Incidental Mutation 'R7380:Myo10'
| ID |
572667 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myo10
|
| Ensembl Gene |
ENSMUSG00000022272 |
| Gene Name |
myosin X |
| Synonyms |
myosin-X, D15Ertd600e |
| MMRRC Submission |
045462-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7380 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
15 |
| Chromosomal Location |
25622636-25813759 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 25779706 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Leucine
at position 772
(I772L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000106087
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000022882]
[ENSMUST00000110457]
[ENSMUST00000124966]
[ENSMUST00000125667]
[ENSMUST00000131834]
[ENSMUST00000135173]
[ENSMUST00000137601]
[ENSMUST00000151360]
|
| AlphaFold |
F8VQB6 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000022882
AA Change: I26L
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000022882
Gene: ENSMUSG00000022272
AA Change: I26L
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
PDB:2LW9|B
|
136 |
171 |
7e-13 |
PDB |
|
low complexity region
|
172 |
186 |
N/A |
INTRINSIC |
|
low complexity region
|
213 |
235 |
N/A |
INTRINSIC |
|
low complexity region
|
344 |
356 |
N/A |
INTRINSIC |
|
low complexity region
|
401 |
419 |
N/A |
INTRINSIC |
|
PH
|
471 |
570 |
1.39e-21 |
SMART |
|
SCOP:d1faoa_
|
588 |
639 |
3e-6 |
SMART |
|
PH
|
651 |
757 |
6.76e-11 |
SMART |
|
MyTH4
|
805 |
953 |
4.12e-37 |
SMART |
|
B41
|
954 |
1216 |
1.72e-44 |
SMART |
|
Blast:B41
|
1218 |
1303 |
3e-45 |
BLAST |
|
low complexity region
|
1304 |
1316 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000110457
AA Change: I772L
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000106087
Gene: ENSMUSG00000022272
AA Change: I772L
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
57 |
740 |
N/A |
SMART |
|
IQ
|
741 |
763 |
1.27e-3 |
SMART |
|
IQ
|
764 |
786 |
1.06e0 |
SMART |
|
IQ
|
787 |
809 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
881 |
932 |
4.2e-22 |
PFAM |
|
low complexity region
|
959 |
981 |
N/A |
INTRINSIC |
|
low complexity region
|
1090 |
1102 |
N/A |
INTRINSIC |
|
low complexity region
|
1147 |
1165 |
N/A |
INTRINSIC |
|
PH
|
1217 |
1316 |
1.39e-21 |
SMART |
|
PH
|
1397 |
1503 |
6.76e-11 |
SMART |
|
MyTH4
|
1551 |
1699 |
4.12e-37 |
SMART |
|
B41
|
1700 |
1962 |
1.72e-44 |
SMART |
|
low complexity region
|
2050 |
2062 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124966
AA Change: I26L
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000120817
Gene: ENSMUSG00000022272
AA Change: I26L
| Domain | Start | End | E-Value | Type |
|---|
|
IQ
|
1 |
17 |
7.83e1 |
SMART |
|
IQ
|
18 |
40 |
1.06e0 |
SMART |
|
IQ
|
41 |
63 |
7.07e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125667
AA Change: I130L
PolyPhen 2
Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
|
| SMART Domains |
Protein: ENSMUSP00000120566
Gene: ENSMUSG00000022272
AA Change: I130L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
85 |
5.8e-22 |
PFAM |
|
IQ
|
99 |
121 |
1.27e-3 |
SMART |
|
IQ
|
122 |
144 |
1.06e0 |
SMART |
|
IQ
|
145 |
167 |
7.07e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000131834
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000135173
AA Change: I129L
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000118744
Gene: ENSMUSG00000022272
AA Change: I129L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
84 |
1.4e-21 |
PFAM |
|
IQ
|
98 |
120 |
1.27e-3 |
SMART |
|
IQ
|
121 |
143 |
1.06e0 |
SMART |
|
IQ
|
144 |
166 |
7.07e-2 |
SMART |
|
low complexity region
|
168 |
179 |
N/A |
INTRINSIC |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000123057
Gene: ENSMUSG00000022272
AA Change: I89L
| Domain | Start | End | E-Value | Type |
|---|
|
PDB:2DFS|M
|
2 |
38 |
6e-7 |
PDB |
|
Blast:MYSc
|
2 |
42 |
3e-19 |
BLAST |
|
IQ
|
59 |
81 |
1.27e-3 |
SMART |
|
IQ
|
82 |
104 |
1.06e0 |
SMART |
|
IQ
|
105 |
127 |
7.07e-2 |
SMART |
|
Pfam:MYO10_CC
|
199 |
242 |
1.7e-20 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000137601
AA Change: I739L
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000118280
Gene: ENSMUSG00000022272
AA Change: I739L
| Domain | Start | End | E-Value | Type |
|---|
|
MYSc
|
24 |
707 |
N/A |
SMART |
|
IQ
|
708 |
730 |
1.27e-3 |
SMART |
|
IQ
|
731 |
753 |
1.06e0 |
SMART |
|
IQ
|
754 |
776 |
7.07e-2 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151360
|
| SMART Domains |
Protein: ENSMUSP00000119367
Gene: ENSMUSG00000022272
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_head
|
1 |
51 |
7.1e-16 |
PFAM |
|
| Meta Mutation Damage Score |
0.0868 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.6%
- 20x: 98.8%
|
| Validation Efficiency |
98% (79/81) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700030J22Rik |
T |
C |
8: 117,700,376 (GRCm39) |
T9A |
probably benign |
Het |
| Abcc5 |
A |
T |
16: 20,215,784 (GRCm39) |
S414R |
possibly damaging |
Het |
| Acads |
C |
A |
5: 115,249,057 (GRCm39) |
Q365H |
probably damaging |
Het |
| Ankib1 |
G |
T |
5: 3,772,576 (GRCm39) |
Q487K |
probably benign |
Het |
| BC034090 |
T |
G |
1: 155,108,229 (GRCm39) |
S11R |
probably damaging |
Het |
| Car12 |
A |
G |
9: 66,654,945 (GRCm39) |
N125S |
probably benign |
Het |
| Casq1 |
A |
G |
1: 172,044,416 (GRCm39) |
V137A |
probably benign |
Het |
| Cfap54 |
C |
A |
10: 92,883,840 (GRCm39) |
V305F |
probably damaging |
Het |
| Clstn3 |
T |
C |
6: 124,433,948 (GRCm39) |
E404G |
probably benign |
Het |
| Copg1 |
T |
G |
6: 87,870,824 (GRCm39) |
L209R |
probably damaging |
Het |
| Cpb2 |
A |
T |
14: 75,493,449 (GRCm39) |
Q42L |
possibly damaging |
Het |
| Cpd |
G |
A |
11: 76,693,151 (GRCm39) |
Q712* |
probably null |
Het |
| Csmd3 |
T |
A |
15: 47,450,361 (GRCm39) |
Y2690F |
|
Het |
| Dchs1 |
G |
T |
7: 105,407,835 (GRCm39) |
T1999K |
probably benign |
Het |
| Ddx10 |
T |
A |
9: 53,151,786 (GRCm39) |
T80S |
probably damaging |
Het |
| Dmtn |
G |
A |
14: 70,854,768 (GRCm39) |
T69I |
probably damaging |
Het |
| Dnah5 |
T |
A |
15: 28,370,524 (GRCm39) |
H2821Q |
probably damaging |
Het |
| Fam162b |
T |
A |
10: 51,466,572 (GRCm39) |
|
probably benign |
Het |
| Fam193b |
A |
C |
13: 55,690,612 (GRCm39) |
S717A |
probably benign |
Het |
| Far2 |
T |
C |
6: 148,082,493 (GRCm39) |
F500L |
unknown |
Het |
| Focad |
T |
A |
4: 88,192,435 (GRCm39) |
V588D |
unknown |
Het |
| Gm12728 |
T |
C |
4: 105,651,593 (GRCm39) |
F68L |
probably damaging |
Het |
| Gm1527 |
T |
A |
3: 28,974,621 (GRCm39) |
M478K |
probably benign |
Het |
| Gm57858 |
T |
A |
3: 36,080,070 (GRCm39) |
D229V |
possibly damaging |
Het |
| Gpd2 |
A |
T |
2: 57,230,171 (GRCm39) |
I308F |
probably damaging |
Het |
| Igf2bp3 |
T |
C |
6: 49,085,933 (GRCm39) |
T249A |
probably benign |
Het |
| Igfn1 |
C |
A |
1: 135,889,746 (GRCm39) |
V2434F |
probably damaging |
Het |
| Inhca |
G |
A |
9: 103,156,680 (GRCm39) |
Q127* |
probably null |
Het |
| Kdm5a |
C |
A |
6: 120,382,879 (GRCm39) |
Q737K |
probably benign |
Het |
| Khdrbs2 |
T |
C |
1: 32,372,685 (GRCm39) |
S120P |
unknown |
Het |
| Lmx1a |
T |
C |
1: 167,519,609 (GRCm39) |
F46L |
probably damaging |
Het |
| Lrba |
C |
G |
3: 86,232,381 (GRCm39) |
T776R |
probably damaging |
Het |
| Lrrc8c |
A |
G |
5: 105,755,701 (GRCm39) |
N492S |
possibly damaging |
Het |
| Mapk3 |
A |
T |
7: 126,363,967 (GRCm39) |
I365F |
|
Het |
| Mcee |
A |
G |
7: 64,061,657 (GRCm39) |
I153M |
possibly damaging |
Het |
| Mllt3 |
T |
C |
4: 87,710,180 (GRCm39) |
D415G |
possibly damaging |
Het |
| Muc4 |
A |
T |
16: 32,575,740 (GRCm39) |
T1747S |
unknown |
Het |
| Myh14 |
A |
T |
7: 44,310,466 (GRCm39) |
V139E |
probably damaging |
Het |
| Naa15 |
T |
G |
3: 51,367,268 (GRCm39) |
|
probably null |
Het |
| Nbeal1 |
T |
A |
1: 60,283,969 (GRCm39) |
I841N |
probably damaging |
Het |
| Nf1 |
C |
T |
11: 79,437,102 (GRCm39) |
T2006I |
probably damaging |
Het |
| Npr2 |
T |
A |
4: 43,641,254 (GRCm39) |
W427R |
probably damaging |
Het |
| Nr1h3 |
A |
T |
2: 91,020,540 (GRCm39) |
F324L |
possibly damaging |
Het |
| Obscn |
T |
C |
11: 58,947,740 (GRCm39) |
K4430E |
|
Het |
| Or1e1d-ps1 |
T |
A |
11: 73,819,013 (GRCm39) |
Y61N |
possibly damaging |
Het |
| Or5ac21 |
A |
G |
16: 59,124,391 (GRCm39) |
R292G |
probably damaging |
Het |
| Or6c2 |
A |
T |
10: 129,362,530 (GRCm39) |
T145S |
probably benign |
Het |
| Or6d13 |
T |
C |
6: 116,517,894 (GRCm39) |
L160P |
probably benign |
Het |
| Osgin1 |
T |
A |
8: 120,172,170 (GRCm39) |
H321Q |
probably benign |
Het |
| P4ha1 |
A |
G |
10: 59,186,273 (GRCm39) |
I251V |
probably benign |
Het |
| Padi2 |
G |
A |
4: 140,644,997 (GRCm39) |
W77* |
probably null |
Het |
| Pkd1 |
T |
A |
17: 24,800,616 (GRCm39) |
I3086N |
probably damaging |
Het |
| Plk3 |
T |
C |
4: 116,988,350 (GRCm39) |
N360S |
probably benign |
Het |
| Prr14 |
A |
T |
7: 127,075,614 (GRCm39) |
S541C |
probably null |
Het |
| Ptch2 |
C |
A |
4: 116,971,843 (GRCm39) |
Q1122K |
possibly damaging |
Het |
| Rab3gap1 |
T |
C |
1: 127,865,727 (GRCm39) |
V764A |
possibly damaging |
Het |
| Rad50 |
T |
C |
11: 53,586,223 (GRCm39) |
I258V |
probably benign |
Het |
| Rapgef3 |
G |
T |
15: 97,664,672 (GRCm39) |
R64S |
probably benign |
Het |
| Rbm44 |
A |
G |
1: 91,079,938 (GRCm39) |
N42S |
possibly damaging |
Het |
| Ring1 |
T |
C |
17: 34,240,694 (GRCm39) |
Y361C |
probably damaging |
Het |
| Robo3 |
T |
C |
9: 37,329,852 (GRCm39) |
T1155A |
probably damaging |
Het |
| Rsf1 |
GGCGG |
GGCGGTGGCCGCGG |
7: 97,229,122 (GRCm39) |
|
probably benign |
Het |
| Ryr3 |
T |
C |
2: 112,470,502 (GRCm39) |
T4682A |
probably damaging |
Het |
| Scart1 |
A |
T |
7: 139,804,790 (GRCm39) |
N598Y |
possibly damaging |
Het |
| Sema7a |
T |
C |
9: 57,868,847 (GRCm39) |
V653A |
unknown |
Het |
| Slc16a13 |
T |
C |
11: 70,110,105 (GRCm39) |
Y132C |
probably damaging |
Het |
| Slc24a1 |
A |
G |
9: 64,855,815 (GRCm39) |
V364A |
unknown |
Het |
| Slc8a2 |
C |
T |
7: 15,868,278 (GRCm39) |
A170V |
probably damaging |
Het |
| Slfn8 |
C |
T |
11: 82,894,566 (GRCm39) |
R691Q |
not run |
Het |
| Snx2 |
T |
C |
18: 53,327,640 (GRCm39) |
V122A |
probably benign |
Het |
| Sstr1 |
A |
T |
12: 58,260,066 (GRCm39) |
M230L |
probably benign |
Het |
| Themis2 |
C |
T |
4: 132,513,528 (GRCm39) |
V233I |
possibly damaging |
Het |
| Tmem106b |
T |
C |
6: 13,078,167 (GRCm39) |
S121P |
probably damaging |
Het |
| Tmem63c |
A |
G |
12: 87,124,722 (GRCm39) |
I529V |
probably benign |
Het |
| Tmem94 |
T |
C |
11: 115,686,971 (GRCm39) |
|
probably null |
Het |
| Trmt10c |
A |
T |
16: 55,854,619 (GRCm39) |
W339R |
probably damaging |
Het |
| Ugt2b1 |
A |
T |
5: 87,065,578 (GRCm39) |
F487Y |
not run |
Het |
| Vmn2r91 |
T |
A |
17: 18,356,838 (GRCm39) |
L835* |
probably null |
Het |
| Vps52 |
C |
A |
17: 34,177,283 (GRCm39) |
N108K |
possibly damaging |
Het |
| Wdpcp |
T |
A |
11: 21,661,585 (GRCm39) |
C286S |
possibly damaging |
Het |
| Zfp959 |
T |
A |
17: 56,205,551 (GRCm39) |
H529Q |
possibly damaging |
Het |
|
| Other mutations in Myo10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00557:Myo10
|
APN |
15 |
25,776,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01068:Myo10
|
APN |
15 |
25,739,395 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01352:Myo10
|
APN |
15 |
25,701,783 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01388:Myo10
|
APN |
15 |
25,736,703 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
IGL01460:Myo10
|
APN |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01553:Myo10
|
APN |
15 |
25,776,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01732:Myo10
|
APN |
15 |
25,732,149 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL01992:Myo10
|
APN |
15 |
25,799,634 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02000:Myo10
|
APN |
15 |
25,808,152 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02045:Myo10
|
APN |
15 |
25,726,574 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02307:Myo10
|
APN |
15 |
25,776,401 (GRCm39) |
splice site |
probably benign |
|
|
IGL02511:Myo10
|
APN |
15 |
25,723,975 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL03240:Myo10
|
APN |
15 |
25,701,688 (GRCm39) |
missense |
probably damaging |
1.00 |
|
least
|
UTSW |
15 |
25,726,561 (GRCm39) |
nonsense |
probably null |
|
|
R0037:Myo10
|
UTSW |
15 |
25,666,618 (GRCm39) |
intron |
probably benign |
|
|
R0153:Myo10
|
UTSW |
15 |
25,781,324 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R0282:Myo10
|
UTSW |
15 |
25,793,253 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0360:Myo10
|
UTSW |
15 |
25,804,454 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0585:Myo10
|
UTSW |
15 |
25,736,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0617:Myo10
|
UTSW |
15 |
25,738,091 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0729:Myo10
|
UTSW |
15 |
25,722,243 (GRCm39) |
splice site |
probably benign |
|
|
R0771:Myo10
|
UTSW |
15 |
25,778,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0960:Myo10
|
UTSW |
15 |
25,801,275 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1562:Myo10
|
UTSW |
15 |
25,780,497 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R1651:Myo10
|
UTSW |
15 |
25,742,455 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1789:Myo10
|
UTSW |
15 |
25,726,611 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1816:Myo10
|
UTSW |
15 |
25,800,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Myo10
|
UTSW |
15 |
25,805,673 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1908:Myo10
|
UTSW |
15 |
25,801,308 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2082:Myo10
|
UTSW |
15 |
25,786,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2101:Myo10
|
UTSW |
15 |
25,722,345 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2129:Myo10
|
UTSW |
15 |
25,781,885 (GRCm39) |
missense |
probably benign |
0.09 |
|
R2141:Myo10
|
UTSW |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
|
|
R2142:Myo10
|
UTSW |
15 |
25,714,194 (GRCm39) |
missense |
probably benign |
|
|
R2920:Myo10
|
UTSW |
15 |
25,801,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2938:Myo10
|
UTSW |
15 |
25,795,803 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3723:Myo10
|
UTSW |
15 |
25,803,374 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3852:Myo10
|
UTSW |
15 |
25,779,712 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4162:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4163:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4164:Myo10
|
UTSW |
15 |
25,726,501 (GRCm39) |
splice site |
probably null |
|
|
R4177:Myo10
|
UTSW |
15 |
25,734,137 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4409:Myo10
|
UTSW |
15 |
25,807,955 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4667:Myo10
|
UTSW |
15 |
25,793,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4905:Myo10
|
UTSW |
15 |
25,800,298 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4933:Myo10
|
UTSW |
15 |
25,781,204 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4968:Myo10
|
UTSW |
15 |
25,808,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5081:Myo10
|
UTSW |
15 |
25,786,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5123:Myo10
|
UTSW |
15 |
25,726,569 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5310:Myo10
|
UTSW |
15 |
25,778,164 (GRCm39) |
splice site |
probably null |
|
|
R6073:Myo10
|
UTSW |
15 |
25,736,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6117:Myo10
|
UTSW |
15 |
25,805,745 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6185:Myo10
|
UTSW |
15 |
25,726,596 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6749:Myo10
|
UTSW |
15 |
25,714,196 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6819:Myo10
|
UTSW |
15 |
25,781,496 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6875:Myo10
|
UTSW |
15 |
25,805,745 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6908:Myo10
|
UTSW |
15 |
25,804,469 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6963:Myo10
|
UTSW |
15 |
25,734,149 (GRCm39) |
missense |
probably benign |
0.31 |
|
R7144:Myo10
|
UTSW |
15 |
25,724,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7266:Myo10
|
UTSW |
15 |
25,783,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7460:Myo10
|
UTSW |
15 |
25,807,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Myo10
|
UTSW |
15 |
25,701,709 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7618:Myo10
|
UTSW |
15 |
25,726,561 (GRCm39) |
nonsense |
probably null |
|
|
R7717:Myo10
|
UTSW |
15 |
25,732,056 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7811:Myo10
|
UTSW |
15 |
25,804,610 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7830:Myo10
|
UTSW |
15 |
25,738,057 (GRCm39) |
nonsense |
probably null |
|
|
R7862:Myo10
|
UTSW |
15 |
25,666,522 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8232:Myo10
|
UTSW |
15 |
25,804,400 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8264:Myo10
|
UTSW |
15 |
25,800,195 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8377:Myo10
|
UTSW |
15 |
25,804,481 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8385:Myo10
|
UTSW |
15 |
25,804,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8426:Myo10
|
UTSW |
15 |
25,799,576 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8439:Myo10
|
UTSW |
15 |
25,725,158 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8696:Myo10
|
UTSW |
15 |
25,799,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8775:Myo10
|
UTSW |
15 |
25,800,145 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8775-TAIL:Myo10
|
UTSW |
15 |
25,800,145 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8970:Myo10
|
UTSW |
15 |
25,803,467 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R9024:Myo10
|
UTSW |
15 |
25,793,295 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9196:Myo10
|
UTSW |
15 |
25,805,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9224:Myo10
|
UTSW |
15 |
25,808,081 (GRCm39) |
missense |
probably benign |
0.33 |
|
R9308:Myo10
|
UTSW |
15 |
25,781,862 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9358:Myo10
|
UTSW |
15 |
25,781,520 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R9606:Myo10
|
UTSW |
15 |
25,776,401 (GRCm39) |
frame shift |
probably null |
|
|
R9722:Myo10
|
UTSW |
15 |
25,801,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF013:Myo10
|
UTSW |
15 |
25,799,565 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Myo10
|
UTSW |
15 |
25,799,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
Z1177:Myo10
|
UTSW |
15 |
25,781,487 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATAAGAGACCGGGTCCAAGTC -3'
(R):5'- TGAACCGTTCTGTTTCAGCCG -3'
Sequencing Primer
(F):5'- AAGTCTGGATCCTCTCCTTTTTG -3'
(R):5'- TCTGTTTCAGCCGGCAGAG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation