Incidental Mutation 'R0646:Mast4'
| ID |
57207 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mast4
|
| Ensembl Gene |
ENSMUSG00000034751 |
| Gene Name |
microtubule associated serine/threonine kinase family member 4 |
| Synonyms |
4930420O11Rik |
| MMRRC Submission |
038831-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.226)
|
| Stock # |
R0646 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
102868994-103471005 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to C
at 102895252 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099202]
[ENSMUST00000166726]
[ENSMUST00000167058]
[ENSMUST00000167462]
[ENSMUST00000171791]
[ENSMUST00000172264]
|
| AlphaFold |
Q811L6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099202
|
| SMART Domains |
Protein: ENSMUSP00000096808
Gene: ENSMUSG00000034751
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
13 |
38 |
N/A |
INTRINSIC |
|
Pfam:DUF1908
|
76 |
353 |
2.2e-146 |
PFAM |
|
S_TKc
|
391 |
664 |
4.13e-98 |
SMART |
|
S_TK_X
|
665 |
729 |
3.79e-2 |
SMART |
|
low complexity region
|
745 |
758 |
N/A |
INTRINSIC |
|
low complexity region
|
818 |
831 |
N/A |
INTRINSIC |
|
low complexity region
|
840 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
960 |
N/A |
INTRINSIC |
|
PDZ
|
970 |
1050 |
2.34e-15 |
SMART |
|
low complexity region
|
1070 |
1087 |
N/A |
INTRINSIC |
|
low complexity region
|
1111 |
1122 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1142 |
1164 |
N/A |
INTRINSIC |
|
low complexity region
|
1202 |
1219 |
N/A |
INTRINSIC |
|
low complexity region
|
1290 |
1306 |
N/A |
INTRINSIC |
|
low complexity region
|
1345 |
1361 |
N/A |
INTRINSIC |
|
low complexity region
|
1937 |
1953 |
N/A |
INTRINSIC |
|
low complexity region
|
1996 |
2010 |
N/A |
INTRINSIC |
|
low complexity region
|
2150 |
2161 |
N/A |
INTRINSIC |
|
low complexity region
|
2296 |
2307 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000166726
|
| SMART Domains |
Protein: ENSMUSP00000132263
Gene: ENSMUSG00000034751
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
51 |
N/A |
INTRINSIC |
|
Pfam:DUF1908
|
256 |
530 |
4.2e-145 |
PFAM |
|
S_TKc
|
568 |
841 |
4.13e-98 |
SMART |
|
S_TK_X
|
842 |
906 |
3.79e-2 |
SMART |
|
low complexity region
|
922 |
935 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1035 |
1070 |
N/A |
INTRINSIC |
|
PDZ
|
1080 |
1160 |
2.34e-15 |
SMART |
|
low complexity region
|
1180 |
1201 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167058
|
| SMART Domains |
Protein: ENSMUSP00000128464
Gene: ENSMUSG00000034751
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
23 |
51 |
N/A |
INTRINSIC |
|
Pfam:DUF1908
|
256 |
529 |
5.1e-134 |
PFAM |
|
S_TKc
|
568 |
841 |
4.13e-98 |
SMART |
|
S_TK_X
|
842 |
906 |
3.79e-2 |
SMART |
|
low complexity region
|
922 |
935 |
N/A |
INTRINSIC |
|
low complexity region
|
995 |
1008 |
N/A |
INTRINSIC |
|
low complexity region
|
1017 |
1034 |
N/A |
INTRINSIC |
|
low complexity region
|
1102 |
1137 |
N/A |
INTRINSIC |
|
PDZ
|
1147 |
1227 |
2.34e-15 |
SMART |
|
low complexity region
|
1247 |
1264 |
N/A |
INTRINSIC |
|
low complexity region
|
1288 |
1299 |
N/A |
INTRINSIC |
|
low complexity region
|
1304 |
1316 |
N/A |
INTRINSIC |
|
low complexity region
|
1319 |
1341 |
N/A |
INTRINSIC |
|
low complexity region
|
1379 |
1396 |
N/A |
INTRINSIC |
|
low complexity region
|
1467 |
1483 |
N/A |
INTRINSIC |
|
low complexity region
|
1522 |
1538 |
N/A |
INTRINSIC |
|
low complexity region
|
2114 |
2130 |
N/A |
INTRINSIC |
|
low complexity region
|
2173 |
2187 |
N/A |
INTRINSIC |
|
low complexity region
|
2327 |
2338 |
N/A |
INTRINSIC |
|
low complexity region
|
2473 |
2484 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000167462
|
| SMART Domains |
Protein: ENSMUSP00000131910
Gene: ENSMUSG00000034751
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF1908
|
64 |
338 |
3e-145 |
PFAM |
|
S_TKc
|
376 |
649 |
4.13e-98 |
SMART |
|
S_TK_X
|
650 |
714 |
3.79e-2 |
SMART |
|
low complexity region
|
730 |
743 |
N/A |
INTRINSIC |
|
low complexity region
|
803 |
816 |
N/A |
INTRINSIC |
|
low complexity region
|
843 |
878 |
N/A |
INTRINSIC |
|
PDZ
|
888 |
968 |
2.34e-15 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167834
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000170645
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000171722
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000194446
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000171791
|
| SMART Domains |
Protein: ENSMUSP00000131651
Gene: ENSMUSG00000034751
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF1908
|
64 |
338 |
1.2e-144 |
PFAM |
|
S_TKc
|
376 |
649 |
4.13e-98 |
SMART |
|
S_TK_X
|
650 |
714 |
3.79e-2 |
SMART |
|
low complexity region
|
730 |
743 |
N/A |
INTRINSIC |
|
low complexity region
|
803 |
816 |
N/A |
INTRINSIC |
|
low complexity region
|
825 |
842 |
N/A |
INTRINSIC |
|
low complexity region
|
910 |
945 |
N/A |
INTRINSIC |
|
PDZ
|
955 |
1035 |
2.34e-15 |
SMART |
|
low complexity region
|
1055 |
1072 |
N/A |
INTRINSIC |
|
low complexity region
|
1096 |
1107 |
N/A |
INTRINSIC |
|
low complexity region
|
1112 |
1124 |
N/A |
INTRINSIC |
|
low complexity region
|
1127 |
1149 |
N/A |
INTRINSIC |
|
low complexity region
|
1187 |
1204 |
N/A |
INTRINSIC |
|
low complexity region
|
1275 |
1291 |
N/A |
INTRINSIC |
|
low complexity region
|
1330 |
1346 |
N/A |
INTRINSIC |
|
low complexity region
|
1922 |
1938 |
N/A |
INTRINSIC |
|
low complexity region
|
1981 |
1995 |
N/A |
INTRINSIC |
|
low complexity region
|
2135 |
2146 |
N/A |
INTRINSIC |
|
low complexity region
|
2281 |
2292 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000172264
|
| SMART Domains |
Protein: ENSMUSP00000128129
Gene: ENSMUSG00000034751
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DUF1908
|
49 |
326 |
4.1e-147 |
PFAM |
|
S_TKc
|
364 |
637 |
4.13e-98 |
SMART |
|
S_TK_X
|
638 |
702 |
3.79e-2 |
SMART |
|
low complexity region
|
718 |
731 |
N/A |
INTRINSIC |
|
low complexity region
|
791 |
804 |
N/A |
INTRINSIC |
|
low complexity region
|
813 |
830 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.7%
- 10x: 97.4%
- 20x: 95.7%
|
| Validation Efficiency |
95% (123/130) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for an ENU-induced allele exhibit malocclusion. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(8) : Gene trapped(8)
|
| Other mutations in this stock |
Total: 125 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930432E11Rik |
C |
T |
7: 29,260,710 (GRCm39) |
|
noncoding transcript |
Het |
| Abcb11 |
A |
G |
2: 69,115,627 (GRCm39) |
I579T |
probably damaging |
Het |
| Abcc9 |
T |
C |
6: 142,627,830 (GRCm39) |
N400S |
probably benign |
Het |
| Adarb2 |
T |
C |
13: 8,781,855 (GRCm39) |
L577P |
probably damaging |
Het |
| Agt |
A |
C |
8: 125,283,852 (GRCm39) |
N422K |
probably damaging |
Het |
| Ahnak |
A |
T |
19: 8,990,766 (GRCm39) |
K4017* |
probably null |
Het |
| Akap13 |
C |
A |
7: 75,397,494 (GRCm39) |
Q2575K |
probably damaging |
Het |
| Aldh3a2 |
A |
T |
11: 61,144,541 (GRCm39) |
I339K |
probably damaging |
Het |
| Alox15 |
G |
T |
11: 70,236,450 (GRCm39) |
Y483* |
probably null |
Het |
| Ampd1 |
A |
T |
3: 103,006,913 (GRCm39) |
I713F |
probably damaging |
Het |
| Amph |
A |
T |
13: 19,297,286 (GRCm39) |
E344V |
possibly damaging |
Het |
| Arhgef18 |
T |
C |
8: 3,436,959 (GRCm39) |
Y250H |
probably damaging |
Het |
| Arid5b |
A |
G |
10: 67,932,807 (GRCm39) |
S1032P |
probably damaging |
Het |
| Armc8 |
C |
A |
9: 99,387,741 (GRCm39) |
L393F |
probably damaging |
Het |
| Bpnt1 |
A |
G |
1: 185,077,623 (GRCm39) |
|
probably null |
Het |
| Cachd1 |
G |
A |
4: 100,845,418 (GRCm39) |
R970H |
probably damaging |
Het |
| Cd207 |
T |
C |
6: 83,652,738 (GRCm39) |
T131A |
probably benign |
Het |
| Cd83 |
G |
A |
13: 43,951,009 (GRCm39) |
V54I |
probably benign |
Het |
| Cfap43 |
T |
C |
19: 47,752,115 (GRCm39) |
K1086E |
probably benign |
Het |
| Cfap65 |
A |
T |
1: 74,941,328 (GRCm39) |
V1837E |
probably benign |
Het |
| Clcnka |
T |
A |
4: 141,123,917 (GRCm39) |
H89L |
probably benign |
Het |
| Cnga4 |
T |
C |
7: 105,054,182 (GRCm39) |
I50T |
possibly damaging |
Het |
| Cog5 |
A |
G |
12: 31,887,358 (GRCm39) |
|
probably benign |
Het |
| Col11a2 |
T |
A |
17: 34,278,322 (GRCm39) |
|
probably null |
Het |
| Col28a1 |
T |
G |
6: 8,175,291 (GRCm39) |
I186L |
possibly damaging |
Het |
| Col4a2 |
T |
A |
8: 11,481,252 (GRCm39) |
M808K |
probably benign |
Het |
| Copb2 |
A |
G |
9: 98,445,528 (GRCm39) |
|
probably benign |
Het |
| Dbnl |
G |
A |
11: 5,745,441 (GRCm39) |
|
probably benign |
Het |
| Dbx2 |
T |
C |
15: 95,552,493 (GRCm39) |
T51A |
possibly damaging |
Het |
| Dcp1a |
A |
T |
14: 30,224,842 (GRCm39) |
M123L |
probably damaging |
Het |
| Ddx42 |
T |
A |
11: 106,123,659 (GRCm39) |
F217I |
probably benign |
Het |
| Dlc1 |
T |
C |
8: 37,325,205 (GRCm39) |
T367A |
probably benign |
Het |
| Dmgdh |
A |
T |
13: 93,888,863 (GRCm39) |
T834S |
probably benign |
Het |
| Dnah8 |
T |
C |
17: 30,903,147 (GRCm39) |
S929P |
probably damaging |
Het |
| Dnase1l2 |
C |
A |
17: 24,660,056 (GRCm39) |
V271L |
possibly damaging |
Het |
| Dsc1 |
T |
C |
18: 20,229,114 (GRCm39) |
Y392C |
probably damaging |
Het |
| Edn1 |
T |
C |
13: 42,458,718 (GRCm39) |
|
probably benign |
Het |
| Efcab3 |
G |
A |
11: 104,611,327 (GRCm39) |
D390N |
probably benign |
Het |
| Eps8l3 |
T |
C |
3: 107,792,126 (GRCm39) |
L351P |
probably damaging |
Het |
| F12 |
G |
A |
13: 55,570,296 (GRCm39) |
|
probably benign |
Het |
| Fam47e |
T |
C |
5: 92,726,317 (GRCm39) |
|
probably benign |
Het |
| Fcrl5 |
C |
A |
3: 87,349,320 (GRCm39) |
Q32K |
probably benign |
Het |
| Fndc1 |
C |
T |
17: 7,960,505 (GRCm39) |
V1637I |
possibly damaging |
Het |
| Foxg1 |
G |
T |
12: 49,431,350 (GRCm39) |
|
probably benign |
Het |
| Frrs1 |
A |
T |
3: 116,696,070 (GRCm39) |
I530F |
possibly damaging |
Het |
| Galnt5 |
A |
T |
2: 57,889,097 (GRCm39) |
K232N |
probably benign |
Het |
| Ggt5 |
G |
A |
10: 75,438,482 (GRCm39) |
V68M |
probably damaging |
Het |
| Gm16519 |
T |
C |
17: 71,236,101 (GRCm39) |
C17R |
probably benign |
Het |
| Gm17535 |
A |
G |
9: 3,035,804 (GRCm39) |
Y224C |
probably null |
Het |
| Gm9631 |
T |
G |
11: 121,836,455 (GRCm39) |
D28A |
probably damaging |
Het |
| Gpx2 |
T |
C |
12: 76,842,087 (GRCm39) |
I21M |
probably benign |
Het |
| H2-Q2 |
T |
G |
17: 35,564,661 (GRCm39) |
D354E |
probably damaging |
Het |
| Icam2 |
A |
T |
11: 106,271,717 (GRCm39) |
I71K |
probably damaging |
Het |
| Il12a |
T |
C |
3: 68,605,223 (GRCm39) |
|
probably benign |
Het |
| Insm2 |
C |
G |
12: 55,647,225 (GRCm39) |
A323G |
probably benign |
Het |
| Itga1 |
T |
C |
13: 115,104,835 (GRCm39) |
T1064A |
probably benign |
Het |
| Itgad |
T |
A |
7: 127,773,176 (GRCm39) |
V11E |
possibly damaging |
Het |
| Kctd15 |
C |
T |
7: 34,344,306 (GRCm39) |
S115N |
probably damaging |
Het |
| Klra5 |
A |
G |
6: 129,880,527 (GRCm39) |
W124R |
probably damaging |
Het |
| Kng2 |
T |
A |
16: 22,806,486 (GRCm39) |
D571V |
probably benign |
Het |
| Kpna6 |
A |
T |
4: 129,544,583 (GRCm39) |
F380I |
probably benign |
Het |
| Lipo3 |
A |
T |
19: 33,762,169 (GRCm39) |
Y109* |
probably null |
Het |
| Lrrc37 |
T |
A |
11: 103,503,986 (GRCm39) |
K485* |
probably null |
Het |
| Man2a2 |
T |
C |
7: 80,012,945 (GRCm39) |
H540R |
possibly damaging |
Het |
| Map2k4 |
T |
C |
11: 65,603,101 (GRCm39) |
E188G |
probably damaging |
Het |
| Mbtd1 |
A |
G |
11: 93,796,038 (GRCm39) |
D25G |
probably damaging |
Het |
| Med13 |
T |
A |
11: 86,221,915 (GRCm39) |
Q238L |
possibly damaging |
Het |
| Mmachc |
A |
G |
4: 116,560,851 (GRCm39) |
Y215H |
probably damaging |
Het |
| Mtor |
T |
A |
4: 148,568,811 (GRCm39) |
Y1110* |
probably null |
Het |
| Nek2 |
A |
G |
1: 191,554,331 (GRCm39) |
N57D |
probably damaging |
Het |
| Nek7 |
ACCCC |
ACCC |
1: 138,443,431 (GRCm39) |
|
probably null |
Het |
| Neo1 |
G |
T |
9: 58,838,317 (GRCm39) |
T489K |
probably damaging |
Het |
| Neu1 |
T |
A |
17: 35,153,736 (GRCm39) |
Y387N |
probably damaging |
Het |
| Nfasc |
A |
T |
1: 132,536,176 (GRCm39) |
C586* |
probably null |
Het |
| Nle1 |
G |
A |
11: 82,795,671 (GRCm39) |
L259F |
probably damaging |
Het |
| Nrde2 |
G |
A |
12: 100,110,105 (GRCm39) |
Q309* |
probably null |
Het |
| Nufip2 |
C |
T |
11: 77,577,279 (GRCm39) |
H76Y |
probably benign |
Het |
| Or10ak16 |
A |
C |
4: 118,750,687 (GRCm39) |
T136P |
probably damaging |
Het |
| Or2y13 |
A |
T |
11: 49,415,405 (GRCm39) |
N285I |
probably damaging |
Het |
| Or4k6 |
A |
T |
14: 50,476,096 (GRCm39) |
I82N |
probably damaging |
Het |
| Or52e18 |
A |
T |
7: 104,609,018 (GRCm39) |
I307N |
probably benign |
Het |
| Or52r1c |
T |
C |
7: 102,735,358 (GRCm39) |
F206S |
probably damaging |
Het |
| Or9s18 |
A |
T |
13: 65,300,877 (GRCm39) |
I280F |
probably damaging |
Het |
| Pcdhb5 |
A |
G |
18: 37,454,675 (GRCm39) |
T352A |
probably benign |
Het |
| Pcdhb7 |
A |
T |
18: 37,476,442 (GRCm39) |
D526V |
probably damaging |
Het |
| Phkg1 |
A |
T |
5: 129,893,394 (GRCm39) |
|
probably null |
Het |
| Plg |
C |
T |
17: 12,637,623 (GRCm39) |
T744M |
probably damaging |
Het |
| Plxnd1 |
A |
C |
6: 115,935,660 (GRCm39) |
|
probably benign |
Het |
| Poglut1 |
A |
T |
16: 38,349,837 (GRCm39) |
I312N |
probably damaging |
Het |
| Ppp1r16a |
C |
T |
15: 76,574,999 (GRCm39) |
|
probably benign |
Het |
| Ppt1 |
A |
G |
4: 122,737,892 (GRCm39) |
M77V |
probably benign |
Het |
| Pramel26 |
A |
C |
4: 143,539,155 (GRCm39) |
S113A |
possibly damaging |
Het |
| Pramel5 |
G |
T |
4: 143,998,190 (GRCm39) |
T351N |
probably damaging |
Het |
| Psmb4 |
G |
A |
3: 94,792,275 (GRCm39) |
R216C |
probably benign |
Het |
| Ptprd |
T |
C |
4: 76,002,640 (GRCm39) |
T699A |
probably damaging |
Het |
| Retreg3 |
A |
T |
11: 100,989,455 (GRCm39) |
|
probably benign |
Het |
| Sanbr |
C |
T |
11: 23,525,491 (GRCm39) |
R716H |
probably damaging |
Het |
| Scaper |
G |
A |
9: 55,665,340 (GRCm39) |
A389V |
probably damaging |
Het |
| Serinc5 |
G |
A |
13: 92,825,245 (GRCm39) |
D225N |
possibly damaging |
Het |
| Slco1a1 |
T |
G |
6: 141,871,480 (GRCm39) |
|
probably benign |
Het |
| Snapc1 |
C |
T |
12: 74,021,806 (GRCm39) |
R81C |
probably damaging |
Het |
| Sod3 |
A |
T |
5: 52,525,421 (GRCm39) |
D40V |
probably benign |
Het |
| Sorcs3 |
C |
A |
19: 48,194,734 (GRCm39) |
A39E |
probably benign |
Het |
| Spon1 |
A |
T |
7: 113,639,056 (GRCm39) |
T761S |
probably benign |
Het |
| Syde2 |
A |
G |
3: 145,720,004 (GRCm39) |
|
probably null |
Het |
| Synm |
T |
A |
7: 67,408,916 (GRCm39) |
D154V |
probably benign |
Het |
| Synpo2 |
T |
C |
3: 122,908,098 (GRCm39) |
E406G |
probably damaging |
Het |
| Tcea3 |
T |
A |
4: 135,975,382 (GRCm39) |
L8* |
probably null |
Het |
| Tec |
G |
A |
5: 72,980,840 (GRCm39) |
L33F |
probably damaging |
Het |
| Tex15 |
T |
A |
8: 34,072,354 (GRCm39) |
S2634T |
possibly damaging |
Het |
| Tg |
T |
A |
15: 66,601,475 (GRCm39) |
Y162N |
probably damaging |
Het |
| Tmem8b |
G |
A |
4: 43,690,123 (GRCm39) |
V853I |
probably benign |
Het |
| Togaram1 |
A |
G |
12: 65,068,240 (GRCm39) |
K1748E |
probably damaging |
Het |
| Ttn |
T |
C |
2: 76,728,822 (GRCm39) |
|
probably benign |
Het |
| Usp36 |
C |
T |
11: 118,163,847 (GRCm39) |
D234N |
probably damaging |
Het |
| Usp40 |
G |
A |
1: 87,906,244 (GRCm39) |
P664S |
probably benign |
Het |
| Vmn1r54 |
T |
A |
6: 90,246,635 (GRCm39) |
L183H |
probably benign |
Het |
| Vmn1r58 |
T |
G |
7: 5,413,676 (GRCm39) |
I185L |
probably benign |
Het |
| Wnt8a |
A |
T |
18: 34,680,618 (GRCm39) |
R328W |
probably benign |
Het |
| Yars1 |
A |
G |
4: 129,107,732 (GRCm39) |
|
probably benign |
Het |
| Zbtb49 |
A |
C |
5: 38,358,018 (GRCm39) |
M745R |
probably damaging |
Het |
| Zeb1 |
T |
G |
18: 5,759,027 (GRCm39) |
F162V |
probably damaging |
Het |
| Zfp369 |
A |
T |
13: 65,445,362 (GRCm39) |
H835L |
probably damaging |
Het |
| Zic5 |
A |
G |
14: 122,701,351 (GRCm39) |
V460A |
unknown |
Het |
| Zp3 |
A |
G |
5: 136,013,210 (GRCm39) |
N181D |
possibly damaging |
Het |
|
| Other mutations in Mast4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00703:Mast4
|
APN |
13 |
102,907,275 (GRCm39) |
nonsense |
probably null |
|
|
IGL00933:Mast4
|
APN |
13 |
102,871,874 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01113:Mast4
|
APN |
13 |
102,910,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01461:Mast4
|
APN |
13 |
102,890,576 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01569:Mast4
|
APN |
13 |
102,897,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01697:Mast4
|
APN |
13 |
102,904,401 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01725:Mast4
|
APN |
13 |
102,887,020 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01734:Mast4
|
APN |
13 |
102,874,123 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01738:Mast4
|
APN |
13 |
102,873,749 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01739:Mast4
|
APN |
13 |
102,910,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02299:Mast4
|
APN |
13 |
102,874,482 (GRCm39) |
missense |
probably benign |
0.44 |
|
IGL02479:Mast4
|
APN |
13 |
102,878,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02485:Mast4
|
APN |
13 |
102,872,004 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02528:Mast4
|
APN |
13 |
102,990,331 (GRCm39) |
makesense |
probably null |
|
|
IGL02850:Mast4
|
APN |
13 |
102,890,740 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02900:Mast4
|
APN |
13 |
102,872,184 (GRCm39) |
missense |
probably benign |
|
|
IGL03064:Mast4
|
APN |
13 |
102,897,472 (GRCm39) |
nonsense |
probably null |
|
|
IGL03124:Mast4
|
APN |
13 |
102,874,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03146:Mast4
|
APN |
13 |
102,874,163 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03221:Mast4
|
APN |
13 |
102,890,764 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03284:Mast4
|
APN |
13 |
102,887,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03406:Mast4
|
APN |
13 |
102,873,615 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
buck
|
UTSW |
13 |
102,897,801 (GRCm39) |
critical splice donor site |
probably null |
|
|
doe
|
UTSW |
13 |
103,042,185 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
skinnybones
|
UTSW |
13 |
102,941,149 (GRCm39) |
critical splice donor site |
probably null |
|
|
BB010:Mast4
|
UTSW |
13 |
102,909,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
BB020:Mast4
|
UTSW |
13 |
102,909,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
FR4304:Mast4
|
UTSW |
13 |
102,871,370 (GRCm39) |
utr 3 prime |
probably benign |
|
|
FR4340:Mast4
|
UTSW |
13 |
102,872,825 (GRCm39) |
small insertion |
probably benign |
|
|
FR4340:Mast4
|
UTSW |
13 |
102,871,365 (GRCm39) |
frame shift |
probably null |
|
|
FR4548:Mast4
|
UTSW |
13 |
102,872,826 (GRCm39) |
small insertion |
probably benign |
|
|
FR4976:Mast4
|
UTSW |
13 |
102,875,755 (GRCm39) |
frame shift |
probably null |
|
|
FR4976:Mast4
|
UTSW |
13 |
102,872,820 (GRCm39) |
small insertion |
probably benign |
|
|
NA:Mast4
|
UTSW |
13 |
102,878,565 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4466001:Mast4
|
UTSW |
13 |
102,941,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4469001:Mast4
|
UTSW |
13 |
102,941,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4472001:Mast4
|
UTSW |
13 |
102,941,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0009:Mast4
|
UTSW |
13 |
102,878,566 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Mast4
|
UTSW |
13 |
103,470,723 (GRCm39) |
start gained |
probably benign |
|
|
R0242:Mast4
|
UTSW |
13 |
102,990,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0310:Mast4
|
UTSW |
13 |
102,890,669 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0395:Mast4
|
UTSW |
13 |
102,871,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0454:Mast4
|
UTSW |
13 |
102,888,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Mast4
|
UTSW |
13 |
102,873,895 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0883:Mast4
|
UTSW |
13 |
102,990,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0905:Mast4
|
UTSW |
13 |
102,907,292 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1023:Mast4
|
UTSW |
13 |
102,872,004 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1281:Mast4
|
UTSW |
13 |
102,887,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1376:Mast4
|
UTSW |
13 |
102,872,916 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1376:Mast4
|
UTSW |
13 |
102,872,916 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1473:Mast4
|
UTSW |
13 |
102,909,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1572:Mast4
|
UTSW |
13 |
102,873,431 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R1575:Mast4
|
UTSW |
13 |
102,875,771 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Mast4
|
UTSW |
13 |
102,930,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2050:Mast4
|
UTSW |
13 |
102,887,917 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2060:Mast4
|
UTSW |
13 |
102,875,354 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2062:Mast4
|
UTSW |
13 |
102,895,601 (GRCm39) |
missense |
probably benign |
0.18 |
|
R2106:Mast4
|
UTSW |
13 |
102,887,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2118:Mast4
|
UTSW |
13 |
102,890,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2143:Mast4
|
UTSW |
13 |
102,871,983 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R2256:Mast4
|
UTSW |
13 |
102,872,259 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R2261:Mast4
|
UTSW |
13 |
102,934,715 (GRCm39) |
splice site |
probably benign |
|
|
R2370:Mast4
|
UTSW |
13 |
102,910,695 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2504:Mast4
|
UTSW |
13 |
102,875,147 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R2509:Mast4
|
UTSW |
13 |
102,990,350 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Mast4
|
UTSW |
13 |
102,872,939 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3087:Mast4
|
UTSW |
13 |
102,990,434 (GRCm39) |
splice site |
probably benign |
|
|
R3434:Mast4
|
UTSW |
13 |
102,923,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3435:Mast4
|
UTSW |
13 |
102,923,887 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3763:Mast4
|
UTSW |
13 |
102,923,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3826:Mast4
|
UTSW |
13 |
102,875,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3829:Mast4
|
UTSW |
13 |
102,875,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3830:Mast4
|
UTSW |
13 |
102,875,319 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Mast4
|
UTSW |
13 |
102,895,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3914:Mast4
|
UTSW |
13 |
102,875,829 (GRCm39) |
nonsense |
probably null |
|
|
R4021:Mast4
|
UTSW |
13 |
102,875,829 (GRCm39) |
nonsense |
probably null |
|
|
R4022:Mast4
|
UTSW |
13 |
102,990,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4022:Mast4
|
UTSW |
13 |
102,875,829 (GRCm39) |
nonsense |
probably null |
|
|
R4210:Mast4
|
UTSW |
13 |
102,875,713 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4342:Mast4
|
UTSW |
13 |
102,910,756 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4580:Mast4
|
UTSW |
13 |
102,873,766 (GRCm39) |
nonsense |
probably null |
|
|
R4627:Mast4
|
UTSW |
13 |
103,470,529 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4711:Mast4
|
UTSW |
13 |
103,470,627 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4732:Mast4
|
UTSW |
13 |
102,909,080 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4733:Mast4
|
UTSW |
13 |
102,909,080 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4833:Mast4
|
UTSW |
13 |
102,910,692 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4995:Mast4
|
UTSW |
13 |
103,042,262 (GRCm39) |
intron |
probably benign |
|
|
R5059:Mast4
|
UTSW |
13 |
102,887,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5073:Mast4
|
UTSW |
13 |
102,875,391 (GRCm39) |
nonsense |
probably null |
|
|
R5101:Mast4
|
UTSW |
13 |
102,872,864 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5526:Mast4
|
UTSW |
13 |
102,890,723 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R5599:Mast4
|
UTSW |
13 |
102,873,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5673:Mast4
|
UTSW |
13 |
102,930,580 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5694:Mast4
|
UTSW |
13 |
102,910,701 (GRCm39) |
nonsense |
probably null |
|
|
R5906:Mast4
|
UTSW |
13 |
102,872,252 (GRCm39) |
missense |
probably benign |
0.31 |
|
R5908:Mast4
|
UTSW |
13 |
102,874,764 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5947:Mast4
|
UTSW |
13 |
102,872,148 (GRCm39) |
missense |
probably benign |
|
|
R5987:Mast4
|
UTSW |
13 |
102,895,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6143:Mast4
|
UTSW |
13 |
102,990,391 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6154:Mast4
|
UTSW |
13 |
102,923,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6169:Mast4
|
UTSW |
13 |
102,923,929 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6239:Mast4
|
UTSW |
13 |
102,872,717 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6327:Mast4
|
UTSW |
13 |
102,897,890 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6356:Mast4
|
UTSW |
13 |
102,872,493 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6432:Mast4
|
UTSW |
13 |
103,042,185 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6522:Mast4
|
UTSW |
13 |
102,897,801 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6667:Mast4
|
UTSW |
13 |
102,874,004 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6941:Mast4
|
UTSW |
13 |
102,941,222 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6968:Mast4
|
UTSW |
13 |
102,941,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6968:Mast4
|
UTSW |
13 |
102,934,586 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6970:Mast4
|
UTSW |
13 |
102,941,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6980:Mast4
|
UTSW |
13 |
102,941,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6991:Mast4
|
UTSW |
13 |
102,941,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6992:Mast4
|
UTSW |
13 |
102,941,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6993:Mast4
|
UTSW |
13 |
102,872,482 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6993:Mast4
|
UTSW |
13 |
102,941,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7083:Mast4
|
UTSW |
13 |
102,874,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7241:Mast4
|
UTSW |
13 |
103,470,508 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7242:Mast4
|
UTSW |
13 |
102,874,986 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7246:Mast4
|
UTSW |
13 |
102,930,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7332:Mast4
|
UTSW |
13 |
102,887,932 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R7453:Mast4
|
UTSW |
13 |
102,941,149 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7514:Mast4
|
UTSW |
13 |
102,923,934 (GRCm39) |
nonsense |
probably null |
|
|
R7697:Mast4
|
UTSW |
13 |
102,875,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Mast4
|
UTSW |
13 |
102,890,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7874:Mast4
|
UTSW |
13 |
102,875,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7933:Mast4
|
UTSW |
13 |
102,909,071 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8042:Mast4
|
UTSW |
13 |
102,917,753 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8060:Mast4
|
UTSW |
13 |
102,874,184 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8172:Mast4
|
UTSW |
13 |
103,089,633 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8206:Mast4
|
UTSW |
13 |
102,872,247 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8248:Mast4
|
UTSW |
13 |
102,875,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Mast4
|
UTSW |
13 |
102,895,177 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8346:Mast4
|
UTSW |
13 |
102,887,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8434:Mast4
|
UTSW |
13 |
102,897,900 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8796:Mast4
|
UTSW |
13 |
102,919,899 (GRCm39) |
missense |
probably benign |
0.07 |
|
R8850:Mast4
|
UTSW |
13 |
102,895,174 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9012:Mast4
|
UTSW |
13 |
102,934,606 (GRCm39) |
missense |
probably benign |
0.05 |
|
R9375:Mast4
|
UTSW |
13 |
102,917,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9389:Mast4
|
UTSW |
13 |
103,470,438 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9404:Mast4
|
UTSW |
13 |
102,887,933 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9520:Mast4
|
UTSW |
13 |
102,925,532 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9525:Mast4
|
UTSW |
13 |
102,872,944 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9526:Mast4
|
UTSW |
13 |
102,873,593 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9709:Mast4
|
UTSW |
13 |
102,910,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9790:Mast4
|
UTSW |
13 |
102,890,705 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9791:Mast4
|
UTSW |
13 |
102,890,705 (GRCm39) |
missense |
probably benign |
0.01 |
|
RF005:Mast4
|
UTSW |
13 |
102,872,815 (GRCm39) |
small insertion |
probably benign |
|
|
RF015:Mast4
|
UTSW |
13 |
102,875,755 (GRCm39) |
frame shift |
probably null |
|
|
RF019:Mast4
|
UTSW |
13 |
102,872,815 (GRCm39) |
small insertion |
probably benign |
|
|
RF037:Mast4
|
UTSW |
13 |
102,875,749 (GRCm39) |
small deletion |
probably benign |
|
|
RF039:Mast4
|
UTSW |
13 |
102,875,749 (GRCm39) |
small deletion |
probably benign |
|
|
RF040:Mast4
|
UTSW |
13 |
102,875,749 (GRCm39) |
small deletion |
probably benign |
|
|
Z1088:Mast4
|
UTSW |
13 |
102,875,027 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Mast4
|
UTSW |
13 |
102,874,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTAGAGCCACTTGACAGTATGGTGC -3'
(R):5'- TATTCGCCCCGCAGGTTTTCAG -3'
Sequencing Primer
(F):5'- ACACTTACCTGACAGTGTGG -3'
(R):5'- gagacccacgcccagag -3'
|
| Posted On |
2013-07-11 |
Incidental Mutation