Incidental Mutation 'R7363:Zkscan3'
ID 571494
Institutional Source Beutler Lab
Gene Symbol Zkscan3
Ensembl Gene ENSMUSG00000021327
Gene Name zinc finger with KRAB and SCAN domains 3
Synonyms Zfp306, 2810435N07Rik, Skz1, Zfp307
MMRRC Submission 045448-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.117) question?
Stock # R7363 (G1)
Quality Score 225.009
Status Validated
Chromosome 13
Chromosomal Location 21571173-21586925 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 21571992 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Serine at position 547 (G547S)
Ref Sequence ENSEMBL: ENSMUSP00000068424 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000070785] [ENSMUST00000116434] [ENSMUST00000117721] [ENSMUST00000223831] [ENSMUST00000224820]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000070785
AA Change: G547S

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000068424
Gene: ENSMUSG00000021327
AA Change: G547S

DomainStartEndE-ValueType
SCAN 47 159 4.18e-71 SMART
KRAB 213 273 4.07e-6 SMART
ZnF_C2H2 313 335 4.17e-3 SMART
ZnF_C2H2 341 363 1.38e-3 SMART
ZnF_C2H2 369 391 9.88e-5 SMART
ZnF_C2H2 397 419 1.95e-3 SMART
ZnF_C2H2 425 447 3.95e-4 SMART
ZnF_C2H2 479 501 5.21e-4 SMART
ZnF_C2H2 507 529 1.2e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000116434
AA Change: G547S

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000112135
Gene: ENSMUSG00000021327
AA Change: G547S

DomainStartEndE-ValueType
SCAN 47 159 4.18e-71 SMART
KRAB 213 273 4.07e-6 SMART
ZnF_C2H2 313 335 4.17e-3 SMART
ZnF_C2H2 341 363 1.38e-3 SMART
ZnF_C2H2 369 391 9.88e-5 SMART
ZnF_C2H2 397 419 1.95e-3 SMART
ZnF_C2H2 425 447 3.95e-4 SMART
ZnF_C2H2 479 501 5.21e-4 SMART
ZnF_C2H2 507 529 1.2e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000117721
SMART Domains Protein: ENSMUSP00000112862
Gene: ENSMUSG00000021327

DomainStartEndE-ValueType
SCAN 47 159 4.18e-71 SMART
KRAB 213 256 3.96e-2 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000223831
AA Change: G380S

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Predicted Effect probably benign
Transcript: ENSMUST00000224820
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (72/72)
Allele List at MGI

All alleles(5) : Gene trapped(5)

Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930568D16Rik T A 2: 35,244,782 (GRCm39) N190I probably damaging Het
Ablim1 G T 19: 57,204,173 (GRCm39) L73I probably benign Het
Adamts4 A T 1: 171,086,608 (GRCm39) Q800L probably benign Het
Atm A T 9: 53,376,598 (GRCm39) I2014N probably damaging Het
Atp2a1 A G 7: 126,062,061 (GRCm39) C12R possibly damaging Het
B3galnt1 A T 3: 69,483,157 (GRCm39) Y35N probably damaging Het
Bnc2 A T 4: 84,210,308 (GRCm39) M687K probably benign Het
Cacna2d4 A G 6: 119,320,939 (GRCm39) Y917C probably damaging Het
Cemip2 T C 19: 21,833,575 (GRCm39) F1338L probably benign Het
Ces2e A G 8: 105,659,632 (GRCm39) probably null Het
Cldn23 A G 8: 36,292,659 (GRCm39) probably null Het
Cntn5 G T 9: 10,172,021 (GRCm39) S54R probably benign Het
Cyria T A 12: 12,390,665 (GRCm39) probably null Het
Dido1 G T 2: 180,304,310 (GRCm39) S1198* probably null Het
Dnah12 A G 14: 26,445,766 (GRCm39) M776V probably benign Het
Dnah14 A G 1: 181,518,089 (GRCm39) probably null Het
Dnttip1 GGGCCGGC GGGC 2: 164,599,605 (GRCm39) probably null Het
Dusp28 A T 1: 92,834,861 (GRCm39) T29S probably benign Het
Erich1 A T 8: 14,083,688 (GRCm39) S127R probably benign Het
Fam151a T A 4: 106,602,681 (GRCm39) L200H probably damaging Het
Fbxw8 A T 5: 118,263,057 (GRCm39) H207Q probably damaging Het
Fgf22 A G 10: 79,592,676 (GRCm39) E116G probably benign Het
Gapvd1 C A 2: 34,602,207 (GRCm39) V647F probably benign Het
Garin4 A T 1: 190,895,910 (GRCm39) S244R probably damaging Het
Gja4 T A 4: 127,206,487 (GRCm39) Y92F probably damaging Het
Gtf3c2 G A 5: 31,327,600 (GRCm39) R288W probably damaging Het
Hira G T 16: 18,716,532 (GRCm39) R99L possibly damaging Het
Ighv16-1 C T 12: 114,032,721 (GRCm39) G27D probably damaging Het
Igkv1-133 C T 6: 67,702,395 (GRCm39) P38S probably benign Het
Igkv4-59 T C 6: 69,415,396 (GRCm39) Y53C probably damaging Het
Il23a T C 10: 128,133,020 (GRCm39) E113G probably damaging Het
Kcnip1 A G 11: 33,584,589 (GRCm39) V188A probably benign Het
L3mbtl3 T C 10: 26,216,850 (GRCm39) K155E unknown Het
Lancl2 T G 6: 57,699,664 (GRCm39) C169G probably benign Het
Lrrc26 A G 2: 25,180,581 (GRCm39) D194G probably benign Het
Lrrfip1 C T 1: 91,050,842 (GRCm39) A545V probably benign Het
Lrtm1 T C 14: 28,743,850 (GRCm39) F106S probably damaging Het
Lypd2 A T 15: 74,604,848 (GRCm39) M49K probably damaging Het
Mbd1 A C 18: 74,406,357 (GRCm39) D63A probably damaging Het
Mdn1 T C 4: 32,691,729 (GRCm39) F990L probably damaging Het
Mtfr1l T C 4: 134,256,577 (GRCm39) E196G probably benign Het
Myh10 A G 11: 68,705,874 (GRCm39) T2007A probably benign Het
Nckap1 G A 2: 80,370,512 (GRCm39) R393C probably damaging Het
Nup205 C T 6: 35,209,508 (GRCm39) T1605M probably benign Het
Or1e33 T C 11: 73,738,741 (GRCm39) D70G probably damaging Het
Or5j3 GTACTTTTT GT 2: 86,128,338 (GRCm39) probably null Het
Pgap2 T A 7: 101,875,467 (GRCm39) probably null Het
Pitrm1 A G 13: 6,619,387 (GRCm39) S741G probably benign Het
Plcd4 A T 1: 74,590,231 (GRCm39) S155C probably null Het
Poc5 A T 13: 96,540,925 (GRCm39) T365S possibly damaging Het
Ppp2r5c G A 12: 110,489,041 (GRCm39) A71T probably benign Het
Prdm6 T A 18: 53,598,199 (GRCm39) I187N possibly damaging Het
Pxk A G 14: 8,152,118 (GRCm38) Q478R probably benign Het
Rgl1 T C 1: 152,394,914 (GRCm39) Y718C probably damaging Het
Ring1 G T 17: 34,243,336 (GRCm39) T2K possibly damaging Het
Sdk1 A G 5: 142,173,897 (GRCm39) S2022G probably benign Het
Sec61a1 C A 6: 88,492,533 (GRCm39) V32F probably benign Het
Sv2b G A 7: 74,797,402 (GRCm39) P331S probably damaging Het
Syne1 T C 10: 5,090,970 (GRCm39) S795G possibly damaging Het
Tmod2 T C 9: 75,484,023 (GRCm39) E309G probably damaging Het
Tpp2 T G 1: 44,024,582 (GRCm39) S987A probably benign Het
Trim75 G C 8: 65,435,539 (GRCm39) H304D probably damaging Het
Trp53bp2 G T 1: 182,272,231 (GRCm39) D447Y probably damaging Het
Ube3a A G 7: 58,936,751 (GRCm39) K697E probably benign Het
Vmn2r13 T A 5: 109,339,909 (GRCm39) H22L probably benign Het
Vmn2r4 G A 3: 64,314,432 (GRCm39) S183F probably damaging Het
Vwa8 T C 14: 79,256,147 (GRCm39) Y721H probably benign Het
Wbp1l C T 19: 46,642,569 (GRCm39) P190L possibly damaging Het
Zcchc4 A T 5: 52,942,510 (GRCm39) Q105L possibly damaging Het
Zfp236 T C 18: 82,639,456 (GRCm39) R1264G probably damaging Het
Zfpm2 T A 15: 40,616,413 (GRCm39) N54K probably damaging Het
Other mutations in Zkscan3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01574:Zkscan3 APN 13 21,578,261 (GRCm39) splice site probably benign
IGL02406:Zkscan3 APN 13 21,572,348 (GRCm39) missense possibly damaging 0.71
IGL02725:Zkscan3 APN 13 21,579,063 (GRCm39) missense possibly damaging 0.85
IGL02741:Zkscan3 APN 13 21,578,164 (GRCm39) missense probably benign 0.05
3-1:Zkscan3 UTSW 13 21,572,051 (GRCm39) missense probably benign 0.32
R0040:Zkscan3 UTSW 13 21,579,090 (GRCm39) splice site probably null
R0040:Zkscan3 UTSW 13 21,579,090 (GRCm39) splice site probably null
R0133:Zkscan3 UTSW 13 21,578,944 (GRCm39) missense possibly damaging 0.73
R0660:Zkscan3 UTSW 13 21,572,630 (GRCm39) missense probably damaging 1.00
R0737:Zkscan3 UTSW 13 21,572,766 (GRCm39) missense probably benign
R1250:Zkscan3 UTSW 13 21,572,694 (GRCm39) missense probably benign 0.32
R1671:Zkscan3 UTSW 13 21,580,305 (GRCm39) missense possibly damaging 0.93
R1926:Zkscan3 UTSW 13 21,580,616 (GRCm39) missense possibly damaging 0.88
R2899:Zkscan3 UTSW 13 21,578,143 (GRCm39) missense probably damaging 1.00
R4119:Zkscan3 UTSW 13 21,578,119 (GRCm39) missense possibly damaging 0.65
R4120:Zkscan3 UTSW 13 21,578,119 (GRCm39) missense possibly damaging 0.65
R4606:Zkscan3 UTSW 13 21,577,953 (GRCm39) missense probably benign 0.00
R5459:Zkscan3 UTSW 13 21,578,982 (GRCm39) missense probably damaging 0.96
R5549:Zkscan3 UTSW 13 21,578,233 (GRCm39) missense probably damaging 1.00
R5631:Zkscan3 UTSW 13 21,578,703 (GRCm39) missense probably damaging 1.00
R5988:Zkscan3 UTSW 13 21,580,461 (GRCm39) missense probably damaging 1.00
R6495:Zkscan3 UTSW 13 21,572,075 (GRCm39) missense probably damaging 0.97
R7286:Zkscan3 UTSW 13 21,578,983 (GRCm39) missense probably benign
R7443:Zkscan3 UTSW 13 21,572,608 (GRCm39) nonsense probably null
R7787:Zkscan3 UTSW 13 21,572,034 (GRCm39) missense possibly damaging 0.53
R9008:Zkscan3 UTSW 13 21,572,383 (GRCm39) missense possibly damaging 0.71
R9048:Zkscan3 UTSW 13 21,580,686 (GRCm39) start codon destroyed probably null 0.01
R9260:Zkscan3 UTSW 13 21,578,210 (GRCm39) missense probably damaging 0.98
R9281:Zkscan3 UTSW 13 21,579,045 (GRCm39) missense possibly damaging 0.96
R9300:Zkscan3 UTSW 13 21,577,667 (GRCm39) missense unknown
Z1088:Zkscan3 UTSW 13 21,572,735 (GRCm39) missense possibly damaging 0.53
Predicted Primers PCR Primer
(F):5'- AATTTGACAGTCAGGAAGCCC -3'
(R):5'- AGGATTACAAGCCTTATTGAACACC -3'

Sequencing Primer
(F):5'- GACAGTCAGGAAGCCCATTTAGTTC -3'
(R):5'- TTGAACACCAAAAAGTACACACTGG -3'
Posted On 2019-09-13