Incidental Mutation 'R7389:Dusp9'
ID 573335
Institutional Source Beutler Lab
Gene Symbol Dusp9
Ensembl Gene ENSMUSG00000031383
Gene Name dual specificity phosphatase 9
Synonyms Mpk4, Pyst3
MMRRC Submission 045471-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.191) question?
Stock # R7389 (G1)
Quality Score 142.474
Status Validated
Chromosome X
Chromosomal Location 72683025-72687120 bp(+) (GRCm39)
Type of Mutation small deletion (16 aa in frame mutation)
DNA Base Change (assembly) TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG to TAAAGCGGAGGCCAAAGCGGAGGCCAAAGCGGAGGCTAAAGCGGAGGCCAAAGCGGAGGCCAAAG at 72684217 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000019701 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000019701]
AlphaFold Q7TNL7
Predicted Effect probably benign
Transcript: ENSMUST00000019701
SMART Domains Protein: ENSMUSP00000019701
Gene: ENSMUSG00000031383

DomainStartEndE-ValueType
RHOD 8 204 2.51e-9 SMART
low complexity region 236 249 N/A INTRINSIC
DSPc 271 411 6.09e-67 SMART
Meta Mutation Damage Score 0.0846 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (49/50)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases and is localized to the cytoplasm and nucleus. Aberrant expression of this gene is associated with type 2 diabetes and cancer progression in several cell types. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
PHENOTYPE: Hemizygous null male and heterozygous null female mice display embryonic lethality during organogenesis with abnormal placental labyrinth morphology when the allele is maternally inherited. Tetraploid rescue produces viable heterozygous and hemizygous mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 48 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Anxa11 C A 14: 25,873,312 (GRCm39) P182Q probably damaging Het
Asns C A 6: 7,689,291 (GRCm39) L70F probably damaging Het
Cntrl A T 2: 35,017,529 (GRCm39) K445N probably benign Het
Cyp2c50 G T 19: 40,079,107 (GRCm39) R150L probably benign Het
Dqx1 G T 6: 83,041,775 (GRCm39) S539I probably null Het
Epha3 T C 16: 63,593,347 (GRCm39) E247G probably damaging Het
Etl4 C T 2: 20,789,904 (GRCm39) Q801* probably null Het
Fabp2 G T 3: 122,689,014 (GRCm39) probably benign Het
Fsip2 G A 2: 82,819,140 (GRCm39) V4958I possibly damaging Het
Fstl3 G A 10: 79,615,865 (GRCm39) C117Y probably damaging Het
Hdgfl2 T G 17: 56,406,389 (GRCm39) probably null Het
Igfn1 T C 1: 135,894,785 (GRCm39) D1927G probably benign Het
Ino80 A C 2: 119,273,010 (GRCm39) S489A probably benign Het
Krt15 A T 11: 100,026,386 (GRCm39) V100E possibly damaging Het
Lrriq3 A G 3: 154,893,741 (GRCm39) T481A probably benign Het
Map2k3 A T 11: 60,822,862 (GRCm39) probably benign Het
Matr3 A G 18: 35,717,638 (GRCm39) T617A probably benign Het
Mybpc2 T G 7: 44,155,028 (GRCm39) T960P probably benign Het
Ncoa2 T C 1: 13,257,049 (GRCm39) N150S possibly damaging Het
Nup153 A T 13: 46,854,463 (GRCm39) probably null Het
Obscn A G 11: 58,927,226 (GRCm39) L5498P probably benign Het
Or5b21 G T 19: 12,839,981 (GRCm39) V281L probably benign Het
Or5v1b A G 17: 37,841,548 (GRCm39) R227G possibly damaging Het
Paqr8 C A 1: 21,005,389 (GRCm39) P181Q probably damaging Het
Pcdhgb4 T C 18: 37,855,416 (GRCm39) Y604H probably damaging Het
Pja2 T A 17: 64,604,722 (GRCm39) E487V probably damaging Het
Pnpla6 C T 8: 3,593,981 (GRCm39) R1331* probably null Het
Ppl T A 16: 4,924,577 (GRCm39) probably null Het
Rhbdl3 T A 11: 80,237,665 (GRCm39) M299K possibly damaging Het
Scart1 A G 7: 139,808,704 (GRCm39) K872E possibly damaging Het
Slc26a9 A G 1: 131,696,986 (GRCm39) *791W probably null Het
Slc7a2 A G 8: 41,365,552 (GRCm39) Y461C probably benign Het
Sptb G T 12: 76,671,003 (GRCm39) Q447K probably damaging Het
Ssh1 A T 5: 114,096,892 (GRCm39) I205N probably benign Het
Stab1 C T 14: 30,869,196 (GRCm39) V1511I probably benign Het
Tex19.1 T C 11: 121,037,986 (GRCm39) W115R possibly damaging Het
Tinf2 G T 14: 55,918,167 (GRCm39) probably null Het
Tmeff1 A G 4: 48,617,097 (GRCm39) probably null Het
Tnip2 G T 5: 34,671,145 (GRCm39) Q33K probably benign Het
Traf3 C A 12: 111,204,187 (GRCm39) L59M probably damaging Het
Trav14d-3-dv8 T C 14: 53,316,328 (GRCm39) Y63H possibly damaging Het
Trim11 C T 11: 58,881,481 (GRCm39) S458L probably damaging Het
Tspan18 A T 2: 93,040,272 (GRCm39) V161E probably benign Het
Usf3 T A 16: 44,038,304 (GRCm39) V928E probably benign Het
Usp29 G A 7: 6,966,457 (GRCm39) V767I possibly damaging Het
Usp34 T G 11: 23,295,200 (GRCm39) F287L Het
Vmn1r213 T C 13: 23,196,556 (GRCm39) C380R probably benign Het
Zfyve9 A G 4: 108,550,515 (GRCm39) probably null Het
Other mutations in Dusp9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02968:Dusp9 APN X 72,685,039 (GRCm39) missense probably benign 0.00
R4654:Dusp9 UTSW X 72,684,378 (GRCm39) missense probably benign 0.31
R7075:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7412:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R7930:Dusp9 UTSW X 72,684,128 (GRCm39) small deletion probably benign
R7958:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8228:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8258:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8334:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R8970:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9010:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9140:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9173:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9241:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9359:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9373:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9474:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9548:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
R9780:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
RF030:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
RF039:Dusp9 UTSW X 72,684,217 (GRCm39) small deletion probably benign
Predicted Primers PCR Primer
(F):5'- ATGGAGAGTCTGAGTCGGTC -3'
(R):5'- TGACCCTCACTTACCCTGTAGG -3'

Sequencing Primer
(F):5'- AGAGTCTGAGTCGGTCATGCC -3'
(R):5'- CCCTGTAGGTAGTATGCTGGG -3'
Posted On 2019-09-13