Mutagenetix > Incidental Mutations

Incidental Mutation 'R7380:Olfr791'

572653

Institutional Source

Beutler Lab

Gene Symbol

Olfr791

Ensembl Gene

ENSMUSG00000047626

Gene Name

olfactory receptor 791

Synonyms

GA_x6K02T2PULF-11205096-11206034, MOR114-1

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.130) question?

Stock #

R7380 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

129521792-129528353 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 129526661 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Serine at position 145 (T145S)

Ref Sequence

ENSEMBL: ENSMUSP00000150497 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000057477] [ENSMUST00000217228]

Predicted Effect

probably benign
Transcript: ENSMUST00000057477
AA Change: T145S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000052722
Gene: ENSMUSG00000047626
AA Change: T145S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	29	307	7.6e-45	PFAM
Pfam:7TM_GPCR_Srsx	33	303	4.3e-6	PFAM
Pfam:7tm_1	39	288	4.7e-24	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000217228
AA Change: T145S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

98% (79/81)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 81 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1300017J02Rik	G	A	9: 103,279,481	Q127*	probably null	Het
1700030J22Rik	T	C	8: 116,973,637	T9A	probably benign	Het
Abcc5	A	T	16: 20,397,034	S414R	possibly damaging	Het
Acads	C	A	5: 115,110,998	Q365H	probably damaging	Het
Ankib1	G	T	5: 3,722,576	Q487K	probably benign	Het
BC034090	T	G	1: 155,232,483	S11R	probably damaging	Het
Car12	A	G	9: 66,747,663	N125S	probably benign	Het
Casq1	A	G	1: 172,216,849	V137A	probably benign	Het
Ccdc144b	T	A	3: 36,025,921	D229V	possibly damaging	Het
Cd163l1	A	T	7: 140,224,877	N598Y	possibly damaging	Het
Cfap54	C	A	10: 93,047,978	V305F	probably damaging	Het
Clstn3	T	C	6: 124,456,989	E404G	probably benign	Het
Copg1	T	G	6: 87,893,842	L209R	probably damaging	Het
Cpb2	A	T	14: 75,256,009	Q42L	possibly damaging	Het
Cpd	G	A	11: 76,802,325	Q712*	probably null	Het
Csmd3	T	A	15: 47,586,965	Y2690F		Het
Dchs1	G	T	7: 105,758,628	T1999K	probably benign	Het
Ddx10	T	A	9: 53,240,486	T80S	probably damaging	Het
Dmtn	G	A	14: 70,617,328	T69I	probably damaging	Het
Dnah5	T	A	15: 28,370,378	H2821Q	probably damaging	Het
Fam162b	T	A	10: 51,590,476		probably benign	Het
Fam193b	A	C	13: 55,542,799	S717A	probably benign	Het
Far2	T	C	6: 148,180,995	F500L	unknown	Het
Focad	T	A	4: 88,274,198	V588D	unknown	Het
Gm12728	T	C	4: 105,794,396	F68L	probably damaging	Het
Gm1527	T	A	3: 28,920,472	M478K	probably benign	Het
Gpd2	A	T	2: 57,340,159	I308F	probably damaging	Het
Igf2bp3	T	C	6: 49,108,999	T249A	probably benign	Het
Igfn1	C	A	1: 135,962,008	V2434F	probably damaging	Het
Kdm5a	C	A	6: 120,405,918	Q737K	probably benign	Het
Khdrbs2	T	C	1: 32,333,604	S120P	unknown	Het
Lmx1a	T	C	1: 167,692,040	F46L	probably damaging	Het
Lrba	C	G	3: 86,325,074	T776R	probably damaging	Het
Lrrc8c	A	G	5: 105,607,835	N492S	possibly damaging	Het
Mapk3	A	T	7: 126,764,795	I365F		Het
Mcee	A	G	7: 64,411,909	I153M	possibly damaging	Het
Mllt3	T	C	4: 87,791,943	D415G	possibly damaging	Het
Muc4	A	T	16: 32,755,366	T1747S	unknown	Het
Myh14	A	T	7: 44,661,042	V139E	probably damaging	Het
Myo10	A	T	15: 25,779,620	I772L	probably benign	Het
Naa15	T	G	3: 51,459,847		probably null	Het
Nbeal1	T	A	1: 60,244,810	I841N	probably damaging	Het
Nf1	C	T	11: 79,546,276	T2006I	probably damaging	Het
Npr2	T	A	4: 43,641,254	W427R	probably damaging	Het
Nr1h3	A	T	2: 91,190,195	F324L	possibly damaging	Het
Obscn	T	C	11: 59,056,914	K4430E		Het
Olfr203	A	G	16: 59,304,028	R292G	probably damaging	Het
Olfr213	T	C	6: 116,540,933	L160P	probably benign	Het
Olfr396-ps1	T	A	11: 73,928,187	Y61N	possibly damaging	Het
Osgin1	T	A	8: 119,445,431	H321Q	probably benign	Het
P4ha1	A	G	10: 59,350,451	I251V	probably benign	Het
Padi2	G	A	4: 140,917,686	W77*	probably null	Het
Pkd1	T	A	17: 24,581,642	I3086N	probably damaging	Het
Plk3	T	C	4: 117,131,153	N360S	probably benign	Het
Prr14	A	T	7: 127,476,442	S541C	probably null	Het
Ptch2	C	A	4: 117,114,646	Q1122K	possibly damaging	Het
Rab3gap1	T	C	1: 127,937,990	V764A	possibly damaging	Het
Rad50	T	C	11: 53,695,396	I258V	probably benign	Het
Rapgef3	G	T	15: 97,766,791	R64S	probably benign	Het
Rbm44	A	G	1: 91,152,216	N42S	possibly damaging	Het
Ring1	T	C	17: 34,021,720	Y361C	probably damaging	Het
Robo3	T	C	9: 37,418,556	T1155A	probably damaging	Het
Rsf1	GGCGG	GGCGGTGGCCGCGG	7: 97,579,915		probably benign	Het
Ryr3	T	C	2: 112,640,157	T4682A	probably damaging	Het
Sema7a	T	C	9: 57,961,564	V653A	unknown	Het
Slc16a13	T	C	11: 70,219,279	Y132C	probably damaging	Het
Slc24a1	A	G	9: 64,948,533	V364A	unknown	Het
Slc8a2	C	T	7: 16,134,353	A170V	probably damaging	Het
Slfn8	C	T	11: 83,003,740	R691Q	not run	Het
Snx2	T	C	18: 53,194,568	V122A	probably benign	Het
Sstr1	A	T	12: 58,213,280	M230L	probably benign	Het
Themis2	C	T	4: 132,786,217	V233I	possibly damaging	Het
Tmem106b	T	C	6: 13,078,168	S121P	probably damaging	Het
Tmem63c	A	G	12: 87,077,948	I529V	probably benign	Het
Tmem94	T	C	11: 115,796,145		probably null	Het
Trmt10c	A	T	16: 56,034,256	W339R	probably damaging	Het
Ugt2b1	A	T	5: 86,917,719	F487Y	not run	Het
Vmn2r91	T	A	17: 18,136,576	L835*	probably null	Het
Vps52	C	A	17: 33,958,309	N108K	possibly damaging	Het
Wdpcp	T	A	11: 21,711,585	C286S	possibly damaging	Het
Zfp959	T	A	17: 55,898,551	H529Q	possibly damaging	Het

Other mutations in Olfr791

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01153:Olfr791	APN	10	129526995	missense	probably damaging	0.97
IGL03034:Olfr791	APN	10	129526658	missense	probably benign
IGL03281:Olfr791	APN	10	129526403	missense	probably benign	0.31
R0555:Olfr791	UTSW	10	129526896	missense	possibly damaging	0.90
R1474:Olfr791	UTSW	10	129526955	missense	probably benign	0.03
R1638:Olfr791	UTSW	10	129526619	missense	probably benign	0.00
R1917:Olfr791	UTSW	10	129527049	missense	probably damaging	0.99
R1918:Olfr791	UTSW	10	129527049	missense	probably damaging	0.99
R1919:Olfr791	UTSW	10	129527049	missense	probably damaging	0.99
R2303:Olfr791	UTSW	10	129527049	missense	probably benign	0.10
R3113:Olfr791	UTSW	10	129527143	missense	probably benign	0.08
R3929:Olfr791	UTSW	10	129526231	start codon destroyed	probably null	1.00
R4704:Olfr791	UTSW	10	129526302	missense	possibly damaging	0.90
R4831:Olfr791	UTSW	10	129526580	missense	probably damaging	1.00
R5207:Olfr791	UTSW	10	129526904	missense	probably benign	0.08
R5313:Olfr791	UTSW	10	129527081	missense	probably damaging	1.00
R5644:Olfr791	UTSW	10	129527103	missense	probably damaging	1.00
R5661:Olfr791	UTSW	10	129526749	missense	probably benign	0.45
R5894:Olfr791	UTSW	10	129526488	missense	probably damaging	0.98
R6988:Olfr791	UTSW	10	129526673	missense	probably benign	0.02
R6996:Olfr791	UTSW	10	129526863	missense	probably damaging	1.00
R7539:Olfr791	UTSW	10	129527105	nonsense	probably null
R7552:Olfr791	UTSW	10	129526560	missense	possibly damaging	0.95
R7635:Olfr791	UTSW	10	129526682	missense	probably benign	0.00
R8084:Olfr791	UTSW	10	129526940	missense	probably damaging	1.00
R8260:Olfr791	UTSW	10	129527088	missense	possibly damaging	0.55
X0066:Olfr791	UTSW	10	129526745	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGAAGTTTCCTTTACCACTGTCTG -3'
(R):5'- TAATGAGTGCAAAGACAGCCAC -3'

Sequencing Primer
(F):5'- ACAGTATATCAAGTGGAGACAATACC -3'
(R):5'- GCCACAAGTATAACCATCTGTTC -3'

Posted On

2019-09-13