Incidental Mutation 'R7383:Ipo9'
ID 572844
Institutional Source Beutler Lab
Gene Symbol Ipo9
Ensembl Gene ENSMUSG00000041879
Gene Name importin 9
Synonyms 0710008K06Rik, Imp9
MMRRC Submission 045465-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7383 (G1)
Quality Score 225.009
Status Not validated
Chromosome 1
Chromosomal Location 135310050-135358237 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 135316411 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 805 (L805P)
Ref Sequence ENSEMBL: ENSMUSP00000036093 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041023] [ENSMUST00000161032] [ENSMUST00000161189]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000041023
AA Change: L805P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000036093
Gene: ENSMUSG00000041879
AA Change: L805P

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
IBN_N 43 119 3.83e-7 SMART
low complexity region 911 922 N/A INTRINSIC
low complexity region 978 990 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000161032
SMART Domains Protein: ENSMUSP00000124779
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
IBN_N 43 119 3.83e-7 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161189
SMART Domains Protein: ENSMUSP00000124492
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 2 10 N/A INTRINSIC
SCOP:d1i6la_ 21 52 4e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000161934
SMART Domains Protein: ENSMUSP00000124210
Gene: ENSMUSG00000041879

DomainStartEndE-ValueType
low complexity region 81 92 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a transgenic gene disruption exhibit embryonic lethality at E7. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aebp1 T A 11: 5,818,548 (GRCm39) I511N probably damaging Het
Ap5m1 T G 14: 49,311,653 (GRCm39) V241G possibly damaging Het
BC049715 T A 6: 136,817,453 (GRCm39) I231N probably damaging Het
Bckdhb T G 9: 83,835,766 (GRCm39) V90G possibly damaging Het
Cep20 TTGTG TTG 16: 14,118,009 (GRCm39) probably null Het
Chd8 T C 14: 52,452,776 (GRCm39) I1248V probably damaging Het
Ckap2l A T 2: 129,111,172 (GRCm39) M675K possibly damaging Het
Ckap4 A T 10: 84,364,148 (GRCm39) V305E probably damaging Het
Clasrp C A 7: 19,319,198 (GRCm39) R489L unknown Het
Col24a1 A G 3: 145,004,599 (GRCm39) I26V probably benign Het
Cort C T 4: 149,209,861 (GRCm39) A64T possibly damaging Het
Dmkn T A 7: 30,464,793 (GRCm39) N255K unknown Het
Dph2 A T 4: 117,748,566 (GRCm39) L69Q probably damaging Het
Fbxo11 A G 17: 88,310,282 (GRCm39) I432T Het
Fgd3 T C 13: 49,421,785 (GRCm39) K531R possibly damaging Het
Fgd5 A G 6: 91,964,099 (GRCm39) K111E probably benign Het
Gdf6 T A 4: 9,859,537 (GRCm39) D206E probably benign Het
Gtpbp1 T A 15: 79,600,354 (GRCm39) L429Q probably damaging Het
Hk2 A G 6: 82,726,276 (GRCm39) F90S probably damaging Het
Hrnr A T 3: 93,239,098 (GRCm39) Q3112L unknown Het
Hsd17b4 A C 18: 50,297,917 (GRCm39) K402T probably benign Het
Htr1f T C 16: 64,747,206 (GRCm39) T29A probably benign Het
Ikbkb C A 8: 23,159,066 (GRCm39) A471S probably benign Het
Inpp5f A G 7: 128,296,310 (GRCm39) D887G probably damaging Het
Jmjd1c A T 10: 67,025,537 (GRCm39) N118I probably benign Het
Kif26b T G 1: 178,358,275 (GRCm39) C129G probably damaging Het
Mga G A 2: 119,790,821 (GRCm39) A2236T probably damaging Het
Micu2 T C 14: 58,154,810 (GRCm39) Q405R possibly damaging Het
Myo1e T A 9: 70,204,577 (GRCm39) V59D probably damaging Het
Nav3 A G 10: 109,552,532 (GRCm39) I1770T probably damaging Het
Ndufa10 A T 1: 92,392,183 (GRCm39) I190N probably damaging Het
Niban3 A C 8: 72,056,470 (GRCm39) E390A possibly damaging Het
Npat T A 9: 53,474,078 (GRCm39) H623Q probably benign Het
Npc1l1 T C 11: 6,167,777 (GRCm39) T1005A probably benign Het
Or10ag58 A G 2: 87,265,721 (GRCm39) S297G possibly damaging Het
Or14c39 A T 7: 86,343,960 (GRCm39) I99F probably damaging Het
Or1e22 A G 11: 73,376,715 (GRCm39) *312Q probably null Het
Or2b4 A G 17: 38,116,972 (GRCm39) K312R probably benign Het
Or2w3 T C 11: 58,557,011 (GRCm39) S209P possibly damaging Het
Or5t7 A G 2: 86,507,263 (GRCm39) V138A possibly damaging Het
Or8s8 C G 15: 98,354,578 (GRCm39) P129R probably damaging Het
Pafah1b2 C T 9: 45,880,147 (GRCm39) G177R probably benign Het
Phc1 A G 6: 122,300,317 (GRCm39) S521P unknown Het
Plpp2 A T 10: 79,366,841 (GRCm39) L25Q probably null Het
Plxna4 A G 6: 32,129,734 (GRCm39) probably null Het
Ppl G T 16: 4,915,835 (GRCm39) P576Q probably damaging Het
Rab38 T C 7: 88,079,637 (GRCm39) Y10H possibly damaging Het
Rbfox1 G A 16: 6,887,899 (GRCm39) G13S probably benign Het
Rhot1 C G 11: 80,114,760 (GRCm39) P56R probably damaging Het
Sipa1l2 A G 8: 126,174,385 (GRCm39) W1298R probably damaging Het
Slc16a14 G A 1: 84,890,292 (GRCm39) H338Y probably damaging Het
Slc8a3 T G 12: 81,362,579 (GRCm39) Y80S probably damaging Het
Slco6c1 A T 1: 97,003,608 (GRCm39) Y513* probably null Het
Smarcd2 A G 11: 106,155,602 (GRCm39) C405R probably damaging Het
Szt2 G A 4: 118,222,411 (GRCm39) R3198* probably null Het
Tmeff1 T A 4: 48,636,841 (GRCm39) C180S probably damaging Het
Tmem132a A T 19: 10,844,358 (GRCm39) M80K probably benign Het
Tnfsf12 A G 11: 69,577,892 (GRCm39) V175A probably damaging Het
Tnpo2 G A 8: 85,776,748 (GRCm39) R485H probably damaging Het
Togaram2 A T 17: 72,007,512 (GRCm39) I354F probably damaging Het
Uchl5 T A 1: 143,659,753 (GRCm39) S42R probably benign Het
Virma C A 4: 11,514,026 (GRCm39) L627I probably damaging Het
Vmn2r12 A T 5: 109,240,684 (GRCm39) I143K probably benign Het
Vmn2r95 T G 17: 18,660,734 (GRCm39) V382G probably benign Het
Wipf3 G T 6: 54,462,263 (GRCm39) A158S probably benign Het
Ylpm1 T G 12: 85,091,242 (GRCm39) S1809A possibly damaging Het
Zdhhc5 A T 2: 84,524,748 (GRCm39) C191S probably benign Het
Zer1 G A 2: 30,001,253 (GRCm39) R84C probably damaging Het
Zfhx2 A T 14: 55,305,710 (GRCm39) V991D probably benign Het
Zscan4b C A 7: 10,637,960 (GRCm39) M61I possibly damaging Het
Zswim2 A T 2: 83,745,672 (GRCm39) S589T possibly damaging Het
Other mutations in Ipo9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00896:Ipo9 APN 1 135,327,797 (GRCm39) missense probably damaging 1.00
IGL01611:Ipo9 APN 1 135,314,431 (GRCm39) missense possibly damaging 0.76
IGL01941:Ipo9 APN 1 135,335,811 (GRCm39) missense possibly damaging 0.95
IGL01944:Ipo9 APN 1 135,333,624 (GRCm39) missense probably damaging 0.98
IGL01959:Ipo9 APN 1 135,348,093 (GRCm39) critical splice acceptor site probably null
IGL02649:Ipo9 APN 1 135,313,672 (GRCm39) missense possibly damaging 0.92
IGL02697:Ipo9 APN 1 135,318,314 (GRCm39) missense probably benign 0.00
IGL03286:Ipo9 APN 1 135,334,816 (GRCm39) intron probably benign
FR4304:Ipo9 UTSW 1 135,314,017 (GRCm39) nonsense probably null
FR4304:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
FR4340:Ipo9 UTSW 1 135,314,009 (GRCm39) small insertion probably benign
FR4340:Ipo9 UTSW 1 135,314,007 (GRCm39) small insertion probably benign
FR4548:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
FR4589:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
FR4589:Ipo9 UTSW 1 135,314,004 (GRCm39) small insertion probably benign
FR4976:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
R0111:Ipo9 UTSW 1 135,333,662 (GRCm39) missense probably damaging 0.97
R0238:Ipo9 UTSW 1 135,332,074 (GRCm39) splice site probably benign
R0239:Ipo9 UTSW 1 135,332,074 (GRCm39) splice site probably benign
R0279:Ipo9 UTSW 1 135,348,101 (GRCm39) intron probably benign
R0704:Ipo9 UTSW 1 135,314,006 (GRCm39) small deletion probably benign
R1070:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1282:Ipo9 UTSW 1 135,330,030 (GRCm39) missense possibly damaging 0.48
R1467:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1467:Ipo9 UTSW 1 135,334,281 (GRCm39) missense possibly damaging 0.89
R1728:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1728:Ipo9 UTSW 1 135,314,009 (GRCm39) small insertion probably benign
R1728:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1729:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1729:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1730:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1730:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1739:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1739:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1762:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1762:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1783:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1783:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1784:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1784:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1785:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R1785:Ipo9 UTSW 1 135,314,019 (GRCm39) small insertion probably benign
R1785:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R1899:Ipo9 UTSW 1 135,327,884 (GRCm39) missense probably damaging 0.99
R2049:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2049:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2130:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2130:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2131:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2131:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2133:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2133:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
R2133:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2136:Ipo9 UTSW 1 135,322,023 (GRCm39) missense probably damaging 0.98
R2141:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2141:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,314,020 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,329,988 (GRCm39) missense probably benign
R2142:Ipo9 UTSW 1 135,314,006 (GRCm39) small insertion probably benign
R2142:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
R2356:Ipo9 UTSW 1 135,334,555 (GRCm39) missense probably benign 0.00
R2923:Ipo9 UTSW 1 135,327,867 (GRCm39) missense probably benign 0.25
R3161:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R3162:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R3162:Ipo9 UTSW 1 135,337,214 (GRCm39) missense probably benign 0.43
R4086:Ipo9 UTSW 1 135,316,428 (GRCm39) unclassified probably benign
R4679:Ipo9 UTSW 1 135,321,907 (GRCm39) missense probably benign
R4816:Ipo9 UTSW 1 135,334,288 (GRCm39) missense probably benign 0.21
R4956:Ipo9 UTSW 1 135,331,960 (GRCm39) critical splice donor site probably null
R5052:Ipo9 UTSW 1 135,316,349 (GRCm39) splice site probably null
R5055:Ipo9 UTSW 1 135,330,097 (GRCm39) nonsense probably null
R5230:Ipo9 UTSW 1 135,347,808 (GRCm39) missense probably damaging 1.00
R5240:Ipo9 UTSW 1 135,317,344 (GRCm39) unclassified probably benign
R5257:Ipo9 UTSW 1 135,313,173 (GRCm39) missense probably damaging 1.00
R5340:Ipo9 UTSW 1 135,313,170 (GRCm39) missense probably benign 0.00
R5560:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5602:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5604:Ipo9 UTSW 1 135,329,983 (GRCm39) missense probably damaging 0.99
R5654:Ipo9 UTSW 1 135,313,210 (GRCm39) nonsense probably null
R6018:Ipo9 UTSW 1 135,318,274 (GRCm39) critical splice donor site probably null
R6128:Ipo9 UTSW 1 135,318,311 (GRCm39) missense possibly damaging 0.90
R6841:Ipo9 UTSW 1 135,314,046 (GRCm39) missense probably benign
R7230:Ipo9 UTSW 1 135,334,496 (GRCm39) critical splice donor site probably benign
R7255:Ipo9 UTSW 1 135,313,726 (GRCm39) missense probably benign 0.01
R7844:Ipo9 UTSW 1 135,322,062 (GRCm39) missense probably benign 0.00
R7889:Ipo9 UTSW 1 135,334,591 (GRCm39) missense probably benign 0.22
R8125:Ipo9 UTSW 1 135,331,078 (GRCm39) missense probably benign 0.00
R8823:Ipo9 UTSW 1 135,347,077 (GRCm39) missense probably damaging 0.99
R8889:Ipo9 UTSW 1 135,314,544 (GRCm39) missense possibly damaging 0.50
R8892:Ipo9 UTSW 1 135,314,544 (GRCm39) missense possibly damaging 0.50
R8906:Ipo9 UTSW 1 135,321,951 (GRCm39) missense probably damaging 1.00
R8926:Ipo9 UTSW 1 135,313,952 (GRCm39) splice site probably benign
R9084:Ipo9 UTSW 1 135,334,563 (GRCm39) missense probably benign 0.01
R9215:Ipo9 UTSW 1 135,347,033 (GRCm39) missense probably benign 0.05
R9756:Ipo9 UTSW 1 135,314,057 (GRCm39) missense probably benign 0.00
Y5405:Ipo9 UTSW 1 135,314,022 (GRCm39) small insertion probably benign
Y5405:Ipo9 UTSW 1 135,314,013 (GRCm39) small insertion probably benign
Y5405:Ipo9 UTSW 1 135,314,007 (GRCm39) small insertion probably benign
Predicted Primers PCR Primer
(F):5'- CGGGCCTTACCTAACTTTGC -3'
(R):5'- CCCATGTTCTGTCCTATGAGTG -3'

Sequencing Primer
(F):5'- CCTTCATACTGTCCATAGAACAGGTG -3'
(R):5'- GAGTCCAGTCTCTTGGAACTACAG -3'
Posted On 2019-09-13