Incidental Mutation 'R7374:Trav9d-4'
ID 572292
Institutional Source Beutler Lab
Gene Symbol Trav9d-4
Ensembl Gene ENSMUSG00000090868
Gene Name T cell receptor alpha variable 9D-4
Synonyms
MMRRC Submission 045457-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.086) question?
Stock # R7374 (G1)
Quality Score 225.009
Status Not validated
Chromosome 14
Chromosomal Location 53220913-53221227 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 53221300 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 98 (Y98C)
Ref Sequence ENSEMBL: ENSMUSP00000143411 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167409] [ENSMUST00000200548]
AlphaFold A0A075B685
Predicted Effect probably damaging
Transcript: ENSMUST00000167409
AA Change: Y97C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000132136
Gene: ENSMUSG00000090868
AA Change: Y97C

DomainStartEndE-ValueType
IG 26 102 4.74e0 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000200548
AA Change: Y98C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000143411
Gene: ENSMUSG00000090868
AA Change: Y98C

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
IG 27 103 2e-2 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca13 C T 11: 9,242,136 (GRCm39) T1333I possibly damaging Het
Abcd4 A T 12: 84,653,017 (GRCm39) L395* probably null Het
Cdh23 G A 10: 60,153,679 (GRCm39) R2304W probably damaging Het
Ckap2l T C 2: 129,126,883 (GRCm39) T432A probably damaging Het
Cplane1 T A 15: 8,276,731 (GRCm39) W2792R unknown Het
Cyp2c68 T C 19: 39,727,648 (GRCm39) probably null Het
Ddx51 C A 5: 110,804,998 (GRCm39) T580K probably damaging Het
Fbxo44 T A 4: 148,241,094 (GRCm39) D112V probably benign Het
Ffar2 T C 7: 30,519,465 (GRCm39) N25S probably damaging Het
Gas6 A T 8: 13,524,802 (GRCm39) V330D probably damaging Het
Gfpt1 A G 6: 87,027,959 (GRCm39) T22A probably benign Het
Gm3371 A G 14: 44,641,240 (GRCm39) V108A Het
Gm8257 T C 14: 44,887,740 (GRCm39) E215G probably benign Het
Gria1 T A 11: 57,080,634 (GRCm39) S206T probably benign Het
Gria2 T C 3: 80,648,383 (GRCm39) T118A probably benign Het
Hfe T G 13: 23,890,030 (GRCm39) T248P probably damaging Het
Kdm5d T C Y: 941,491 (GRCm39) W1231R probably benign Het
Ltbp2 C T 12: 84,876,949 (GRCm39) D419N probably damaging Het
Mei1 G A 15: 81,980,109 (GRCm39) A232T Het
Mgam G A 6: 40,734,373 (GRCm39) E1473K possibly damaging Het
Mtbp A C 15: 55,426,355 (GRCm39) E99A possibly damaging Het
Muc5b A T 7: 141,416,863 (GRCm39) T3270S probably benign Het
Myl2 A G 5: 122,239,726 (GRCm39) Y28C Het
Nrxn1 A G 17: 90,896,097 (GRCm39) probably null Het
Ntn4 A G 10: 93,518,434 (GRCm39) H247R probably benign Het
Numa1 T C 7: 101,658,335 (GRCm39) V1568A probably benign Het
Nyap1 C T 5: 137,733,791 (GRCm39) G414D probably damaging Het
Or5p68 A G 7: 107,946,095 (GRCm39) F31S probably damaging Het
Or8k25 C A 2: 86,244,196 (GRCm39) A67S probably benign Het
Pdgfrb G A 18: 61,204,780 (GRCm39) V547I possibly damaging Het
Pom121l12 A T 11: 14,549,962 (GRCm39) M223L probably benign Het
Prps1l1 T C 12: 35,035,424 (GRCm39) S180P possibly damaging Het
Ptprf A G 4: 118,114,689 (GRCm39) S189P probably damaging Het
Radil G A 5: 142,471,235 (GRCm39) R1014W probably damaging Het
Rfx5 C T 3: 94,866,053 (GRCm39) P451S unknown Het
Rhbdl2 G C 4: 123,711,658 (GRCm39) V132L probably benign Het
Slc15a2 G T 16: 36,572,207 (GRCm39) T719K probably benign Het
Slc9a9 A G 9: 94,937,542 (GRCm39) T465A possibly damaging Het
Son AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG AGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCG 16: 91,457,222 (GRCm39) probably benign Het
Sv2a A T 3: 96,095,525 (GRCm39) Y306F probably benign Het
Sv2c A T 13: 96,125,644 (GRCm39) H364Q probably damaging Het
Tmem181a T A 17: 6,354,533 (GRCm39) L401Q possibly damaging Het
Trim33 T A 3: 103,217,639 (GRCm39) C195S probably damaging Het
Uroc1 T C 6: 90,315,815 (GRCm39) Y191H probably damaging Het
Usp9y T C Y: 1,381,305 (GRCm39) I839V probably benign Het
Vmn1r52 A T 6: 90,156,118 (GRCm39) I141F probably benign Het
Vmn1r59 T C 7: 5,457,160 (GRCm39) H200R probably damaging Het
Vmn2r68 A T 7: 84,881,607 (GRCm39) M491K possibly damaging Het
Vmn2r74 T C 7: 85,606,630 (GRCm39) I239V probably benign Het
Wrn A C 8: 33,758,939 (GRCm39) C1006W probably damaging Het
Other mutations in Trav9d-4
AlleleSourceChrCoordTypePredicted EffectPPH Score
R4760:Trav9d-4 UTSW 14 53,221,258 (GRCm39) missense probably damaging 0.98
R6553:Trav9d-4 UTSW 14 53,221,198 (GRCm39) missense probably benign 0.38
R8441:Trav9d-4 UTSW 14 53,221,284 (GRCm39) missense probably benign 0.23
Predicted Primers PCR Primer
(F):5'- TGTCTCTGAAGGAGCCTCTC -3'
(R):5'- TCAGATAGTGGATATTTCAGCTGG -3'

Sequencing Primer
(F):5'- TCTGAAGGAGCCTCTCTGCAG -3'
(R):5'- GCTGGAAATGAGCTGCGC -3'
Posted On 2019-09-13