Incidental Mutation 'R7398:Lrrc34'
ID 573952
Institutional Source Beutler Lab
Gene Symbol Lrrc34
Ensembl Gene ENSMUSG00000027702
Gene Name leucine rich repeat containing 34
Synonyms Spata34, 1700007J06Rik
MMRRC Submission 045480-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R7398 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 30678416-30701967 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30697491 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 80 (D80G)
Ref Sequence ENSEMBL: ENSMUSP00000029252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000029252] [ENSMUST00000108265] [ENSMUST00000108267] [ENSMUST00000172350]
AlphaFold Q9DAM1
Predicted Effect probably damaging
Transcript: ENSMUST00000029252
AA Change: D80G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000029252
Gene: ENSMUSG00000027702
AA Change: D80G

DomainStartEndE-ValueType
LRR 73 100 2.23e2 SMART
LRR 101 128 6.92e-1 SMART
LRR 129 156 1.78e0 SMART
LRR 157 184 1.67e-2 SMART
Blast:LRR 216 242 2e-9 BLAST
LRR 244 271 2.57e-3 SMART
LRR 272 299 5.59e-4 SMART
LRR 301 328 4.16e0 SMART
LRR 329 356 1.66e2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000108265
SMART Domains Protein: ENSMUSP00000103900
Gene: ENSMUSG00000027703

DomainStartEndE-ValueType
LRR 68 90 7.05e-1 SMART
LRR 91 114 1.19e1 SMART
Pfam:LRR_7 115 133 1.1e-1 PFAM
LRR 138 161 9.75e0 SMART
LRR 162 185 8.72e0 SMART
LRR 208 230 3.47e0 SMART
LRR 231 254 9.3e-1 SMART
LRR 255 276 1.22e2 SMART
LRR 277 300 4.83e0 SMART
LRR 323 345 6.22e0 SMART
LRR 346 368 6.4e0 SMART
LRR 369 392 1.51e0 SMART
LRR 418 440 2.03e1 SMART
LRR 441 464 2.82e0 SMART
IQ 524 546 8.84e-3 SMART
low complexity region 553 581 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108267
SMART Domains Protein: ENSMUSP00000103902
Gene: ENSMUSG00000027703

DomainStartEndE-ValueType
LRR 83 105 7.05e-1 SMART
LRR 106 129 1.19e1 SMART
Pfam:LRR_7 130 148 1.2e-1 PFAM
LRR 153 176 9.75e0 SMART
LRR 177 200 8.72e0 SMART
LRR 223 245 3.47e0 SMART
LRR 246 269 9.3e-1 SMART
LRR 270 291 1.22e2 SMART
LRR 292 315 4.83e0 SMART
LRR 338 360 6.22e0 SMART
LRR 361 383 6.4e0 SMART
LRR 384 407 1.51e0 SMART
LRR 433 455 2.03e1 SMART
LRR 456 479 2.82e0 SMART
IQ 539 561 8.84e-3 SMART
low complexity region 568 596 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000172350
SMART Domains Protein: ENSMUSP00000127052
Gene: ENSMUSG00000027703

DomainStartEndE-ValueType
LRR 83 105 7.05e-1 SMART
LRR 106 129 1.19e1 SMART
LRR 153 176 9.75e0 SMART
LRR 177 200 8.72e0 SMART
LRR 223 245 3.47e0 SMART
LRR 246 269 9.3e-1 SMART
LRR 270 291 1.22e2 SMART
LRR 292 315 4.83e0 SMART
LRR 338 360 6.22e0 SMART
LRR 361 383 6.4e0 SMART
LRR 384 407 1.51e0 SMART
LRR 433 455 2.03e1 SMART
LRR 456 479 2.82e0 SMART
IQ 539 561 8.84e-3 SMART
low complexity region 568 596 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 55 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abl1 T A 2: 31,680,811 (GRCm39) S368T probably damaging Het
Acmsd A G 1: 127,657,172 (GRCm39) probably benign Het
Arid3b A T 9: 57,703,495 (GRCm39) S445T probably benign Het
Brinp1 A G 4: 68,759,591 (GRCm39) V91A probably benign Het
Ccne1 A G 7: 37,805,702 (GRCm39) probably null Het
Col3a1 A T 1: 45,366,973 (GRCm39) I249F unknown Het
Crybg3 T C 16: 59,377,688 (GRCm39) I1189V probably benign Het
Cyp2d34 A T 15: 82,500,964 (GRCm39) D389E probably benign Het
D130043K22Rik A C 13: 25,077,360 (GRCm39) I998L probably damaging Het
Dgkq A G 5: 108,803,056 (GRCm39) I298T possibly damaging Het
Dnah17 T C 11: 117,971,550 (GRCm39) E2161G probably damaging Het
Dnajc25 T C 4: 59,017,824 (GRCm39) probably null Het
Dpp9 G A 17: 56,496,405 (GRCm39) R768* probably null Het
Dusp6 T A 10: 99,100,740 (GRCm39) N245K probably damaging Het
Eea1 C A 10: 95,831,493 (GRCm39) H195N probably benign Het
Efhc1 A G 1: 21,059,744 (GRCm39) E598G probably benign Het
Epb41l1 T C 2: 156,376,682 (GRCm39) V809A probably damaging Het
Gas8 T A 8: 124,245,690 (GRCm39) M1K probably null Het
Gcm1 G A 9: 77,971,961 (GRCm39) V301I probably benign Het
Gm11554 T A 11: 99,695,085 (GRCm39) S43C unknown Het
Gm7298 A G 6: 121,758,912 (GRCm39) I1177V probably benign Het
Gm8011 A G 14: 42,285,918 (GRCm39) T27A Het
Hmcn1 A G 1: 150,522,421 (GRCm39) I3493T probably benign Het
Insrr T G 3: 87,716,039 (GRCm39) I578S probably damaging Het
Kif13b A G 14: 64,994,972 (GRCm39) D908G probably null Het
Lhcgr G C 17: 89,079,474 (GRCm39) Q71E probably benign Het
Lrrc7 C A 3: 157,997,595 (GRCm39) E156* probably null Het
Lrrc9 A G 12: 72,547,590 (GRCm39) D1255G probably damaging Het
Mcidas A G 13: 113,133,416 (GRCm39) N116D probably benign Het
Mmp7 A G 9: 7,697,594 (GRCm39) N210D probably damaging Het
Morc3 A G 16: 93,671,748 (GRCm39) D926G probably damaging Het
Mrgpra9 A G 7: 46,885,385 (GRCm39) I94T possibly damaging Het
Muc16 C A 9: 18,549,038 (GRCm39) V5752F possibly damaging Het
Myo16 A T 8: 10,612,183 (GRCm39) D1276V unknown Het
Nlrc4 T G 17: 74,753,537 (GRCm39) E282A probably damaging Het
Nos2 T A 11: 78,827,297 (GRCm39) Y227* probably null Het
Obox5 A C 7: 15,492,713 (GRCm39) M223L probably benign Het
Or10ak13 C A 4: 118,638,896 (GRCm39) L295F possibly damaging Het
Pygm G A 19: 6,435,966 (GRCm39) R139H probably damaging Het
Ranbp2 C A 10: 58,303,099 (GRCm39) P789T probably damaging Het
Riok2 T G 17: 17,607,501 (GRCm39) S350A probably benign Het
Rnf214 C T 9: 45,778,845 (GRCm39) V445I possibly damaging Het
Skida1 C T 2: 18,051,083 (GRCm39) V603I unknown Het
Skint6 T A 4: 112,755,335 (GRCm39) R747S probably benign Het
Slc24a5 G A 2: 124,927,694 (GRCm39) W331* probably null Het
Slc5a10 A T 11: 61,564,405 (GRCm39) C525S probably benign Het
Styxl2 A G 1: 165,928,044 (GRCm39) S523P probably damaging Het
Sult2b1 T C 7: 45,380,718 (GRCm39) Y288C probably damaging Het
Tagln3 G T 16: 45,543,440 (GRCm39) N67K probably damaging Het
Trav21-dv12 A T 14: 54,114,162 (GRCm39) H94L probably benign Het
Tshz2 A G 2: 169,726,094 (GRCm39) E230G probably damaging Het
Usb1 T A 8: 96,071,931 (GRCm39) H210Q probably damaging Het
Vill C T 9: 118,899,716 (GRCm39) P767L probably benign Het
Vmn2r94 A T 17: 18,477,603 (GRCm39) N269K probably benign Het
Zfp764l1 C T 7: 126,992,496 (GRCm39) C38Y probably null Het
Other mutations in Lrrc34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02502:Lrrc34 APN 3 30,699,394 (GRCm39) missense probably benign 0.12
IGL02738:Lrrc34 APN 3 30,685,441 (GRCm39) missense possibly damaging 0.82
IGL02985:Lrrc34 APN 3 30,690,444 (GRCm39) missense probably benign 0.32
IGL02999:Lrrc34 APN 3 30,688,782 (GRCm39) missense probably damaging 0.99
R0367:Lrrc34 UTSW 3 30,684,142 (GRCm39) missense probably benign 0.08
R0761:Lrrc34 UTSW 3 30,685,425 (GRCm39) splice site probably null
R1426:Lrrc34 UTSW 3 30,697,728 (GRCm39) unclassified probably benign
R1980:Lrrc34 UTSW 3 30,696,890 (GRCm39) missense probably benign 0.33
R2215:Lrrc34 UTSW 3 30,697,678 (GRCm39) missense probably benign 0.03
R2414:Lrrc34 UTSW 3 30,688,711 (GRCm39) missense probably benign 0.00
R4379:Lrrc34 UTSW 3 30,685,524 (GRCm39) missense probably damaging 1.00
R5214:Lrrc34 UTSW 3 30,690,397 (GRCm39) nonsense probably null
R5418:Lrrc34 UTSW 3 30,696,923 (GRCm39) missense possibly damaging 0.85
R5662:Lrrc34 UTSW 3 30,685,473 (GRCm39) missense probably benign 0.03
R6736:Lrrc34 UTSW 3 30,679,008 (GRCm39) missense probably benign 0.03
R6809:Lrrc34 UTSW 3 30,688,749 (GRCm39) missense possibly damaging 0.80
R6941:Lrrc34 UTSW 3 30,678,969 (GRCm39) missense probably benign 0.01
R7017:Lrrc34 UTSW 3 30,699,465 (GRCm39) critical splice acceptor site probably null
R7080:Lrrc34 UTSW 3 30,688,705 (GRCm39) missense probably damaging 0.96
R7139:Lrrc34 UTSW 3 30,679,036 (GRCm39) missense probably benign 0.22
R7191:Lrrc34 UTSW 3 30,679,027 (GRCm39) missense possibly damaging 0.61
R7662:Lrrc34 UTSW 3 30,697,452 (GRCm39) missense probably benign 0.16
R7707:Lrrc34 UTSW 3 30,679,041 (GRCm39) missense probably benign 0.00
R7945:Lrrc34 UTSW 3 30,696,886 (GRCm39) critical splice donor site probably null
R8799:Lrrc34 UTSW 3 30,678,979 (GRCm39) missense probably benign 0.06
R9764:Lrrc34 UTSW 3 30,697,467 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CCATGTGTTCCAAGCATTAGACAC -3'
(R):5'- ACAATCGCTTAGACTCCGGAC -3'

Sequencing Primer
(F):5'- CATAGTGCAGATTTAGGACCCTCTG -3'
(R):5'- GCTTAGACTCCGGACAAAGAATAAC -3'
Posted On 2019-09-13