Incidental Mutation 'R7366:Ubr2'
| ID |
571842 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ubr2
|
| Ensembl Gene |
ENSMUSG00000023977 |
| Gene Name |
ubiquitin protein ligase E3 component n-recognin 2 |
| Synonyms |
ENSMUSG00000043296, E130209G04Rik, 9930021A08Rik |
| MMRRC Submission |
045450-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.872)
|
| Stock # |
R7366 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
47239221-47321482 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 47266771 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 1127
(A1127T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108961
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000113335]
[ENSMUST00000113337]
[ENSMUST00000225599]
|
| AlphaFold |
Q6WKZ8 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113335
AA Change: A1127T
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000108961
Gene: ENSMUSG00000023977
AA Change: A1127T
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_UBR1
|
97 |
167 |
3.14e-32 |
SMART |
|
Pfam:ClpS
|
221 |
302 |
2.4e-23 |
PFAM |
|
low complexity region
|
635 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
760 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
886 |
N/A |
INTRINSIC |
|
coiled coil region
|
1019 |
1046 |
N/A |
INTRINSIC |
|
RING
|
1108 |
1213 |
7.66e-1 |
SMART |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113337
AA Change: A1127T
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000108963
Gene: ENSMUSG00000023977
AA Change: A1127T
| Domain | Start | End | E-Value | Type |
|---|
|
ZnF_UBR1
|
97 |
167 |
3.14e-32 |
SMART |
|
Pfam:ClpS
|
222 |
301 |
6.2e-26 |
PFAM |
|
low complexity region
|
635 |
646 |
N/A |
INTRINSIC |
|
low complexity region
|
749 |
760 |
N/A |
INTRINSIC |
|
low complexity region
|
872 |
886 |
N/A |
INTRINSIC |
|
coiled coil region
|
1019 |
1046 |
N/A |
INTRINSIC |
|
RING
|
1108 |
1213 |
7.66e-1 |
SMART |
|
low complexity region
|
1221 |
1235 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000225599
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.1%
|
| Validation Efficiency |
99% (94/95) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
PHENOTYPE: On a mixed genetic background, female homozygotes for a targeted null mutation exhibit embryonic lethality, while males are viable, but sterile due to postnatal testicular degeneration. On an inbred background, both genders die in utero. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 95 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030K09Rik |
C |
T |
8: 73,203,303 (GRCm39) |
P244S |
possibly damaging |
Het |
| 4930562C15Rik |
A |
G |
16: 4,653,633 (GRCm39) |
I61V |
unknown |
Het |
| Abcb11 |
C |
T |
2: 69,130,211 (GRCm39) |
D282N |
probably damaging |
Het |
| Acbd3 |
A |
G |
1: 180,562,064 (GRCm39) |
E181G |
probably benign |
Het |
| Ano3 |
T |
C |
2: 110,587,412 (GRCm39) |
Y43C |
probably damaging |
Het |
| Aspa |
T |
A |
11: 73,210,716 (GRCm39) |
|
probably null |
Het |
| AU018091 |
A |
T |
7: 3,206,170 (GRCm39) |
N620K |
probably damaging |
Het |
| Bicc1 |
G |
T |
10: 70,779,216 (GRCm39) |
T724K |
probably benign |
Het |
| Bmper |
T |
C |
9: 23,395,300 (GRCm39) |
I677T |
probably damaging |
Het |
| C3 |
T |
A |
17: 57,528,162 (GRCm39) |
T686S |
probably benign |
Het |
| Cc2d2a |
G |
T |
5: 43,887,332 (GRCm39) |
R1315L |
probably damaging |
Het |
| Ccdc150 |
G |
T |
1: 54,339,541 (GRCm39) |
E462* |
probably null |
Het |
| Ccdc88c |
C |
A |
12: 100,911,209 (GRCm39) |
R875L |
possibly damaging |
Het |
| Cd177 |
C |
T |
7: 24,456,147 (GRCm39) |
G207D |
probably damaging |
Het |
| Cdh23 |
A |
T |
10: 60,151,471 (GRCm39) |
Y2471* |
probably null |
Het |
| Cep89 |
G |
A |
7: 35,129,353 (GRCm39) |
R630H |
probably damaging |
Het |
| Cmbl |
A |
T |
15: 31,590,002 (GRCm39) |
Y244F |
probably benign |
Het |
| Dcaf10 |
T |
C |
4: 45,373,919 (GRCm39) |
V448A |
probably damaging |
Het |
| Ddr2 |
A |
G |
1: 169,825,533 (GRCm39) |
W356R |
probably damaging |
Het |
| Depdc1a |
A |
G |
3: 159,228,849 (GRCm39) |
I534V |
probably benign |
Het |
| Dhtkd1 |
T |
A |
2: 5,922,717 (GRCm39) |
I481L |
probably benign |
Het |
| Dlst |
A |
T |
12: 85,175,089 (GRCm39) |
I260L |
probably benign |
Het |
| Dnajc13 |
T |
G |
9: 104,061,905 (GRCm39) |
K1350Q |
probably benign |
Het |
| Dpp4 |
T |
C |
2: 62,184,943 (GRCm39) |
Y520C |
probably damaging |
Het |
| Dr1 |
C |
A |
5: 108,423,594 (GRCm39) |
A127E |
unknown |
Het |
| Dsel |
C |
T |
1: 111,789,303 (GRCm39) |
G411S |
probably damaging |
Het |
| E130308A19Rik |
T |
C |
4: 59,752,770 (GRCm39) |
C628R |
probably damaging |
Het |
| Edem3 |
T |
A |
1: 151,688,365 (GRCm39) |
|
probably null |
Het |
| Efcab15 |
T |
C |
11: 103,098,944 (GRCm39) |
|
probably null |
Het |
| Fam20a |
T |
A |
11: 109,564,168 (GRCm39) |
Q528H |
possibly damaging |
Het |
| Fanca |
T |
C |
8: 124,007,952 (GRCm39) |
E981G |
probably benign |
Het |
| Fbp2 |
A |
G |
13: 62,985,012 (GRCm39) |
V303A |
possibly damaging |
Het |
| Flii |
C |
T |
11: 60,611,945 (GRCm39) |
V353M |
possibly damaging |
Het |
| Gm10277 |
T |
A |
11: 77,676,584 (GRCm39) |
Y129F |
unknown |
Het |
| Gm3159 |
A |
T |
14: 4,398,525 (GRCm38) |
H72L |
probably benign |
Het |
| Gm5114 |
T |
G |
7: 39,058,768 (GRCm39) |
T284P |
possibly damaging |
Het |
| Gm7168 |
T |
C |
17: 14,170,147 (GRCm39) |
S505P |
probably damaging |
Het |
| Gnal |
T |
C |
18: 67,344,142 (GRCm39) |
V239A |
possibly damaging |
Het |
| Gtf2i |
C |
T |
5: 134,294,603 (GRCm39) |
E370K |
probably damaging |
Het |
| Hivep3 |
CGG |
CG |
4: 119,955,108 (GRCm39) |
1141 |
probably null |
Het |
| Il3 |
T |
A |
11: 54,156,709 (GRCm39) |
R93S |
probably benign |
Het |
| Itsn1 |
A |
G |
16: 91,705,338 (GRCm39) |
E1573G |
unknown |
Het |
| Kif26a |
G |
A |
12: 112,129,976 (GRCm39) |
|
probably null |
Het |
| Klb |
T |
C |
5: 65,529,774 (GRCm39) |
M434T |
probably damaging |
Het |
| Lrp2 |
T |
A |
2: 69,314,150 (GRCm39) |
R2194W |
probably damaging |
Het |
| Lrp6 |
G |
T |
6: 134,427,781 (GRCm39) |
P1604T |
probably damaging |
Het |
| Mak16 |
A |
G |
8: 31,656,127 (GRCm39) |
Y119H |
possibly damaging |
Het |
| Map3k19 |
T |
A |
1: 127,745,192 (GRCm39) |
M1421L |
probably damaging |
Het |
| Mbd5 |
A |
G |
2: 49,164,580 (GRCm39) |
I1186V |
probably benign |
Het |
| Mboat1 |
T |
A |
13: 30,386,345 (GRCm39) |
C120S |
possibly damaging |
Het |
| Mctp2 |
T |
A |
7: 71,908,962 (GRCm39) |
D117V |
probably benign |
Het |
| Mocos |
C |
A |
18: 24,809,673 (GRCm39) |
N425K |
probably damaging |
Het |
| Nav2 |
A |
G |
7: 49,203,951 (GRCm39) |
|
probably null |
Het |
| Ngfr |
A |
T |
11: 95,465,255 (GRCm39) |
W198R |
possibly damaging |
Het |
| Nr4a3 |
T |
G |
4: 48,051,290 (GRCm39) |
S15A |
possibly damaging |
Het |
| Obsl1 |
T |
C |
1: 75,479,608 (GRCm39) |
S596G |
probably damaging |
Het |
| Or2ag1 |
G |
T |
7: 106,472,603 (GRCm39) |
P283Q |
probably damaging |
Het |
| Or51g1 |
A |
T |
7: 102,633,723 (GRCm39) |
I216K |
probably damaging |
Het |
| Or52e3 |
T |
G |
7: 102,869,740 (GRCm39) |
Y272D |
probably benign |
Het |
| Or5v1b |
T |
A |
17: 37,841,708 (GRCm39) |
V280D |
probably damaging |
Het |
| Or6b3 |
A |
G |
1: 92,439,400 (GRCm39) |
S117P |
possibly damaging |
Het |
| Pithd1 |
T |
C |
4: 135,714,361 (GRCm39) |
Y29C |
probably benign |
Het |
| Plcb3 |
T |
C |
19: 6,939,389 (GRCm39) |
T530A |
probably benign |
Het |
| Prss40 |
A |
T |
1: 34,598,952 (GRCm39) |
Y70* |
probably null |
Het |
| Ralgps1 |
T |
C |
2: 33,214,700 (GRCm39) |
M61V |
possibly damaging |
Het |
| Rbp4 |
C |
T |
19: 38,113,410 (GRCm39) |
R36H |
possibly damaging |
Het |
| Rnf125 |
A |
G |
18: 21,107,490 (GRCm39) |
N7S |
not run |
Het |
| Rpe65 |
G |
A |
3: 159,330,366 (GRCm39) |
S511N |
probably benign |
Het |
| Rspo4 |
A |
T |
2: 151,709,793 (GRCm39) |
Y66F |
probably damaging |
Het |
| Ruvbl2 |
A |
G |
7: 45,071,573 (GRCm39) |
S437P |
probably benign |
Het |
| Sele |
C |
A |
1: 163,876,288 (GRCm39) |
R12S |
probably benign |
Het |
| Sgo2b |
T |
A |
8: 64,391,451 (GRCm39) |
K139* |
probably null |
Het |
| Shroom3 |
C |
A |
5: 93,112,465 (GRCm39) |
S1942* |
probably null |
Het |
| Slc12a9 |
G |
A |
5: 137,326,885 (GRCm39) |
R191* |
probably null |
Het |
| Spag9 |
G |
T |
11: 93,999,347 (GRCm39) |
V1088L |
possibly damaging |
Het |
| Sptb |
T |
G |
12: 76,650,968 (GRCm39) |
D1669A |
probably damaging |
Het |
| Sptlc2 |
A |
G |
12: 87,360,823 (GRCm39) |
|
probably null |
Het |
| Sult2a8 |
A |
T |
7: 14,150,254 (GRCm39) |
|
probably null |
Het |
| Synpo2 |
A |
G |
3: 122,907,690 (GRCm39) |
V542A |
probably damaging |
Het |
| Tecpr2 |
T |
C |
12: 110,881,914 (GRCm39) |
|
probably null |
Het |
| Tektip1 |
T |
C |
10: 81,200,025 (GRCm39) |
D165G |
possibly damaging |
Het |
| Tenm2 |
T |
C |
11: 35,960,241 (GRCm39) |
T1029A |
probably benign |
Het |
| Tgoln1 |
G |
C |
6: 72,593,261 (GRCm39) |
T73R |
probably benign |
Het |
| Tnfaip8l1 |
C |
A |
17: 56,478,897 (GRCm39) |
N62K |
probably damaging |
Het |
| Tollip |
A |
G |
7: 141,443,334 (GRCm39) |
S174P |
probably benign |
Het |
| Trp53tg5 |
A |
G |
2: 164,313,027 (GRCm39) |
I216T |
possibly damaging |
Het |
| Tssk5 |
A |
G |
15: 76,258,713 (GRCm39) |
S58P |
probably benign |
Het |
| Ttc9b |
T |
C |
7: 27,354,384 (GRCm39) |
Y157H |
probably damaging |
Het |
| Tuba8 |
A |
G |
6: 121,199,871 (GRCm39) |
Y185C |
probably damaging |
Het |
| Urb1 |
CACTTAC |
CAC |
16: 90,569,461 (GRCm39) |
|
probably benign |
Het |
| Yipf3 |
T |
A |
17: 46,559,855 (GRCm39) |
L57Q |
possibly damaging |
Het |
| Zbtb32 |
A |
C |
7: 30,289,606 (GRCm39) |
C19G |
probably damaging |
Het |
| Zfp735 |
A |
T |
11: 73,602,979 (GRCm39) |
H641L |
possibly damaging |
Het |
| Zfyve28 |
A |
T |
5: 34,389,571 (GRCm39) |
Y210N |
probably damaging |
Het |
| Zpr1 |
T |
A |
9: 46,184,671 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Ubr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00324:Ubr2
|
APN |
17 |
47,296,986 (GRCm39) |
splice site |
probably benign |
|
|
IGL00332:Ubr2
|
APN |
17 |
47,301,916 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL00518:Ubr2
|
APN |
17 |
47,303,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00693:Ubr2
|
APN |
17 |
47,283,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00785:Ubr2
|
APN |
17 |
47,255,791 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01144:Ubr2
|
APN |
17 |
47,268,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01459:Ubr2
|
APN |
17 |
47,241,435 (GRCm39) |
splice site |
probably benign |
|
|
IGL01637:Ubr2
|
APN |
17 |
47,267,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01710:Ubr2
|
APN |
17 |
47,254,335 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01726:Ubr2
|
APN |
17 |
47,303,907 (GRCm39) |
splice site |
probably benign |
|
|
IGL01925:Ubr2
|
APN |
17 |
47,265,875 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL01960:Ubr2
|
APN |
17 |
47,284,893 (GRCm39) |
missense |
probably benign |
0.45 |
|
IGL02170:Ubr2
|
APN |
17 |
47,278,123 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02308:Ubr2
|
APN |
17 |
47,245,119 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02387:Ubr2
|
APN |
17 |
47,274,076 (GRCm39) |
missense |
probably benign |
|
|
IGL02696:Ubr2
|
APN |
17 |
47,274,691 (GRCm39) |
missense |
probably benign |
|
|
IGL02726:Ubr2
|
APN |
17 |
47,283,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02750:Ubr2
|
APN |
17 |
47,280,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02934:Ubr2
|
APN |
17 |
47,268,266 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL02959:Ubr2
|
APN |
17 |
47,286,877 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03018:Ubr2
|
APN |
17 |
47,264,972 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03343:Ubr2
|
APN |
17 |
47,262,844 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4280001:Ubr2
|
UTSW |
17 |
47,255,789 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Ubr2
|
UTSW |
17 |
47,303,911 (GRCm39) |
splice site |
probably benign |
|
|
R0044:Ubr2
|
UTSW |
17 |
47,303,911 (GRCm39) |
splice site |
probably benign |
|
|
R0446:Ubr2
|
UTSW |
17 |
47,294,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0513:Ubr2
|
UTSW |
17 |
47,297,705 (GRCm39) |
nonsense |
probably null |
|
|
R0565:Ubr2
|
UTSW |
17 |
47,266,812 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0600:Ubr2
|
UTSW |
17 |
47,278,174 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0690:Ubr2
|
UTSW |
17 |
47,249,579 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0710:Ubr2
|
UTSW |
17 |
47,249,607 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0761:Ubr2
|
UTSW |
17 |
47,294,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0798:Ubr2
|
UTSW |
17 |
47,280,102 (GRCm39) |
splice site |
probably benign |
|
|
R0862:Ubr2
|
UTSW |
17 |
47,278,009 (GRCm39) |
nonsense |
probably null |
|
|
R0947:Ubr2
|
UTSW |
17 |
47,252,038 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0972:Ubr2
|
UTSW |
17 |
47,245,187 (GRCm39) |
splice site |
probably null |
|
|
R1500:Ubr2
|
UTSW |
17 |
47,297,615 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R1514:Ubr2
|
UTSW |
17 |
47,311,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1533:Ubr2
|
UTSW |
17 |
47,278,173 (GRCm39) |
nonsense |
probably null |
|
|
R1554:Ubr2
|
UTSW |
17 |
47,283,877 (GRCm39) |
missense |
probably benign |
|
|
R1575:Ubr2
|
UTSW |
17 |
47,243,418 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1602:Ubr2
|
UTSW |
17 |
47,251,987 (GRCm39) |
missense |
probably benign |
0.30 |
|
R1941:Ubr2
|
UTSW |
17 |
47,284,952 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1966:Ubr2
|
UTSW |
17 |
47,265,845 (GRCm39) |
missense |
probably benign |
0.05 |
|
R2041:Ubr2
|
UTSW |
17 |
47,296,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2067:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2111:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2189:Ubr2
|
UTSW |
17 |
47,254,290 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2219:Ubr2
|
UTSW |
17 |
47,296,968 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2307:Ubr2
|
UTSW |
17 |
47,277,141 (GRCm39) |
nonsense |
probably null |
|
|
R3426:Ubr2
|
UTSW |
17 |
47,279,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3428:Ubr2
|
UTSW |
17 |
47,279,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3608:Ubr2
|
UTSW |
17 |
47,255,449 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4080:Ubr2
|
UTSW |
17 |
47,299,648 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4330:Ubr2
|
UTSW |
17 |
47,278,204 (GRCm39) |
missense |
probably null |
1.00 |
|
R4383:Ubr2
|
UTSW |
17 |
47,250,313 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4460:Ubr2
|
UTSW |
17 |
47,255,971 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4794:Ubr2
|
UTSW |
17 |
47,241,371 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4902:Ubr2
|
UTSW |
17 |
47,296,922 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4913:Ubr2
|
UTSW |
17 |
47,270,385 (GRCm39) |
splice site |
probably null |
|
|
R5092:Ubr2
|
UTSW |
17 |
47,280,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5209:Ubr2
|
UTSW |
17 |
47,279,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5226:Ubr2
|
UTSW |
17 |
47,294,196 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5250:Ubr2
|
UTSW |
17 |
47,241,368 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5437:Ubr2
|
UTSW |
17 |
47,274,623 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5607:Ubr2
|
UTSW |
17 |
47,245,126 (GRCm39) |
nonsense |
probably null |
|
|
R5848:Ubr2
|
UTSW |
17 |
47,267,581 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6089:Ubr2
|
UTSW |
17 |
47,293,218 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6382:Ubr2
|
UTSW |
17 |
47,268,241 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R6552:Ubr2
|
UTSW |
17 |
47,277,194 (GRCm39) |
splice site |
probably null |
|
|
R6630:Ubr2
|
UTSW |
17 |
47,262,910 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R6892:Ubr2
|
UTSW |
17 |
47,245,034 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6936:Ubr2
|
UTSW |
17 |
47,283,957 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7039:Ubr2
|
UTSW |
17 |
47,321,139 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7050:Ubr2
|
UTSW |
17 |
47,272,528 (GRCm39) |
missense |
probably benign |
0.30 |
|
R7078:Ubr2
|
UTSW |
17 |
47,266,779 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R7126:Ubr2
|
UTSW |
17 |
47,284,982 (GRCm39) |
splice site |
probably null |
|
|
R7219:Ubr2
|
UTSW |
17 |
47,246,360 (GRCm39) |
nonsense |
probably null |
|
|
R7262:Ubr2
|
UTSW |
17 |
47,311,665 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7352:Ubr2
|
UTSW |
17 |
47,241,352 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7449:Ubr2
|
UTSW |
17 |
47,275,714 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7496:Ubr2
|
UTSW |
17 |
47,301,917 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7759:Ubr2
|
UTSW |
17 |
47,296,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7869:Ubr2
|
UTSW |
17 |
47,301,934 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7916:Ubr2
|
UTSW |
17 |
47,279,308 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8236:Ubr2
|
UTSW |
17 |
47,262,835 (GRCm39) |
missense |
probably benign |
|
|
R8376:Ubr2
|
UTSW |
17 |
47,253,721 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9026:Ubr2
|
UTSW |
17 |
47,245,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9216:Ubr2
|
UTSW |
17 |
47,292,285 (GRCm39) |
missense |
probably benign |
0.36 |
|
R9339:Ubr2
|
UTSW |
17 |
47,284,865 (GRCm39) |
missense |
probably benign |
0.30 |
|
R9558:Ubr2
|
UTSW |
17 |
47,262,843 (GRCm39) |
missense |
probably benign |
|
|
R9606:Ubr2
|
UTSW |
17 |
47,245,020 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9644:Ubr2
|
UTSW |
17 |
47,266,706 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9731:Ubr2
|
UTSW |
17 |
47,274,071 (GRCm39) |
critical splice donor site |
probably null |
|
|
X0027:Ubr2
|
UTSW |
17 |
47,311,555 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0061:Ubr2
|
UTSW |
17 |
47,281,037 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
Z1177:Ubr2
|
UTSW |
17 |
47,311,692 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
Z1177:Ubr2
|
UTSW |
17 |
47,270,435 (GRCm39) |
missense |
probably benign |
|
|
Z1177:Ubr2
|
UTSW |
17 |
47,321,069 (GRCm39) |
missense |
probably benign |
0.33 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCAGAAATGCTAAGGGCTATGC -3'
(R):5'- GGCTCATTCAGTATTACAGTCATAACC -3'
Sequencing Primer
(F):5'- GGCTGGCTTTGAACTCTCAGC -3'
(R):5'- ACAGTCATAACCTTTGTATTGCAGCC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation