|Institutional Source||Beutler Lab|
|Gene Name||G protein-coupled receptor 37|
|Synonyms||parkin-associated endothelin B-like receptor, Pael-R|
|Is this an essential gene?||Probably non essential (E-score: 0.209)|
|Stock #||R7278 (G1)|
|Chromosomal Location||25665878-25690729 bp(-) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 25669342 bp|
|Amino Acid Change||Valine to Alanine at position 501 (V501A)|
|Ref Sequence||ENSEMBL: ENSMUSP00000052185 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000054867] [ENSMUST00000200812]|
|Predicted Effect||possibly damaging
AA Change: V501A
PolyPhen 2 Score 0.681 (Sensitivity: 0.86; Specificity: 0.92)
AA Change: V501A
|Predicted Effect||probably benign
|Coding Region Coverage||
|Validation Efficiency||99% (78/79)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
PHENOTYPE: Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Gpr37||
(F):5'- TCGTTGTCGTCACTGGTCAC -3'
(R):5'- CCTATGATGGTGCAAGGCTTTG -3'
(F):5'- GTGGAAGACTTCTGGATACACTCC -3'
(R):5'- GGCTGCTACTTTTGTCTGCC -3'