Mutagenetix > Incidental Mutation

Incidental Mutation 'R7381:Ptpro'

572717

Institutional Source

Beutler Lab

Gene Symbol

Ptpro

Ensembl Gene

ENSMUSG00000030223

Gene Name

protein tyrosine phosphatase, receptor type, O

Synonyms

Ptpn15, PTP-oc, GLEPP1, PTP-U2, PTP-BK, PTP-phi, D28, PTPROt

MMRRC Submission

045463-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7381 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

137252319-137463233 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 137399561 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 680 (V680I)

Ref Sequence

ENSEMBL: ENSMUSP00000076364 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000077115] [ENSMUST00000167679]

AlphaFold

E9Q612

Predicted Effect

possibly damaging
Transcript: ENSMUST00000077115
AA Change: V680I

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000076364
Gene: ENSMUSG00000030223
AA Change: V680I

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
transmembrane domain	890	912	N/A	INTRINSIC
PTPc	947	1207	1.43e-127	SMART

Predicted Effect

possibly damaging
Transcript: ENSMUST00000167679
AA Change: V680I

PolyPhen 2 Score 0.929 (Sensitivity: 0.81; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000127112
Gene: ENSMUSG00000030223
AA Change: V680I

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	269	291	N/A	INTRINSIC
FN3	443	528	1.07e-1	SMART
FN3	540	626	7.07e-2	SMART
FN3	642	722	4.47e1	SMART
FN3	733	812	5.92e-4	SMART
transmembrane domain	831	853	N/A	INTRINSIC
PTPc	919	1179	1.43e-127	SMART

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.2%

Validation Efficiency

98% (88/90)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]
PHENOTYPE: Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 93 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700016K19Rik	A	T	11: 76,003,007 (GRCm38)	D70V	probably damaging	Het
4930550C14Rik	T	C	9: 53,411,822 (GRCm38)	Y53H	probably damaging	Het
Abca8a	A	T	11: 110,030,087 (GRCm38)		probably null	Het
Acads	C	A	5: 115,110,998 (GRCm38)	Q365H	probably damaging	Het
Acsm3	A	G	7: 119,780,826 (GRCm38)	D462G	probably damaging	Het
Adam39	T	A	8: 40,825,963 (GRCm38)	C464S	probably damaging	Het
Adgra3	A	G	5: 50,058,774 (GRCm38)	M1T	probably null	Het
AI182371	T	C	2: 35,085,359 (GRCm38)	Y276C	probably damaging	Het
Ank2	T	A	3: 126,936,628 (GRCm38)	H719L	possibly damaging	Het
Ano7	G	A	1: 93,395,335 (GRCm38)	V466I	probably benign	Het
Art5	A	G	7: 102,098,170 (GRCm38)	L134P	probably damaging	Het
Atcay	A	G	10: 81,210,597 (GRCm38)	Y298H	possibly damaging	Het
Atp1a4	A	T	1: 172,240,115 (GRCm38)	F527Y	possibly damaging	Het
Bpifb2	A	T	2: 153,892,348 (GRCm38)	M428L	probably benign	Het
Brinp2	A	C	1: 158,246,343 (GRCm38)	V736G	probably benign	Het
Cdc5l	C	T	17: 45,411,923 (GRCm38)	A437T	probably benign	Het
Cdx2	G	A	5: 147,306,630 (GRCm38)	P118L	possibly damaging	Het
Chpt1	G	A	10: 88,475,331 (GRCm38)		probably null	Het
Creb3l2	T	A	6: 37,335,848 (GRCm38)	E417V	probably damaging	Het
Csnk2a1	A	G	2: 152,258,694 (GRCm38)	T129A	probably benign	Het
Dennd6b	A	T	15: 89,186,173 (GRCm38)	L431Q	possibly damaging	Het
Dgkz	C	T	2: 91,944,835 (GRCm38)	A260T	probably benign	Het
Dhx34	T	A	7: 16,215,448 (GRCm38)	T352S	probably benign	Het
Elp4	C	T	2: 105,792,307 (GRCm38)	R349Q	not run	Het
Emsy	A	C	7: 98,590,803 (GRCm38)	F1228V	probably damaging	Het
Eps8l1	T	A	7: 4,470,438 (GRCm38)		probably null	Het
Faf1	T	A	4: 109,861,937 (GRCm38)	D413E	probably damaging	Het
Fam71e2	C	A	7: 4,757,682 (GRCm38)	R677L		Het
Fat3	T	C	9: 16,246,987 (GRCm38)	Y1109C	probably damaging	Het
Fbp1	T	C	13: 62,865,053 (GRCm38)	K314E	probably benign	Het
Fbxl20	A	G	11: 98,090,788 (GRCm38)	V358A	probably benign	Het
Fbxo34	C	G	14: 47,530,535 (GRCm38)	R502G	probably benign	Het
Fxr2	G	A	11: 69,642,049 (GRCm38)	C151Y	possibly damaging	Het
Gja8	T	C	3: 96,920,022 (GRCm38)	D108G	probably benign	Het
Gm10722	C	A	9: 3,001,235 (GRCm38)	L104I	probably benign	Het
Grsf1	A	G	5: 88,665,807 (GRCm38)	V361A	probably benign	Het
Gsap	T	A	5: 21,226,787 (GRCm38)	I228N	probably damaging	Het
Hagh	T	C	17: 24,856,712 (GRCm38)	I131T	probably damaging	Het
Heca	A	T	10: 17,915,524 (GRCm38)	Y261*	probably null	Het
Hipk3	A	G	2: 104,439,351 (GRCm38)	F498L	probably damaging	Het
Hps4	T	A	5: 112,375,458 (GRCm38)	I614N	possibly damaging	Het
Icam1	T	C	9: 21,027,590 (GRCm38)	S450P	probably benign	Het
Il22	G	A	10: 118,205,164 (GRCm38)	M58I	possibly damaging	Het
Khdrbs2	T	A	1: 32,333,802 (GRCm38)	S186T	not run	Het
Kif16b	A	G	2: 142,857,423 (GRCm38)	F79S	probably damaging	Het
Kntc1	C	A	5: 123,810,908 (GRCm38)	F1905L	probably benign	Het
Lrp1b	C	T	2: 40,802,917 (GRCm38)	G3423D		Het
Lrp5	G	T	19: 3,593,588 (GRCm38)	Q1346K	probably benign	Het
Map3k21	A	C	8: 125,944,978 (GRCm38)	T1002P	possibly damaging	Het
Mdga2	G	T	12: 66,568,896 (GRCm38)	R646S	probably benign	Het
Mex3b	G	T	7: 82,868,865 (GRCm38)	M129I	possibly damaging	Het
Mfsd10	G	T	5: 34,636,426 (GRCm38)	N85K	probably damaging	Het
Mios	A	G	6: 8,216,064 (GRCm38)	D420G	probably damaging	Het
Mogs	C	A	6: 83,115,632 (GRCm38)	P18T	unknown	Het
Mrgpre	A	G	7: 143,781,413 (GRCm38)	C118R	probably damaging	Het
Muc4	A	T	16: 32,780,915 (GRCm38)	H1321L		Het
Nkapl	T	C	13: 21,467,589 (GRCm38)	K285E	probably damaging	Het
Nphp4	C	T	4: 152,499,003 (GRCm38)	P200S	possibly damaging	Het
Piezo1	A	G	8: 122,501,658 (GRCm38)	F297L		Het
Pkhd1	T	G	1: 20,200,973 (GRCm38)	S3119R	probably damaging	Het
Pla2g15	G	A	8: 106,162,944 (GRCm38)	V283I	probably benign	Het
Ppp1r13l	T	A	7: 19,368,861 (GRCm38)		probably null	Het
Prex1	A	G	2: 166,587,127 (GRCm38)	Y849H	probably damaging	Het
Psg27	C	A	7: 18,567,083 (GRCm38)	W15L	probably benign	Het
Ptar1	A	T	19: 23,708,970 (GRCm38)		probably null	Het
Ptpn6	G	A	6: 124,728,172 (GRCm38)	R264C	probably damaging	Het
Ptprb	A	G	10: 116,341,133 (GRCm38)	I988V	probably benign	Het
Rnf170	C	T	8: 26,123,848 (GRCm38)	P28S	probably benign	Het
Rnpepl1	A	G	1: 92,919,195 (GRCm38)	S580G	possibly damaging	Het
Rtel1	C	T	2: 181,330,815 (GRCm38)	R29*	probably null	Het
Rtkn	T	C	6: 83,151,745 (GRCm38)	L26P	probably damaging	Het
Sdk2	A	C	11: 113,838,489 (GRCm38)	S1087R	probably damaging	Het
Sema7a	C	T	9: 57,953,569 (GRCm38)	P71L	probably benign	Het
Sgpp1	C	T	12: 75,716,264 (GRCm38)	C381Y	probably damaging	Het
Sis	A	T	3: 72,913,292 (GRCm38)		probably null	Het
Slc24a5	A	C	2: 125,068,949 (GRCm38)	D100A	probably benign	Het
Slc25a23	A	T	17: 57,053,587 (GRCm38)	I251K	probably damaging	Het
Slc6a5	T	A	7: 49,930,056 (GRCm38)	L394H	probably damaging	Het
Slc7a4	A	T	16: 17,575,056 (GRCm38)	M293K	probably damaging	Het
Syne2	T	A	12: 75,926,489 (GRCm38)	S1089T	probably benign	Het
Tanc1	A	T	2: 59,785,326 (GRCm38)	T226S	probably damaging	Het
Tdrd6	T	C	17: 43,626,093 (GRCm38)	T1355A	probably benign	Het
Tmem101	A	G	11: 102,153,350 (GRCm38)	M237T	possibly damaging	Het
Ttn	G	A	2: 76,919,015 (GRCm38)	H3897Y	possibly damaging	Het
Tubb4a	C	T	17: 57,080,698 (GRCm38)	V443M	unknown	Het
Ucp2	G	A	7: 100,498,369 (GRCm38)	R185H	possibly damaging	Het
Vmn1r116	G	T	7: 20,872,511 (GRCm38)	E86*	probably null	Het
Vmn2r37	T	C	7: 9,210,033 (GRCm38)	E530G	probably benign	Het
Vwa8	A	G	14: 79,095,685 (GRCm38)	T1293A	probably benign	Het
Zfc3h1	T	A	10: 115,424,630 (GRCm38)	Y1711N	probably benign	Het
Zfp873	A	T	10: 82,060,971 (GRCm38)	E512V	probably damaging	Het
Zfyve16	T	A	13: 92,521,146 (GRCm38)	K752N	probably damaging	Het
Zhx1	T	C	15: 58,053,165 (GRCm38)	N562D	possibly damaging	Het

Other mutations in Ptpro

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00334:Ptpro	APN	6	137,394,909 (GRCm38)	critical splice donor site	probably null
IGL00844:Ptpro	APN	6	137,414,239 (GRCm38)	missense	probably damaging	1.00
IGL00983:Ptpro	APN	6	137,418,248 (GRCm38)	missense	probably benign	0.01
IGL01073:Ptpro	APN	6	137,377,088 (GRCm38)	missense	probably damaging	1.00
IGL01832:Ptpro	APN	6	137,393,668 (GRCm38)	missense	possibly damaging	0.93
IGL02308:Ptpro	APN	6	137,454,700 (GRCm38)	missense	probably benign	0.37
IGL02387:Ptpro	APN	6	137,410,980 (GRCm38)	missense	probably damaging	0.96
IGL02605:Ptpro	APN	6	137,380,318 (GRCm38)	missense	probably benign	0.02
IGL02666:Ptpro	APN	6	137,378,059 (GRCm38)	missense	probably damaging	0.96
IGL03275:Ptpro	APN	6	137,450,006 (GRCm38)	missense	probably damaging	1.00
Brau	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
court	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
Hoff	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
Jester	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
mann	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0017:Ptpro	UTSW	6	137,416,827 (GRCm38)	missense	probably benign	0.03
R0020:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0022:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0023:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0024:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0094:Ptpro	UTSW	6	137,386,352 (GRCm38)	missense	probably benign	0.08
R0103:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0106:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0316:Ptpro	UTSW	6	137,376,989 (GRCm38)	missense	possibly damaging	0.81
R0427:Ptpro	UTSW	6	137,368,296 (GRCm38)	missense	possibly damaging	0.81
R0456:Ptpro	UTSW	6	137,414,230 (GRCm38)	missense	probably benign	0.04
R0536:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0537:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0552:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0555:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0664:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0708:Ptpro	UTSW	6	137,386,253 (GRCm38)	missense	probably benign	0.26
R0730:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0735:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0738:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0786:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0811:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0812:Ptpro	UTSW	6	137,368,079 (GRCm38)	missense	probably benign	0.00
R0881:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R0973:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1145:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1146:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1147:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1259:Ptpro	UTSW	6	137,392,741 (GRCm38)	missense	probably damaging	0.98
R1340:Ptpro	UTSW	6	137,441,081 (GRCm38)	missense	possibly damaging	0.95
R1381:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1382:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1385:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1396:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1401:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1416:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1422:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1448:Ptpro	UTSW	6	137,441,116 (GRCm38)	missense	probably damaging	1.00
R1513:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1518:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1526:Ptpro	UTSW	6	137,461,726 (GRCm38)	missense	probably damaging	1.00
R1540:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1571:Ptpro	UTSW	6	137,378,130 (GRCm38)	missense	probably benign
R1573:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1587:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1588:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1649:Ptpro	UTSW	6	137,444,017 (GRCm38)	nonsense	probably null
R1700:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1701:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1745:Ptpro	UTSW	6	137,400,645 (GRCm38)	missense	probably benign	0.03
R1772:Ptpro	UTSW	6	137,430,743 (GRCm38)	missense	probably damaging	1.00
R1911:Ptpro	UTSW	6	137,400,619 (GRCm38)	splice site	probably benign
R1958:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R1967:Ptpro	UTSW	6	137,416,865 (GRCm38)	missense	probably benign	0.38
R2025:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2026:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2040:Ptpro	UTSW	6	137,386,164 (GRCm38)	splice site	probably benign
R2115:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2117:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R2130:Ptpro	UTSW	6	137,411,116 (GRCm38)	splice site	probably null
R2161:Ptpro	UTSW	6	137,449,887 (GRCm38)	missense	probably benign	0.01
R2431:Ptpro	UTSW	6	137,443,585 (GRCm38)	nonsense	probably null
R2915:Ptpro	UTSW	6	137,414,241 (GRCm38)	start gained	probably benign
R2988:Ptpro	UTSW	6	137,443,599 (GRCm38)	nonsense	probably null
R3772:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3773:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3795:Ptpro	UTSW	6	137,380,309 (GRCm38)	missense	probably benign
R3885:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3886:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3887:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3888:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R3893:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4032:Ptpro	UTSW	6	137,461,742 (GRCm38)	missense	probably damaging	1.00
R4133:Ptpro	UTSW	6	137,420,372 (GRCm38)	missense	probably damaging	1.00
R4377:Ptpro	UTSW	6	137,380,266 (GRCm38)	missense	probably benign	0.26
R4455:Ptpro	UTSW	6	137,393,659 (GRCm38)	missense	probably damaging	1.00
R4613:Ptpro	UTSW	6	137,416,836 (GRCm38)	nonsense	probably null
R4827:Ptpro	UTSW	6	137,442,710 (GRCm38)	missense	probably damaging	1.00
R4863:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R4870:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R4910:Ptpro	UTSW	6	137,368,338 (GRCm38)	missense	probably damaging	0.99
R4932:Ptpro	UTSW	6	137,411,105 (GRCm38)	nonsense	probably null
R4941:Ptpro	UTSW	6	137,392,765 (GRCm38)	missense	probably damaging	1.00
R4989:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5009:Ptpro	UTSW	6	137,377,132 (GRCm38)	missense	probably damaging	0.96
R5032:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5033:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5162:Ptpro	UTSW	6	137,443,594 (GRCm38)	missense	probably damaging	1.00
R5393:Ptpro	UTSW	6	137,380,224 (GRCm38)	missense	probably benign	0.04
R5423:Ptpro	UTSW	6	137,442,707 (GRCm38)	missense	probably damaging	1.00
R5782:Ptpro	UTSW	6	137,399,498 (GRCm38)	missense	possibly damaging	0.80
R6103:Ptpro	UTSW	6	137,400,706 (GRCm38)	missense	possibly damaging	0.76
R6239:Ptpro	UTSW	6	137,380,608 (GRCm38)	missense	probably benign	0.28
R6488:Ptpro	UTSW	6	137,393,675 (GRCm38)	nonsense	probably null
R6494:Ptpro	UTSW	6	137,382,642 (GRCm38)	missense	probably benign	0.20
R6746:Ptpro	UTSW	6	137,394,823 (GRCm38)	missense	probably damaging	1.00
R6763:Ptpro	UTSW	6	137,418,281 (GRCm38)	splice site	probably null
R6888:Ptpro	UTSW	6	137,380,200 (GRCm38)	missense	probably benign	0.30
R6983:Ptpro	UTSW	6	137,449,917 (GRCm38)	missense	probably damaging	1.00
R7019:Ptpro	UTSW	6	137,380,478 (GRCm38)	missense	probably benign
R7218:Ptpro	UTSW	6	137,454,598 (GRCm38)	missense	probably damaging	1.00
R7236:Ptpro	UTSW	6	137,368,337 (GRCm38)	missense	probably damaging	1.00
R7299:Ptpro	UTSW	6	137,441,144 (GRCm38)	critical splice donor site	probably null
R7493:Ptpro	UTSW	6	137,382,649 (GRCm38)	missense	probably benign	0.01
R7733:Ptpro	UTSW	6	137,414,286 (GRCm38)	nonsense	probably null
R7793:Ptpro	UTSW	6	137,416,820 (GRCm38)	missense	probably damaging	0.99
R7804:Ptpro	UTSW	6	137,399,601 (GRCm38)	splice site	probably null
R7833:Ptpro	UTSW	6	137,416,863 (GRCm38)	nonsense	probably null
R7859:Ptpro	UTSW	6	137,392,807 (GRCm38)	critical splice donor site	probably null
R7873:Ptpro	UTSW	6	137,430,739 (GRCm38)	missense	probably benign	0.44
R8042:Ptpro	UTSW	6	137,416,883 (GRCm38)	missense	possibly damaging	0.71
R8859:Ptpro	UTSW	6	137,426,784 (GRCm38)	nonsense	probably null
R8979:Ptpro	UTSW	6	137,368,142 (GRCm38)	missense	probably benign
R9138:Ptpro	UTSW	6	137,411,115 (GRCm38)	critical splice donor site	probably null
R9309:Ptpro	UTSW	6	137,454,658 (GRCm38)	missense	probably damaging	1.00
R9420:Ptpro	UTSW	6	137,443,935 (GRCm38)	missense	probably benign	0.08
R9612:Ptpro	UTSW	6	137,414,320 (GRCm38)	missense	probably benign	0.31
R9625:Ptpro	UTSW	6	137,394,875 (GRCm38)	missense	probably damaging	1.00
R9697:Ptpro	UTSW	6	137,386,290 (GRCm38)	missense	probably damaging	1.00
R9715:Ptpro	UTSW	6	137,368,110 (GRCm38)	missense	probably damaging	0.96
Z1177:Ptpro	UTSW	6	137,378,140 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATTGCGGCTCTCACACTTGG -3'
(R):5'- AGCTTGTTTGATAGCACACAGC -3'

Sequencing Primer
(F):5'- TCTCACACTTGGCTGGGGAG -3'
(R):5'- AAAGCTCTCATGTGTCCTAGG -3'

Posted On

2019-09-13