Mutagenetix > Incidental Mutation

Incidental Mutation 'R7379:Or10g1'

572591

Institutional Source

Beutler Lab

Gene Symbol

Or10g1

Ensembl Gene

ENSMUSG00000063106

Gene Name

olfactory receptor family 10 subfamily G member 1

Synonyms

MOR223-6, GA_x6K02T2RJGY-583652-584608, Olfr1510

MMRRC Submission

045461-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7379 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

52647346-52648384 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 52647718 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 204 (T204A)

Ref Sequence

ENSEMBL: ENSMUSP00000150294 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000079459] [ENSMUST00000215928]

AlphaFold

E9PZZ6

Predicted Effect

probably benign
Transcript: ENSMUST00000079459
AA Change: T204A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000078424
Gene: ENSMUSG00000063106
AA Change: T204A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	35	311	8.1e-50	PFAM
Pfam:7tm_1	45	293	1.8e-20	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000215928
AA Change: T204A

PolyPhen 2 Score 0.076 (Sensitivity: 0.93; Specificity: 0.85)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.6%

Validation Efficiency

100% (48/48)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ankrd12	G	A	17: 66,292,242 (GRCm39)	R1064*	probably null	Het
Ccdc149	A	G	5: 52,562,408 (GRCm39)	I206T	probably damaging	Het
Ctu1	AGGACCGGGCAGGAGCCACCTGTGTATCGCAGAGGGACCTGAGCCTTGGGAATGGAGGGGACCGGGCAGGAGCCACCTGTGTATCGCAG	AGGACCGGGCAGGAGCCACCTGTGTATCGCAG	7: 43,326,490 (GRCm39)		probably benign	Het
Cyp2j6	T	C	4: 96,414,183 (GRCm39)	T361A	probably damaging	Het
Cyp4a14	A	T	4: 115,350,907 (GRCm39)		probably null	Het
Cyp7b1	A	G	3: 18,151,538 (GRCm39)	V225A	probably benign	Het
Esf1	A	G	2: 139,996,854 (GRCm39)	I503T	probably benign	Het
Flrt2	G	A	12: 95,747,329 (GRCm39)	V556I	possibly damaging	Het
Gaa	T	C	11: 119,174,525 (GRCm39)	S791P	probably benign	Het
H2-T22	A	G	17: 36,353,232 (GRCm39)		probably null	Het
Hexb	A	G	13: 97,317,672 (GRCm39)	S342P	probably damaging	Het
Ift122	C	T	6: 115,903,263 (GRCm39)	R1176C	probably benign	Het
Ift57	A	G	16: 49,581,357 (GRCm39)	E341G	probably damaging	Het
Itpkc	A	T	7: 26,927,194 (GRCm39)	I240K	probably benign	Het
Kit	A	T	5: 75,808,412 (GRCm39)	S719C	probably damaging	Het
Klf1	T	A	8: 85,629,846 (GRCm39)	Y224N	possibly damaging	Het
Krt77	T	C	15: 101,769,709 (GRCm39)	E387G	probably damaging	Het
L3mbtl1	T	A	2: 162,802,899 (GRCm39)	D347E	probably damaging	Het
Map1s	A	G	8: 71,366,219 (GRCm39)	T375A	possibly damaging	Het
Mturn	A	G	6: 54,666,069 (GRCm39)	T81A	possibly damaging	Het
Mug2	A	G	6: 122,024,446 (GRCm39)	E506G	possibly damaging	Het
Notch1	A	G	2: 26,369,479 (GRCm39)	F512S	probably damaging	Het
Or12e13	T	A	2: 87,664,123 (GRCm39)	C247S	probably damaging	Het
Or4c12b	T	A	2: 89,647,033 (GRCm39)	V115E	probably benign	Het
Or9s14	G	T	1: 92,536,189 (GRCm39)	C210F	possibly damaging	Het
Pcdhga10	A	G	18: 37,880,619 (GRCm39)	N127D	probably damaging	Het
Plb1	A	G	5: 32,502,983 (GRCm39)	I1148V	probably damaging	Het
Plcb1	A	G	2: 135,212,430 (GRCm39)	D1007G	probably benign	Het
Prdm16	T	A	4: 154,613,316 (GRCm39)	E37V	probably damaging	Het
Prss45	C	A	9: 110,668,261 (GRCm39)	N151K	possibly damaging	Het
Rngtt	A	T	4: 33,498,981 (GRCm39)	K513*	probably null	Het
Serpinb10	T	C	1: 107,460,117 (GRCm39)		probably benign	Het
Shc1	T	C	3: 89,334,129 (GRCm39)	V402A	probably benign	Het
Slc25a38	T	A	9: 119,949,902 (GRCm39)	L227Q	probably benign	Het
Slc6a13	A	T	6: 121,313,798 (GRCm39)	K514*	probably null	Het
Sorcs3	T	C	19: 48,760,705 (GRCm39)	V911A	possibly damaging	Het
Sptb	A	T	12: 76,657,651 (GRCm39)	I1290N	probably damaging	Het
Sptbn1	T	C	11: 30,089,292 (GRCm39)	K657E	possibly damaging	Het
Stpg4	T	A	17: 87,735,068 (GRCm39)		probably null	Het
Stx2	A	G	5: 129,064,863 (GRCm39)	V278A	possibly damaging	Het
Thoc1	A	T	18: 9,992,902 (GRCm39)	N558I	probably benign	Het
Trpm2	T	C	10: 77,750,568 (GRCm39)	T1343A	probably benign	Het
Usf3	T	A	16: 44,040,939 (GRCm39)	D1806E	probably benign	Het
Vmn2r106	C	T	17: 20,488,037 (GRCm39)	M787I	possibly damaging	Het
Wdfy4	A	G	14: 32,873,566 (GRCm39)	S248P		Het
Zeb2	G	T	2: 44,891,829 (GRCm39)		probably null	Het

Other mutations in Or10g1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01564:Or10g1	APN	14	52,648,299 (GRCm39)	missense	probably benign	0.04
IGL02097:Or10g1	APN	14	52,647,511 (GRCm39)	missense	probably benign
R0282:Or10g1	UTSW	14	52,647,720 (GRCm39)	missense	possibly damaging	0.94
R1449:Or10g1	UTSW	14	52,648,024 (GRCm39)	missense	probably damaging	1.00
R2113:Or10g1	UTSW	14	52,647,753 (GRCm39)	missense	probably damaging	1.00
R2870:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2870:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2872:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2872:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R2873:Or10g1	UTSW	14	52,648,318 (GRCm39)	missense	probably benign
R3409:Or10g1	UTSW	14	52,647,818 (GRCm39)	missense	possibly damaging	0.64
R3411:Or10g1	UTSW	14	52,647,818 (GRCm39)	missense	possibly damaging	0.64
R4480:Or10g1	UTSW	14	52,647,765 (GRCm39)	missense	probably damaging	1.00
R5292:Or10g1	UTSW	14	52,647,902 (GRCm39)	missense	possibly damaging	0.90
R5297:Or10g1	UTSW	14	52,647,675 (GRCm39)	missense	probably damaging	1.00
R5441:Or10g1	UTSW	14	52,647,414 (GRCm39)	missense	probably benign	0.02
R5749:Or10g1	UTSW	14	52,647,961 (GRCm39)	missense	probably damaging	1.00
R5872:Or10g1	UTSW	14	52,648,225 (GRCm39)	missense	probably damaging	1.00
R5941:Or10g1	UTSW	14	52,647,525 (GRCm39)	missense	probably benign	0.01
R7209:Or10g1	UTSW	14	52,647,550 (GRCm39)	missense	possibly damaging	0.80
R7463:Or10g1	UTSW	14	52,648,168 (GRCm39)	missense	probably benign	0.00
R7692:Or10g1	UTSW	14	52,647,945 (GRCm39)	missense	probably damaging	1.00
R8894:Or10g1	UTSW	14	52,647,465 (GRCm39)	missense	probably damaging	1.00
R9286:Or10g1	UTSW	14	52,648,075 (GRCm39)	nonsense	probably null
R9394:Or10g1	UTSW	14	52,647,570 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AACTGCTCCGTCAAAGGGAC -3'
(R):5'- GAAAATTATGCACAATCCTAGTGGC -3'

Sequencing Primer
(F):5'- TCCGTCAAAGGGACTCTTGGAAC -3'
(R):5'- ATTATGCACAATCCTAGTGGCTGGAG -3'

Posted On

2019-09-13