or6c208 |
T |
A |
10: 129,224,162 (GRCm39) |
I220N |
possibly damaging |
Het |
| Or6k2 |
A |
T |
1: 173,986,920 (GRCm39) |
T194S |
probably benign |
Het |
| Pbk |
G |
A |
14: 66,051,245 (GRCm39) |
|
probably benign |
Het |
| Pcnx2 |
G |
A |
8: 126,487,459 (GRCm39) |
T1848M |
possibly damaging |
Het |
| Pdzd7 |
C |
T |
19: 45,033,914 (GRCm39) |
G57R |
possibly damaging |
Het |
| Pik3r4 |
C |
A |
9: 105,546,386 (GRCm39) |
|
probably benign |
Het |
| Plce1 |
A |
G |
19: 38,766,433 (GRCm39) |
S2153G |
probably damaging |
Het |
| Potefam1 |
C |
T |
2: 111,044,928 (GRCm39) |
|
probably null |
Het |
| Pphln1 |
G |
A |
15: 93,318,192 (GRCm39) |
V34M |
possibly damaging |
Het |
| Prrc2a |
T |
C |
17: 35,375,308 (GRCm39) |
D1114G |
probably damaging |
Het |
| Prss16 |
T |
C |
13: 22,193,546 (GRCm39) |
|
probably benign |
Het |
| Rtp3 |
T |
C |
9: 110,816,168 (GRCm39) |
K128E |
probably damaging |
Het |
| Scn3a |
T |
A |
2: 65,355,194 (GRCm39) |
I241F |
possibly damaging |
Het |
| Setd1a |
G |
A |
7: 127,386,382 (GRCm39) |
V336I |
probably damaging |
Het |
| Sfpq |
A |
G |
4: 126,916,762 (GRCm39) |
I320V |
possibly damaging |
Het |
| Skint5 |
A |
T |
4: 113,620,679 (GRCm39) |
D678E |
unknown |
Het |
| Slc12a9 |
G |
A |
5: 137,313,638 (GRCm39) |
P774S |
probably benign |
Het |
| Slc25a54 |
C |
G |
3: 109,019,481 (GRCm39) |
L362V |
possibly damaging |
Het |
| Smarcd1 |
A |
G |
15: 99,605,267 (GRCm39) |
|
probably null |
Het |
| Spata31e5 |
T |
A |
1: 28,816,011 (GRCm39) |
N674Y |
probably damaging |
Het |
| Suco |
A |
T |
1: 161,661,683 (GRCm39) |
M916K |
probably damaging |
Het |
| Topors |
T |
C |
4: 40,260,333 (GRCm39) |
T984A |
unknown |
Het |
| Trabd2b |
A |
T |
4: 114,443,767 (GRCm39) |
K308M |
probably damaging |
Het |
| Trmo |
A |
T |
4: 46,377,083 (GRCm39) |
|
probably benign |
Het |
| Trpc3 |
A |
T |
3: 36,725,654 (GRCm39) |
D107E |
probably benign |
Het |
| Ugcg |
C |
T |
4: 59,207,798 (GRCm39) |
P46S |
probably benign |
Het |
| Uggt2 |
A |
C |
14: 119,295,010 (GRCm39) |
Y539D |
probably benign |
Het |
| Wwc2 |
T |
G |
8: 48,353,674 (GRCm39) |
|
probably benign |
Het |
| Zdbf2 |
T |
A |
1: 63,344,109 (GRCm39) |
D829E |
possibly damaging |
Het |
|
| Other mutations in Tiam2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01011:Tiam2
|
APN |
17 |
3,465,303 (GRCm39) |
missense |
probably benign |
0.21 |
|
IGL01320:Tiam2
|
APN |
17 |
3,556,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01384:Tiam2
|
APN |
17 |
3,477,477 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL01575:Tiam2
|
APN |
17 |
3,504,591 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01769:Tiam2
|
APN |
17 |
3,477,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02395:Tiam2
|
APN |
17 |
3,471,756 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL02652:Tiam2
|
APN |
17 |
3,489,971 (GRCm39) |
splice site |
probably benign |
|
|
IGL03102:Tiam2
|
APN |
17 |
3,559,823 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03222:Tiam2
|
APN |
17 |
3,488,983 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Feste_burg
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R0257:Tiam2
|
UTSW |
17 |
3,501,088 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R0420:Tiam2
|
UTSW |
17 |
3,553,193 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0528:Tiam2
|
UTSW |
17 |
3,561,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Tiam2
|
UTSW |
17 |
3,471,921 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0551:Tiam2
|
UTSW |
17 |
3,479,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0554:Tiam2
|
UTSW |
17 |
3,488,956 (GRCm39) |
nonsense |
probably null |
|
|
R0726:Tiam2
|
UTSW |
17 |
3,563,108 (GRCm39) |
unclassified |
probably benign |
|
|
R1139:Tiam2
|
UTSW |
17 |
3,527,542 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1392:Tiam2
|
UTSW |
17 |
3,464,472 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1529:Tiam2
|
UTSW |
17 |
3,566,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1671:Tiam2
|
UTSW |
17 |
3,557,109 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1731:Tiam2
|
UTSW |
17 |
3,568,698 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1759:Tiam2
|
UTSW |
17 |
3,566,278 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1850:Tiam2
|
UTSW |
17 |
3,487,510 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1853:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1855:Tiam2
|
UTSW |
17 |
3,465,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1931:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1932:Tiam2
|
UTSW |
17 |
3,565,000 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1993:Tiam2
|
UTSW |
17 |
3,465,401 (GRCm39) |
nonsense |
probably null |
|
|
R2211:Tiam2
|
UTSW |
17 |
3,465,193 (GRCm39) |
nonsense |
probably null |
|
|
R2217:Tiam2
|
UTSW |
17 |
3,465,389 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2278:Tiam2
|
UTSW |
17 |
3,477,495 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2407:Tiam2
|
UTSW |
17 |
3,527,536 (GRCm39) |
missense |
probably benign |
0.14 |
|
R2516:Tiam2
|
UTSW |
17 |
3,503,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2991:Tiam2
|
UTSW |
17 |
3,568,525 (GRCm39) |
missense |
probably benign |
|
|
R3086:Tiam2
|
UTSW |
17 |
3,471,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3121:Tiam2
|
UTSW |
17 |
3,489,977 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3686:Tiam2
|
UTSW |
17 |
3,471,959 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R3740:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3742:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R3826:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3829:Tiam2
|
UTSW |
17 |
3,557,976 (GRCm39) |
splice site |
probably benign |
|
|
R3844:Tiam2
|
UTSW |
17 |
3,471,926 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3970:Tiam2
|
UTSW |
17 |
3,479,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4060:Tiam2
|
UTSW |
17 |
3,479,255 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4296:Tiam2
|
UTSW |
17 |
3,501,120 (GRCm39) |
missense |
probably benign |
|
|
R4357:Tiam2
|
UTSW |
17 |
3,501,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4368:Tiam2
|
UTSW |
17 |
3,464,958 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4369:Tiam2
|
UTSW |
17 |
3,464,242 (GRCm39) |
start gained |
probably benign |
|
|
R4524:Tiam2
|
UTSW |
17 |
3,564,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4619:Tiam2
|
UTSW |
17 |
3,568,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4715:Tiam2
|
UTSW |
17 |
3,504,443 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4723:Tiam2
|
UTSW |
17 |
3,500,592 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4979:Tiam2
|
UTSW |
17 |
3,555,985 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5182:Tiam2
|
UTSW |
17 |
3,488,996 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5451:Tiam2
|
UTSW |
17 |
3,479,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5728:Tiam2
|
UTSW |
17 |
3,465,231 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5827:Tiam2
|
UTSW |
17 |
3,498,764 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5879:Tiam2
|
UTSW |
17 |
3,487,540 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5960:Tiam2
|
UTSW |
17 |
3,488,915 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5974:Tiam2
|
UTSW |
17 |
3,465,084 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6198:Tiam2
|
UTSW |
17 |
3,464,396 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6222:Tiam2
|
UTSW |
17 |
3,503,613 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6295:Tiam2
|
UTSW |
17 |
3,559,831 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6355:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6356:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6454:Tiam2
|
UTSW |
17 |
3,488,938 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6497:Tiam2
|
UTSW |
17 |
3,557,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6579:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6580:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6581:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6582:Tiam2
|
UTSW |
17 |
3,464,897 (GRCm39) |
frame shift |
probably null |
|
|
R6648:Tiam2
|
UTSW |
17 |
3,557,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6705:Tiam2
|
UTSW |
17 |
3,568,518 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6758:Tiam2
|
UTSW |
17 |
3,568,678 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6836:Tiam2
|
UTSW |
17 |
3,464,655 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6924:Tiam2
|
UTSW |
17 |
3,558,070 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6977:Tiam2
|
UTSW |
17 |
3,568,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7051:Tiam2
|
UTSW |
17 |
3,498,758 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7151:Tiam2
|
UTSW |
17 |
3,498,660 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7214:Tiam2
|
UTSW |
17 |
3,568,687 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7332:Tiam2
|
UTSW |
17 |
3,503,644 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7334:Tiam2
|
UTSW |
17 |
3,553,283 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7414:Tiam2
|
UTSW |
17 |
3,464,388 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R7660:Tiam2
|
UTSW |
17 |
3,532,880 (GRCm39) |
start codon destroyed |
probably null |
0.66 |
|
R7743:Tiam2
|
UTSW |
17 |
3,568,431 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7755:Tiam2
|
UTSW |
17 |
3,471,591 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7805:Tiam2
|
UTSW |
17 |
3,559,685 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7813:Tiam2
|
UTSW |
17 |
3,487,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7842:Tiam2
|
UTSW |
17 |
3,568,399 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7989:Tiam2
|
UTSW |
17 |
3,568,524 (GRCm39) |
nonsense |
probably null |
|
|
R8011:Tiam2
|
UTSW |
17 |
3,498,671 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8221:Tiam2
|
UTSW |
17 |
3,568,860 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8260:Tiam2
|
UTSW |
17 |
3,568,594 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8292:Tiam2
|
UTSW |
17 |
3,557,142 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8406:Tiam2
|
UTSW |
17 |
3,558,065 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,317 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8424:Tiam2
|
UTSW |
17 |
3,566,316 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8430:Tiam2
|
UTSW |
17 |
3,568,537 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8530:Tiam2
|
UTSW |
17 |
3,501,087 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8692:Tiam2
|
UTSW |
17 |
3,479,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8902:Tiam2
|
UTSW |
17 |
3,527,471 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9067:Tiam2
|
UTSW |
17 |
3,561,407 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9080:Tiam2
|
UTSW |
17 |
3,464,519 (GRCm39) |
missense |
probably benign |
|
|
R9090:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9211:Tiam2
|
UTSW |
17 |
3,498,729 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9271:Tiam2
|
UTSW |
17 |
3,465,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9347:Tiam2
|
UTSW |
17 |
3,471,923 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9353:Tiam2
|
UTSW |
17 |
3,558,074 (GRCm39) |
nonsense |
probably null |
|
|
R9407:Tiam2
|
UTSW |
17 |
3,553,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9460:Tiam2
|
UTSW |
17 |
3,487,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9550:Tiam2
|
UTSW |
17 |
3,559,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9748:Tiam2
|
UTSW |
17 |
3,561,440 (GRCm39) |
missense |
probably benign |
0.20 |
|
X0027:Tiam2
|
UTSW |
17 |
3,464,275 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
|
X0060:Tiam2
|
UTSW |
17 |
3,500,629 (GRCm39) |
splice site |
probably null |
|
|
X0065:Tiam2
|
UTSW |
17 |
3,555,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Tiam2
|
UTSW |
17 |
3,465,294 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1176:Tiam2
|
UTSW |
17 |
3,556,051 (GRCm39) |
missense |
probably null |
1.00 |
|
Z1177:Tiam2
|
UTSW |
17 |
3,477,538 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTTGGCATAGTCCCAGCTCCAAGC -3'
(R):5'- ACCCCAGGTGCAATGGTTCAAAG -3'
Sequencing Primer
(F):5'- TCCAAGCCTGGGAGGTC -3'
(R):5'- cccactcctgtcttcctctc -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation