Mutagenetix > Incidental Mutations

Incidental Mutation 'R7388:Vmn1r79'

573256

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r79

Ensembl Gene

ENSMUSG00000096735

Gene Name

vomeronasal 1 receptor 79

Synonyms

Gm9807

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.068) question?

Stock #

R7388 (G1)

Quality Score

208.009

Status

Not validated

Chromosome

Chromosomal Location

12171279-12181533 bp(+) (GRCm38)

Type of Mutation

nonsense

DNA Base Change (assembly)

T to A at 12176741 bp

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Stop codon at position 183 (Y183*)

Ref Sequence

ENSEMBL: ENSMUSP00000056232 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062811] [ENSMUST00000226953] [ENSMUST00000227530]

Predicted Effect

probably null
Transcript: ENSMUST00000062811
AA Change: Y183*

SMART Domains

Protein: ENSMUSP00000056232
Gene: ENSMUSG00000096735
AA Change: Y183*

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	4.9e-9	PFAM
Pfam:7tm_1	27	292	2.8e-7	PFAM
Pfam:V1R	34	298	1.7e-35	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000226953
AA Change: Y183*

Predicted Effect

probably null
Transcript: ENSMUST00000227530
AA Change: Y183*

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.3%

Validation Efficiency

100% (63/63)

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700013F07Rik	T	C	3: 108,543,499	F86L	possibly damaging	Het
Afg3l2	T	C	18: 67,422,953	E436G	probably damaging	Het
Agbl5	T	A	5: 30,903,239	L759*	probably null	Het
Ankrd13b	T	C	11: 77,472,757	D460G	probably benign	Het
Apol10a	A	G	15: 77,489,025	D287G	possibly damaging	Het
Arhgap44	A	T	11: 65,024,268	Y391*	probably null	Het
Asz1	G	T	6: 18,074,901	S271R	probably benign	Het
AW554918	A	G	18: 25,340,113	N325D	probably benign	Het
Brinp2	A	T	1: 158,255,009	L247Q	probably damaging	Het
Casz1	A	G	4: 148,952,393	D1704G	unknown	Het
Cdk5rap1	G	A	2: 154,360,675	R212W	probably damaging	Het
Cdkl2	T	A	5: 92,019,459	T444S	probably benign	Het
Cers2	T	G	3: 95,321,345	F160V	probably benign	Het
Cga	T	A	4: 34,907,076	M99K	probably benign	Het
Cspp1	C	T	1: 10,065,347	R138*	probably null	Het
Dao	T	G	5: 114,015,212	*133E	probably null	Het
Ddx1	A	T	12: 13,225,455	C544S	probably null	Het
Dgkq	A	T	5: 108,658,246	V98E	probably damaging	Het
Dnah6	T	A	6: 73,192,317	T434S	possibly damaging	Het
Dntt	A	G	19: 41,038,979	N162D	probably benign	Het
Dpysl5	T	C	5: 30,745,461	V79A	probably benign	Het
E130309D02Rik	G	A	5: 143,311,845	A149V	probably benign	Het
Ep300	T	C	15: 81,648,366	C1602R	unknown	Het
Flrt3	C	T	2: 140,661,752		probably null	Het
Gk2	A	G	5: 97,456,898	V27A	probably damaging	Het
Gm11639	T	C	11: 104,721,045	L571P	probably damaging	Het
Gnpat	T	G	8: 124,887,814	M663R	probably benign	Het
Hc	A	T	2: 34,984,847		probably null	Het
Il12rb1	A	G	8: 70,810,627	Y67C	probably damaging	Het
Kmt2b	C	T	7: 30,581,960	D1229N	probably damaging	Het
Lamc1	T	C	1: 153,249,076	T650A	probably damaging	Het
Lrp1	G	A	10: 127,583,897	R948*	probably null	Het
Map3k21	T	C	8: 125,927,597	I385T	probably damaging	Het
Mmrn1	T	A	6: 60,976,252	S506T	probably benign	Het
Nlrp1a	A	G	11: 71,123,197	F409S	probably damaging	Het
Nlrp3	T	A	11: 59,565,066	I896N	probably benign	Het
Noxred1	C	A	12: 87,227,025	V81L	probably damaging	Het
Nrcam	A	T	12: 44,598,489	I1225F	probably damaging	Het
Olfr30	C	T	11: 58,455,655	C98Y	probably damaging	Het
Otos	T	A	1: 92,644,519		probably null	Het
Pcdh20	A	G	14: 88,468,667	I399T	probably benign	Het
Pkhd1	C	T	1: 20,239,304	V2807I	not run	Het
Prrx2	A	G	2: 30,880,890	E235G	probably damaging	Het
Rab13	T	C	3: 90,221,020	I41T	probably damaging	Het
Rai1	A	C	11: 60,189,375	T1422P	possibly damaging	Het
Rcn1	C	T	2: 105,391,991	V217M	probably damaging	Het
Scn2a	T	A	2: 65,688,654	V408E	probably damaging	Het
Sec16a	C	T	2: 26,428,364	A121T		Het
Slc35d1	A	G	4: 103,189,785		probably null	Het
Slc39a6	A	T	18: 24,584,049	V642E	probably damaging	Het
Slc6a19	G	A	13: 73,693,084	A69V	probably benign	Het
Spink6	A	T	18: 44,082,319	T79S	probably damaging	Het
Spire1	T	C	18: 67,519,880	D170G	probably damaging	Het
Sugp1	T	C	8: 70,052,619	S79P	probably damaging	Het
Syne3	A	G	12: 104,967,908	Y201H	probably damaging	Het
Tbc1d10a	T	C	11: 4,205,858		probably null	Het
Tmem14a	C	T	1: 21,229,511	Q122*	probably null	Het
Tmem161b	C	A	13: 84,222,418		probably benign	Het
Trmt61a	A	G	12: 111,678,887	I86V	possibly damaging	Het
Tubgcp4	G	A	2: 121,189,966		probably null	Het
Vmn2r11	A	T	5: 109,054,876	W112R	probably benign	Het
Vpreb1	T	C	16: 16,868,652	K125E	probably benign	Het
Wdr6	A	T	9: 108,574,772	F637L	probably damaging	Het

Other mutations in Vmn1r79

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00592:Vmn1r79	APN	7	12177007	missense	probably benign	0.05
IGL01431:Vmn1r79	APN	7	12176400	missense	possibly damaging	0.88
IGL01953:Vmn1r79	APN	7	12176455	missense	probably damaging	1.00
PIT4418001:Vmn1r79	UTSW	7	12176839	missense	probably damaging	1.00
R0831:Vmn1r79	UTSW	7	12177063	missense	probably damaging	0.98
R1791:Vmn1r79	UTSW	7	12176431	missense	probably damaging	1.00
R1869:Vmn1r79	UTSW	7	12176647	missense	probably benign	0.00
R3713:Vmn1r79	UTSW	7	12176212	missense	possibly damaging	0.66
R4210:Vmn1r79	UTSW	7	12176488	missense	possibly damaging	0.46
R4243:Vmn1r79	UTSW	7	12177044	nonsense	probably null
R4244:Vmn1r79	UTSW	7	12177044	nonsense	probably null
R4839:Vmn1r79	UTSW	7	12176434	missense	probably benign	0.30
R5677:Vmn1r79	UTSW	7	12177001	missense	possibly damaging	0.77
R6048:Vmn1r79	UTSW	7	12176521	missense	probably damaging	0.99
R7751:Vmn1r79	UTSW	7	12176835	nonsense	probably null
R8207:Vmn1r79	UTSW	7	12176488	missense	possibly damaging	0.46

Predicted Primers

PCR Primer
(F):5'- CCCAATAACTCCAGGTGGATAAAG -3'
(R):5'- TGACAAATGTGCACAGCAGG -3'

Sequencing Primer
(F):5'- CTCCAGGTGGATAAAGCTTAAATAC -3'
(R):5'- CACAGCAGGATGAGGATAGTTTG -3'

Posted On

2019-09-13