Mutagenetix > Incidental Mutation

Incidental Mutation 'R7395:Hdac10'

573776

Institutional Source

Beutler Lab

Gene Symbol

Hdac10

Ensembl Gene

ENSMUSG00000062906

Gene Name

histone deacetylase 10

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Non essential (E-score: 0.000) question?

Stock #

R7395 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

89123307-89128700 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 89128284 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 32 (T32I)

Ref Sequence

ENSEMBL: ENSMUSP00000080832 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000082197] [ENSMUST00000088827] [ENSMUST00000109347]

AlphaFold

Q6P3E7

Predicted Effect

probably benign
Transcript: ENSMUST00000082197
AA Change: T32I

PolyPhen 2 Score 0.141 (Sensitivity: 0.92; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000080832
Gene: ENSMUSG00000062906
AA Change: T32I

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	322	2.1e-85	PFAM
low complexity region	478	489	N/A	INTRINSIC
low complexity region	583	595	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000088827

SMART Domains

Protein: ENSMUSP00000086207
Gene: ENSMUSG00000022610

Domain	Start	End	E-Value	Type
S_TKc	27	311	1.63e-96	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000109347
AA Change: T32I

PolyPhen 2 Score 0.028 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000104971
Gene: ENSMUSG00000062906
AA Change: T32I

Domain	Start	End	E-Value	Type
Pfam:Hist_deacetyl	13	251	6.1e-66	PFAM
low complexity region	270	282	N/A	INTRINSIC
low complexity region	398	409	N/A	INTRINSIC

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

99% (92/93)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Allele List at MGI

Other mutations in this stock

Total: 94 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
3830403N18Rik	G	T	X: 56,138,780		probably null	Het
4930433I11Rik	A	T	7: 40,989,678	T13S	probably damaging	Het
Abca13	A	G	11: 9,291,658	I1174V	probably benign	Het
Acoxl	G	A	2: 127,884,416	V237M	probably damaging	Het
Adam33	A	C	2: 131,061,169	W52G	probably benign	Het
Adgrv1	T	C	13: 81,559,348	H1313R	probably damaging	Het
Ap3d1	T	C	10: 80,730,882	T89A	probably benign	Het
Armc8	T	C	9: 99,533,132	E165G	probably damaging	Het
Atp6v1c1	T	C	15: 38,691,705	*383Q	probably null	Het
Atp8b4	A	T	2: 126,375,694	L634Q	possibly damaging	Het
B3glct	A	G	5: 149,725,604		probably null	Het
Bhlhe40	TG	TGG	6: 108,664,857	254	probably null	Het
Bicd2	A	G	13: 49,378,230	D316G	possibly damaging	Het
Bop1	A	T	15: 76,453,841	S610T	probably damaging	Het
Car11	T	A	7: 45,701,321	Y80*	probably null	Het
Ccdc96	T	C	5: 36,485,265	I205T	probably benign	Het
Ces2a	A	G	8: 104,739,641	E390G	probably benign	Het
Cfap54	C	A	10: 92,884,703	V2630L	unknown	Het
Chek2	G	T	5: 110,872,108		probably null	Het
Cntn3	C	T	6: 102,337,394		probably null	Het
Cpne3	A	T	4: 19,528,239	D339E	probably damaging	Het
Crocc2	C	T	1: 93,216,107	Q1403*	probably null	Het
Csnka2ip	G	A	16: 64,479,440	T187I		Het
Ctu1	A	G	7: 43,676,595	H226R	possibly damaging	Het
Cubn	G	T	2: 13,287,064	Q3317K	probably damaging	Het
Cyp17a1	A	G	19: 46,670,695	L169P	probably benign	Het
Dcc	T	A	18: 71,374,569	K911*	probably null	Het
Dcun1d2	G	A	8: 13,278,675	R75*	probably null	Het
Defb19	A	T	2: 152,580,023		probably null	Het
Dffb	A	T	4: 153,969,113	S257R	probably damaging	Het
Dip2c	A	C	13: 9,614,377	N942T	probably damaging	Het
Dnah3	T	A	7: 119,966,251	I169F		Het
Dnah3	T	C	7: 120,060,960	M830V	probably benign	Het
Dnajc5g	G	A	5: 31,111,665	S130N	possibly damaging	Het
Dscaml1	C	A	9: 45,702,405	Q939K	possibly damaging	Het
Evpl	G	C	11: 116,227,079	N761K	possibly damaging	Het
Fbxw8	A	T	5: 118,068,215	I556N	probably damaging	Het
Fry	G	T	5: 150,380,883	M579I	possibly damaging	Het
Ggt7	A	T	2: 155,495,880	M488K	probably benign	Het
Gm6588	A	T	5: 112,450,169	E194V	possibly damaging	Het
Gnpnat1	T	A	14: 45,381,581	H107L	probably benign	Het
Golga2	C	A	2: 32,305,587	P798Q	possibly damaging	Het
Gpr35	G	A	1: 92,983,207	A214T	probably damaging	Het
Greb1	A	T	12: 16,709,430		probably null	Het
Hkdc1	G	A	10: 62,385,699	T860I	probably damaging	Het
Icam5	C	A	9: 21,035,442	P422Q	possibly damaging	Het
Ispd	A	T	12: 36,501,995	I283F	possibly damaging	Het
Ist1	A	C	8: 109,677,527	S238A	probably benign	Het
Lrig2	T	C	3: 104,497,520	N91D	probably benign	Het
Mapt	A	C	11: 104,328,123	D352A	probably damaging	Het
Micall2	G	A	5: 139,716,369	P373L	possibly damaging	Het
Mocs1	A	G	17: 49,454,557	S560G	possibly damaging	Het
Mpo	A	G	11: 87,801,124	D461G	probably damaging	Het
Myo1a	G	T	10: 127,710,440	V271L	probably damaging	Het
Ncoa1	G	A	12: 4,295,188	P720S	not run	Het
Ncr1	T	A	7: 4,338,151	I47N	probably damaging	Het
Ndufb6	G	A	4: 40,277,730	R66C	probably damaging	Het
Obox5	A	T	7: 15,758,743	S208C	probably damaging	Het
Olfr136	A	T	17: 38,335,864	K236*	probably null	Het
Olfr1494	T	C	19: 13,749,138	S11P	probably damaging	Het
Olfr39	T	A	9: 20,286,530	M285K	probably damaging	Het
Olfr501-ps1	T	A	7: 108,508,404	F116Y	unknown	Het
Padi4	A	C	4: 140,761,672	V152G	probably damaging	Het
Pdzd7	A	T	19: 45,037,011	D348E	probably damaging	Het
Pdzph1	T	A	17: 58,879,159	K1212N	possibly damaging	Het
Piezo2	C	T	18: 63,027,563	G2341R	probably damaging	Het
Plb1	A	G	5: 32,353,684	K1298E	probably benign	Het
Prr14l	A	G	5: 32,828,638	L1171P	probably benign	Het
Rab11fip5	T	C	6: 85,341,868	T680A	probably benign	Het
Rev1	A	T	1: 38,088,065	N371K	possibly damaging	Het
Rsf1	CGGCGGCGG	CGGCGGCGGGGGCGGCGG	7: 97,579,926		probably benign	Het
Ryr2	A	G	13: 11,785,111	C917R	probably damaging	Het
Sall1	A	T	8: 89,030,921	S852T	possibly damaging	Het
Serpine2	A	G	1: 79,801,555	F296L	probably damaging	Het
Slc12a6	A	T	2: 112,352,542	N754I	probably damaging	Het
Slc39a6	A	T	18: 24,585,275	L575Q	probably damaging	Het
Smarcc2	T	A	10: 128,485,606	L890Q	probably damaging	Het
Smg5	T	A	3: 88,361,071	V1006D	probably damaging	Het
Ssh2	T	C	11: 77,393,073	V51A	probably damaging	Het
St14	T	C	9: 31,096,899	K547E	probably benign	Het
Stag1	T	G	9: 100,796,728	V234G	probably damaging	Het
Stag3	A	T	5: 138,281,945	Q24L	probably benign	Het
Stra6	T	C	9: 58,141,097	Y158H	probably damaging	Het
Tcstv1	A	T	13: 119,894,130		probably null	Het
Tmem196	G	A	12: 120,011,267	C62Y	probably damaging	Het
Tmem265	T	A	7: 127,564,867	F84L		Het
Tph1	C	T	7: 46,657,203		probably null	Het
Ttn	A	G	2: 76,946,490	I1522T	unknown	Het
Ulk4	T	A	9: 121,255,112	Q129L	probably benign	Het
Usp17la	T	A	7: 104,861,585	S466T	probably benign	Het
Vmn2r31	A	T	7: 7,384,745	V609E	probably damaging	Het
Vmn2r52	C	T	7: 10,170,817	C365Y	probably benign	Het
Zbtb4	A	T	11: 69,776,111	T81S	possibly damaging	Het
Zfp605	A	T	5: 110,112,019		probably benign	Het

Other mutations in Hdac10

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00229:Hdac10	APN	15	89128442	missense	probably damaging	1.00
IGL01063:Hdac10	APN	15	89123868	missense	possibly damaging	0.68
IGL01577:Hdac10	APN	15	89126213	missense	possibly damaging	0.90
IGL01690:Hdac10	APN	15	89125991	missense	probably benign	0.00
IGL01724:Hdac10	APN	15	89124709	unclassified	probably benign
IGL01866:Hdac10	APN	15	89124533	missense	probably damaging	1.00
IGL01989:Hdac10	APN	15	89125343	missense	probably damaging	1.00
IGL01995:Hdac10	APN	15	89127598	missense	probably damaging	1.00
IGL02256:Hdac10	APN	15	89125894	unclassified	probably benign
IGL02668:Hdac10	APN	15	89125644	missense	probably benign	0.10
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0240:Hdac10	UTSW	15	89125882	missense	possibly damaging	0.65
R0454:Hdac10	UTSW	15	89125758	splice site	probably null
R0723:Hdac10	UTSW	15	89126418	missense	probably damaging	1.00
R0924:Hdac10	UTSW	15	89125862	missense	probably benign
R1553:Hdac10	UTSW	15	89125515	missense	possibly damaging	0.51
R1608:Hdac10	UTSW	15	89125318	missense	probably benign	0.04
R1619:Hdac10	UTSW	15	89126675	missense	probably damaging	1.00
R1715:Hdac10	UTSW	15	89126709	splice site	probably null
R2284:Hdac10	UTSW	15	89127404	missense	probably benign	0.00
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R2872:Hdac10	UTSW	15	89125856	missense	possibly damaging	0.46
R3688:Hdac10	UTSW	15	89123564	critical splice donor site	probably null
R4283:Hdac10	UTSW	15	89125623	missense	possibly damaging	0.94
R4604:Hdac10	UTSW	15	89125397	critical splice acceptor site	probably null
R4654:Hdac10	UTSW	15	89126833	unclassified	probably benign
R4898:Hdac10	UTSW	15	89128447	start codon destroyed	probably null	1.00
R4998:Hdac10	UTSW	15	89123940	missense	possibly damaging	0.94
R5393:Hdac10	UTSW	15	89126684	missense	probably damaging	1.00
R5769:Hdac10	UTSW	15	89123616	missense	probably benign	0.00
R5785:Hdac10	UTSW	15	89126945	missense	probably benign
R6992:Hdac10	UTSW	15	89125331	missense	probably benign	0.01
R7149:Hdac10	UTSW	15	89127449	missense	probably damaging	1.00
R7237:Hdac10	UTSW	15	89125377	missense	probably benign
R7276:Hdac10	UTSW	15	89128285	missense	probably benign	0.01
R9294:Hdac10	UTSW	15	89126277	missense	probably damaging	1.00
R9684:Hdac10	UTSW	15	89127199	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGGAGCAGAGATTCCTGGTG -3'
(R):5'- TGACCACGGTGTAGCTATGG -3'

Sequencing Primer
(F):5'- GGAGTGCCCACCCAGTAATC -3'
(R):5'- TAGCTATGGGCACAGCACTTG -3'

Posted On

2019-09-13