Incidental Mutation 'R0648:Vmn2r10'
ID 57336
Institutional Source Beutler Lab
Gene Symbol Vmn2r10
Ensembl Gene ENSMUSG00000067010
Gene Name vomeronasal 2, receptor 10
Synonyms VR16, V2r16
MMRRC Submission 038833-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.085) question?
Stock # R0648 (G1)
Quality Score 179
Status Validated
Chromosome 5
Chromosomal Location 109141278-109154337 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 109143782 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Valine at position 723 (M723V)
Ref Sequence ENSEMBL: ENSMUSP00000078162 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079163] [ENSMUST00000176594]
AlphaFold K7N621
Predicted Effect probably benign
Transcript: ENSMUST00000079163
AA Change: M723V

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000078162
Gene: ENSMUSG00000067010
AA Change: M723V

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 75 464 8.5e-29 PFAM
Pfam:NCD3G 506 560 3.8e-17 PFAM
Pfam:7tm_3 593 828 4e-55 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000176594
SMART Domains Protein: ENSMUSP00000135274
Gene: ENSMUSG00000067010

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 100% (80/80)
Allele List at MGI
Other mutations in this stock
Total: 80 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc5 A G 16: 20,184,632 (GRCm39) V1009A possibly damaging Het
Acta2 T C 19: 34,225,934 (GRCm39) I87V probably benign Het
Arid1a A G 4: 133,412,515 (GRCm39) Y1560H unknown Het
Bcor C T X: 11,925,290 (GRCm39) R102Q probably damaging Het
Camsap2 A T 1: 136,232,057 (GRCm39) D179E probably damaging Het
Ccdc168 A G 1: 44,095,723 (GRCm39) S1792P possibly damaging Het
Ccdc18 T A 5: 108,283,426 (GRCm39) S46T probably damaging Het
Ccdc18 A C 5: 108,322,853 (GRCm39) Q651P probably damaging Het
Cdc73 T C 1: 143,571,200 (GRCm39) T80A probably benign Het
Cdh20 T A 1: 109,993,337 (GRCm39) probably benign Het
Cenpe G A 3: 134,935,843 (GRCm39) G426D probably damaging Het
Cenpt A G 8: 106,571,592 (GRCm39) V487A probably damaging Het
Clec2m A G 6: 129,307,932 (GRCm39) F46L probably benign Het
Col4a1 G A 8: 11,296,892 (GRCm39) P84S unknown Het
Dennd2d A G 3: 106,407,871 (GRCm39) I450M probably damaging Het
Dhps C A 8: 85,799,911 (GRCm39) probably null Het
Ebf1 A T 11: 44,882,337 (GRCm39) H431L probably damaging Het
Efcab6 A G 15: 83,817,265 (GRCm39) probably benign Het
Egflam T C 15: 7,237,190 (GRCm39) H990R probably damaging Het
Ercc6l2 A G 13: 63,992,459 (GRCm39) T303A probably benign Het
Fam167b T C 4: 129,472,150 (GRCm39) K7E probably benign Het
Fgd3 T C 13: 49,450,049 (GRCm39) I67V probably benign Het
Fhip1a A C 3: 85,637,921 (GRCm39) V126G probably damaging Het
Fn1 A T 1: 71,636,744 (GRCm39) V2045D possibly damaging Het
Gnl1 A G 17: 36,293,490 (GRCm39) N225S probably damaging Het
Gpx6 A T 13: 21,503,047 (GRCm39) N154Y probably benign Het
H2bc21 A G 3: 96,128,851 (GRCm39) S124G probably benign Het
Haus8 C A 8: 71,709,174 (GRCm39) G79V probably damaging Het
Hdgfl1 A T 13: 26,953,836 (GRCm39) L79Q probably damaging Het
Impdh2 T C 9: 108,440,665 (GRCm39) Y83H probably benign Het
Lama2 T C 10: 26,865,372 (GRCm39) T2929A probably benign Het
Lpin2 T C 17: 71,536,307 (GRCm39) S199P probably benign Het
Moap1 T C 12: 102,708,776 (GRCm39) T258A probably benign Het
Mrps35 C A 6: 146,957,443 (GRCm39) S156* probably null Het
Mrtfa A G 15: 80,901,121 (GRCm39) S457P probably damaging Het
Mtbp C T 15: 55,466,597 (GRCm39) P537S probably benign Het
Ncstn C A 1: 171,895,454 (GRCm39) V565F probably benign Het
Nhsl1 A G 10: 18,407,474 (GRCm39) N1536S possibly damaging Het
Nkain4 T C 2: 180,584,905 (GRCm39) Q103R possibly damaging Het
Nsun2 T A 13: 69,775,706 (GRCm39) N383K probably damaging Het
Or13p4 C T 4: 118,547,269 (GRCm39) V127I probably benign Het
Or6c33 A G 10: 129,853,350 (GRCm39) N40S probably damaging Het
Parp1 C T 1: 180,428,005 (GRCm39) probably benign Het
Pkd1 G A 17: 24,813,911 (GRCm39) R4125H probably damaging Het
Plxnd1 T C 6: 115,970,962 (GRCm39) I269V possibly damaging Het
Polr1f C T 12: 33,487,999 (GRCm39) Q305* probably null Het
Ppp1r36dn A G 12: 76,498,070 (GRCm39) noncoding transcript Het
Qrich1 T A 9: 108,422,076 (GRCm39) N563K probably damaging Het
Rab3il1 TGAAG TGAAGAAG 19: 10,004,752 (GRCm39) probably benign Het
Rell1 G A 5: 64,082,088 (GRCm39) T271M probably benign Het
Rgl1 A G 1: 152,412,016 (GRCm39) probably null Het
Rph3a C T 5: 121,097,333 (GRCm39) R261H possibly damaging Het
Ryr2 A T 13: 11,739,219 (GRCm39) M2161K possibly damaging Het
Scaf11 T C 15: 96,316,339 (GRCm39) N1075S possibly damaging Het
Serpina3j A G 12: 104,280,938 (GRCm39) D37G probably benign Het
Siah2 A G 3: 58,583,635 (GRCm39) V217A probably damaging Het
Sik2 T C 9: 50,810,045 (GRCm39) D506G probably benign Het
Skap2 A C 6: 51,856,765 (GRCm39) V279G probably benign Het
Slc8a3 G T 12: 81,361,220 (GRCm39) T533N probably damaging Het
Slc9a7 A T X: 20,028,659 (GRCm39) probably benign Het
Snai3 G T 8: 123,181,733 (GRCm39) F241L probably damaging Het
Speg T C 1: 75,404,622 (GRCm39) S2805P probably benign Het
Spink5 A T 18: 44,132,864 (GRCm39) probably benign Het
Tctn1 C T 5: 122,389,761 (GRCm39) E254K probably benign Het
Tdrd3 C T 14: 87,709,618 (GRCm39) T100M probably damaging Het
Tex47 T C 5: 7,355,215 (GRCm39) V132A probably benign Het
Thbs3 A G 3: 89,123,972 (GRCm39) probably null Het
Tigit T A 16: 43,482,401 (GRCm39) Y111F probably damaging Het
Tmem245 A G 4: 56,906,270 (GRCm39) I148T probably benign Het
Tmem97 A G 11: 78,441,365 (GRCm39) Y39H probably benign Het
Tnks2 T A 19: 36,839,474 (GRCm39) probably null Het
Trp53bp1 A G 2: 121,066,188 (GRCm39) V846A probably benign Het
Tulp2 T G 7: 45,169,210 (GRCm39) I259S probably damaging Het
Ubxn1 G A 19: 8,851,612 (GRCm39) R215H probably damaging Het
Vmn1r17 A G 6: 57,337,460 (GRCm39) F253L probably damaging Het
Xndc1 T C 7: 101,728,031 (GRCm39) V14A possibly damaging Het
Xpnpep1 A G 19: 52,986,294 (GRCm39) probably benign Het
Yes1 T A 5: 32,812,862 (GRCm39) M322K possibly damaging Het
Zdhhc14 C A 17: 5,543,877 (GRCm39) N52K probably benign Het
Zfp42 A G 8: 43,749,015 (GRCm39) V162A probably benign Het
Other mutations in Vmn2r10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00816:Vmn2r10 APN 5 109,150,451 (GRCm39) missense possibly damaging 0.75
IGL01618:Vmn2r10 APN 5 109,150,345 (GRCm39) missense probably damaging 1.00
IGL01624:Vmn2r10 APN 5 109,154,112 (GRCm39) missense possibly damaging 0.83
IGL01941:Vmn2r10 APN 5 109,143,820 (GRCm39) missense probably damaging 1.00
IGL01959:Vmn2r10 APN 5 109,145,571 (GRCm39) missense probably benign 0.00
IGL01973:Vmn2r10 APN 5 109,143,543 (GRCm39) missense probably damaging 1.00
IGL01985:Vmn2r10 APN 5 109,154,125 (GRCm39) missense probably benign 0.21
IGL02451:Vmn2r10 APN 5 109,143,788 (GRCm39) nonsense probably null
IGL02503:Vmn2r10 APN 5 109,151,341 (GRCm39) missense probably damaging 1.00
IGL03275:Vmn2r10 APN 5 109,151,243 (GRCm39) missense probably benign 0.00
R0035:Vmn2r10 UTSW 5 109,145,467 (GRCm39) splice site probably benign
R0395:Vmn2r10 UTSW 5 109,149,859 (GRCm39) missense probably damaging 1.00
R0454:Vmn2r10 UTSW 5 109,151,327 (GRCm39) missense probably benign 0.25
R1251:Vmn2r10 UTSW 5 109,143,890 (GRCm39) missense probably benign 0.01
R1580:Vmn2r10 UTSW 5 109,154,117 (GRCm39) missense possibly damaging 0.82
R1845:Vmn2r10 UTSW 5 109,149,861 (GRCm39) nonsense probably null
R1986:Vmn2r10 UTSW 5 109,154,120 (GRCm39) nonsense probably null
R2137:Vmn2r10 UTSW 5 109,151,410 (GRCm39) missense possibly damaging 0.87
R2495:Vmn2r10 UTSW 5 109,143,961 (GRCm39) missense probably damaging 1.00
R3932:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R3933:Vmn2r10 UTSW 5 109,150,088 (GRCm39) missense possibly damaging 0.47
R4899:Vmn2r10 UTSW 5 109,151,324 (GRCm39) missense probably damaging 1.00
R4992:Vmn2r10 UTSW 5 109,145,592 (GRCm39) missense possibly damaging 0.89
R5124:Vmn2r10 UTSW 5 109,154,286 (GRCm39) missense probably benign 0.01
R5145:Vmn2r10 UTSW 5 109,143,761 (GRCm39) missense possibly damaging 0.64
R5156:Vmn2r10 UTSW 5 109,143,466 (GRCm39) missense probably benign 0.11
R5265:Vmn2r10 UTSW 5 109,143,586 (GRCm39) missense probably damaging 1.00
R5311:Vmn2r10 UTSW 5 109,154,121 (GRCm39) missense probably damaging 1.00
R5321:Vmn2r10 UTSW 5 109,143,505 (GRCm39) missense probably damaging 1.00
R5666:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5670:Vmn2r10 UTSW 5 109,146,910 (GRCm39) nonsense probably null
R5872:Vmn2r10 UTSW 5 109,151,377 (GRCm39) missense possibly damaging 0.84
R6004:Vmn2r10 UTSW 5 109,146,944 (GRCm39) missense probably benign 0.30
R6108:Vmn2r10 UTSW 5 109,143,667 (GRCm39) missense probably damaging 1.00
R6332:Vmn2r10 UTSW 5 109,151,328 (GRCm39) missense probably damaging 1.00
R6599:Vmn2r10 UTSW 5 109,143,944 (GRCm39) missense probably benign 0.09
R6651:Vmn2r10 UTSW 5 109,143,488 (GRCm39) missense probably null 0.22
R6891:Vmn2r10 UTSW 5 109,149,845 (GRCm39) missense probably damaging 1.00
R7023:Vmn2r10 UTSW 5 109,149,894 (GRCm39) missense probably damaging 0.96
R7146:Vmn2r10 UTSW 5 109,151,200 (GRCm39) missense probably damaging 1.00
R7941:Vmn2r10 UTSW 5 109,144,306 (GRCm39) missense probably damaging 1.00
R8058:Vmn2r10 UTSW 5 109,149,955 (GRCm39) missense probably benign 0.00
R8478:Vmn2r10 UTSW 5 109,143,636 (GRCm39) missense probably damaging 1.00
R8526:Vmn2r10 UTSW 5 109,145,572 (GRCm39) missense possibly damaging 0.51
R8698:Vmn2r10 UTSW 5 109,151,390 (GRCm39) missense probably benign 0.00
R8796:Vmn2r10 UTSW 5 109,143,917 (GRCm39) missense possibly damaging 0.74
R8854:Vmn2r10 UTSW 5 109,144,126 (GRCm39) missense probably benign 0.20
R8871:Vmn2r10 UTSW 5 109,146,899 (GRCm39) missense possibly damaging 0.67
R8893:Vmn2r10 UTSW 5 109,143,677 (GRCm39) missense probably benign 0.09
R8907:Vmn2r10 UTSW 5 109,149,791 (GRCm39) missense probably benign
R8957:Vmn2r10 UTSW 5 109,149,780 (GRCm39) missense possibly damaging 0.60
R8976:Vmn2r10 UTSW 5 109,145,479 (GRCm39) missense probably damaging 1.00
R9155:Vmn2r10 UTSW 5 109,144,212 (GRCm39) missense probably benign 0.10
R9308:Vmn2r10 UTSW 5 109,145,476 (GRCm39) nonsense probably null
R9800:Vmn2r10 UTSW 5 109,150,404 (GRCm39) missense probably damaging 0.99
Z1088:Vmn2r10 UTSW 5 109,143,979 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r10 UTSW 5 109,149,854 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCTGCACTAGAAGCCAAGATGGAG -3'
(R):5'- GGCCAATAACCGCATTCTCAGCTAC -3'

Sequencing Primer
(F):5'- AAGGTGATCCAGACACTGC -3'
(R):5'- TGCAGCAGACCACATTTGG -3'
Posted On 2013-07-11