Incidental Mutation 'R7360:Or14j8'
ID 571287
Institutional Source Beutler Lab
Gene Symbol Or14j8
Ensembl Gene ENSMUSG00000109376
Gene Name olfactory receptor family 14 subfamily J member 8
Synonyms Olfr1552-ps1, MOR218-6P, GA_x6K02T2PSCP-2403971-2403000, Olfr761, MOR218-12, MOR218-5P, MOR218-6P
MMRRC Submission 045446-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.784) question?
Stock # R7360 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 38262942-38263913 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 38263900 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 5 (N5I)
Ref Sequence ENSEMBL: ENSMUSP00000092917 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000049620]
AlphaFold Q7TRJ0
Predicted Effect probably damaging
Transcript: ENSMUST00000049620
AA Change: N5I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092917
Gene: ENSMUSG00000109376
AA Change: N5I

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 6.8e-45 PFAM
Pfam:7TM_GPCR_Srsx 35 305 2.1e-6 PFAM
Pfam:7tm_1 41 290 3.7e-22 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (54/54)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acot11 G C 4: 106,606,548 (GRCm39) P534A possibly damaging Het
Arhgef26 T A 3: 62,355,626 (GRCm39) Y733N possibly damaging Het
Aste1 G T 9: 105,274,835 (GRCm39) M358I probably damaging Het
B4galnt3 C T 6: 120,209,940 (GRCm39) W61* probably null Het
Brd9 C T 13: 74,092,942 (GRCm39) R311W probably benign Het
Cdkn1c T C 7: 143,014,431 (GRCm39) D5G possibly damaging Het
Cerk A G 15: 86,043,327 (GRCm39) F158S probably damaging Het
Clec2m C T 6: 129,303,710 (GRCm39) R85H probably benign Het
Cnot4 T A 6: 35,041,941 (GRCm39) E235V probably damaging Het
Crmp1 T C 5: 37,433,624 (GRCm39) V275A possibly damaging Het
Dcbld2 C A 16: 58,285,683 (GRCm39) probably null Het
Dip2a T C 10: 76,114,394 (GRCm39) R1029G probably damaging Het
Dnaaf1 A G 8: 120,304,090 (GRCm39) T43A probably benign Het
Eaf2 C T 16: 36,648,514 (GRCm39) S2N probably benign Het
Eif2b4 T C 5: 31,348,719 (GRCm39) D164G probably benign Het
Fpgs T C 2: 32,584,005 (GRCm39) Y45C possibly damaging Het
Gm1527 C T 3: 28,968,691 (GRCm39) Q248* probably null Het
Gm29666 C T 15: 84,798,469 (GRCm39) A31T unknown Het
Gmip C A 8: 70,263,892 (GRCm39) A112D probably damaging Het
Hibadh C T 6: 52,617,197 (GRCm39) G13S probably benign Het
Hmcn1 A T 1: 150,494,597 (GRCm39) V4164D probably damaging Het
Kif15 A T 9: 122,820,202 (GRCm39) N580I probably benign Het
Krt25 G A 11: 99,208,232 (GRCm39) T332M probably benign Het
Krt88 G T 15: 101,345,643 (GRCm39) probably benign Het
Lrrk2 T C 15: 91,615,858 (GRCm39) probably null Het
Mapkapk5 A G 5: 121,675,169 (GRCm39) probably benign Het
Myh7b C T 2: 155,474,460 (GRCm39) S1725L probably benign Het
Nckap1l T G 15: 103,384,526 (GRCm39) probably null Het
Nphp3 A G 9: 103,893,277 (GRCm39) probably null Het
Obscn A C 11: 58,973,185 (GRCm39) V1996G probably damaging Het
Or4a66 A T 2: 88,531,331 (GRCm39) V114E probably damaging Het
Parp8 T C 13: 117,032,307 (GRCm39) T289A probably benign Het
Pcsk5 T C 19: 17,492,577 (GRCm39) K932R probably benign Het
Pde4dip T C 3: 97,625,632 (GRCm39) D1322G probably benign Het
Peli3 A T 19: 4,985,103 (GRCm39) M136K possibly damaging Het
Pgm5 A G 19: 24,812,181 (GRCm39) I117T probably damaging Het
Ppm1g T C 5: 31,360,621 (GRCm39) D478G probably damaging Het
Ppp2r5c A G 12: 110,541,272 (GRCm39) T474A probably benign Het
Ptger3 T C 3: 157,272,764 (GRCm39) V37A probably benign Het
Ptprz1 T C 6: 23,000,906 (GRCm39) S999P probably damaging Het
Pygl C T 12: 70,274,306 (GRCm39) G18S probably benign Het
Rest T C 5: 77,428,976 (GRCm39) V465A probably benign Het
Sart1 T C 19: 5,433,231 (GRCm39) D422G probably damaging Het
Sgk1 A G 10: 21,869,972 (GRCm39) M4V probably benign Het
Slc33a1 A G 3: 63,855,075 (GRCm39) V395A possibly damaging Het
Slc38a11 A T 2: 65,184,139 (GRCm39) S171T possibly damaging Het
Slc4a2 T A 5: 24,634,713 (GRCm39) S76T probably benign Het
Spata31h1 T C 10: 82,132,341 (GRCm39) D223G unknown Het
Ssc4d T A 5: 135,994,965 (GRCm39) S184C probably damaging Het
Tspoap1 A G 11: 87,669,347 (GRCm39) Y1540C probably benign Het
Ube3a T A 7: 58,926,383 (GRCm39) L408Q probably damaging Het
Usp43 C A 11: 67,767,155 (GRCm39) probably null Het
Zan A C 5: 137,385,232 (GRCm39) V5067G unknown Het
Zfp180 C A 7: 23,804,915 (GRCm39) L445I probably damaging Het
Other mutations in Or14j8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01557:Or14j8 APN 17 38,263,742 (GRCm39) missense probably damaging 1.00
IGL02104:Or14j8 APN 17 38,263,182 (GRCm39) missense probably damaging 1.00
IGL02431:Or14j8 APN 17 38,263,413 (GRCm39) missense probably benign 0.06
IGL02649:Or14j8 APN 17 38,263,864 (GRCm39) missense probably damaging 1.00
IGL03109:Or14j8 APN 17 38,263,378 (GRCm39) missense probably damaging 1.00
IGL03261:Or14j8 APN 17 38,263,697 (GRCm39) missense possibly damaging 0.76
R0898:Or14j8 UTSW 17 38,263,127 (GRCm39) missense probably benign 0.17
R1373:Or14j8 UTSW 17 38,263,251 (GRCm39) missense probably damaging 1.00
R1527:Or14j8 UTSW 17 38,263,720 (GRCm39) missense possibly damaging 0.88
R1664:Or14j8 UTSW 17 38,263,784 (GRCm39) missense probably benign 0.44
R1835:Or14j8 UTSW 17 38,263,276 (GRCm39) missense possibly damaging 0.79
R4124:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4125:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4128:Or14j8 UTSW 17 38,263,681 (GRCm39) missense probably benign 0.16
R4534:Or14j8 UTSW 17 38,263,613 (GRCm39) missense probably benign
R4557:Or14j8 UTSW 17 38,263,142 (GRCm39) missense probably benign 0.10
R4790:Or14j8 UTSW 17 38,263,633 (GRCm39) missense probably damaging 0.99
R4856:Or14j8 UTSW 17 38,262,962 (GRCm39) missense probably benign 0.15
R4886:Or14j8 UTSW 17 38,262,962 (GRCm39) missense probably benign 0.15
R4955:Or14j8 UTSW 17 38,263,789 (GRCm39) missense probably damaging 1.00
R5162:Or14j8 UTSW 17 38,263,255 (GRCm39) missense probably benign 0.00
R6016:Or14j8 UTSW 17 38,262,967 (GRCm39) missense probably benign 0.13
R6282:Or14j8 UTSW 17 38,263,315 (GRCm39) missense possibly damaging 0.80
R7018:Or14j8 UTSW 17 38,263,393 (GRCm39) missense probably damaging 1.00
R7199:Or14j8 UTSW 17 38,263,048 (GRCm39) missense probably damaging 1.00
R7340:Or14j8 UTSW 17 38,263,413 (GRCm39) missense probably benign 0.06
R7464:Or14j8 UTSW 17 38,263,171 (GRCm39) missense probably damaging 1.00
R7974:Or14j8 UTSW 17 38,263,672 (GRCm39) missense probably damaging 1.00
R8719:Or14j8 UTSW 17 38,263,895 (GRCm39) missense probably damaging 0.97
R8738:Or14j8 UTSW 17 38,263,673 (GRCm39) missense possibly damaging 0.79
R8817:Or14j8 UTSW 17 38,263,273 (GRCm39) missense probably damaging 0.99
R8856:Or14j8 UTSW 17 38,263,091 (GRCm39) missense possibly damaging 0.87
R9006:Or14j8 UTSW 17 38,263,545 (GRCm39) nonsense probably null
R9432:Or14j8 UTSW 17 38,263,559 (GRCm39) missense probably damaging 1.00
X0064:Or14j8 UTSW 17 38,263,705 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TCCAGAATGGAAAGGTGCTTC -3'
(R):5'- AGCTTGATGAACTGCAATTCC -3'

Sequencing Primer
(F):5'- GGTGCTTCAGAAAGTAATACATTGG -3'
(R):5'- GCTTGATGAACTGCAATTCCTTAAAC -3'
Posted On 2019-09-13