Incidental Mutation 'R7361:Neurl4'
| ID |
571352 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Neurl4
|
| Ensembl Gene |
ENSMUSG00000047284 |
| Gene Name |
neuralized E3 ubiquitin protein ligase 4 |
| Synonyms |
0610025P10Rik |
| MMRRC Submission |
045447-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7361 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
69792545-69804648 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 69802905 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Glutamine
at position 1467
(L1467Q)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135277
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000043419]
[ENSMUST00000057884]
[ENSMUST00000061837]
[ENSMUST00000070996]
[ENSMUST00000071026]
[ENSMUST00000072581]
[ENSMUST00000108609]
[ENSMUST00000177138]
[ENSMUST00000108610]
[ENSMUST00000108611]
[ENSMUST00000108612]
[ENSMUST00000108613]
[ENSMUST00000108617]
[ENSMUST00000116358]
[ENSMUST00000129475]
[ENSMUST00000133203]
[ENSMUST00000134581]
[ENSMUST00000164359]
[ENSMUST00000177476]
|
| AlphaFold |
Q5NCX5 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000043419
|
| SMART Domains |
Protein: ENSMUSP00000047008
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
eIF-5a
|
83 |
150 |
2.43e-29 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000057884
|
| SMART Domains |
Protein: ENSMUSP00000054072
Gene: ENSMUSG00000023170
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:G_path_suppress
|
5 |
294 |
6.1e-93 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000061837
AA Change: L1491Q
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000053235
Gene: ENSMUSG00000047284
AA Change: L1491Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
913 |
1043 |
2.27e-17 |
SMART |
|
low complexity region
|
1108 |
1117 |
N/A |
INTRINSIC |
|
NEUZ
|
1130 |
1250 |
4.93e-6 |
SMART |
|
low complexity region
|
1453 |
1464 |
N/A |
INTRINSIC |
|
low complexity region
|
1474 |
1483 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000070996
|
| SMART Domains |
Protein: ENSMUSP00000067077
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000071026
|
| SMART Domains |
Protein: ENSMUSP00000068651
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000072581
|
| SMART Domains |
Protein: ENSMUSP00000072389
Gene: ENSMUSG00000023170
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108609
|
| SMART Domains |
Protein: ENSMUSP00000104249
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177138
AA Change: L1467Q
PolyPhen 2
Score 0.007 (Sensitivity: 0.96; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000135277
Gene: ENSMUSG00000047284
AA Change: L1467Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
7.22e-52 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
6.15e-46 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
7.81e-39 |
SMART |
|
NEUZ
|
889 |
1019 |
2.27e-17 |
SMART |
|
low complexity region
|
1084 |
1093 |
N/A |
INTRINSIC |
|
NEUZ
|
1106 |
1226 |
4.93e-6 |
SMART |
|
low complexity region
|
1429 |
1440 |
N/A |
INTRINSIC |
|
low complexity region
|
1450 |
1459 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108610
|
| SMART Domains |
Protein: ENSMUSP00000104250
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108611
|
| SMART Domains |
Protein: ENSMUSP00000104251
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108612
|
| SMART Domains |
Protein: ENSMUSP00000104252
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108613
|
| SMART Domains |
Protein: ENSMUSP00000104253
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108617
AA Change: L1469Q
PolyPhen 2
Score 0.922 (Sensitivity: 0.81; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000104257
Gene: ENSMUSG00000047284
AA Change: L1469Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
3.5e-31 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
295 |
420 |
2.5e-54 |
SMART |
|
low complexity region
|
470 |
481 |
N/A |
INTRINSIC |
|
NEUZ
|
498 |
622 |
2e-48 |
SMART |
|
low complexity region
|
664 |
678 |
N/A |
INTRINSIC |
|
NEUZ
|
694 |
818 |
2.6e-41 |
SMART |
|
NEUZ
|
891 |
1021 |
7.6e-20 |
SMART |
|
low complexity region
|
1086 |
1095 |
N/A |
INTRINSIC |
|
NEUZ
|
1108 |
1228 |
1.7e-8 |
SMART |
|
low complexity region
|
1431 |
1442 |
N/A |
INTRINSIC |
|
low complexity region
|
1452 |
1461 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000116358
|
| SMART Domains |
Protein: ENSMUSP00000112062
Gene: ENSMUSG00000023170
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1jjva_
|
22 |
83 |
9e-3 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129475
|
| SMART Domains |
Protein: ENSMUSP00000135733
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
NEUZ
|
1 |
119 |
4.22e-44 |
SMART |
|
low complexity region
|
169 |
180 |
N/A |
INTRINSIC |
|
low complexity region
|
182 |
201 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
206 |
246 |
1.46e-10 |
PROSPERO |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000118868
Gene: ENSMUSG00000047284
AA Change: L198Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
161 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
182 |
191 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000133203
|
| SMART Domains |
Protein: ENSMUSP00000117917
Gene: ENSMUSG00000047284
| Domain | Start | End | E-Value | Type |
|---|
|
NEUZ
|
60 |
185 |
7.22e-52 |
SMART |
|
low complexity region
|
235 |
246 |
N/A |
INTRINSIC |
|
NEUZ
|
263 |
387 |
6.15e-46 |
SMART |
|
low complexity region
|
429 |
443 |
N/A |
INTRINSIC |
|
NEUZ
|
459 |
583 |
7.81e-39 |
SMART |
|
NEUZ
|
656 |
786 |
2.27e-17 |
SMART |
|
low complexity region
|
851 |
860 |
N/A |
INTRINSIC |
|
Pfam:Neuralized
|
875 |
942 |
6.5e-10 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000134581
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164359
|
| SMART Domains |
Protein: ENSMUSP00000132717
Gene: ENSMUSG00000078812
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1bkb_1
|
16 |
82 |
4e-39 |
SMART |
|
Pfam:eIF-5a
|
83 |
150 |
4.8e-27 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177476
AA Change: L1489Q
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000135185
Gene: ENSMUSG00000047284
AA Change: L1489Q
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
44 |
N/A |
INTRINSIC |
|
NEUZ
|
47 |
165 |
1.02e-28 |
SMART |
|
low complexity region
|
207 |
237 |
N/A |
INTRINSIC |
|
NEUZ
|
317 |
442 |
7.22e-52 |
SMART |
|
low complexity region
|
492 |
503 |
N/A |
INTRINSIC |
|
NEUZ
|
520 |
644 |
6.15e-46 |
SMART |
|
low complexity region
|
686 |
700 |
N/A |
INTRINSIC |
|
NEUZ
|
716 |
840 |
7.81e-39 |
SMART |
|
NEUZ
|
911 |
1041 |
2.27e-17 |
SMART |
|
low complexity region
|
1106 |
1115 |
N/A |
INTRINSIC |
|
NEUZ
|
1128 |
1248 |
4.93e-6 |
SMART |
|
low complexity region
|
1451 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1472 |
1481 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is predicted and it includes two isoforms resulting from two alternatively spliced transcript variants. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A630073D07Rik |
C |
T |
6: 132,604,434 (GRCm39) |
V4I |
unknown |
Het |
| Actn1 |
A |
T |
12: 80,240,489 (GRCm39) |
D199E |
probably benign |
Het |
| Adam17 |
T |
C |
12: 21,375,602 (GRCm39) |
D739G |
probably damaging |
Het |
| Agmat |
T |
C |
4: 141,474,163 (GRCm39) |
S15P |
probably benign |
Het |
| Ahsa2 |
A |
G |
11: 23,441,099 (GRCm39) |
S229P |
probably damaging |
Het |
| Arhgef3 |
A |
G |
14: 26,987,535 (GRCm39) |
D36G |
possibly damaging |
Het |
| C6 |
C |
A |
15: 4,826,404 (GRCm39) |
Y662* |
probably null |
Het |
| Ccs |
T |
C |
19: 4,883,378 (GRCm39) |
D140G |
probably benign |
Het |
| Cdc42bpb |
A |
G |
12: 111,312,039 (GRCm39) |
L65P |
probably damaging |
Het |
| Cdh24 |
A |
T |
14: 54,876,378 (GRCm39) |
V149E |
possibly damaging |
Het |
| Cdk12 |
C |
A |
11: 98,101,294 (GRCm39) |
S384* |
probably null |
Het |
| Cep350 |
G |
A |
1: 155,777,237 (GRCm39) |
A1701V |
probably damaging |
Het |
| Ces1g |
T |
C |
8: 94,060,307 (GRCm39) |
Q104R |
not run |
Het |
| Chd5 |
A |
G |
4: 152,447,745 (GRCm39) |
H537R |
probably damaging |
Het |
| Cln5 |
T |
A |
14: 103,313,339 (GRCm39) |
V197D |
probably damaging |
Het |
| Coq7 |
A |
G |
7: 118,128,798 (GRCm39) |
V79A |
probably benign |
Het |
| Cp |
A |
T |
3: 20,018,470 (GRCm39) |
N58I |
probably benign |
Het |
| Cplx2 |
A |
T |
13: 54,526,639 (GRCm39) |
M16L |
probably benign |
Het |
| Crot |
A |
G |
5: 9,027,534 (GRCm39) |
L266S |
probably damaging |
Het |
| Ctbs |
T |
A |
3: 146,164,509 (GRCm39) |
Y221N |
probably damaging |
Het |
| Cul7 |
T |
A |
17: 46,967,933 (GRCm39) |
L707Q |
probably damaging |
Het |
| D430041D05Rik |
G |
A |
2: 104,085,363 (GRCm39) |
T378I |
possibly damaging |
Het |
| Dixdc1 |
T |
C |
9: 50,599,953 (GRCm39) |
I364V |
probably damaging |
Het |
| Dnah11 |
T |
A |
12: 117,982,477 (GRCm39) |
H2564L |
probably damaging |
Het |
| Dnajc3 |
T |
C |
14: 119,175,576 (GRCm39) |
Y26H |
probably benign |
Het |
| Dpysl2 |
G |
A |
14: 67,071,664 (GRCm39) |
H159Y |
possibly damaging |
Het |
| Ehmt1 |
T |
A |
2: 24,746,713 (GRCm39) |
K423I |
possibly damaging |
Het |
| Eif1ad4 |
A |
G |
12: 87,862,170 (GRCm39) |
N11D |
unknown |
Het |
| Enpp7 |
A |
G |
11: 118,882,985 (GRCm39) |
N353S |
probably benign |
Het |
| Ext1 |
G |
A |
15: 53,208,119 (GRCm39) |
A214V |
probably damaging |
Het |
| Fbh1 |
A |
T |
2: 11,751,887 (GRCm39) |
I937N |
probably damaging |
Het |
| Fbxo39 |
T |
C |
11: 72,207,800 (GRCm39) |
Y51H |
possibly damaging |
Het |
| Firrm |
A |
T |
1: 163,813,602 (GRCm39) |
D207E |
possibly damaging |
Het |
| Fry |
A |
G |
5: 150,360,312 (GRCm39) |
H1986R |
possibly damaging |
Het |
| Grem2 |
T |
C |
1: 174,664,514 (GRCm39) |
K112E |
probably benign |
Het |
| Gucy1a1 |
A |
G |
3: 82,005,027 (GRCm39) |
V586A |
probably damaging |
Het |
| Il12rb2 |
G |
T |
6: 67,280,450 (GRCm39) |
L586I |
possibly damaging |
Het |
| Il18 |
T |
C |
9: 50,490,614 (GRCm39) |
I83T |
probably damaging |
Het |
| Irs1 |
A |
T |
1: 82,266,835 (GRCm39) |
Y460* |
probably null |
Het |
| Jak1 |
G |
T |
4: 101,041,536 (GRCm39) |
Q161K |
possibly damaging |
Het |
| Jakmip1 |
T |
A |
5: 37,276,148 (GRCm39) |
L486Q |
probably damaging |
Het |
| Jmjd1c |
C |
A |
10: 67,054,143 (GRCm39) |
Q16K |
probably benign |
Het |
| Kidins220 |
T |
C |
12: 25,106,999 (GRCm39) |
L1393P |
probably benign |
Het |
| Klhl24 |
A |
C |
16: 19,936,750 (GRCm39) |
I453L |
probably benign |
Het |
| Krtap2-4 |
C |
T |
11: 99,505,420 (GRCm39) |
D64N |
probably damaging |
Het |
| Man1a |
T |
A |
10: 53,784,105 (GRCm39) |
D592V |
probably damaging |
Het |
| Mepe |
T |
A |
5: 104,485,009 (GRCm39) |
Y50N |
probably benign |
Het |
| Mier3 |
G |
A |
13: 111,841,783 (GRCm39) |
G115S |
possibly damaging |
Het |
| Muc4 |
T |
A |
16: 32,754,670 (GRCm38) |
S1515T |
probably benign |
Het |
| Nalcn |
T |
C |
14: 123,529,251 (GRCm39) |
D1408G |
probably benign |
Het |
| Nav1 |
T |
C |
1: 135,380,591 (GRCm39) |
M1443V |
unknown |
Het |
| Nckap1l |
A |
C |
15: 103,379,709 (GRCm39) |
N332T |
possibly damaging |
Het |
| Notch2 |
A |
G |
3: 98,038,718 (GRCm39) |
N1287S |
probably benign |
Het |
| Nr4a3 |
C |
T |
4: 48,083,203 (GRCm39) |
P579S |
probably benign |
Het |
| Nrxn2 |
A |
T |
19: 6,567,112 (GRCm39) |
H1329L |
probably benign |
Het |
| Nynrin |
A |
T |
14: 56,107,857 (GRCm39) |
H988L |
possibly damaging |
Het |
| Or1e34 |
T |
A |
11: 73,778,827 (GRCm39) |
I124F |
probably damaging |
Het |
| Or4c31 |
A |
G |
2: 88,291,836 (GRCm39) |
T70A |
probably benign |
Het |
| Or4c3d |
A |
G |
2: 89,882,089 (GRCm39) |
I193T |
probably benign |
Het |
| Or52e3 |
G |
T |
7: 102,869,830 (GRCm39) |
D302Y |
possibly damaging |
Het |
| Or7g35 |
T |
A |
9: 19,495,856 (GRCm39) |
F8I |
probably benign |
Het |
| Pclo |
G |
A |
5: 14,843,882 (GRCm39) |
S1534N |
probably damaging |
Het |
| Pign |
A |
G |
1: 105,512,778 (GRCm39) |
V635A |
probably benign |
Het |
| Pkhd1 |
T |
C |
1: 20,664,177 (GRCm39) |
T134A |
probably damaging |
Het |
| Plcb4 |
A |
T |
2: 135,818,068 (GRCm39) |
N790I |
possibly damaging |
Het |
| Plxna2 |
G |
T |
1: 194,482,087 (GRCm39) |
C1453F |
probably damaging |
Het |
| Plxna4 |
A |
G |
6: 32,173,057 (GRCm39) |
|
probably null |
Het |
| Pnpla2 |
A |
G |
7: 141,037,344 (GRCm39) |
I116V |
possibly damaging |
Het |
| Polq |
A |
G |
16: 36,880,790 (GRCm39) |
T985A |
probably benign |
Het |
| Pramel11 |
T |
C |
4: 143,622,456 (GRCm39) |
T300A |
possibly damaging |
Het |
| Prex1 |
T |
C |
2: 166,555,490 (GRCm39) |
N50S |
probably benign |
Het |
| Ptgfrn |
G |
A |
3: 100,984,760 (GRCm39) |
A144V |
probably benign |
Het |
| Rad54b |
G |
A |
4: 11,599,782 (GRCm39) |
G329S |
probably damaging |
Het |
| Rrbp1 |
A |
G |
2: 143,809,364 (GRCm39) |
L931S |
probably benign |
Het |
| Saxo4 |
T |
G |
19: 10,456,943 (GRCm39) |
D134A |
probably damaging |
Het |
| Sipa1l2 |
A |
G |
8: 126,180,071 (GRCm39) |
S1109P |
probably damaging |
Het |
| Slc26a7 |
G |
T |
4: 14,546,305 (GRCm39) |
N341K |
probably damaging |
Het |
| Smg1 |
A |
C |
7: 117,784,200 (GRCm39) |
D958E |
unknown |
Het |
| Smg6 |
T |
A |
11: 74,820,979 (GRCm39) |
S417T |
probably benign |
Het |
| Srgap3 |
A |
G |
6: 112,723,882 (GRCm39) |
V550A |
probably damaging |
Het |
| Terb1 |
T |
A |
8: 105,195,431 (GRCm39) |
D570V |
probably damaging |
Het |
| Tet3 |
A |
G |
6: 83,345,076 (GRCm39) |
V1787A |
probably benign |
Het |
| Tor1a |
A |
T |
2: 30,853,753 (GRCm39) |
D192E |
probably benign |
Het |
| Tpr |
T |
C |
1: 150,323,372 (GRCm39) |
S2379P |
possibly damaging |
Het |
| Trip12 |
A |
T |
1: 84,728,163 (GRCm39) |
F1138L |
probably damaging |
Het |
| Trpv1 |
T |
C |
11: 73,151,203 (GRCm39) |
L797P |
probably damaging |
Het |
| Tut1 |
T |
C |
19: 8,942,698 (GRCm39) |
L595P |
probably damaging |
Het |
| Ubl7 |
T |
C |
9: 57,821,905 (GRCm39) |
S85P |
probably damaging |
Het |
| Urb1 |
C |
A |
16: 90,571,656 (GRCm39) |
S1051I |
probably damaging |
Het |
| Usp17le |
A |
G |
7: 104,418,084 (GRCm39) |
W353R |
probably damaging |
Het |
| Usp44 |
T |
C |
10: 93,682,330 (GRCm39) |
L260S |
probably benign |
Het |
| Wsb1 |
T |
A |
11: 79,131,623 (GRCm39) |
|
probably null |
Het |
| Xrcc2 |
A |
T |
5: 25,897,755 (GRCm39) |
C65S |
probably damaging |
Het |
| Zfp316 |
T |
A |
5: 143,240,430 (GRCm39) |
M530L |
probably benign |
Het |
| Zfp473 |
T |
C |
7: 44,382,563 (GRCm39) |
H590R |
probably damaging |
Het |
| Zfp983 |
T |
A |
17: 21,880,850 (GRCm39) |
H259Q |
probably damaging |
Het |
|
| Other mutations in Neurl4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00339:Neurl4
|
APN |
11 |
69,795,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00516:Neurl4
|
APN |
11 |
69,801,219 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01409:Neurl4
|
APN |
11 |
69,797,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01951:Neurl4
|
APN |
11 |
69,800,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02056:Neurl4
|
APN |
11 |
69,796,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02206:Neurl4
|
APN |
11 |
69,801,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02557:Neurl4
|
APN |
11 |
69,797,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02878:Neurl4
|
APN |
11 |
69,797,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0022:Neurl4
|
UTSW |
11 |
69,799,891 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
PIT4377001:Neurl4
|
UTSW |
11 |
69,801,232 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0388:Neurl4
|
UTSW |
11 |
69,802,559 (GRCm39) |
splice site |
probably benign |
|
|
R0421:Neurl4
|
UTSW |
11 |
69,799,360 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0449:Neurl4
|
UTSW |
11 |
69,796,393 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1174:Neurl4
|
UTSW |
11 |
69,794,547 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1345:Neurl4
|
UTSW |
11 |
69,794,702 (GRCm39) |
missense |
probably benign |
0.21 |
|
R1536:Neurl4
|
UTSW |
11 |
69,794,252 (GRCm39) |
nonsense |
probably null |
|
|
R1642:Neurl4
|
UTSW |
11 |
69,794,485 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1857:Neurl4
|
UTSW |
11 |
69,796,361 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1935:Neurl4
|
UTSW |
11 |
69,797,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1936:Neurl4
|
UTSW |
11 |
69,797,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1967:Neurl4
|
UTSW |
11 |
69,794,036 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R1973:Neurl4
|
UTSW |
11 |
69,800,118 (GRCm39) |
missense |
probably benign |
|
|
R2046:Neurl4
|
UTSW |
11 |
69,799,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2165:Neurl4
|
UTSW |
11 |
69,794,047 (GRCm39) |
missense |
probably benign |
|
|
R2393:Neurl4
|
UTSW |
11 |
69,797,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3810:Neurl4
|
UTSW |
11 |
69,794,859 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4299:Neurl4
|
UTSW |
11 |
69,799,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4749:Neurl4
|
UTSW |
11 |
69,801,894 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4898:Neurl4
|
UTSW |
11 |
69,793,997 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4968:Neurl4
|
UTSW |
11 |
69,798,134 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4969:Neurl4
|
UTSW |
11 |
69,801,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5503:Neurl4
|
UTSW |
11 |
69,797,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6655:Neurl4
|
UTSW |
11 |
69,801,742 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6791:Neurl4
|
UTSW |
11 |
69,799,336 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7029:Neurl4
|
UTSW |
11 |
69,801,562 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7216:Neurl4
|
UTSW |
11 |
69,801,088 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7367:Neurl4
|
UTSW |
11 |
69,799,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7804:Neurl4
|
UTSW |
11 |
69,796,700 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7871:Neurl4
|
UTSW |
11 |
69,794,012 (GRCm39) |
missense |
probably benign |
|
|
R8092:Neurl4
|
UTSW |
11 |
69,801,891 (GRCm39) |
missense |
probably benign |
|
|
R8121:Neurl4
|
UTSW |
11 |
69,799,056 (GRCm39) |
splice site |
probably null |
|
|
R8131:Neurl4
|
UTSW |
11 |
69,800,067 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8289:Neurl4
|
UTSW |
11 |
69,800,206 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8354:Neurl4
|
UTSW |
11 |
69,800,062 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8494:Neurl4
|
UTSW |
11 |
69,801,871 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8529:Neurl4
|
UTSW |
11 |
69,799,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8850:Neurl4
|
UTSW |
11 |
69,794,788 (GRCm39) |
unclassified |
probably benign |
|
|
R8992:Neurl4
|
UTSW |
11 |
69,798,958 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9334:Neurl4
|
UTSW |
11 |
69,796,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9509:Neurl4
|
UTSW |
11 |
69,792,971 (GRCm39) |
nonsense |
probably null |
|
|
R9705:Neurl4
|
UTSW |
11 |
69,799,679 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9707:Neurl4
|
UTSW |
11 |
69,799,679 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9746:Neurl4
|
UTSW |
11 |
69,798,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0025:Neurl4
|
UTSW |
11 |
69,797,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Neurl4
|
UTSW |
11 |
69,794,916 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
| Predicted Primers |
PCR Primer
(F):5'- CCCAGGTCTCTTCACAGGTAC -3'
(R):5'- TTTGAAAGACTTGGTATCCATACAC -3'
Sequencing Primer
(F):5'- GGTACTACCTCCATCCTGAGCTG -3'
(R):5'- AGAGGTCCTGAGTTCAATTCCCAG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation