Incidental Mutation 'R7386:Scn9a'
ID 573079
Institutional Source Beutler Lab
Gene Symbol Scn9a
Ensembl Gene ENSMUSG00000075316
Gene Name sodium channel, voltage-gated, type IX, alpha
Synonyms PN1
MMRRC Submission 045468-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R7386 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 66480080-66634962 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to A at 66540550 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Valine at position 562 (D562V)
Ref Sequence ENSEMBL: ENSMUSP00000097642 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000100063] [ENSMUST00000100064] [ENSMUST00000112354] [ENSMUST00000164384] [ENSMUST00000169900]
AlphaFold Q62205
Predicted Effect probably benign
Transcript: ENSMUST00000100063
AA Change: D564V

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000097641
Gene: ENSMUSG00000075316
AA Change: D564V

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 403 9.5e-78 PFAM
coiled coil region 404 442 N/A INTRINSIC
Pfam:DUF3451 465 685 1.3e-62 PFAM
Pfam:Ion_trans 768 957 9.9e-48 PFAM
Pfam:Na_trans_assoc 972 1191 2.9e-72 PFAM
low complexity region 1203 1214 N/A INTRINSIC
Pfam:Ion_trans 1217 1445 2.8e-55 PFAM
PDB:1BYY|A 1447 1499 9e-27 PDB
Pfam:Ion_trans 1538 1748 3.4e-52 PFAM
Pfam:PKD_channel 1599 1755 1.1e-7 PFAM
IQ 1877 1899 1.03e-3 SMART
low complexity region 1956 1972 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000100064
AA Change: D562V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000097642
Gene: ENSMUSG00000075316
AA Change: D562V

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 125 412 2.2e-84 PFAM
low complexity region 433 446 N/A INTRINSIC
Pfam:Na_trans_cytopl 483 693 7.5e-76 PFAM
Pfam:Ion_trans 742 977 4.1e-57 PFAM
Pfam:Na_trans_assoc 981 1185 1.4e-58 PFAM
Pfam:Ion_trans 1189 1466 7e-67 PFAM
Pfam:Ion_trans 1512 1769 1e-55 PFAM
Pfam:PKD_channel 1605 1763 2.6e-7 PFAM
IQ 1886 1908 1.03e-3 SMART
low complexity region 1965 1981 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000112354
AA Change: D562V

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000107973
Gene: ENSMUSG00000075316
AA Change: D562V

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 401 1.2e-77 PFAM
coiled coil region 402 449 N/A INTRINSIC
Pfam:DUF3451 463 683 1.3e-62 PFAM
Pfam:Ion_trans 766 955 9.9e-48 PFAM
Pfam:Na_trans_assoc 970 1189 2.9e-72 PFAM
low complexity region 1201 1212 N/A INTRINSIC
Pfam:Ion_trans 1215 1443 2.8e-55 PFAM
PDB:1BYY|A 1445 1497 7e-29 PDB
Pfam:Ion_trans 1536 1746 3.4e-52 PFAM
Pfam:PKD_channel 1597 1753 1.1e-7 PFAM
IQ 1875 1897 1.03e-3 SMART
low complexity region 1954 1970 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000164384
AA Change: D562V

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000126528
Gene: ENSMUSG00000075316
AA Change: D562V

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 401 1.1e-77 PFAM
coiled coil region 402 449 N/A INTRINSIC
Pfam:DUF3451 463 694 4.2e-66 PFAM
Pfam:Ion_trans 777 966 8.8e-48 PFAM
Pfam:Na_trans_assoc 981 1200 6e-72 PFAM
low complexity region 1212 1223 N/A INTRINSIC
Pfam:Ion_trans 1226 1454 2.5e-55 PFAM
PDB:1BYY|A 1456 1508 6e-29 PDB
Pfam:Ion_trans 1547 1757 3e-52 PFAM
Pfam:PKD_channel 1608 1764 8.1e-8 PFAM
IQ 1886 1908 1.03e-3 SMART
low complexity region 1965 1981 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000169900
AA Change: D562V

PolyPhen 2 Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000131711
Gene: ENSMUSG00000075316
AA Change: D562V

DomainStartEndE-ValueType
low complexity region 29 49 N/A INTRINSIC
Pfam:Ion_trans 154 401 3.7e-78 PFAM
coiled coil region 402 449 N/A INTRINSIC
Pfam:DUF3451 463 683 1.3e-62 PFAM
Pfam:Ion_trans 766 955 9.9e-48 PFAM
Pfam:Na_trans_assoc 970 1189 2.9e-72 PFAM
low complexity region 1201 1212 N/A INTRINSIC
Pfam:Ion_trans 1215 1443 2.8e-55 PFAM
PDB:1BYY|A 1445 1497 7e-29 PDB
Pfam:Ion_trans 1536 1746 3.4e-52 PFAM
Pfam:PKD_channel 1597 1753 1.1e-7 PFAM
IQ 1875 1897 1.03e-3 SMART
low complexity region 1954 1970 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder. [provided by RefSeq, Aug 2009]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit prenatal/neonatal lethality. Mice homozygous for a knock-in allele exhibit increased susceptibility to electrically induced seizures. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930546C10Rik A T 18: 68,950,137 (GRCm38) M2K unknown Het
6430531B16Rik A T 7: 139,976,052 (GRCm38) C225* probably null Het
Ablim3 T C 18: 61,821,994 (GRCm38) D308G probably damaging Het
Adamts17 A T 7: 66,968,849 (GRCm38) K370N probably benign Het
Adcy4 T C 14: 55,778,327 (GRCm38) Y435C probably damaging Het
Adgb A T 10: 10,377,949 (GRCm38) F1216I possibly damaging Het
Akr1a1 G A 4: 116,641,054 (GRCm38) T98I probably damaging Het
Alyref2 G T 1: 171,503,533 (GRCm38) probably benign Het
Ank3 T A 10: 69,822,249 (GRCm38) H168Q unknown Het
Bnc1 A C 7: 81,974,492 (GRCm38) L329R possibly damaging Het
Btaf1 G A 19: 36,958,382 (GRCm38) A191T probably benign Het
Carmil3 T G 14: 55,497,747 (GRCm38) probably null Het
Cd200r1 C A 16: 44,789,848 (GRCm38) D143E probably benign Het
Cep112 A G 11: 108,808,681 (GRCm38) H98R probably benign Het
Cmya5 T A 13: 93,069,323 (GRCm38) Q3346L probably damaging Het
Cpne4 T A 9: 104,872,740 (GRCm38) V81E possibly damaging Het
Ctnnd2 T A 15: 30,966,768 (GRCm38) M955K probably damaging Het
Ctsj A T 13: 61,000,559 (GRCm38) M307K possibly damaging Het
Ddhd2 G T 8: 25,754,290 (GRCm38) R103S possibly damaging Het
Depdc5 A G 5: 32,927,936 (GRCm38) T700A probably benign Het
Dhx57 A C 17: 80,267,577 (GRCm38) D657E possibly damaging Het
Dmbt1 G A 7: 131,112,236 (GRCm38) G1678S unknown Het
Dnajb1 A G 8: 83,610,303 (GRCm38) D234G probably benign Het
Dsc2 C T 18: 20,041,926 (GRCm38) V431M possibly damaging Het
Evi5 C A 5: 107,809,823 (GRCm38) probably null Het
Exoc2 T C 13: 30,906,663 (GRCm38) probably null Het
Foxo3 T C 10: 42,197,360 (GRCm38) D387G probably benign Het
Gda A G 19: 21,409,886 (GRCm38) I325T probably benign Het
Gm960 G A 19: 4,663,558 (GRCm38) R285* probably null Het
Iqgap1 A G 7: 80,726,042 (GRCm38) S1362P probably damaging Het
Klf10 G T 15: 38,296,949 (GRCm38) N282K possibly damaging Het
Mettl13 A G 1: 162,548,154 (GRCm38) Y35H probably damaging Het
Mill2 A G 7: 18,858,290 (GRCm38) T279A probably benign Het
Ncaph2 G A 15: 89,370,256 (GRCm38) W386* probably null Het
Nploc4 A T 11: 120,408,881 (GRCm38) S338T probably benign Het
Nrip1 T C 16: 76,293,887 (GRCm38) S261G probably damaging Het
Olfr1042 A G 2: 86,159,530 (GRCm38) V280A possibly damaging Het
Olfr1354 T A 10: 78,916,843 (GRCm38) M1K probably null Het
Olfr1388 T C 11: 49,444,400 (GRCm38) F183S possibly damaging Het
Palld A G 8: 61,532,052 (GRCm38) F1060L unknown Het
Pfas C G 11: 69,003,774 (GRCm38) V22L probably benign Het
Pygo2 T G 3: 89,432,821 (GRCm38) F175L probably benign Het
Rnf2 T C 1: 151,471,380 (GRCm38) E316G probably damaging Het
Rtn4 T A 11: 29,707,772 (GRCm38) M642K probably damaging Het
Saa3 A G 7: 46,714,923 (GRCm38) C60R unknown Het
Scap A G 9: 110,373,169 (GRCm38) T202A probably benign Het
Slc6a19 A T 13: 73,689,891 (GRCm38) V163E possibly damaging Het
Smc5 G A 19: 23,215,175 (GRCm38) H850Y possibly damaging Het
Sqle G A 15: 59,330,754 (GRCm38) R519Q probably benign Het
Sulf1 T C 1: 12,838,361 (GRCm38) Y533H probably benign Het
Tex45 A G 8: 3,487,079 (GRCm38) K475R probably benign Het
Thbs2 A G 17: 14,673,150 (GRCm38) S923P possibly damaging Het
Themis A G 10: 28,789,747 (GRCm38) D602G probably benign Het
Tmem132c A G 5: 127,563,926 (GRCm38) K1054E probably benign Het
Tmem161b C A 13: 84,222,418 (GRCm38) probably benign Het
Tnrc6c T A 11: 117,721,954 (GRCm38) C313S probably benign Het
Tpm1 T C 9: 67,028,167 (GRCm38) I284M probably benign Het
Trpm4 A T 7: 45,314,640 (GRCm38) L722H possibly damaging Het
Trub2 T G 2: 29,786,595 (GRCm38) Q41P probably benign Het
Usp17le A C 7: 104,768,307 (GRCm38) probably null Het
Zfp398 G A 6: 47,858,950 (GRCm38) V148I probably benign Het
Zfp40 T C 17: 23,177,007 (GRCm38) E202G probably damaging Het
Zfp618 T A 4: 63,095,385 (GRCm38) probably null Het
Zfp667 T A 7: 6,305,950 (GRCm38) I539N possibly damaging Het
Zfp738 A T 13: 67,670,250 (GRCm38) C541S probably damaging Het
Other mutations in Scn9a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Scn9a APN 2 66,563,601 (GRCm38) missense probably damaging 1.00
IGL00570:Scn9a APN 2 66,484,142 (GRCm38) missense probably damaging 1.00
IGL00809:Scn9a APN 2 66,483,935 (GRCm38) missense probably damaging 1.00
IGL00977:Scn9a APN 2 66,484,301 (GRCm38) missense probably damaging 0.99
IGL01120:Scn9a APN 2 66,526,972 (GRCm38) missense probably benign 0.00
IGL01134:Scn9a APN 2 66,504,968 (GRCm38) missense probably damaging 1.00
IGL01300:Scn9a APN 2 66,488,053 (GRCm38) nonsense probably null
IGL01452:Scn9a APN 2 66,527,072 (GRCm38) missense probably damaging 1.00
IGL01531:Scn9a APN 2 66,537,378 (GRCm38) missense probably benign 0.11
IGL01572:Scn9a APN 2 66,493,886 (GRCm38) missense probably benign 0.00
IGL01645:Scn9a APN 2 66,487,642 (GRCm38) missense possibly damaging 0.62
IGL01823:Scn9a APN 2 66,484,042 (GRCm38) missense probably damaging 1.00
IGL01965:Scn9a APN 2 66,484,433 (GRCm38) missense probably damaging 1.00
IGL02127:Scn9a APN 2 66,494,826 (GRCm38) missense probably damaging 1.00
IGL02127:Scn9a APN 2 66,547,135 (GRCm38) missense probably damaging 1.00
IGL02166:Scn9a APN 2 66,493,103 (GRCm38) missense possibly damaging 0.95
IGL02183:Scn9a APN 2 66,484,611 (GRCm38) splice site probably benign
IGL02640:Scn9a APN 2 66,536,096 (GRCm38) critical splice donor site probably null
IGL02685:Scn9a APN 2 66,537,293 (GRCm38) missense probably damaging 1.00
IGL02798:Scn9a APN 2 66,540,559 (GRCm38) missense possibly damaging 0.52
IGL02832:Scn9a APN 2 66,568,029 (GRCm38) missense probably damaging 1.00
IGL03008:Scn9a APN 2 66,562,511 (GRCm38) missense probably damaging 1.00
IGL03270:Scn9a APN 2 66,484,014 (GRCm38) missense probably damaging 1.00
IGL03408:Scn9a APN 2 66,526,747 (GRCm38) missense probably benign 0.00
BB007:Scn9a UTSW 2 66,504,849 (GRCm38) missense probably damaging 0.99
BB017:Scn9a UTSW 2 66,504,849 (GRCm38) missense probably damaging 0.99
R0039:Scn9a UTSW 2 66,562,444 (GRCm38) missense probably damaging 0.98
R0173:Scn9a UTSW 2 66,533,093 (GRCm38) missense probably damaging 1.00
R0323:Scn9a UTSW 2 66,568,131 (GRCm38) missense probably damaging 1.00
R0344:Scn9a UTSW 2 66,505,010 (GRCm38) missense probably damaging 0.99
R0421:Scn9a UTSW 2 66,543,277 (GRCm38) missense probably benign
R0465:Scn9a UTSW 2 66,526,996 (GRCm38) missense probably damaging 1.00
R0514:Scn9a UTSW 2 66,483,678 (GRCm38) missense probably damaging 1.00
R0599:Scn9a UTSW 2 66,526,799 (GRCm38) missense probably damaging 0.96
R0627:Scn9a UTSW 2 66,537,377 (GRCm38) missense probably benign 0.00
R0644:Scn9a UTSW 2 66,533,061 (GRCm38) critical splice donor site probably null
R0653:Scn9a UTSW 2 66,533,377 (GRCm38) missense probably damaging 1.00
R0685:Scn9a UTSW 2 66,483,499 (GRCm38) missense probably benign 0.02
R0718:Scn9a UTSW 2 66,547,112 (GRCm38) missense probably damaging 1.00
R0827:Scn9a UTSW 2 66,536,124 (GRCm38) nonsense probably null
R0890:Scn9a UTSW 2 66,483,735 (GRCm38) missense probably damaging 1.00
R1139:Scn9a UTSW 2 66,504,997 (GRCm38) missense probably benign 0.02
R1385:Scn9a UTSW 2 66,563,542 (GRCm38) missense probably damaging 1.00
R1398:Scn9a UTSW 2 66,484,586 (GRCm38) missense probably benign 0.11
R1496:Scn9a UTSW 2 66,526,888 (GRCm38) missense probably benign
R1511:Scn9a UTSW 2 66,526,813 (GRCm38) missense probably benign 0.01
R1517:Scn9a UTSW 2 66,505,027 (GRCm38) splice site probably benign
R1564:Scn9a UTSW 2 66,484,304 (GRCm38) missense probably damaging 1.00
R1634:Scn9a UTSW 2 66,488,017 (GRCm38) missense probably damaging 1.00
R1662:Scn9a UTSW 2 66,483,459 (GRCm38) missense probably benign 0.00
R1695:Scn9a UTSW 2 66,504,876 (GRCm38) nonsense probably null
R1709:Scn9a UTSW 2 66,483,506 (GRCm38) missense probably damaging 1.00
R1741:Scn9a UTSW 2 66,487,594 (GRCm38) missense probably damaging 0.99
R1755:Scn9a UTSW 2 66,501,716 (GRCm38) missense probably benign 0.38
R1914:Scn9a UTSW 2 66,566,250 (GRCm38) missense probably damaging 1.00
R1962:Scn9a UTSW 2 66,484,311 (GRCm38) missense probably damaging 1.00
R1970:Scn9a UTSW 2 66,515,380 (GRCm38) missense probably damaging 0.97
R2017:Scn9a UTSW 2 66,515,321 (GRCm38) missense probably damaging 0.99
R2092:Scn9a UTSW 2 66,533,376 (GRCm38) missense probably damaging 0.99
R2105:Scn9a UTSW 2 66,568,183 (GRCm38) missense probably benign 0.25
R2114:Scn9a UTSW 2 66,484,052 (GRCm38) missense probably damaging 1.00
R2115:Scn9a UTSW 2 66,484,052 (GRCm38) missense probably damaging 1.00
R2128:Scn9a UTSW 2 66,526,654 (GRCm38) missense probably damaging 1.00
R2157:Scn9a UTSW 2 66,536,325 (GRCm38) missense probably damaging 1.00
R2162:Scn9a UTSW 2 66,534,229 (GRCm38) missense probably damaging 0.98
R2350:Scn9a UTSW 2 66,504,968 (GRCm38) missense probably damaging 1.00
R3694:Scn9a UTSW 2 66,562,405 (GRCm38) missense probably benign
R3771:Scn9a UTSW 2 66,483,648 (GRCm38) missense probably benign 0.26
R3772:Scn9a UTSW 2 66,483,648 (GRCm38) missense probably benign 0.26
R3773:Scn9a UTSW 2 66,483,648 (GRCm38) missense probably benign 0.26
R3922:Scn9a UTSW 2 66,526,873 (GRCm38) missense possibly damaging 0.88
R3926:Scn9a UTSW 2 66,526,873 (GRCm38) missense possibly damaging 0.88
R4258:Scn9a UTSW 2 66,565,054 (GRCm38) intron probably benign
R4385:Scn9a UTSW 2 66,484,556 (GRCm38) missense probably damaging 1.00
R4415:Scn9a UTSW 2 66,526,693 (GRCm38) missense probably damaging 1.00
R4570:Scn9a UTSW 2 66,483,558 (GRCm38) missense possibly damaging 0.85
R4682:Scn9a UTSW 2 66,547,018 (GRCm38) missense probably benign
R4783:Scn9a UTSW 2 66,540,623 (GRCm38) missense probably benign 0.01
R4822:Scn9a UTSW 2 66,483,749 (GRCm38) missense possibly damaging 0.55
R4829:Scn9a UTSW 2 66,551,713 (GRCm38) missense probably benign
R4908:Scn9a UTSW 2 66,526,743 (GRCm38) missense probably benign 0.03
R4983:Scn9a UTSW 2 66,566,270 (GRCm38) missense probably benign 0.02
R5047:Scn9a UTSW 2 66,562,480 (GRCm38) missense probably damaging 1.00
R5100:Scn9a UTSW 2 66,534,119 (GRCm38) missense probably damaging 1.00
R5140:Scn9a UTSW 2 66,565,167 (GRCm38) missense possibly damaging 0.81
R5398:Scn9a UTSW 2 66,488,043 (GRCm38) missense probably damaging 1.00
R5557:Scn9a UTSW 2 66,547,103 (GRCm38) missense probably damaging 0.99
R5582:Scn9a UTSW 2 66,565,029 (GRCm38) intron probably benign
R6108:Scn9a UTSW 2 66,484,049 (GRCm38) missense probably damaging 1.00
R6115:Scn9a UTSW 2 66,563,629 (GRCm38) missense possibly damaging 0.70
R6143:Scn9a UTSW 2 66,487,524 (GRCm38) missense probably benign 0.00
R6261:Scn9a UTSW 2 66,483,896 (GRCm38) missense probably damaging 1.00
R6335:Scn9a UTSW 2 66,568,264 (GRCm38) start codon destroyed possibly damaging 0.91
R6429:Scn9a UTSW 2 66,526,963 (GRCm38) missense possibly damaging 0.95
R6632:Scn9a UTSW 2 66,483,502 (GRCm38) missense probably benign 0.23
R6681:Scn9a UTSW 2 66,563,342 (GRCm38) missense possibly damaging 0.90
R6830:Scn9a UTSW 2 66,568,029 (GRCm38) missense probably damaging 1.00
R7102:Scn9a UTSW 2 66,549,015 (GRCm38) missense probably damaging 1.00
R7186:Scn9a UTSW 2 66,534,223 (GRCm38) missense probably damaging 1.00
R7243:Scn9a UTSW 2 66,540,530 (GRCm38) missense probably damaging 1.00
R7311:Scn9a UTSW 2 66,484,404 (GRCm38) missense possibly damaging 0.54
R7328:Scn9a UTSW 2 66,484,587 (GRCm38) missense probably benign
R7438:Scn9a UTSW 2 66,547,187 (GRCm38) missense possibly damaging 0.81
R7483:Scn9a UTSW 2 66,533,348 (GRCm38) missense probably damaging 0.99
R7485:Scn9a UTSW 2 66,534,217 (GRCm38) missense probably damaging 1.00
R7526:Scn9a UTSW 2 66,483,646 (GRCm38) missense probably benign
R7617:Scn9a UTSW 2 66,540,549 (GRCm38) missense possibly damaging 0.55
R7642:Scn9a UTSW 2 66,536,236 (GRCm38) missense probably benign 0.02
R7653:Scn9a UTSW 2 66,527,080 (GRCm38) missense probably damaging 1.00
R7747:Scn9a UTSW 2 66,484,298 (GRCm38) missense probably damaging 1.00
R7823:Scn9a UTSW 2 66,483,791 (GRCm38) missense probably damaging 1.00
R7864:Scn9a UTSW 2 66,484,560 (GRCm38) missense possibly damaging 0.73
R7890:Scn9a UTSW 2 66,543,112 (GRCm38) missense probably benign 0.00
R7930:Scn9a UTSW 2 66,504,849 (GRCm38) missense probably damaging 0.99
R7975:Scn9a UTSW 2 66,484,253 (GRCm38) missense probably damaging 1.00
R8057:Scn9a UTSW 2 66,515,430 (GRCm38) missense probably benign 0.06
R8145:Scn9a UTSW 2 66,487,410 (GRCm38) missense probably damaging 1.00
R8163:Scn9a UTSW 2 66,484,401 (GRCm38) missense probably damaging 1.00
R8165:Scn9a UTSW 2 66,540,530 (GRCm38) missense probably damaging 1.00
R8342:Scn9a UTSW 2 66,536,282 (GRCm38) missense probably benign
R8345:Scn9a UTSW 2 66,494,622 (GRCm38) missense probably damaging 0.96
R8464:Scn9a UTSW 2 66,566,281 (GRCm38) missense probably damaging 0.99
R8467:Scn9a UTSW 2 66,501,671 (GRCm38) missense probably damaging 1.00
R8698:Scn9a UTSW 2 66,536,284 (GRCm38) missense probably benign 0.00
R8810:Scn9a UTSW 2 66,501,666 (GRCm38) missense probably damaging 1.00
R8822:Scn9a UTSW 2 66,540,635 (GRCm38) missense probably damaging 0.99
R8829:Scn9a UTSW 2 66,483,617 (GRCm38) missense probably benign
R9009:Scn9a UTSW 2 66,508,583 (GRCm38) missense probably damaging 1.00
R9038:Scn9a UTSW 2 66,494,803 (GRCm38) missense probably damaging 1.00
R9126:Scn9a UTSW 2 66,484,400 (GRCm38) missense probably damaging 1.00
R9205:Scn9a UTSW 2 66,533,313 (GRCm38) missense probably damaging 1.00
R9300:Scn9a UTSW 2 66,504,892 (GRCm38) missense probably benign 0.39
R9373:Scn9a UTSW 2 66,483,917 (GRCm38) missense probably benign 0.00
R9404:Scn9a UTSW 2 66,526,696 (GRCm38) missense probably benign 0.02
R9443:Scn9a UTSW 2 66,565,209 (GRCm38) missense probably damaging 1.00
R9590:Scn9a UTSW 2 66,483,984 (GRCm38) missense probably benign 0.05
R9612:Scn9a UTSW 2 66,533,364 (GRCm38) missense probably damaging 1.00
R9617:Scn9a UTSW 2 66,562,465 (GRCm38) missense probably damaging 1.00
R9717:Scn9a UTSW 2 66,526,658 (GRCm38) missense probably benign
X0003:Scn9a UTSW 2 66,508,647 (GRCm38) missense probably benign 0.02
X0062:Scn9a UTSW 2 66,568,077 (GRCm38) missense probably damaging 1.00
Z1176:Scn9a UTSW 2 66,540,592 (GRCm38) missense probably benign 0.00
Z1177:Scn9a UTSW 2 66,494,685 (GRCm38) missense possibly damaging 0.68
Predicted Primers PCR Primer
(F):5'- AGGGTCCATCAACAAGCGAC -3'
(R):5'- CAAACACGAGATCACTGGGCTC -3'

Sequencing Primer
(F):5'- ACGCCATTGCAGTCCACTG -3'
(R):5'- CTGGGCTCAGTGATTTTAGTGG -3'
Posted On 2019-09-13