|Institutional Source||Beutler Lab|
|Gene Name||CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)|
|Essential gene?||Probably non essential (E-score: 0.175)|
|Stock #||R7394 (G1)|
|Chromosomal Location||60803848-60812646 bp(+) (GRCm38)|
|Type of Mutation||start gained|
|DNA Base Change (assembly)||A to T at 60803893 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000126688 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000050487] [ENSMUST00000097563] [ENSMUST00000167610]|
|Meta Mutation Damage Score||0.0898|
|Coding Region Coverage||
|Validation Efficiency||99% (66/67)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired transport of MHC class II molecules, poor antigen presentation, and deficiency of CD4+ T cell development and positive selection. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Cd74||
(F):5'- GATCATGCAGGCCTTTCTACC -3'
(R):5'- GCATTCTGTGTCCTCCAGAG -3'
(F):5'- CCAGGGAGGCAGCTTTGAG -3'
(R):5'- TCCAGAGGTAAGGGCTCTCTG -3'