|Institutional Source||Beutler Lab|
|Gene Name||matrix metallopeptidase 7|
|Is this an essential gene?||Probably non essential (E-score: 0.172)|
|Stock #||R7398 (G1)|
|Chromosomal Location||7692090-7699585 bp(+) (GRCm38)|
|Type of Mutation||missense|
|DNA Base Change (assembly)||A to G at 7697593 bp|
|Amino Acid Change||Asparagine to Aspartic acid at position 210 (N210D)|
|Ref Sequence||ENSEMBL: ENSMUSP00000018767 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000018767]|
|Predicted Effect||probably damaging
AA Change: N210D
PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
AA Change: N210D
|Coding Region Coverage||
FUNCTION: This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that are involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded preproprotein undergoes proteolytic processing to generate a mature, zinc-dependent endopeptidase enzyme. Mice lacking the encoded protein are deficient in functional cryptdins. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Feb 2016]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased sensitivity to induced colitis and corneal wound neovascularization, decreased sensitivity to myocardial infarction and pancreatic duct ligation, impaired tracheal wound healing, and altered tumor susceptibility. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Mmp7||
(F):5'- CTCACTGAAGGACCAAAGTTCT -3'
(R):5'- TTCAAGCCCGACAGTCTCTTTT -3'
(F):5'- CCTTTAGAAGGTGACATCTTGC -3'
(R):5'- CAAGCCCGACAGTCTCTTTTTGAAAG -3'