Mutagenetix > Incidental Mutation

Incidental Mutation 'R7394:Nbeal2'

573671

Institutional Source

Beutler Lab

Gene Symbol

Nbeal2

Ensembl Gene

ENSMUSG00000056724

Gene Name

neurobeachin-like 2

Synonyms

1110014F23Rik

MMRRC Submission

045476-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.228) question?

Stock #

R7394 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

110624789-110654161 bp(-) (GRCm38)

Type of Mutation

critical splice donor site (1 bp from exon)

DNA Base Change (assembly)

C to T at 110630189 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000128586 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000133191] [ENSMUST00000167320] [ENSMUST00000196488]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000123996

Predicted Effect

probably null
Transcript: ENSMUST00000130024

SMART Domains

Protein: ENSMUSP00000118061
Gene: ENSMUSG00000056724

Domain	Start	End	E-Value	Type
low complexity region	1	13	N/A	INTRINSIC
low complexity region	236	248	N/A	INTRINSIC
Pfam:DUF4704	345	607	2.5e-29	PFAM
low complexity region	649	664	N/A	INTRINSIC
low complexity region	804	819	N/A	INTRINSIC
Pfam:DUF4800	872	1138	9.9e-113	PFAM
low complexity region	1164	1193	N/A	INTRINSIC
Pfam:PH_BEACH	1204	1291	2.2e-21	PFAM
Beach	1343	1623	5.2e-205	SMART
WD40	1721	1766	1.03e1	SMART
WD40	1769	1808	6.19e-5	SMART
WD40	1820	1859	1.02e-5	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000131017

SMART Domains

Protein: ENSMUSP00000114660
Gene: ENSMUSG00000056724

Domain	Start	End	E-Value	Type
Pfam:DUF4800	1	209	7.5e-97	PFAM
low complexity region	235	264	N/A	INTRINSIC
Pfam:PH_BEACH	275	362	1e-21	PFAM
Beach	414	694	5.2e-205	SMART
WD40	762	807	1.03e1	SMART
WD40	810	849	6.19e-5	SMART
WD40	861	900	1.02e-5	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000133191

SMART Domains

Protein: ENSMUSP00000121373
Gene: ENSMUSG00000056724

Domain	Start	End	E-Value	Type
low complexity region	56	84	N/A	INTRINSIC
low complexity region	192	201	N/A	INTRINSIC
low complexity region	227	238	N/A	INTRINSIC
low complexity region	514	522	N/A	INTRINSIC
low complexity region	527	542	N/A	INTRINSIC
Pfam:Laminin_G_3	578	818	5.9e-8	PFAM
low complexity region	1014	1028	N/A	INTRINSIC
low complexity region	1128	1136	N/A	INTRINSIC
low complexity region	1149	1163	N/A	INTRINSIC
low complexity region	1359	1375	N/A	INTRINSIC
low complexity region	1515	1530	N/A	INTRINSIC
low complexity region	1621	1647	N/A	INTRINSIC
low complexity region	1875	1904	N/A	INTRINSIC
Pfam:PH_BEACH	1908	2002	6.2e-28	PFAM
Beach	2054	2334	5.2e-205	SMART
WD40	2432	2477	1.03e1	SMART
WD40	2480	2519	6.19e-5	SMART
WD40	2531	2570	1.02e-5	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000167320

SMART Domains

Protein: ENSMUSP00000128586
Gene: ENSMUSG00000056724

Domain	Start	End	E-Value	Type
low complexity region	56	84	N/A	INTRINSIC
low complexity region	192	201	N/A	INTRINSIC
low complexity region	227	238	N/A	INTRINSIC
low complexity region	514	522	N/A	INTRINSIC
low complexity region	527	542	N/A	INTRINSIC
low complexity region	763	775	N/A	INTRINSIC
Pfam:DUF4704	872	1148	9.2e-32	PFAM
low complexity region	1149	1163	N/A	INTRINSIC
low complexity region	1366	1382	N/A	INTRINSIC
low complexity region	1522	1537	N/A	INTRINSIC
Pfam:DUF4800	1590	1856	1.5e-112	PFAM
low complexity region	1882	1911	N/A	INTRINSIC
Pfam:PH_BEACH	1922	2009	3.1e-21	PFAM
Beach	2061	2341	5.2e-205	SMART
WD40	2439	2484	1.03e1	SMART
WD40	2487	2526	6.19e-5	SMART
WD40	2538	2577	1.02e-5	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000196488

SMART Domains

Protein: ENSMUSP00000143265
Gene: ENSMUSG00000056724

Domain	Start	End	E-Value	Type
low complexity region	56	84	N/A	INTRINSIC
low complexity region	192	201	N/A	INTRINSIC
low complexity region	227	238	N/A	INTRINSIC
low complexity region	487	495	N/A	INTRINSIC
low complexity region	500	515	N/A	INTRINSIC
Pfam:Laminin_G_3	551	791	5.3e-6	PFAM
low complexity region	987	1001	N/A	INTRINSIC
low complexity region	1101	1109	N/A	INTRINSIC
low complexity region	1122	1136	N/A	INTRINSIC
low complexity region	1332	1348	N/A	INTRINSIC
low complexity region	1488	1503	N/A	INTRINSIC
low complexity region	1594	1620	N/A	INTRINSIC
low complexity region	1848	1877	N/A	INTRINSIC
Pfam:PH_BEACH	1881	1975	3.1e-25	PFAM
Beach	2027	2307	3.8e-209	SMART
WD40	2405	2450	6.3e-2	SMART
WD40	2453	2492	3.8e-7	SMART
WD40	2504	2543	6.5e-8	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.7%
20x: 99.0%

Validation Efficiency

99% (66/67)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011]
PHENOTYPE: Homozygous null mice exhibit megakaryocyte and platelet abnormalities resulting in impaired arterial thrombus formation and protection from infarction following cerebral ischemia. Wound repair is impaired. These abnormalities result in a bleeding disorder similiar to Gray Platelet Syndrome. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 69 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017N19Rik	A	G	10: 100,609,176 (GRCm38)	I208V	probably benign	Het
Abcb11	C	T	2: 69,299,867 (GRCm38)	D282N	probably damaging	Het
Aldh1l2	T	A	10: 83,502,457 (GRCm38)	I646F	probably damaging	Het
Alms1	C	T	6: 85,622,223 (GRCm38)	P1344S	possibly damaging	Het
Ank2	T	A	3: 126,936,653 (GRCm38)	I711L	possibly damaging	Het
Ankrd6	T	C	4: 32,821,298 (GRCm38)	N251D	probably damaging	Het
Ap3m1	T	C	14: 21,038,079 (GRCm38)	T304A	probably benign	Het
Arhgef39	T	C	4: 43,499,532 (GRCm38)	T26A	possibly damaging	Het
C530008M17Rik	GCGCGAGGCCGAGAGGCAGGAGGAGGAAGCAAGACAACGCGAGGCCGAGAGGCAGG	GCGCGAGGCCGAGAGGCAGG	5: 76,856,954 (GRCm38)		probably benign	Het
Carnmt1	G	T	19: 18,670,837 (GRCm38)		probably benign	Het
Ccr4	C	T	9: 114,491,926 (GRCm38)	R357H	probably benign	Het
Cd4	T	A	6: 124,873,041 (GRCm38)	M104L	probably benign	Het
Cd74	A	T	18: 60,803,893 (GRCm38)		probably benign	Het
Cdcp1	T	C	9: 123,173,813 (GRCm38)	Y731C	probably damaging	Het
Cdyl2	A	G	8: 116,624,051 (GRCm38)	S114P	not run	Het
Cenpv	T	C	11: 62,536,288 (GRCm38)	D148G	probably damaging	Het
Cep89	G	A	7: 35,429,928 (GRCm38)	R630H	probably damaging	Het
Cfap57	T	A	4: 118,593,137 (GRCm38)	Y596F	probably benign	Het
Clec4a2	C	A	6: 123,139,120 (GRCm38)	A122E	unknown	Het
Col4a2	A	G	8: 11,446,184 (GRCm38)	T1602A	probably benign	Het
Cyp2j11	A	T	4: 96,316,440 (GRCm38)	Y290N	probably benign	Het
Dhx38	A	T	8: 109,556,523 (GRCm38)	V554E	probably damaging	Het
Ebf2	T	C	14: 67,237,526 (GRCm38)	V70A	probably damaging	Het
Enpp5	G	A	17: 44,085,264 (GRCm38)	G356S	probably damaging	Het
Fam217a	A	T	13: 34,910,279 (GRCm38)	I499K	possibly damaging	Het
Fras1	C	A	5: 96,712,450 (GRCm38)	Y2118*	probably null	Het
Gm3248	A	T	14: 5,945,781 (GRCm38)		probably null	Het
Gm5460	T	G	14: 34,043,922 (GRCm38)	D165E	possibly damaging	Het
Grk4	A	T	5: 34,751,618 (GRCm38)	N490Y	probably benign	Het
Iglc2	T	A	16: 19,195,136 (GRCm38)	K59*	probably null	Het
Iqsec3	T	A	6: 121,386,610 (GRCm38)	H895L	possibly damaging	Het
Itgb7	A	G	15: 102,219,254 (GRCm38)	S410P	probably damaging	Het
Kmt2d	C	A	15: 98,856,384 (GRCm38)	V1613F	unknown	Het
Lama1	T	C	17: 67,717,261 (GRCm38)	L118P		Het
Lrrc25	A	T	8: 70,618,180 (GRCm38)	S204C	possibly damaging	Het
Malrd1	A	G	2: 15,695,199 (GRCm38)	D619G	unknown	Het
Ms4a6d	G	A	19: 11,590,073 (GRCm38)	Q155*	probably null	Het
Mup17	G	A	4: 61,594,398 (GRCm38)	S86F	probably benign	Het
Nfkb1	A	C	3: 135,613,697 (GRCm38)	V291G	possibly damaging	Het
Nomo1	G	T	7: 46,066,479 (GRCm38)	V757F	probably benign	Het
Nutm2	T	A	13: 50,470,007 (GRCm38)	S247T	probably damaging	Het
Olfr1225	C	T	2: 89,170,361 (GRCm38)	V284I	probably benign	Het
Olfr1291-ps1	G	T	2: 111,499,896 (GRCm38)	A215S	probably damaging	Het
Olfr521	C	A	7: 99,767,346 (GRCm38)	H61Q	probably damaging	Het
Olfr826	T	A	10: 130,180,254 (GRCm38)	I209F	probably damaging	Het
Olfr834	T	A	9: 18,988,710 (GRCm38)	C241S	probably damaging	Het
Pcdhb14	A	G	18: 37,448,908 (GRCm38)	I356V	probably benign	Het
Pnkp	T	A	7: 44,858,678 (GRCm38)	S142T	probably damaging	Het
Ppia	T	C	11: 6,419,218 (GRCm38)	S99P	possibly damaging	Het
Prss47	C	T	13: 65,044,993 (GRCm38)	V325I	probably benign	Het
Ptk7	T	C	17: 46,591,757 (GRCm38)	D34G	probably damaging	Het
Pwp2	C	T	10: 78,182,480 (GRCm38)	G126R	probably damaging	Het
Rasa3	G	T	8: 13,595,353 (GRCm38)	D195E	probably benign	Het
Rnf150	T	A	8: 82,990,471 (GRCm38)	Y202*	probably null	Het
Sh2d1b2	T	C	1: 170,248,147 (GRCm38)	V50A	probably damaging	Het
Slc30a4	C	T	2: 122,685,304 (GRCm38)	V390I	possibly damaging	Het
Slc30a9	G	T	5: 67,352,766 (GRCm38)		probably null	Het
Slc8a3	T	A	12: 81,214,058 (GRCm38)		probably null	Het
Smpd3	G	A	8: 106,265,010 (GRCm38)	R304W	probably damaging	Het
Snta1	A	G	2: 154,376,860 (GRCm38)	S490P	probably damaging	Het
Srcap	T	G	7: 127,534,828 (GRCm38)	M887R	probably damaging	Het
St3gal1	A	G	15: 67,111,346 (GRCm38)	V187A	possibly damaging	Het
Sult2a3	T	C	7: 14,111,524 (GRCm38)	T137A	probably benign	Het
Tspoap1	C	T	11: 87,766,119 (GRCm38)	Q367*	probably null	Het
Uroc1	C	T	6: 90,345,333 (GRCm38)	R280C	probably damaging	Het
Ush2a	T	C	1: 188,911,416 (GRCm38)	I4325T	possibly damaging	Het
Vmn1r32	A	G	6: 66,553,189 (GRCm38)	I201T	probably benign	Het
Zadh2	C	T	18: 84,088,190 (GRCm38)	A9V	probably benign	Het
Zfp651	T	A	9: 121,767,345 (GRCm38)	M626K	probably damaging	Het

Other mutations in Nbeal2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Nbeal2	APN	9	110,635,869 (GRCm38)	missense	probably damaging	1.00
IGL00784:Nbeal2	APN	9	110,629,763 (GRCm38)	splice site	probably benign
IGL00826:Nbeal2	APN	9	110,626,903 (GRCm38)	missense	probably benign
IGL00885:Nbeal2	APN	9	110,638,661 (GRCm38)	missense	probably damaging	1.00
IGL01348:Nbeal2	APN	9	110,629,146 (GRCm38)	missense	probably damaging	0.99
IGL01511:Nbeal2	APN	9	110,629,234 (GRCm38)	missense	probably damaging	1.00
IGL01571:Nbeal2	APN	9	110,632,758 (GRCm38)	missense	possibly damaging	0.63
IGL01612:Nbeal2	APN	9	110,644,678 (GRCm38)	missense	probably damaging	1.00
IGL01924:Nbeal2	APN	9	110,631,414 (GRCm38)	missense	probably benign	0.23
IGL02056:Nbeal2	APN	9	110,627,324 (GRCm38)	missense	probably benign	0.17
IGL02481:Nbeal2	APN	9	110,625,995 (GRCm38)	nonsense	probably null
IGL02483:Nbeal2	APN	9	110,625,995 (GRCm38)	nonsense	probably null
IGL02502:Nbeal2	APN	9	110,633,768 (GRCm38)	missense	probably damaging	1.00
IGL02631:Nbeal2	APN	9	110,630,208 (GRCm38)	missense	probably damaging	0.99
IGL02637:Nbeal2	APN	9	110,625,977 (GRCm38)	missense	possibly damaging	0.62
IGL02727:Nbeal2	APN	9	110,639,285 (GRCm38)	splice site	probably benign
IGL02887:Nbeal2	APN	9	110,628,276 (GRCm38)	missense	probably damaging	1.00
IGL02896:Nbeal2	APN	9	110,639,292 (GRCm38)	critical splice donor site	probably null
IGL03110:Nbeal2	APN	9	110,631,433 (GRCm38)	missense	probably damaging	1.00
Antonym	UTSW	9	110,630,252 (GRCm38)	missense	probably damaging	1.00
Beowulf	UTSW	9	110,637,937 (GRCm38)	missense	possibly damaging	0.65
Blackmail	UTSW	9	110,629,639 (GRCm38)	missense	probably damaging	1.00
dog	UTSW	9	110,635,341 (GRCm38)	missense	possibly damaging	0.89
extortion	UTSW	9	110,630,243 (GRCm38)	missense	probably damaging	1.00
legion	UTSW	9	110,629,179 (GRCm38)	missense	probably damaging	1.00
litigious	UTSW	9	110,628,195 (GRCm38)	missense	probably damaging	1.00
mall	UTSW	9	110,632,886 (GRCm38)	missense	probably damaging	1.00
Mollusca	UTSW	9	110,645,438 (GRCm38)	splice site	probably null
Schleuter	UTSW	9	110,628,744 (GRCm38)	missense	possibly damaging	0.69
shellfish	UTSW	9	110,628,720 (GRCm38)	missense	probably damaging	1.00
Sophomoric	UTSW	9	110,633,047 (GRCm38)	missense	probably damaging	1.00
F5770:Nbeal2	UTSW	9	110,637,937 (GRCm38)	missense	possibly damaging	0.65
R0032:Nbeal2	UTSW	9	110,637,868 (GRCm38)	splice site	probably benign
R0084:Nbeal2	UTSW	9	110,643,710 (GRCm38)	critical splice donor site	probably null
R0147:Nbeal2	UTSW	9	110,642,143 (GRCm38)	nonsense	probably null
R0294:Nbeal2	UTSW	9	110,632,859 (GRCm38)	missense	probably damaging	1.00
R0310:Nbeal2	UTSW	9	110,638,163 (GRCm38)	missense	probably damaging	1.00
R0494:Nbeal2	UTSW	9	110,627,187 (GRCm38)	missense	probably damaging	1.00
R0550:Nbeal2	UTSW	9	110,642,158 (GRCm38)	missense	probably benign	0.01
R0630:Nbeal2	UTSW	9	110,636,034 (GRCm38)	splice site	probably benign
R0762:Nbeal2	UTSW	9	110,643,808 (GRCm38)	splice site	probably benign
R0862:Nbeal2	UTSW	9	110,628,195 (GRCm38)	missense	probably damaging	1.00
R0864:Nbeal2	UTSW	9	110,628,195 (GRCm38)	missense	probably damaging	1.00
R1225:Nbeal2	UTSW	9	110,632,886 (GRCm38)	missense	probably damaging	1.00
R1240:Nbeal2	UTSW	9	110,627,108 (GRCm38)	missense	probably damaging	0.98
R1450:Nbeal2	UTSW	9	110,633,672 (GRCm38)	splice site	probably benign
R1519:Nbeal2	UTSW	9	110,636,305 (GRCm38)	missense	probably damaging	1.00
R1655:Nbeal2	UTSW	9	110,632,872 (GRCm38)	missense	probably damaging	1.00
R1668:Nbeal2	UTSW	9	110,638,893 (GRCm38)	missense	probably damaging	1.00
R1705:Nbeal2	UTSW	9	110,625,196 (GRCm38)	missense	probably damaging	1.00
R1784:Nbeal2	UTSW	9	110,630,857 (GRCm38)	nonsense	probably null
R1834:Nbeal2	UTSW	9	110,627,129 (GRCm38)	missense	probably damaging	1.00
R1997:Nbeal2	UTSW	9	110,632,198 (GRCm38)	missense	probably damaging	1.00
R2013:Nbeal2	UTSW	9	110,634,071 (GRCm38)	missense	probably benign	0.09
R2014:Nbeal2	UTSW	9	110,634,071 (GRCm38)	missense	probably benign	0.09
R2055:Nbeal2	UTSW	9	110,635,307 (GRCm38)	missense	possibly damaging	0.92
R2086:Nbeal2	UTSW	9	110,634,071 (GRCm38)	missense	probably benign	0.09
R2113:Nbeal2	UTSW	9	110,625,406 (GRCm38)	missense	probably damaging	1.00
R2167:Nbeal2	UTSW	9	110,638,308 (GRCm38)	missense	probably damaging	1.00
R2201:Nbeal2	UTSW	9	110,630,250 (GRCm38)	missense	probably benign	0.16
R2309:Nbeal2	UTSW	9	110,626,570 (GRCm38)	missense	probably damaging	1.00
R2378:Nbeal2	UTSW	9	110,630,808 (GRCm38)	missense	probably damaging	0.99
R2945:Nbeal2	UTSW	9	110,628,068 (GRCm38)	missense	possibly damaging	0.82
R3052:Nbeal2	UTSW	9	110,633,085 (GRCm38)	missense	possibly damaging	0.93
R3076:Nbeal2	UTSW	9	110,631,700 (GRCm38)	missense	probably damaging	1.00
R3176:Nbeal2	UTSW	9	110,636,887 (GRCm38)	splice site	probably benign
R3974:Nbeal2	UTSW	9	110,633,846 (GRCm38)	missense	probably damaging	1.00
R4183:Nbeal2	UTSW	9	110,636,675 (GRCm38)	missense	probably benign
R4342:Nbeal2	UTSW	9	110,631,793 (GRCm38)	intron	probably benign
R4654:Nbeal2	UTSW	9	110,632,004 (GRCm38)	missense	probably damaging	1.00
R4707:Nbeal2	UTSW	9	110,632,055 (GRCm38)	missense	probably benign	0.10
R4822:Nbeal2	UTSW	9	110,636,315 (GRCm38)	missense	possibly damaging	0.82
R4854:Nbeal2	UTSW	9	110,631,396 (GRCm38)	missense	probably damaging	1.00
R4860:Nbeal2	UTSW	9	110,635,194 (GRCm38)	missense	probably benign	0.00
R4860:Nbeal2	UTSW	9	110,635,194 (GRCm38)	missense	probably benign	0.00
R4990:Nbeal2	UTSW	9	110,634,803 (GRCm38)	missense	probably benign	0.10
R4991:Nbeal2	UTSW	9	110,638,767 (GRCm38)	missense	probably damaging	1.00
R5021:Nbeal2	UTSW	9	110,637,463 (GRCm38)	missense	probably damaging	0.99
R5057:Nbeal2	UTSW	9	110,631,005 (GRCm38)	missense	probably damaging	1.00
R5092:Nbeal2	UTSW	9	110,626,728 (GRCm38)	splice site	probably null
R5161:Nbeal2	UTSW	9	110,629,868 (GRCm38)	missense	probably benign
R5202:Nbeal2	UTSW	9	110,644,666 (GRCm38)	missense	probably damaging	0.99
R5217:Nbeal2	UTSW	9	110,632,090 (GRCm38)	missense	possibly damaging	0.56
R5408:Nbeal2	UTSW	9	110,637,520 (GRCm38)	missense	possibly damaging	0.91
R5540:Nbeal2	UTSW	9	110,631,733 (GRCm38)	missense	probably damaging	1.00
R5866:Nbeal2	UTSW	9	110,631,492 (GRCm38)	missense	probably damaging	1.00
R5925:Nbeal2	UTSW	9	110,629,880 (GRCm38)	missense	probably benign	0.00
R6057:Nbeal2	UTSW	9	110,641,877 (GRCm38)	missense	possibly damaging	0.81
R6180:Nbeal2	UTSW	9	110,625,147 (GRCm38)	missense	probably damaging	1.00
R6191:Nbeal2	UTSW	9	110,627,990 (GRCm38)	critical splice donor site	probably null
R6232:Nbeal2	UTSW	9	110,638,734 (GRCm38)	missense	probably damaging	1.00
R6372:Nbeal2	UTSW	9	110,628,744 (GRCm38)	missense	possibly damaging	0.69
R6423:Nbeal2	UTSW	9	110,625,994 (GRCm38)	missense	probably damaging	1.00
R6543:Nbeal2	UTSW	9	110,644,458 (GRCm38)	missense	probably benign
R6648:Nbeal2	UTSW	9	110,637,642 (GRCm38)	missense	probably damaging	1.00
R6722:Nbeal2	UTSW	9	110,632,992 (GRCm38)	missense	probably damaging	1.00
R6738:Nbeal2	UTSW	9	110,636,905 (GRCm38)	missense	possibly damaging	0.93
R6916:Nbeal2	UTSW	9	110,626,108 (GRCm38)	missense	probably damaging	1.00
R6935:Nbeal2	UTSW	9	110,639,391 (GRCm38)	missense	probably damaging	1.00
R7022:Nbeal2	UTSW	9	110,638,618 (GRCm38)	missense	probably damaging	1.00
R7023:Nbeal2	UTSW	9	110,638,618 (GRCm38)	missense	probably damaging	1.00
R7050:Nbeal2	UTSW	9	110,628,720 (GRCm38)	missense	probably damaging	1.00
R7072:Nbeal2	UTSW	9	110,626,051 (GRCm38)	missense	probably benign	0.01
R7073:Nbeal2	UTSW	9	110,626,109 (GRCm38)	missense	probably damaging	0.99
R7099:Nbeal2	UTSW	9	110,645,438 (GRCm38)	splice site	probably null
R7354:Nbeal2	UTSW	9	110,629,179 (GRCm38)	missense	probably damaging	1.00
R7397:Nbeal2	UTSW	9	110,628,032 (GRCm38)	missense	possibly damaging	0.78
R7552:Nbeal2	UTSW	9	110,653,917 (GRCm38)	missense	probably benign	0.16
R7619:Nbeal2	UTSW	9	110,625,818 (GRCm38)	missense	probably benign	0.19
R7821:Nbeal2	UTSW	9	110,630,252 (GRCm38)	missense	probably damaging	1.00
R7902:Nbeal2	UTSW	9	110,637,547 (GRCm38)	missense	probably benign
R7923:Nbeal2	UTSW	9	110,631,446 (GRCm38)	nonsense	probably null
R8018:Nbeal2	UTSW	9	110,629,157 (GRCm38)	unclassified	probably benign
R8190:Nbeal2	UTSW	9	110,626,090 (GRCm38)	missense	probably benign	0.04
R8297:Nbeal2	UTSW	9	110,635,341 (GRCm38)	missense	possibly damaging	0.89
R8404:Nbeal2	UTSW	9	110,634,389 (GRCm38)	missense	possibly damaging	0.48
R8502:Nbeal2	UTSW	9	110,634,389 (GRCm38)	missense	possibly damaging	0.48
R8737:Nbeal2	UTSW	9	110,627,881 (GRCm38)	missense	probably damaging	1.00
R8782:Nbeal2	UTSW	9	110,630,805 (GRCm38)	missense	probably benign	0.04
R8807:Nbeal2	UTSW	9	110,629,639 (GRCm38)	missense	probably damaging	1.00
R8877:Nbeal2	UTSW	9	110,630,243 (GRCm38)	missense	probably damaging	1.00
R9057:Nbeal2	UTSW	9	110,627,150 (GRCm38)	missense	probably benign
R9267:Nbeal2	UTSW	9	110,633,047 (GRCm38)	missense	probably damaging	1.00
R9313:Nbeal2	UTSW	9	110,634,368 (GRCm38)	missense	probably damaging	1.00
R9352:Nbeal2	UTSW	9	110,627,848 (GRCm38)	missense	probably benign	0.03
R9482:Nbeal2	UTSW	9	110,633,998 (GRCm38)	missense	probably benign	0.25
R9533:Nbeal2	UTSW	9	110,644,661 (GRCm38)	missense	probably benign	0.01
R9566:Nbeal2	UTSW	9	110,628,921 (GRCm38)	missense	probably benign	0.00
R9769:Nbeal2	UTSW	9	110,626,279 (GRCm38)	missense	probably benign	0.01
V7583:Nbeal2	UTSW	9	110,637,937 (GRCm38)	missense	possibly damaging	0.65
X0017:Nbeal2	UTSW	9	110,644,278 (GRCm38)	missense	probably benign	0.02
X0065:Nbeal2	UTSW	9	110,644,413 (GRCm38)	splice site	probably benign
Z1088:Nbeal2	UTSW	9	110,632,372 (GRCm38)	missense	possibly damaging	0.51
Z1176:Nbeal2	UTSW	9	110,638,835 (GRCm38)	missense	probably benign
Z1176:Nbeal2	UTSW	9	110,625,816 (GRCm38)	missense	probably benign	0.01
Z1177:Nbeal2	UTSW	9	110,629,854 (GRCm38)	missense	probably benign	0.03

Predicted Primers

PCR Primer
(F):5'- TGAAGAAGAGTTCGAGCGCC -3'
(R):5'- TGTGACCTCATGGCTCACTG -3'

Sequencing Primer
(F):5'- CGAGCAACCAAGAATAGGT -3'
(R):5'- TCCCTAGCTGAAGTGAATGC -3'

Posted On

2019-09-13