Incidental Mutation 'R7371:Ralgapa2'
| ID |
572059 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ralgapa2
|
| Ensembl Gene |
ENSMUSG00000037110 |
| Gene Name |
Ral GTPase activating protein, alpha subunit 2 (catalytic) |
| Synonyms |
AS250, A230067G21Rik, RGC2 |
| MMRRC Submission |
045454-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.250)
|
| Stock # |
R7371 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
146081799-146354264 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 146189046 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 1288
(T1288I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105613
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109986]
[ENSMUST00000131824]
[ENSMUST00000228797]
|
| AlphaFold |
A3KGS3 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000109986
AA Change: T1288I
PolyPhen 2
Score 0.055 (Sensitivity: 0.94; Specificity: 0.84)
|
| SMART Domains |
Protein: ENSMUSP00000105613
Gene: ENSMUSG00000037110
AA Change: T1288I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1028 |
N/A |
INTRINSIC |
|
low complexity region
|
1296 |
1301 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1701 |
1877 |
6.8e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131824
AA Change: T1250I
PolyPhen 2
Score 0.023 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000122039
Gene: ENSMUSG00000037110
AA Change: T1250I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
469 |
480 |
N/A |
INTRINSIC |
|
low complexity region
|
979 |
990 |
N/A |
INTRINSIC |
|
low complexity region
|
1258 |
1263 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1663 |
1842 |
1.3e-66 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000114547
Gene: ENSMUSG00000037110
AA Change: T276I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
6 |
17 |
N/A |
INTRINSIC |
|
low complexity region
|
285 |
290 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
690 |
830 |
4.9e-39 |
PFAM |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000122017
Gene: ENSMUSG00000037110
AA Change: T920I
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
140 |
151 |
N/A |
INTRINSIC |
|
low complexity region
|
650 |
661 |
N/A |
INTRINSIC |
|
low complexity region
|
929 |
934 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
1334 |
1511 |
2.4e-48 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000228797
AA Change: T1335I
PolyPhen 2
Score 0.092 (Sensitivity: 0.93; Specificity: 0.85)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
98% (88/90) |
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased incidence and severity of induced urothelial bladder tumors. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 89 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam21 |
A |
C |
12: 81,607,064 (GRCm39) |
S233A |
probably damaging |
Het |
| Adcy8 |
T |
A |
15: 64,571,067 (GRCm39) |
H1222L |
probably benign |
Het |
| Aftph |
T |
C |
11: 20,676,836 (GRCm39) |
T258A |
probably benign |
Het |
| Ano3 |
A |
C |
2: 110,715,194 (GRCm39) |
|
probably null |
Het |
| Aox4 |
A |
G |
1: 58,303,013 (GRCm39) |
D1148G |
probably damaging |
Het |
| Bcl11b |
A |
T |
12: 107,955,750 (GRCm39) |
I133N |
probably damaging |
Het |
| Borcs7 |
T |
A |
19: 46,688,057 (GRCm39) |
D67E |
probably damaging |
Het |
| Cacna2d4 |
T |
A |
6: 119,285,670 (GRCm39) |
I774N |
probably benign |
Het |
| Catsperd |
A |
T |
17: 56,957,801 (GRCm39) |
Y236F |
probably benign |
Het |
| Cblc |
T |
C |
7: 19,526,828 (GRCm39) |
S135G |
probably benign |
Het |
| Ccdc168 |
C |
A |
1: 44,100,537 (GRCm39) |
R187L |
probably benign |
Het |
| Ccdc178 |
A |
G |
18: 22,263,195 (GRCm39) |
V138A |
probably benign |
Het |
| Cd300ld |
C |
T |
11: 114,878,186 (GRCm39) |
G109R |
probably damaging |
Het |
| Cdh3 |
T |
A |
8: 107,279,109 (GRCm39) |
N690K |
probably damaging |
Het |
| Ceacam1 |
T |
A |
7: 25,174,145 (GRCm39) |
Y170F |
possibly damaging |
Het |
| Ceacam9 |
A |
C |
7: 16,457,652 (GRCm39) |
H55P |
possibly damaging |
Het |
| Celsr1 |
C |
T |
15: 85,914,875 (GRCm39) |
V1033I |
possibly damaging |
Het |
| Cep97 |
T |
C |
16: 55,725,683 (GRCm39) |
S807G |
probably benign |
Het |
| Ces1b |
A |
G |
8: 93,783,982 (GRCm39) |
|
probably null |
Het |
| Chn1 |
T |
C |
2: 73,510,234 (GRCm39) |
T92A |
probably damaging |
Het |
| Cimap1b |
C |
A |
15: 89,263,365 (GRCm39) |
W6L |
probably damaging |
Het |
| Cngb3 |
A |
C |
4: 19,425,575 (GRCm39) |
Y461S |
possibly damaging |
Het |
| Col24a1 |
A |
G |
3: 145,049,459 (GRCm39) |
N629S |
probably benign |
Het |
| Cpd |
T |
C |
11: 76,737,437 (GRCm39) |
D119G |
probably benign |
Het |
| Cpsf1 |
T |
C |
15: 76,484,775 (GRCm39) |
D594G |
probably damaging |
Het |
| Cpsf7 |
C |
T |
19: 10,509,203 (GRCm39) |
A38V |
probably benign |
Het |
| Cry1 |
A |
T |
10: 84,983,783 (GRCm39) |
H224Q |
probably benign |
Het |
| Ctr9 |
T |
A |
7: 110,633,014 (GRCm39) |
D87E |
probably damaging |
Het |
| Cyp2u1 |
T |
A |
3: 131,087,144 (GRCm39) |
N479I |
probably benign |
Het |
| Dip2c |
A |
G |
13: 9,642,785 (GRCm39) |
N672D |
probably benign |
Het |
| Dnah14 |
T |
C |
1: 181,454,450 (GRCm39) |
V820A |
probably benign |
Het |
| Efnb2 |
T |
C |
8: 8,710,524 (GRCm39) |
I31V |
probably benign |
Het |
| Fgb |
T |
C |
3: 82,953,359 (GRCm39) |
Y137C |
probably damaging |
Het |
| Fkbp15 |
A |
G |
4: 62,239,293 (GRCm39) |
V604A |
possibly damaging |
Het |
| Flii |
A |
T |
11: 60,609,090 (GRCm39) |
N682K |
probably benign |
Het |
| Fmo3 |
A |
G |
1: 162,781,796 (GRCm39) |
L519P |
possibly damaging |
Het |
| Gapvd1 |
T |
A |
2: 34,607,385 (GRCm39) |
M538L |
probably benign |
Het |
| Gbp11 |
A |
G |
5: 105,489,971 (GRCm39) |
V69A |
probably benign |
Het |
| Ggn |
T |
A |
7: 28,871,605 (GRCm39) |
D364E |
probably benign |
Het |
| Gm10377 |
G |
A |
14: 42,614,853 (GRCm39) |
P171S |
probably benign |
Het |
| Gramd4 |
C |
T |
15: 86,019,607 (GRCm39) |
A625V |
probably benign |
Het |
| Il2ra |
T |
A |
2: 11,647,831 (GRCm39) |
M7K |
probably benign |
Het |
| Iqgap2 |
A |
T |
13: 95,836,846 (GRCm39) |
|
probably null |
Het |
| Itgb4 |
T |
C |
11: 115,888,906 (GRCm39) |
V1083A |
probably benign |
Het |
| Kcnma1 |
G |
A |
14: 23,544,638 (GRCm39) |
A573V |
possibly damaging |
Het |
| Kirrel1 |
T |
C |
3: 86,995,729 (GRCm39) |
T402A |
probably benign |
Het |
| Krt15 |
A |
T |
11: 100,026,386 (GRCm39) |
V100E |
possibly damaging |
Het |
| Krt4 |
T |
A |
15: 101,828,823 (GRCm39) |
Q347L |
probably damaging |
Het |
| Map3k21 |
T |
A |
8: 126,661,804 (GRCm39) |
I467N |
probably damaging |
Het |
| Mastl |
A |
T |
2: 23,030,585 (GRCm39) |
S195T |
probably damaging |
Het |
| Mis18bp1 |
G |
T |
12: 65,205,368 (GRCm39) |
T268K |
probably benign |
Het |
| Mmp17 |
G |
A |
5: 129,682,836 (GRCm39) |
G492S |
probably null |
Het |
| Myc |
T |
A |
15: 61,860,031 (GRCm39) |
S236T |
probably damaging |
Het |
| Nlrp5 |
A |
T |
7: 23,117,848 (GRCm39) |
E524V |
probably damaging |
Het |
| Nopchap1 |
T |
C |
10: 83,201,680 (GRCm39) |
V151A |
probably benign |
Het |
| Npr3 |
T |
A |
15: 11,845,376 (GRCm39) |
|
probably null |
Het |
| Oog4 |
T |
C |
4: 143,165,346 (GRCm39) |
N267S |
possibly damaging |
Het |
| Or2a12 |
T |
A |
6: 42,904,469 (GRCm39) |
Y101* |
probably null |
Het |
| Or4l15 |
A |
T |
14: 50,198,563 (GRCm39) |
|
probably null |
Het |
| Or56a5 |
A |
G |
7: 104,793,086 (GRCm39) |
I138T |
possibly damaging |
Het |
| Pde4dip |
T |
C |
3: 97,664,587 (GRCm39) |
E425G |
probably benign |
Het |
| Piwil4 |
A |
C |
9: 14,638,729 (GRCm39) |
N312K |
probably benign |
Het |
| Pmepa1 |
A |
G |
2: 173,076,212 (GRCm39) |
M47T |
possibly damaging |
Het |
| Potefam1 |
A |
T |
2: 111,023,826 (GRCm39) |
S475T |
unknown |
Het |
| Prkcg |
G |
A |
7: 3,368,069 (GRCm39) |
G372D |
probably benign |
Het |
| Prune2 |
A |
G |
19: 17,096,734 (GRCm39) |
H746R |
probably benign |
Het |
| Ptma |
GGAAGAAG |
GGAAGAAGAAG |
1: 86,457,261 (GRCm39) |
|
probably benign |
Het |
| Rab3gap2 |
C |
G |
1: 184,983,265 (GRCm39) |
A468G |
probably damaging |
Het |
| Ralb |
A |
G |
1: 119,400,129 (GRCm39) |
L123P |
|
Het |
| Samd4b |
C |
A |
7: 28,122,926 (GRCm39) |
C44F |
probably benign |
Het |
| Satb1 |
C |
A |
17: 52,090,008 (GRCm39) |
E280* |
probably null |
Het |
| Sec1 |
T |
C |
7: 45,328,034 (GRCm39) |
T338A |
probably damaging |
Het |
| Sec16a |
T |
C |
2: 26,331,734 (GRCm39) |
T94A |
probably benign |
Het |
| Serpina1f |
G |
A |
12: 103,656,086 (GRCm39) |
R381W |
probably damaging |
Het |
| Sfswap |
A |
T |
5: 129,620,305 (GRCm39) |
T525S |
probably benign |
Het |
| Skor1 |
T |
C |
9: 63,054,169 (GRCm39) |
|
probably null |
Het |
| Spc24 |
A |
G |
9: 21,668,664 (GRCm39) |
L111P |
probably damaging |
Het |
| St8sia2 |
T |
C |
7: 73,616,675 (GRCm39) |
D121G |
probably damaging |
Het |
| Tanc2 |
A |
G |
11: 105,689,422 (GRCm39) |
T195A |
probably benign |
Het |
| Tbc1d9 |
T |
A |
8: 83,997,890 (GRCm39) |
I1149N |
probably damaging |
Het |
| Tph2 |
A |
T |
10: 114,987,016 (GRCm39) |
L258Q |
probably damaging |
Het |
| Trpm3 |
A |
T |
19: 22,879,557 (GRCm39) |
M781L |
probably benign |
Het |
| Ubap2 |
G |
T |
4: 41,195,779 (GRCm39) |
P1005T |
probably benign |
Het |
| Upf2 |
A |
G |
2: 5,965,851 (GRCm39) |
E157G |
unknown |
Het |
| Urb2 |
C |
A |
8: 124,755,008 (GRCm39) |
D238E |
probably benign |
Het |
| Vipr1 |
T |
C |
9: 121,497,621 (GRCm39) |
S380P |
probably damaging |
Het |
| Zc3h18 |
T |
A |
8: 123,139,760 (GRCm39) |
S734T |
unknown |
Het |
| Zmym6 |
T |
A |
4: 126,998,106 (GRCm39) |
Y381N |
probably damaging |
Het |
| Zscan4e |
T |
C |
7: 11,041,251 (GRCm39) |
K207R |
probably benign |
Het |
|
| Other mutations in Ralgapa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00666:Ralgapa2
|
APN |
2 |
146,327,056 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
IGL00915:Ralgapa2
|
APN |
2 |
146,184,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01012:Ralgapa2
|
APN |
2 |
146,263,659 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01018:Ralgapa2
|
APN |
2 |
146,252,113 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01902:Ralgapa2
|
APN |
2 |
146,156,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02160:Ralgapa2
|
APN |
2 |
146,190,360 (GRCm39) |
splice site |
probably benign |
|
|
IGL02321:Ralgapa2
|
APN |
2 |
146,254,736 (GRCm39) |
nonsense |
probably null |
|
|
IGL02412:Ralgapa2
|
APN |
2 |
146,254,052 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL03026:Ralgapa2
|
APN |
2 |
146,302,695 (GRCm39) |
splice site |
probably benign |
|
|
IGL03115:Ralgapa2
|
APN |
2 |
146,266,734 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03256:Ralgapa2
|
APN |
2 |
146,302,632 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03379:Ralgapa2
|
APN |
2 |
146,199,907 (GRCm39) |
missense |
probably benign |
0.01 |
|
Chow
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
purina
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P4748:Ralgapa2
|
UTSW |
2 |
146,188,731 (GRCm39) |
nonsense |
probably null |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0012:Ralgapa2
|
UTSW |
2 |
146,254,672 (GRCm39) |
missense |
probably benign |
|
|
R0165:Ralgapa2
|
UTSW |
2 |
146,230,407 (GRCm39) |
splice site |
probably benign |
|
|
R0344:Ralgapa2
|
UTSW |
2 |
146,188,714 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0402:Ralgapa2
|
UTSW |
2 |
146,276,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0419:Ralgapa2
|
UTSW |
2 |
146,270,592 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0638:Ralgapa2
|
UTSW |
2 |
146,184,112 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0704:Ralgapa2
|
UTSW |
2 |
146,293,704 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0722:Ralgapa2
|
UTSW |
2 |
146,230,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0866:Ralgapa2
|
UTSW |
2 |
146,277,923 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1065:Ralgapa2
|
UTSW |
2 |
146,292,478 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1212:Ralgapa2
|
UTSW |
2 |
146,199,902 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1395:Ralgapa2
|
UTSW |
2 |
146,230,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1614:Ralgapa2
|
UTSW |
2 |
146,230,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Ralgapa2
|
UTSW |
2 |
146,199,920 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1799:Ralgapa2
|
UTSW |
2 |
146,184,648 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1905:Ralgapa2
|
UTSW |
2 |
146,229,621 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1956:Ralgapa2
|
UTSW |
2 |
146,302,679 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2144:Ralgapa2
|
UTSW |
2 |
146,230,524 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2148:Ralgapa2
|
UTSW |
2 |
146,273,807 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2219:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2220:Ralgapa2
|
UTSW |
2 |
146,263,599 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2261:Ralgapa2
|
UTSW |
2 |
146,184,603 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2402:Ralgapa2
|
UTSW |
2 |
146,195,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ralgapa2
|
UTSW |
2 |
146,203,320 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R3752:Ralgapa2
|
UTSW |
2 |
146,263,551 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3953:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3956:Ralgapa2
|
UTSW |
2 |
146,277,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4177:Ralgapa2
|
UTSW |
2 |
146,327,083 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4182:Ralgapa2
|
UTSW |
2 |
146,277,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4193:Ralgapa2
|
UTSW |
2 |
146,184,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4332:Ralgapa2
|
UTSW |
2 |
146,102,288 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4507:Ralgapa2
|
UTSW |
2 |
146,195,168 (GRCm39) |
missense |
probably benign |
0.11 |
|
R4574:Ralgapa2
|
UTSW |
2 |
146,277,919 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4585:Ralgapa2
|
UTSW |
2 |
146,156,944 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4627:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4647:Ralgapa2
|
UTSW |
2 |
146,229,549 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R4677:Ralgapa2
|
UTSW |
2 |
146,187,387 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4724:Ralgapa2
|
UTSW |
2 |
146,187,453 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4760:Ralgapa2
|
UTSW |
2 |
146,188,669 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4831:Ralgapa2
|
UTSW |
2 |
146,246,987 (GRCm39) |
intron |
probably benign |
|
|
R4962:Ralgapa2
|
UTSW |
2 |
146,276,754 (GRCm39) |
nonsense |
probably null |
|
|
R4993:Ralgapa2
|
UTSW |
2 |
146,289,231 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5041:Ralgapa2
|
UTSW |
2 |
146,327,071 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5120:Ralgapa2
|
UTSW |
2 |
146,254,004 (GRCm39) |
missense |
probably benign |
0.26 |
|
R5185:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R5393:Ralgapa2
|
UTSW |
2 |
146,187,375 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Ralgapa2
|
UTSW |
2 |
146,176,414 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5439:Ralgapa2
|
UTSW |
2 |
146,184,430 (GRCm39) |
missense |
probably benign |
0.08 |
|
R5476:Ralgapa2
|
UTSW |
2 |
146,289,356 (GRCm39) |
missense |
probably benign |
|
|
R5695:Ralgapa2
|
UTSW |
2 |
146,175,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5705:Ralgapa2
|
UTSW |
2 |
146,291,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5718:Ralgapa2
|
UTSW |
2 |
146,295,326 (GRCm39) |
splice site |
probably null |
|
|
R5817:Ralgapa2
|
UTSW |
2 |
146,175,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5877:Ralgapa2
|
UTSW |
2 |
146,230,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5994:Ralgapa2
|
UTSW |
2 |
146,203,373 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6048:Ralgapa2
|
UTSW |
2 |
146,276,765 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6158:Ralgapa2
|
UTSW |
2 |
146,266,596 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R6169:Ralgapa2
|
UTSW |
2 |
146,292,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6280:Ralgapa2
|
UTSW |
2 |
146,184,129 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6301:Ralgapa2
|
UTSW |
2 |
146,169,331 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6650:Ralgapa2
|
UTSW |
2 |
146,230,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Ralgapa2
|
UTSW |
2 |
146,184,621 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7020:Ralgapa2
|
UTSW |
2 |
146,188,638 (GRCm39) |
nonsense |
probably null |
|
|
R7035:Ralgapa2
|
UTSW |
2 |
146,353,777 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7167:Ralgapa2
|
UTSW |
2 |
146,190,374 (GRCm39) |
missense |
probably benign |
|
|
R7186:Ralgapa2
|
UTSW |
2 |
146,230,406 (GRCm39) |
splice site |
probably null |
|
|
R7252:Ralgapa2
|
UTSW |
2 |
146,184,671 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R7266:Ralgapa2
|
UTSW |
2 |
146,176,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7432:Ralgapa2
|
UTSW |
2 |
146,276,776 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7470:Ralgapa2
|
UTSW |
2 |
146,266,587 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7663:Ralgapa2
|
UTSW |
2 |
146,260,335 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7780:Ralgapa2
|
UTSW |
2 |
146,184,334 (GRCm39) |
missense |
probably benign |
0.14 |
|
R7973:Ralgapa2
|
UTSW |
2 |
146,230,481 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8018:Ralgapa2
|
UTSW |
2 |
146,182,311 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Ralgapa2
|
UTSW |
2 |
146,285,775 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8070:Ralgapa2
|
UTSW |
2 |
146,195,199 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8264:Ralgapa2
|
UTSW |
2 |
146,175,370 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8309:Ralgapa2
|
UTSW |
2 |
146,246,786 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8409:Ralgapa2
|
UTSW |
2 |
146,086,897 (GRCm39) |
missense |
|
|
|
R8474:Ralgapa2
|
UTSW |
2 |
146,266,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Ralgapa2
|
UTSW |
2 |
146,230,463 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8492:Ralgapa2
|
UTSW |
2 |
146,184,524 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8733:Ralgapa2
|
UTSW |
2 |
146,266,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8856:Ralgapa2
|
UTSW |
2 |
146,184,139 (GRCm39) |
missense |
probably benign |
0.30 |
|
R8858:Ralgapa2
|
UTSW |
2 |
146,102,285 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8862:Ralgapa2
|
UTSW |
2 |
146,266,731 (GRCm39) |
missense |
probably benign |
0.41 |
|
R9146:Ralgapa2
|
UTSW |
2 |
146,184,252 (GRCm39) |
missense |
probably benign |
|
|
R9324:Ralgapa2
|
UTSW |
2 |
146,302,645 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9439:Ralgapa2
|
UTSW |
2 |
146,254,058 (GRCm39) |
missense |
probably benign |
|
|
R9457:Ralgapa2
|
UTSW |
2 |
146,176,474 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF019:Ralgapa2
|
UTSW |
2 |
146,203,423 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0019:Ralgapa2
|
UTSW |
2 |
146,230,572 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
Z1088:Ralgapa2
|
UTSW |
2 |
146,276,825 (GRCm39) |
missense |
probably benign |
0.20 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAATTGTCCCTGTGTATACTCAGTC -3'
(R):5'- TGCAAGGCCATCTAGGGATTC -3'
Sequencing Primer
(F):5'- GTCTTTAATGGACACACAAGTACAGG -3'
(R):5'- GCAAGGCCATCTAGGGATTCTTAAC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation