Incidental Mutation 'R7360:Ptger3'
ID 571249
Institutional Source Beutler Lab
Gene Symbol Ptger3
Ensembl Gene ENSMUSG00000040016
Gene Name prostaglandin E receptor 3 (subtype EP3)
Synonyms Ptgerep3, EP3, Pgerep3
MMRRC Submission 045446-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.067) question?
Stock # R7360 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 157272459-157350392 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 157272764 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 37 (V37A)
Ref Sequence ENSEMBL: ENSMUSP00000134137 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041175] [ENSMUST00000173533]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000041175
AA Change: V37A

PolyPhen 2 Score 0.281 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000043302
Gene: ENSMUSG00000040016
AA Change: V37A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srbc 25 171 6e-8 PFAM
Pfam:7tm_1 42 323 9.5e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000173533
AA Change: V37A

PolyPhen 2 Score 0.180 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000134137
Gene: ENSMUSG00000040016
AA Change: V37A

DomainStartEndE-ValueType
Pfam:7TM_GPCR_Srbc 25 171 4.1e-8 PFAM
Pfam:7tm_1 42 323 1.5e-23 PFAM
low complexity region 345 356 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve digestion, nervous system, kidney reabsorption, and uterine contraction activities. Studies of the mouse counterpart suggest that this receptor may also mediate adrenocorticotropic hormone response as well as fever generation in response to exogenous and endogenous stimuli. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit increased basal renal blood flow, decreased resting renal vascular resistance, impaired duodenal bicarbonate secretion and mucosal integrity, and impaired responses to endotoxin. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 G C 4: 106,606,548 (GRCm39) P534A possibly damaging Het
Arhgef26 T A 3: 62,355,626 (GRCm39) Y733N possibly damaging Het
Aste1 G T 9: 105,274,835 (GRCm39) M358I probably damaging Het
B4galnt3 C T 6: 120,209,940 (GRCm39) W61* probably null Het
Brd9 C T 13: 74,092,942 (GRCm39) R311W probably benign Het
Cdkn1c T C 7: 143,014,431 (GRCm39) D5G possibly damaging Het
Cerk A G 15: 86,043,327 (GRCm39) F158S probably damaging Het
Clec2m C T 6: 129,303,710 (GRCm39) R85H probably benign Het
Cnot4 T A 6: 35,041,941 (GRCm39) E235V probably damaging Het
Crmp1 T C 5: 37,433,624 (GRCm39) V275A possibly damaging Het
Dcbld2 C A 16: 58,285,683 (GRCm39) probably null Het
Dip2a T C 10: 76,114,394 (GRCm39) R1029G probably damaging Het
Dnaaf1 A G 8: 120,304,090 (GRCm39) T43A probably benign Het
Eaf2 C T 16: 36,648,514 (GRCm39) S2N probably benign Het
Eif2b4 T C 5: 31,348,719 (GRCm39) D164G probably benign Het
Fpgs T C 2: 32,584,005 (GRCm39) Y45C possibly damaging Het
Gm1527 C T 3: 28,968,691 (GRCm39) Q248* probably null Het
Gm29666 C T 15: 84,798,469 (GRCm39) A31T unknown Het
Gmip C A 8: 70,263,892 (GRCm39) A112D probably damaging Het
Hibadh C T 6: 52,617,197 (GRCm39) G13S probably benign Het
Hmcn1 A T 1: 150,494,597 (GRCm39) V4164D probably damaging Het
Kif15 A T 9: 122,820,202 (GRCm39) N580I probably benign Het
Krt25 G A 11: 99,208,232 (GRCm39) T332M probably benign Het
Krt88 G T 15: 101,345,643 (GRCm39) probably benign Het
Lrrk2 T C 15: 91,615,858 (GRCm39) probably null Het
Mapkapk5 A G 5: 121,675,169 (GRCm39) probably benign Het
Myh7b C T 2: 155,474,460 (GRCm39) S1725L probably benign Het
Nckap1l T G 15: 103,384,526 (GRCm39) probably null Het
Nphp3 A G 9: 103,893,277 (GRCm39) probably null Het
Obscn A C 11: 58,973,185 (GRCm39) V1996G probably damaging Het
Or14j8 T A 17: 38,263,900 (GRCm39) N5I probably damaging Het
Or4a66 A T 2: 88,531,331 (GRCm39) V114E probably damaging Het
Parp8 T C 13: 117,032,307 (GRCm39) T289A probably benign Het
Pcsk5 T C 19: 17,492,577 (GRCm39) K932R probably benign Het
Pde4dip T C 3: 97,625,632 (GRCm39) D1322G probably benign Het
Peli3 A T 19: 4,985,103 (GRCm39) M136K possibly damaging Het
Pgm5 A G 19: 24,812,181 (GRCm39) I117T probably damaging Het
Ppm1g T C 5: 31,360,621 (GRCm39) D478G probably damaging Het
Ppp2r5c A G 12: 110,541,272 (GRCm39) T474A probably benign Het
Ptprz1 T C 6: 23,000,906 (GRCm39) S999P probably damaging Het
Pygl C T 12: 70,274,306 (GRCm39) G18S probably benign Het
Rest T C 5: 77,428,976 (GRCm39) V465A probably benign Het
Sart1 T C 19: 5,433,231 (GRCm39) D422G probably damaging Het
Sgk1 A G 10: 21,869,972 (GRCm39) M4V probably benign Het
Slc33a1 A G 3: 63,855,075 (GRCm39) V395A possibly damaging Het
Slc38a11 A T 2: 65,184,139 (GRCm39) S171T possibly damaging Het
Slc4a2 T A 5: 24,634,713 (GRCm39) S76T probably benign Het
Spata31h1 T C 10: 82,132,341 (GRCm39) D223G unknown Het
Ssc4d T A 5: 135,994,965 (GRCm39) S184C probably damaging Het
Tspoap1 A G 11: 87,669,347 (GRCm39) Y1540C probably benign Het
Ube3a T A 7: 58,926,383 (GRCm39) L408Q probably damaging Het
Usp43 C A 11: 67,767,155 (GRCm39) probably null Het
Zan A C 5: 137,385,232 (GRCm39) V5067G unknown Het
Zfp180 C A 7: 23,804,915 (GRCm39) L445I probably damaging Het
Other mutations in Ptger3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02389:Ptger3 APN 3 157,272,808 (GRCm39) missense probably damaging 1.00
R1371:Ptger3 UTSW 3 157,273,365 (GRCm39) nonsense probably null
R2437:Ptger3 UTSW 3 157,273,207 (GRCm39) missense probably damaging 1.00
R4616:Ptger3 UTSW 3 157,272,931 (GRCm39) missense probably damaging 1.00
R6526:Ptger3 UTSW 3 157,273,139 (GRCm39) missense probably damaging 0.99
R7571:Ptger3 UTSW 3 157,347,412 (GRCm39) missense probably benign 0.01
R8433:Ptger3 UTSW 3 157,349,592 (GRCm39) makesense probably null
R8829:Ptger3 UTSW 3 157,273,423 (GRCm39) missense probably damaging 1.00
R9168:Ptger3 UTSW 3 157,273,424 (GRCm39) missense probably damaging 1.00
R9281:Ptger3 UTSW 3 157,273,090 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- AGTGCACTCTGCTGCTATC -3'
(R):5'- TGGTTAGCCCGAAGAAGGTG -3'

Sequencing Primer
(F):5'- TGCTATCCCGCAGCTGAG -3'
(R):5'- AGAAGGTGCACAGACGCCC -3'
Posted On 2019-09-13