Mutagenetix > Incidental Mutation

Incidental Mutation 'R7378:Dock4'

572514

Institutional Source

Beutler Lab

Gene Symbol

Dock4

Ensembl Gene

ENSMUSG00000035954

Gene Name

dedicator of cytokinesis 4

Synonyms

EST N28122, 6330411N01Rik

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.186) question?

Stock #

R7378 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

40445952-40846874 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 40788244 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Glutamine at position 1061 (H1061Q)

Ref Sequence

ENSEMBL: ENSMUSP00000047387 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037488] [ENSMUST00000220912]

AlphaFold

P59764

Predicted Effect

possibly damaging
Transcript: ENSMUST00000037488
AA Change: H1061Q

PolyPhen 2 Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000047387
Gene: ENSMUSG00000035954
AA Change: H1061Q

Domain	Start	End	E-Value	Type
SH3	9	66	7.29e-10	SMART
Pfam:DOCK_N	69	392	8.2e-110	PFAM
Pfam:DOCK-C2	397	583	1.9e-55	PFAM
low complexity region	829	842	N/A	INTRINSIC
Pfam:DHR-2	1092	1596	5e-108	PFAM
low complexity region	1651	1664	N/A	INTRINSIC
low complexity region	1681	1696	N/A	INTRINSIC
low complexity region	1700	1713	N/A	INTRINSIC
low complexity region	1842	1872	N/A	INTRINSIC
low complexity region	1883	1896	N/A	INTRINSIC
low complexity region	1940	1950	N/A	INTRINSIC
low complexity region	1958	1973	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000220912
AA Change: H1061Q

PolyPhen 2 Score 0.137 (Sensitivity: 0.92; Specificity: 0.86)

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

99% (138/140)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous disruption of this gene leads to complete embryonic lethality. Heterozygotes display altered blood vessel lumen formation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 142 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2ml1	A	C	6: 128,546,247		probably null	Het
Aars	A	G	8: 111,042,342	Y258C	probably damaging	Het
Acaa2	A	T	18: 74,805,872	Y376F	probably benign	Het
Adcy1	C	T	11: 7,169,543	S1062F	possibly damaging	Het
Adgrb3	A	T	1: 25,531,919	C492*	probably null	Het
Adgrg6	A	G	10: 14,535,892	F22S	probably benign	Het
Adh1	A	G	3: 138,288,887		probably null	Het
Afm	T	A	5: 90,551,400	C568S	probably benign	Het
Ago4	C	T	4: 126,511,464	E439K	probably benign	Het
Aifm2	T	G	10: 61,727,717	V122G	possibly damaging	Het
Akap6	A	G	12: 53,142,574	N2257S	probably benign	Het
Ap3m2	A	G	8: 22,804,010	I8T	probably benign	Het
Apc2	C	A	10: 80,311,394	L761I	probably damaging	Het
Arntl	C	A	7: 113,299,208	T281K	probably benign	Het
Asap2	A	G	12: 21,112,051	D3G	probably benign	Het
Asna1	A	T	8: 85,019,863	F119I	probably benign	Het
Asxl1	T	C	2: 153,401,993	C1489R	probably damaging	Het
Atm	T	G	9: 53,453,437		probably null	Het
Bpifa6	C	A	2: 153,986,433	A153E	probably damaging	Het
Cav2	A	G	6: 17,282,060	T106A	probably benign	Het
Cavin4	A	G	4: 48,663,631	N4D	probably benign	Het
Cenpc1	T	C	5: 86,046,499	N136S	probably benign	Het
Cfap45	T	A	1: 172,538,343		probably null	Het
Col3a1	G	A	1: 45,327,647		probably null	Het
Crocc2	C	T	1: 93,194,087	L653F	probably damaging	Het
Cry2	A	G	2: 92,413,664	L388P	probably damaging	Het
Cstb	T	C	10: 78,426,988	F43S	probably damaging	Het
Ctcfl	A	G	2: 173,112,258	Y349H	probably damaging	Het
Ctu2	T	A	8: 122,481,499	V485D	probably damaging	Het
Cwc25	A	C	11: 97,747,997	L367R	possibly damaging	Het
Dpy19l3	C	A	7: 35,752,642	V26L	probably benign	Het
Dusp27	G	T	1: 166,112,063	S58*	probably null	Het
Elmo1	A	T	13: 20,280,935	I225F	probably benign	Het
Ep300	T	C	15: 81,650,545	S2268P	probably damaging	Het
F2r	C	T	13: 95,618,328	C16Y	probably damaging	Het
Fam126b	T	C	1: 58,530,034	K462R	probably benign	Het
Fbxo33	C	A	12: 59,204,371	E453*	probably null	Het
Flot1	A	T	17: 35,825,513	D186V	probably damaging	Het
Fmn2	CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC	CCCTCCTCTCCCTGGAATGGGAATACCTCCCCCACCTCCTCTCCCTGGAATGGGAATATCTCCCCTACCTCCTCTCCCTGGAATGGGAATACCTCC	1: 174,609,203		probably benign	Het
Fras1	T	C	5: 96,596,785	C560R	probably damaging	Het
Gfi1	A	T	5: 107,723,229	S165T	possibly damaging	Het
Gli2	T	C	1: 118,848,492	D400G	probably damaging	Het
Gm11639	T	C	11: 104,714,702	I298T	probably benign	Het
Gm37240	T	A	3: 84,972,637		probably null	Het
Gml	C	T	15: 74,817,121	V27I	possibly damaging	Het
Htt	A	T	5: 34,803,799	I257F	probably benign	Het
Ier5	C	T	1: 155,098,692	V247M	probably damaging	Het
Ift46	C	T	9: 44,778,595		probably benign	Het
Il12b	A	G	11: 44,407,894	T59A	probably benign	Het
Insr	A	G	8: 3,198,231	L438P	probably damaging	Het
Iqgap2	C	T	13: 95,732,890		probably null	Het
Irx4	A	T	13: 73,267,553	T154S	possibly damaging	Het
Itgbl1	A	G	14: 123,857,489	K309E	probably benign	Het
Kcns2	T	A	15: 34,839,703	L404*	probably null	Het
Kif2c	T	C	4: 117,162,029	E644G	possibly damaging	Het
Klhl22	T	C	16: 17,776,805	L266P	probably damaging	Het
Krt71	T	A	15: 101,738,329	K315*	probably null	Het
Lca5	T	C	9: 83,395,530	N587S	probably benign	Het
Lrp1b	T	A	2: 41,295,669	M1459L		Het
Lrrtm2	T	C	18: 35,213,592	K219R	probably damaging	Het
Mcmbp	T	C	7: 128,704,517	D459G	probably damaging	Het
Megf8	A	G	7: 25,348,942	H1680R	probably damaging	Het
Mia3	A	G	1: 183,334,775	S301P	probably benign	Het
Mtrr	A	G	13: 68,564,402	Y622H	probably damaging	Het
Myo7b	T	A	18: 31,966,239	Q1710L	probably damaging	Het
Nab1	T	C	1: 52,480,995	N276D	probably damaging	Het
Nalcn	C	T	14: 123,302,890	R1127H	probably damaging	Het
Nbas	T	A	12: 13,274,219	I110N	probably damaging	Het
Nfe2l3	C	T	6: 51,457,296	Q279*	probably null	Het
Nlrp9c	C	T	7: 26,365,015	E963K	probably benign	Het
Nsmaf	A	G	4: 6,416,586	V569A	probably benign	Het
Olfr1066	T	C	2: 86,456,068	T68A	probably benign	Het
Olfr1338	T	C	4: 118,754,175	Y123C	possibly damaging	Het
Olfr199	T	A	16: 59,215,920	D231V	probably benign	Het
Olfr273	C	T	4: 52,856,421	V31I	probably benign	Het
Olfr481	T	C	7: 108,081,192	S133P	not run	Het
Olfr669	A	T	7: 104,939,431	I302F	probably benign	Het
Olfr69	T	A	7: 103,767,930	I156F	probably benign	Het
Olfr851	T	A	9: 19,497,102	M118K	probably damaging	Het
Olfr857	A	T	9: 19,712,887	D20V	probably damaging	Het
Olfr933	T	A	9: 38,975,721	V15E	probably benign	Het
Paf1	A	G	7: 28,396,928	Y322C	probably damaging	Het
Pcdha2	C	A	18: 36,939,385	A23D	possibly damaging	Het
Pcdhb6	G	A	18: 37,335,172	C382Y	probably damaging	Het
Pdzd7	C	T	19: 45,045,606	G13D	probably damaging	Het
Pik3r2	T	C	8: 70,769,381	N586S	probably benign	Het
Pik3r3	T	A	4: 116,270,830	D119E	probably benign	Het
Pkd2l1	T	A	19: 44,153,715	I535F	probably benign	Het
Ppfia3	T	C	7: 45,361,446		probably null	Het
Ppl	T	A	16: 5,112,996	Q53L	possibly damaging	Het
Rimbp3	T	G	16: 17,211,204	S831A	probably benign	Het
Rnps1	A	G	17: 24,418,530	T49A	unknown	Het
Rpl7a	T	A	2: 26,912,007		probably null	Het
Rrm2b	T	A	15: 37,931,647	E248D	probably benign	Het
Sdhaf4	A	G	1: 23,996,358	F70L	probably damaging	Het
Sel1l3	A	T	5: 53,116,409	S1038R	probably benign	Het
Selenoo	T	A	15: 89,089,478	F124I	probably benign	Het
Setbp1	A	T	18: 78,857,486	Y989N	probably damaging	Het
Slc1a7	A	G	4: 108,002,203	E163G	possibly damaging	Het
Slc22a2	T	C	17: 12,612,391	F356S	probably damaging	Het
Slc24a4	C	T	12: 102,239,176	P378L	probably benign	Het
Slc4a1ap	A	G	5: 31,527,527	D169G	probably benign	Het
Slc4a7	T	A	14: 14,757,421	V422D	probably damaging	Het
Slitrk6	T	C	14: 110,749,863	Y804C	probably damaging	Het
Smarcad1	T	A	6: 65,110,376	H906Q	probably benign	Het
Smn1	A	G	13: 100,127,865	T109A	probably damaging	Het
Sntb2	A	G	8: 106,981,312	N236S	probably damaging	Het
Spag9	T	A	11: 94,114,351		probably null	Het
Spg11	C	A	2: 122,058,429	G2154W	probably damaging	Het
Srsf6	T	C	2: 162,934,569	S278P	unknown	Het
Stag3	G	A	5: 138,281,960	R29H	probably benign	Het
Stambp	C	T	6: 83,563,906	V98I	not run	Het
Suco	T	C	1: 161,862,211	D89G	possibly damaging	Het
Suox	C	T	10: 128,671,041	V373I	probably benign	Het
Sv2b	T	A	7: 75,147,728		probably null	Het
Tatdn2	T	C	6: 113,704,701	L565P	probably damaging	Het
Tbpl2	T	A	2: 24,094,700	E145V	probably benign	Het
Tlr1	T	C	5: 64,925,228	I669V	not run	Het
Tmc1	A	T	19: 20,868,389	F157I	probably damaging	Het
Tmem26	T	G	10: 68,724,092		probably null	Het
Tmem33	A	T	5: 67,286,133	I218F	probably benign	Het
Tmem94	T	A	11: 115,794,174	D862E	probably damaging	Het
Tnr	T	C	1: 159,884,862		probably null	Het
Tnrc6c	T	C	11: 117,741,780	S1103P	probably benign	Het
Tomm70a	T	A	16: 57,146,044	Y453*	probably null	Het
Trabd	C	A	15: 89,085,290	R229S	possibly damaging	Het
Trappc10	T	C	10: 78,193,418	D1095G	probably damaging	Het
Trim27	A	G	13: 21,192,461	T460A	possibly damaging	Het
Tsen54	T	G	11: 115,821,705	D433E	probably benign	Het
Ubap2	A	G	4: 41,235,515		probably null	Het
Vat1l	A	T	8: 114,289,392	N341Y	possibly damaging	Het
Vmn2r82	C	G	10: 79,396,442	Y758*	probably null	Het
Vps16	T	G	2: 130,438,179	V108G	probably damaging	Het
Vps53	T	A	11: 76,077,074	I585F	possibly damaging	Het
Wrnip1	G	A	13: 32,816,281	V424M	probably benign	Het
Yif1a	G	A	19: 5,089,790	V88M	possibly damaging	Het
Zfat	T	C	15: 68,181,120	Y275C	probably damaging	Het
Zfhx3	A	G	8: 108,793,248	E334G	probably damaging	Het
Zfp277	T	C	12: 40,315,853	D539G	possibly damaging	Het
Zfp292	A	T	4: 34,808,384	N1558K	probably benign	Het
Zfp3	A	G	11: 70,772,073	K286R	probably benign	Het
Zfp366	T	C	13: 99,229,515	C395R	probably damaging	Het

Other mutations in Dock4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Dock4	APN	12	40832306	missense	possibly damaging	0.48
IGL00726:Dock4	APN	12	40790068	splice site	probably benign
IGL00790:Dock4	APN	12	40834391	missense	probably damaging	1.00
IGL01061:Dock4	APN	12	40702969	missense	probably benign	0.01
IGL01083:Dock4	APN	12	40788381	splice site	probably benign
IGL01412:Dock4	APN	12	40730041	splice site	probably benign
IGL01583:Dock4	APN	12	40810467	nonsense	probably null
IGL01603:Dock4	APN	12	40693031	missense	probably damaging	1.00
IGL01766:Dock4	APN	12	40446379	nonsense	probably null
IGL02067:Dock4	APN	12	40834385	missense	probably damaging	1.00
IGL02302:Dock4	APN	12	40725777	missense	probably damaging	1.00
IGL02406:Dock4	APN	12	40777207	missense	probably benign	0.01
IGL02547:Dock4	APN	12	40737479	missense	probably benign
IGL02613:Dock4	APN	12	40810466	missense	probably damaging	1.00
IGL02643:Dock4	APN	12	40668430	missense	probably damaging	1.00
IGL02952:Dock4	APN	12	40710903	critical splice donor site	probably null
IGL02994:Dock4	APN	12	40779160	missense	probably damaging	0.99
IGL03096:Dock4	APN	12	40748001	missense	probably benign	0.00
IGL03144:Dock4	APN	12	40692907	splice site	probably benign
IGL03223:Dock4	APN	12	40817594	missense	probably damaging	1.00
IGL03296:Dock4	APN	12	40733257	missense	possibly damaging	0.84
IGL03349:Dock4	APN	12	40733310	missense	probably benign	0.42
IGL03353:Dock4	APN	12	40817758	splice site	probably null
BB005:Dock4	UTSW	12	40788303	missense	probably damaging	0.98
BB015:Dock4	UTSW	12	40788303	missense	probably damaging	0.98
R0046:Dock4	UTSW	12	40737360	splice site	probably benign
R0046:Dock4	UTSW	12	40737360	splice site	probably benign
R0110:Dock4	UTSW	12	40621312	splice site	probably benign
R0238:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0238:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0239:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0239:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0472:Dock4	UTSW	12	40838438	intron	probably benign
R0616:Dock4	UTSW	12	40704415	missense	probably benign	0.31
R0647:Dock4	UTSW	12	40710884	missense	probably damaging	1.00
R0706:Dock4	UTSW	12	40702923	missense	probably damaging	0.98
R0791:Dock4	UTSW	12	40704481	missense	probably damaging	1.00
R0940:Dock4	UTSW	12	40631627	splice site	probably benign
R1087:Dock4	UTSW	12	40729938	missense	probably benign	0.40
R1180:Dock4	UTSW	12	40640414	missense	possibly damaging	0.52
R1194:Dock4	UTSW	12	40829616	missense	probably damaging	1.00
R1463:Dock4	UTSW	12	40816325	frame shift	probably null
R1468:Dock4	UTSW	12	40755810	missense	probably benign	0.00
R1468:Dock4	UTSW	12	40755810	missense	probably benign	0.00
R1523:Dock4	UTSW	12	40693025	missense	possibly damaging	0.88
R1616:Dock4	UTSW	12	40669045	missense	probably damaging	0.99
R1682:Dock4	UTSW	12	40725780	missense	probably damaging	1.00
R1691:Dock4	UTSW	12	40725755	missense	probably benign	0.26
R1693:Dock4	UTSW	12	40834722	missense	probably benign	0.07
R1737:Dock4	UTSW	12	40807001	splice site	probably null
R1802:Dock4	UTSW	12	40794598	missense	possibly damaging	0.90
R1813:Dock4	UTSW	12	40636228	missense	probably damaging	1.00
R1846:Dock4	UTSW	12	40733268	missense	probably benign	0.00
R1959:Dock4	UTSW	12	40710798	missense	probably damaging	1.00
R1975:Dock4	UTSW	12	40779642	splice site	probably benign
R1986:Dock4	UTSW	12	40730063	missense	probably damaging	1.00
R2105:Dock4	UTSW	12	40692989	missense	probably benign	0.00
R2134:Dock4	UTSW	12	40745668	missense	probably benign
R2135:Dock4	UTSW	12	40745668	missense	probably benign
R2154:Dock4	UTSW	12	40820662	missense	probably damaging	1.00
R2154:Dock4	UTSW	12	40844548	small insertion	probably benign
R2864:Dock4	UTSW	12	40730073	missense	probably damaging	1.00
R2890:Dock4	UTSW	12	40623801	critical splice acceptor site	probably null
R3086:Dock4	UTSW	12	40731863	missense	probably benign	0.02
R3808:Dock4	UTSW	12	40672810	missense	probably damaging	0.99
R3811:Dock4	UTSW	12	40779124	missense	possibly damaging	0.87
R3836:Dock4	UTSW	12	40794624	critical splice donor site	probably null
R3838:Dock4	UTSW	12	40794624	critical splice donor site	probably null
R4091:Dock4	UTSW	12	40844267	missense	probably damaging	0.99
R4735:Dock4	UTSW	12	40631526	missense	probably benign	0.31
R4752:Dock4	UTSW	12	40446365	missense	probably benign	0.04
R4828:Dock4	UTSW	12	40668437	missense	probably damaging	1.00
R5039:Dock4	UTSW	12	40817746	missense	probably damaging	1.00
R5092:Dock4	UTSW	12	40844441	missense	probably benign
R5146:Dock4	UTSW	12	40649492	splice site	probably null
R5213:Dock4	UTSW	12	40676742	missense	probably damaging	1.00
R5214:Dock4	UTSW	12	40704466	missense	probably benign	0.00
R5270:Dock4	UTSW	12	40733271	missense	probably benign	0.02
R5426:Dock4	UTSW	12	40745745	missense	probably damaging	1.00
R5474:Dock4	UTSW	12	40745731	missense	probably benign
R5544:Dock4	UTSW	12	40834702	missense	possibly damaging	0.87
R5615:Dock4	UTSW	12	40649480	missense	probably benign	0.22
R5649:Dock4	UTSW	12	40844540	missense	probably benign	0.03
R5702:Dock4	UTSW	12	40737491	missense	probably benign	0.02
R5846:Dock4	UTSW	12	40817736	missense	probably damaging	1.00
R5847:Dock4	UTSW	12	40621251	missense	probably damaging	0.97
R5895:Dock4	UTSW	12	40755813	missense	probably damaging	1.00
R5997:Dock4	UTSW	12	40755834	missense	probably damaging	0.99
R6011:Dock4	UTSW	12	40817757	critical splice donor site	probably null
R6022:Dock4	UTSW	12	40748110	missense	probably benign	0.04
R6038:Dock4	UTSW	12	40733351	splice site	probably null
R6038:Dock4	UTSW	12	40733351	splice site	probably null
R6179:Dock4	UTSW	12	40731869	missense	probably benign	0.00
R6479:Dock4	UTSW	12	40828955	missense	probably damaging	1.00
R6516:Dock4	UTSW	12	40731899	missense	possibly damaging	0.94
R6748:Dock4	UTSW	12	40704466	missense	probably benign	0.44
R6752:Dock4	UTSW	12	40820617	missense	probably damaging	1.00
R6814:Dock4	UTSW	12	40812326	critical splice donor site	probably null
R6864:Dock4	UTSW	12	40745746	missense	probably damaging	1.00
R6872:Dock4	UTSW	12	40812326	critical splice donor site	probably null
R6891:Dock4	UTSW	12	40779136	missense	probably damaging	1.00
R6937:Dock4	UTSW	12	40834635	missense	probably benign	0.01
R6950:Dock4	UTSW	12	40733314	missense	possibly damaging	0.80
R7081:Dock4	UTSW	12	40621286	missense	probably damaging	1.00
R7129:Dock4	UTSW	12	40828879	missense	probably damaging	1.00
R7140:Dock4	UTSW	12	40636159	missense	probably benign	0.06
R7241:Dock4	UTSW	12	40794860	missense	probably damaging	1.00
R7714:Dock4	UTSW	12	40725649	nonsense	probably null
R7720:Dock4	UTSW	12	40806975	missense	probably damaging	0.99
R7756:Dock4	UTSW	12	40710879	missense	probably benign	0.02
R7758:Dock4	UTSW	12	40710879	missense	probably benign	0.02
R7759:Dock4	UTSW	12	40817736	missense	probably damaging	1.00
R7787:Dock4	UTSW	12	40725677	missense	probably benign
R7879:Dock4	UTSW	12	40730084	missense	possibly damaging	0.76
R7928:Dock4	UTSW	12	40788303	missense	probably damaging	0.98
R8000:Dock4	UTSW	12	40833119	missense	probably benign	0.05
R8042:Dock4	UTSW	12	40745760	missense	probably benign	0.01
R8231:Dock4	UTSW	12	40702951	missense	possibly damaging	0.88
R8234:Dock4	UTSW	12	40834838	splice site	probably null
R8758:Dock4	UTSW	12	40788232	missense	probably benign	0.12
R8871:Dock4	UTSW	12	40745731	missense	probably benign
R8873:Dock4	UTSW	12	40676768	nonsense	probably null
R8884:Dock4	UTSW	12	40806885	missense	probably damaging	1.00
R9164:Dock4	UTSW	12	40704338	missense	probably damaging	1.00
R9225:Dock4	UTSW	12	40829670	missense	probably benign	0.02
R9276:Dock4	UTSW	12	40649405	missense	possibly damaging	0.48
R9307:Dock4	UTSW	12	40636156	missense	probably damaging	1.00
R9675:Dock4	UTSW	12	40844380	small insertion	probably benign
R9675:Dock4	UTSW	12	40844394	small insertion	probably benign
R9676:Dock4	UTSW	12	40844380	small insertion	probably benign
R9676:Dock4	UTSW	12	40844388	small insertion	probably benign
R9676:Dock4	UTSW	12	40844398	small insertion	probably benign
R9676:Dock4	UTSW	12	40844402	small insertion	probably benign
R9678:Dock4	UTSW	12	40844380	small insertion	probably benign
R9678:Dock4	UTSW	12	40844388	small insertion	probably benign
R9678:Dock4	UTSW	12	40844397	small insertion	probably benign
R9691:Dock4	UTSW	12	40636098	missense	probably damaging	1.00
RF018:Dock4	UTSW	12	40844399	frame shift	probably null
RF025:Dock4	UTSW	12	40844393	frame shift	probably null
RF063:Dock4	UTSW	12	40844399	frame shift	probably null
X0028:Dock4	UTSW	12	40669047	missense	probably benign	0.25
Z1176:Dock4	UTSW	12	40631614	missense	probably benign	0.01
Z1176:Dock4	UTSW	12	40631616	missense	probably benign	0.16
Z1177:Dock4	UTSW	12	40817641	missense	possibly damaging	0.88

Predicted Primers

PCR Primer
(F):5'- ACTACAGAACCATCTCTCCAGTTTC -3'
(R):5'- TTGTGAAGACGCCAGACAGG -3'

Sequencing Primer
(F):5'- TGGGGCGATAACTGTAGT -3'
(R):5'- GACAGGGAAGTGACACCCC -3'

Posted On

2019-09-13