Incidental Mutation 'R7382:Cdon'
ID 572805
Institutional Source Beutler Lab
Gene Symbol Cdon
Ensembl Gene ENSMUSG00000038119
Gene Name cell adhesion molecule-related/down-regulated by oncogenes
Synonyms CAM-related/down-regulated by oncogenes, CDO
MMRRC Submission 045464-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.241) question?
Stock # R7382 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 35332836-35418948 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 35389944 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 866 (D866G)
Ref Sequence ENSEMBL: ENSMUSP00000045547 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000042842] [ENSMUST00000119129]
AlphaFold Q32MD9
Predicted Effect probably damaging
Transcript: ENSMUST00000042842
AA Change: D866G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000045547
Gene: ENSMUSG00000038119
AA Change: D866G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000119129
AA Change: D866G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000113977
Gene: ENSMUSG00000038119
AA Change: D866G

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
IGc2 40 103 1.35e-9 SMART
IG 125 212 7.25e-1 SMART
IGc2 233 296 1.38e-6 SMART
IGc2 323 386 4.62e-17 SMART
IGc2 416 506 5e-13 SMART
FN3 573 660 2.18e-2 SMART
FN3 717 800 1.89e-11 SMART
FN3 822 909 7.01e-6 SMART
transmembrane domain 962 984 N/A INTRINSIC
low complexity region 1101 1111 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 99% (77/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygous null mice display facial defects characteristic of microform holoprosencephaly, are runted, and are prone to death prior to weaning. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610008E11Rik A T 10: 78,903,103 (GRCm39) H404Q probably damaging Het
Aadacl2fm2 T A 3: 59,651,037 (GRCm39) M53K probably benign Het
Adam8 T A 7: 139,570,020 (GRCm39) T82S possibly damaging Het
Adgrl2 T G 3: 148,522,919 (GRCm39) Q435P Het
Ahr A T 12: 35,554,514 (GRCm39) M535K probably damaging Het
Akap6 A G 12: 53,188,954 (GRCm39) I2123V probably benign Het
Ankrd2 G T 19: 42,033,411 (GRCm39) G318C Het
Ap4e1 T A 2: 126,850,822 (GRCm39) probably null Het
Atp8a2 G A 14: 59,892,043 (GRCm39) P1102S probably benign Het
Cacna2d4 C T 6: 119,216,048 (GRCm39) S105F probably damaging Het
Cad C A 5: 31,233,173 (GRCm39) P1872T probably benign Het
Catsperg1 A G 7: 28,904,269 (GRCm39) F251L probably benign Het
Ccdc18 C A 5: 108,286,873 (GRCm39) Q136K probably damaging Het
Cd163 A G 6: 124,288,271 (GRCm39) probably null Het
Cd209d A T 8: 3,927,965 (GRCm39) Y46* probably null Het
Cdk5rap2 A T 4: 70,208,262 (GRCm39) M728K probably benign Het
Cenpl A G 1: 160,906,031 (GRCm39) H135R probably benign Het
Cep20 TTGTG TTG 16: 14,118,009 (GRCm39) probably null Het
Clstn2 A T 9: 97,681,451 (GRCm39) L63* probably null Het
Cpeb4 A G 11: 31,822,828 (GRCm39) T181A probably damaging Het
Dlgap1 A G 17: 71,094,169 (GRCm39) E830G probably damaging Het
Endou T A 15: 97,616,807 (GRCm39) K239* probably null Het
Ezh2 T C 6: 47,528,770 (GRCm39) N263S possibly damaging Het
Fbxw2 T C 2: 34,697,314 (GRCm39) D351G probably benign Het
Fer1l4 A T 2: 155,862,669 (GRCm39) Y1720* probably null Het
Fmo9 A T 1: 166,491,229 (GRCm39) probably null Het
Frmpd1 T A 4: 45,278,880 (GRCm39) V535E probably benign Het
Fxr2 T C 11: 69,532,382 (GRCm39) V139A probably benign Het
Gpr180 T G 14: 118,400,035 (GRCm39) V401G possibly damaging Het
Heatr5b G T 17: 79,110,936 (GRCm39) R971S possibly damaging Het
Igkv8-34 C A 6: 70,021,103 (GRCm39) A120S probably benign Het
Inpp5b T A 4: 124,645,370 (GRCm39) H219Q probably benign Het
Itprid1 G T 6: 55,955,404 (GRCm39) G1004V probably benign Het
Kremen2 T C 17: 23,962,526 (GRCm39) probably null Het
Mael G A 1: 166,029,167 (GRCm39) P419S probably benign Het
Map1a A G 2: 121,121,266 (GRCm39) T102A probably damaging Het
Mfsd2a A T 4: 122,845,916 (GRCm39) I119N possibly damaging Het
Muc5b T C 7: 141,412,685 (GRCm39) V1877A unknown Het
Myo5c A C 9: 75,211,332 (GRCm39) S1733R probably damaging Het
Nelfcd T C 2: 174,265,176 (GRCm39) V248A probably benign Het
Npc1 A T 18: 12,334,763 (GRCm39) I663N probably damaging Het
Olig3 T A 10: 19,232,413 (GRCm39) S13T unknown Het
Or1j17 G T 2: 36,578,046 (GRCm39) E11* probably null Het
Or8k39 T C 2: 86,563,129 (GRCm39) I276V probably benign Het
Piezo2 A C 18: 63,150,590 (GRCm39) probably null Het
Pkd1l2 G T 8: 117,781,610 (GRCm39) L812M possibly damaging Het
Plcd1 G A 9: 118,903,759 (GRCm39) T387I probably damaging Het
Ppara C T 15: 85,671,429 (GRCm39) S110L probably damaging Het
Ranbp9 C T 13: 43,578,590 (GRCm39) R161Q probably damaging Het
Rufy2 G T 10: 62,833,748 (GRCm39) R270L probably benign Het
Septin12 C T 16: 4,806,346 (GRCm39) E272K probably damaging Het
Sgms1 T C 19: 32,137,182 (GRCm39) E128G possibly damaging Het
Sh3bgr G A 16: 96,007,093 (GRCm39) S21N probably benign Het
Sil1 A T 18: 35,458,466 (GRCm39) D176E probably benign Het
Slc13a2 A T 11: 78,295,621 (GRCm39) Y82N probably damaging Het
Slc41a1 C T 1: 131,774,370 (GRCm39) P479L probably damaging Het
Smarca4 A G 9: 21,570,229 (GRCm39) K744R probably damaging Het
Stxbp1 T C 2: 32,688,180 (GRCm39) D495G probably damaging Het
Sugp2 T C 8: 70,695,494 (GRCm39) S156P probably benign Het
Syt3 A T 7: 44,042,170 (GRCm39) D343V probably damaging Het
Tbl3 G T 17: 24,924,265 (GRCm39) T164N probably benign Het
Tbpl2 A T 2: 23,977,326 (GRCm39) probably null Het
Tcf7l2 T A 19: 55,915,172 (GRCm39) W461R unknown Het
Tmprss11c A T 5: 86,379,723 (GRCm39) F395Y probably benign Het
Tnc A T 4: 63,932,280 (GRCm39) Y711* probably null Het
Tnpo2 G A 8: 85,776,748 (GRCm39) R485H probably damaging Het
Ttc41 A G 10: 86,612,374 (GRCm39) K1216E probably damaging Het
Ube2q2 A C 9: 55,070,298 (GRCm39) D80A probably damaging Het
Ube2u A T 4: 100,389,379 (GRCm39) K227* probably null Het
Uhrf2 T C 19: 30,048,788 (GRCm39) Y265H possibly damaging Het
Vmn1r208 T G 13: 22,956,756 (GRCm39) Y247S probably damaging Het
Vmn2r27 A G 6: 124,174,276 (GRCm39) C525R probably damaging Het
Vps13a T C 19: 16,596,849 (GRCm39) T3090A probably damaging Het
Whrn T C 4: 63,336,573 (GRCm39) K674R probably benign Het
Zfp202 G T 9: 40,122,801 (GRCm39) R521I probably damaging Het
Zfp433 T C 10: 81,556,659 (GRCm39) V387A probably benign Het
Zpld1 T C 16: 55,067,046 (GRCm39) probably null Het
Other mutations in Cdon
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00832:Cdon APN 9 35,389,412 (GRCm39) missense probably damaging 1.00
IGL01307:Cdon APN 9 35,368,860 (GRCm39) missense probably benign 0.01
IGL01528:Cdon APN 9 35,381,403 (GRCm39) missense possibly damaging 0.95
IGL01663:Cdon APN 9 35,394,510 (GRCm39) missense possibly damaging 0.57
IGL01723:Cdon APN 9 35,414,634 (GRCm39) missense probably benign 0.05
IGL02200:Cdon APN 9 35,394,405 (GRCm39) missense probably benign 0.28
IGL02444:Cdon APN 9 35,384,744 (GRCm39) missense probably benign 0.09
IGL02547:Cdon APN 9 35,389,950 (GRCm39) missense probably damaging 1.00
IGL02620:Cdon APN 9 35,364,095 (GRCm39) missense probably benign 0.00
IGL02861:Cdon APN 9 35,398,253 (GRCm39) missense probably damaging 0.96
IGL02894:Cdon APN 9 35,366,722 (GRCm39) missense probably benign 0.01
IGL03153:Cdon APN 9 35,389,255 (GRCm39) missense probably damaging 1.00
IGL03206:Cdon APN 9 35,414,602 (GRCm39) missense probably benign
IGL03374:Cdon APN 9 35,389,299 (GRCm39) missense possibly damaging 0.46
corleone UTSW 9 35,398,252 (GRCm39) nonsense probably null
indentured UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
Molar UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
Servitude UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
PIT4280001:Cdon UTSW 9 35,398,231 (GRCm39) missense probably damaging 1.00
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0045:Cdon UTSW 9 35,398,103 (GRCm39) missense probably benign
R0064:Cdon UTSW 9 35,400,523 (GRCm39) missense probably benign 0.03
R0396:Cdon UTSW 9 35,381,426 (GRCm39) missense probably damaging 1.00
R0403:Cdon UTSW 9 35,384,796 (GRCm39) missense probably benign 0.00
R0490:Cdon UTSW 9 35,363,978 (GRCm39) missense probably damaging 1.00
R0547:Cdon UTSW 9 35,368,794 (GRCm39) missense possibly damaging 0.88
R0609:Cdon UTSW 9 35,389,907 (GRCm39) missense probably damaging 1.00
R0645:Cdon UTSW 9 35,388,379 (GRCm39) splice site probably null
R0781:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1110:Cdon UTSW 9 35,367,733 (GRCm39) splice site probably benign
R1391:Cdon UTSW 9 35,415,485 (GRCm39) missense possibly damaging 0.51
R1574:Cdon UTSW 9 35,364,233 (GRCm39) splice site probably benign
R1851:Cdon UTSW 9 35,394,454 (GRCm39) missense probably damaging 1.00
R2031:Cdon UTSW 9 35,415,370 (GRCm39) missense probably damaging 0.96
R2230:Cdon UTSW 9 35,403,222 (GRCm39) critical splice donor site probably null
R3683:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3684:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3685:Cdon UTSW 9 35,400,328 (GRCm39) missense possibly damaging 0.89
R3941:Cdon UTSW 9 35,375,467 (GRCm39) missense probably benign 0.09
R4030:Cdon UTSW 9 35,403,202 (GRCm39) missense probably damaging 1.00
R4084:Cdon UTSW 9 35,389,427 (GRCm39) missense probably damaging 0.98
R4462:Cdon UTSW 9 35,368,876 (GRCm39) missense probably damaging 0.97
R4569:Cdon UTSW 9 35,388,265 (GRCm39) missense probably damaging 1.00
R4677:Cdon UTSW 9 35,389,901 (GRCm39) missense probably damaging 1.00
R4869:Cdon UTSW 9 35,364,200 (GRCm39) missense possibly damaging 0.71
R5032:Cdon UTSW 9 35,400,330 (GRCm39) missense probably damaging 1.00
R5047:Cdon UTSW 9 35,389,935 (GRCm39) missense probably damaging 1.00
R5214:Cdon UTSW 9 35,394,504 (GRCm39) missense probably damaging 1.00
R5341:Cdon UTSW 9 35,381,431 (GRCm39) missense probably damaging 1.00
R5410:Cdon UTSW 9 35,381,331 (GRCm39) missense probably damaging 0.99
R5581:Cdon UTSW 9 35,415,377 (GRCm39) missense probably benign 0.01
R5696:Cdon UTSW 9 35,403,162 (GRCm39) missense possibly damaging 0.69
R5757:Cdon UTSW 9 35,364,068 (GRCm39) missense probably damaging 0.98
R5802:Cdon UTSW 9 35,365,716 (GRCm39) missense probably damaging 0.99
R5845:Cdon UTSW 9 35,368,762 (GRCm39) missense probably damaging 1.00
R5949:Cdon UTSW 9 35,398,247 (GRCm39) missense probably benign 0.32
R6106:Cdon UTSW 9 35,366,704 (GRCm39) nonsense probably null
R6245:Cdon UTSW 9 35,388,235 (GRCm39) missense probably damaging 1.00
R6845:Cdon UTSW 9 35,398,252 (GRCm39) nonsense probably null
R6896:Cdon UTSW 9 35,363,402 (GRCm39) start codon destroyed probably null 1.00
R7060:Cdon UTSW 9 35,398,205 (GRCm39) missense probably damaging 1.00
R7076:Cdon UTSW 9 35,415,446 (GRCm39) missense probably benign 0.00
R7184:Cdon UTSW 9 35,375,191 (GRCm39) missense probably benign 0.15
R7763:Cdon UTSW 9 35,365,711 (GRCm39) nonsense probably null
R7857:Cdon UTSW 9 35,367,908 (GRCm39) missense possibly damaging 0.79
R7885:Cdon UTSW 9 35,367,818 (GRCm39) missense probably benign 0.01
R7894:Cdon UTSW 9 35,388,244 (GRCm39) missense probably damaging 1.00
R7984:Cdon UTSW 9 35,414,598 (GRCm39) missense probably benign 0.00
R8287:Cdon UTSW 9 35,375,225 (GRCm39) missense probably benign
R8428:Cdon UTSW 9 35,403,163 (GRCm39) missense probably benign 0.21
R8519:Cdon UTSW 9 35,389,950 (GRCm39) missense probably damaging 1.00
R8698:Cdon UTSW 9 35,398,269 (GRCm39) critical splice donor site probably null
R8797:Cdon UTSW 9 35,389,931 (GRCm39) missense probably damaging 1.00
R8995:Cdon UTSW 9 35,398,093 (GRCm39) missense probably damaging 1.00
R9090:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9177:Cdon UTSW 9 35,381,230 (GRCm39) missense probably benign 0.00
R9200:Cdon UTSW 9 35,414,617 (GRCm39) missense probably benign 0.00
R9271:Cdon UTSW 9 35,403,175 (GRCm39) missense probably damaging 0.98
R9330:Cdon UTSW 9 35,400,275 (GRCm39) nonsense probably null
R9477:Cdon UTSW 9 35,403,201 (GRCm39) missense probably damaging 1.00
R9612:Cdon UTSW 9 35,398,201 (GRCm39) missense probably damaging 1.00
R9730:Cdon UTSW 9 35,398,263 (GRCm39) missense probably benign 0.00
Z1177:Cdon UTSW 9 35,403,196 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTTTATTCTCTTTGAACCAGTGTG -3'
(R):5'- AAATCAGGGCACTGTCGCAG -3'

Sequencing Primer
(F):5'- TTTGAAGCTAATGAAGTGTGTACC -3'
(R):5'- GCACTGTCGCAGGAGAG -3'
Posted On 2019-09-13