Incidental Mutation 'R7386:Cd200r1'
ID 573125
Institutional Source Beutler Lab
Gene Symbol Cd200r1
Ensembl Gene ENSMUSG00000022667
Gene Name CD200 receptor 1
Synonyms CD200R, Mox2r, OX2R
MMRRC Submission 045468-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.059) question?
Stock # R7386 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 44586141-44615341 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 44610211 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 143 (D143E)
Ref Sequence ENSEMBL: ENSMUSP00000053822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000057488] [ENSMUST00000134625] [ENSMUST00000231633]
AlphaFold Q9ES57
PDB Structure Structure of the extracellular portion of mouse CD200R [X-RAY DIFFRACTION]
Structure of the complex of the extracellular portions of mouse CD200R and mouse CD200 [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000057488
AA Change: D143E

PolyPhen 2 Score 0.334 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000053822
Gene: ENSMUSG00000022667
AA Change: D143E

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
IG 44 147 2.41e-6 SMART
Blast:IG_like 149 231 8e-47 BLAST
transmembrane domain 239 261 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000134625
AA Change: D143E

PolyPhen 2 Score 0.334 (Sensitivity: 0.90; Specificity: 0.89)
SMART Domains Protein: ENSMUSP00000138076
Gene: ENSMUSG00000022667
AA Change: D143E

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
IG 44 147 2.41e-6 SMART
Blast:IG_like 149 231 8e-48 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000231633
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (66/66)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption of this gene display abnormal sleep patterns including fragmented vigilance states and diminished duration of wakefulness. Mice homozygous for a different knock-out allele exhibit protection from HSV-1 encephalitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930546C10Rik A T 18: 69,083,208 (GRCm39) M2K unknown Het
Ablim3 T C 18: 61,955,065 (GRCm39) D308G probably damaging Het
Adamts17 A T 7: 66,618,597 (GRCm39) K370N probably benign Het
Adcy4 T C 14: 56,015,784 (GRCm39) Y435C probably damaging Het
Adgb A T 10: 10,253,693 (GRCm39) F1216I possibly damaging Het
Akr1a1 G A 4: 116,498,251 (GRCm39) T98I probably damaging Het
Alyref2 G T 1: 171,331,101 (GRCm39) probably benign Het
Ank3 T A 10: 69,658,079 (GRCm39) H168Q unknown Het
Bnc1 A C 7: 81,624,240 (GRCm39) L329R possibly damaging Het
Btaf1 G A 19: 36,935,782 (GRCm39) A191T probably benign Het
Carmil3 T G 14: 55,735,204 (GRCm39) probably null Het
Cep112 A G 11: 108,699,507 (GRCm39) H98R probably benign Het
Cmya5 T A 13: 93,205,831 (GRCm39) Q3346L probably damaging Het
Cpne4 T A 9: 104,749,939 (GRCm39) V81E possibly damaging Het
Ctnnd2 T A 15: 30,966,914 (GRCm39) M955K probably damaging Het
Ctsj A T 13: 61,148,373 (GRCm39) M307K possibly damaging Het
Ddhd2 G T 8: 26,244,318 (GRCm39) R103S possibly damaging Het
Depdc5 A G 5: 33,085,280 (GRCm39) T700A probably benign Het
Dhx57 A C 17: 80,575,006 (GRCm39) D657E possibly damaging Het
Dmbt1 G A 7: 130,713,965 (GRCm39) G1678S unknown Het
Dnajb1 A G 8: 84,336,932 (GRCm39) D234G probably benign Het
Dsc2 C T 18: 20,174,983 (GRCm39) V431M possibly damaging Het
Evi5 C A 5: 107,957,689 (GRCm39) probably null Het
Exoc2 T C 13: 31,090,646 (GRCm39) probably null Het
Foxo3 T C 10: 42,073,356 (GRCm39) D387G probably benign Het
Gda A G 19: 21,387,250 (GRCm39) I325T probably benign Het
Iqgap1 A G 7: 80,375,790 (GRCm39) S1362P probably damaging Het
Klf10 G T 15: 38,297,193 (GRCm39) N282K possibly damaging Het
Mettl13 A G 1: 162,375,723 (GRCm39) Y35H probably damaging Het
Mill2 A G 7: 18,592,215 (GRCm39) T279A probably benign Het
Ncaph2 G A 15: 89,254,459 (GRCm39) W386* probably null Het
Nploc4 A T 11: 120,299,707 (GRCm39) S338T probably benign Het
Nrip1 T C 16: 76,090,775 (GRCm39) S261G probably damaging Het
Or2y16 T C 11: 49,335,227 (GRCm39) F183S possibly damaging Het
Or5al1 A G 2: 85,989,874 (GRCm39) V280A possibly damaging Het
Or7a38 T A 10: 78,752,677 (GRCm39) M1K probably null Het
Palld A G 8: 61,985,086 (GRCm39) F1060L unknown Het
Pfas C G 11: 68,894,600 (GRCm39) V22L probably benign Het
Pygo2 T G 3: 89,340,128 (GRCm39) F175L probably benign Het
Rnf2 T C 1: 151,347,131 (GRCm39) E316G probably damaging Het
Rtn4 T A 11: 29,657,772 (GRCm39) M642K probably damaging Het
Saa3 A G 7: 46,364,347 (GRCm39) C60R unknown Het
Saxo5 A G 8: 3,537,079 (GRCm39) K475R probably benign Het
Scap A G 9: 110,202,237 (GRCm39) T202A probably benign Het
Scn9a T A 2: 66,370,894 (GRCm39) D562V probably damaging Het
Slc6a19 A T 13: 73,838,010 (GRCm39) V163E possibly damaging Het
Smc5 G A 19: 23,192,539 (GRCm39) H850Y possibly damaging Het
Spef1l A T 7: 139,555,965 (GRCm39) C225* probably null Het
Sqle G A 15: 59,202,603 (GRCm39) R519Q probably benign Het
Sulf1 T C 1: 12,908,585 (GRCm39) Y533H probably benign Het
Thbs2 A G 17: 14,893,412 (GRCm39) S923P possibly damaging Het
Themis A G 10: 28,665,743 (GRCm39) D602G probably benign Het
Tmem132c A G 5: 127,640,990 (GRCm39) K1054E probably benign Het
Tmem161b C A 13: 84,370,537 (GRCm39) probably benign Het
Tnrc6c T A 11: 117,612,780 (GRCm39) C313S probably benign Het
Top6bl G A 19: 4,713,586 (GRCm39) R285* probably null Het
Tpm1 T C 9: 66,935,449 (GRCm39) I284M probably benign Het
Trpm4 A T 7: 44,964,064 (GRCm39) L722H possibly damaging Het
Trub2 T G 2: 29,676,607 (GRCm39) Q41P probably benign Het
Usp17le A C 7: 104,417,514 (GRCm39) probably null Het
Zfp398 G A 6: 47,835,884 (GRCm39) V148I probably benign Het
Zfp40 T C 17: 23,395,981 (GRCm39) E202G probably damaging Het
Zfp618 T A 4: 63,013,622 (GRCm39) probably null Het
Zfp667 T A 7: 6,308,949 (GRCm39) I539N possibly damaging Het
Zfp738 A T 13: 67,818,369 (GRCm39) C541S probably damaging Het
Other mutations in Cd200r1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00990:Cd200r1 APN 16 44,614,672 (GRCm39) missense possibly damaging 0.88
IGL02111:Cd200r1 APN 16 44,609,144 (GRCm39) missense probably damaging 0.99
IGL02549:Cd200r1 APN 16 44,610,341 (GRCm39) missense probably damaging 1.00
IGL03065:Cd200r1 APN 16 44,614,645 (GRCm39) missense probably benign 0.00
R0218:Cd200r1 UTSW 16 44,609,106 (GRCm39) splice site probably benign
R1512:Cd200r1 UTSW 16 44,586,390 (GRCm39) missense probably benign 0.21
R3605:Cd200r1 UTSW 16 44,609,939 (GRCm39) missense possibly damaging 0.90
R3877:Cd200r1 UTSW 16 44,610,374 (GRCm39) missense possibly damaging 0.82
R3963:Cd200r1 UTSW 16 44,613,158 (GRCm39) missense probably benign 0.03
R4109:Cd200r1 UTSW 16 44,610,447 (GRCm39) missense possibly damaging 0.95
R4171:Cd200r1 UTSW 16 44,613,127 (GRCm39) missense probably damaging 0.98
R4296:Cd200r1 UTSW 16 44,610,033 (GRCm39) missense probably damaging 0.98
R4396:Cd200r1 UTSW 16 44,586,417 (GRCm39) missense probably benign 0.01
R4922:Cd200r1 UTSW 16 44,610,039 (GRCm39) missense probably damaging 1.00
R5090:Cd200r1 UTSW 16 44,609,924 (GRCm39) missense possibly damaging 0.79
R5302:Cd200r1 UTSW 16 44,613,172 (GRCm39) missense possibly damaging 0.86
R5686:Cd200r1 UTSW 16 44,610,527 (GRCm39) missense probably damaging 1.00
R5838:Cd200r1 UTSW 16 44,586,397 (GRCm39) missense possibly damaging 0.75
R5886:Cd200r1 UTSW 16 44,610,566 (GRCm39) missense possibly damaging 0.75
R5913:Cd200r1 UTSW 16 44,610,034 (GRCm39) missense possibly damaging 0.50
R6529:Cd200r1 UTSW 16 44,610,065 (GRCm39) missense possibly damaging 0.81
R6959:Cd200r1 UTSW 16 44,610,539 (GRCm39) missense probably damaging 0.99
R7185:Cd200r1 UTSW 16 44,609,975 (GRCm39) missense probably benign 0.30
R7211:Cd200r1 UTSW 16 44,609,120 (GRCm39) missense probably benign 0.00
R7773:Cd200r1 UTSW 16 44,610,050 (GRCm39) missense possibly damaging 0.69
R8293:Cd200r1 UTSW 16 44,610,084 (GRCm39) missense probably benign 0.01
RF007:Cd200r1 UTSW 16 44,610,374 (GRCm39) missense possibly damaging 0.82
Z1176:Cd200r1 UTSW 16 44,613,122 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TCACATGGATAATAAAGCTCAGAGG -3'
(R):5'- TGCCTCACAGACTGCAGATC -3'

Sequencing Primer
(F):5'- TAATAAAGCTCAGAGGCCTGC -3'
(R):5'- CACAGACTGCAGATCTGTTTTTC -3'
Posted On 2019-09-13