Incidental Mutation 'R7399:Vmn2r94'
| ID |
574063 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r94
|
| Ensembl Gene |
ENSMUSG00000090417 |
| Gene Name |
vomeronasal 2, receptor 94 |
| Synonyms |
EG665227 |
| MMRRC Submission |
045481-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.079)
|
| Stock # |
R7399 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
18240994-18277756 bp(-) (GRCm38) |
| Type of Mutation |
critical splice acceptor site |
| DNA Base Change (assembly) |
T to A
at 18244503 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126386
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000172190]
[ENSMUST00000231457]
[ENSMUST00000231815]
|
| AlphaFold |
E9PZK8 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000172190
|
| SMART Domains |
Protein: ENSMUSP00000126386
Gene: ENSMUSG00000090417
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:ANF_receptor
|
42 |
425 |
1.7e-35 |
PFAM |
|
Pfam:NCD3G
|
469 |
522 |
3.5e-21 |
PFAM |
|
Pfam:7tm_3
|
553 |
790 |
1.7e-51 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231457
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231815
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
99% (74/75) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 74 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acaca |
T |
G |
11: 84,260,679 (GRCm38) |
V801G |
possibly damaging |
Het |
| Actbl2 |
T |
A |
13: 111,255,593 (GRCm38) |
M154K |
probably benign |
Het |
| Adam7 |
A |
T |
14: 68,504,466 (GRCm38) |
|
probably null |
Het |
| Arfgef1 |
T |
A |
1: 10,180,897 (GRCm38) |
T888S |
probably benign |
Het |
| AW554918 |
C |
T |
18: 25,169,060 (GRCm38) |
P10L |
possibly damaging |
Het |
| Bcap29 |
A |
G |
12: 31,630,882 (GRCm38) |
I35T |
probably damaging |
Het |
| Bhlhe40 |
TG |
TGG |
6: 108,664,857 (GRCm38) |
254 |
probably null |
Het |
| C87499 |
C |
A |
4: 88,627,965 (GRCm38) |
R380L |
probably benign |
Het |
| Cdc25b |
A |
G |
2: 131,194,654 (GRCm38) |
D458G |
probably damaging |
Het |
| Cdc42bpb |
T |
C |
12: 111,305,667 (GRCm38) |
K1104R |
probably benign |
Het |
| Cep89 |
A |
G |
7: 35,438,378 (GRCm38) |
N729S |
probably damaging |
Het |
| Clec4a4 |
T |
A |
6: 122,991,829 (GRCm38) |
M51K |
possibly damaging |
Het |
| Dcdc2b |
A |
G |
4: 129,609,629 (GRCm38) |
L270P |
probably damaging |
Het |
| Dennd5b |
G |
T |
6: 149,036,483 (GRCm38) |
H639N |
probably damaging |
Het |
| Dnah11 |
T |
C |
12: 118,125,785 (GRCm38) |
E1182G |
probably damaging |
Het |
| Dnah11 |
T |
G |
12: 118,027,477 (GRCm38) |
T2385P |
probably benign |
Het |
| Dok7 |
T |
C |
5: 35,066,471 (GRCm38) |
V81A |
probably damaging |
Het |
| Dtx1 |
T |
A |
5: 120,682,393 (GRCm38) |
M494L |
possibly damaging |
Het |
| Foxj1 |
A |
T |
11: 116,332,254 (GRCm38) |
L241Q |
possibly damaging |
Het |
| Gbp10 |
G |
A |
5: 105,236,149 (GRCm38) |
|
probably benign |
Het |
| Hnmt |
T |
A |
2: 24,003,880 (GRCm38) |
T201S |
probably benign |
Het |
| Jup |
G |
T |
11: 100,378,351 (GRCm38) |
T412K |
possibly damaging |
Het |
| Kcnh2 |
G |
A |
5: 24,322,059 (GRCm38) |
S954F |
probably damaging |
Het |
| Klhdc7b |
A |
C |
15: 89,388,644 (GRCm38) |
K585T |
possibly damaging |
Het |
| Klk7 |
T |
A |
7: 43,812,000 (GRCm38) |
S14T |
probably benign |
Het |
| Lama4 |
G |
A |
10: 39,047,948 (GRCm38) |
E451K |
probably damaging |
Het |
| Ldhb |
A |
G |
6: 142,495,673 (GRCm38) |
C164R |
probably damaging |
Het |
| Malrd1 |
G |
A |
2: 15,610,090 (GRCm38) |
D239N |
|
Het |
| Mgam |
T |
A |
6: 40,666,854 (GRCm38) |
V572E |
probably damaging |
Het |
| Mrgprb2 |
G |
T |
7: 48,552,142 (GRCm38) |
N278K |
probably damaging |
Het |
| Msto1 |
A |
G |
3: 88,911,823 (GRCm38) |
Y206H |
probably damaging |
Het |
| Myo6 |
A |
G |
9: 80,262,291 (GRCm38) |
S467G |
unknown |
Het |
| Mysm1 |
T |
A |
4: 94,961,727 (GRCm38) |
I447L |
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,852,934 (GRCm38) |
E494G |
possibly damaging |
Het |
| Nol10 |
T |
G |
12: 17,402,173 (GRCm38) |
V376G |
probably damaging |
Het |
| Nup205 |
T |
A |
6: 35,214,676 (GRCm38) |
I1032N |
probably damaging |
Het |
| Olfr1002 |
T |
A |
2: 85,647,424 (GRCm38) |
D299V |
possibly damaging |
Het |
| Olfr1100 |
G |
A |
2: 86,978,157 (GRCm38) |
T213I |
probably benign |
Het |
| Olfr1170 |
A |
T |
2: 88,225,022 (GRCm38) |
Y3* |
probably null |
Het |
| Olfr1450 |
A |
G |
19: 12,954,447 (GRCm38) |
N286S |
probably damaging |
Het |
| Olfr449 |
T |
G |
6: 42,838,746 (GRCm38) |
Y288* |
probably null |
Het |
| Olfr455 |
A |
G |
6: 42,538,728 (GRCm38) |
F98S |
possibly damaging |
Het |
| Olfr617 |
A |
T |
7: 103,584,381 (GRCm38) |
I120L |
possibly damaging |
Het |
| Olfr782 |
A |
T |
10: 129,350,557 (GRCm38) |
|
probably benign |
Het |
| Olfr996 |
A |
G |
2: 85,579,296 (GRCm38) |
D19G |
probably benign |
Het |
| Oog2 |
A |
G |
4: 144,195,281 (GRCm38) |
K254E |
probably benign |
Het |
| Osbpl11 |
T |
A |
16: 33,236,279 (GRCm38) |
D694E |
probably benign |
Het |
| Pcm1 |
T |
A |
8: 41,293,510 (GRCm38) |
Y1210N |
probably benign |
Het |
| Pdxk |
T |
C |
10: 78,440,863 (GRCm38) |
M293V |
probably benign |
Het |
| Plcb3 |
T |
C |
19: 6,962,867 (GRCm38) |
I451V |
probably benign |
Het |
| Plekhm2 |
A |
G |
4: 141,634,376 (GRCm38) |
F272S |
probably damaging |
Het |
| Ptgdr |
A |
T |
14: 44,858,232 (GRCm38) |
|
probably null |
Het |
| Ptprf |
C |
T |
4: 118,226,523 (GRCm38) |
V788I |
probably benign |
Het |
| Ralbp1 |
C |
T |
17: 65,854,148 (GRCm38) |
V467I |
probably benign |
Het |
| Ralgds |
A |
C |
2: 28,543,655 (GRCm38) |
Q229P |
possibly damaging |
Het |
| Recql |
T |
C |
6: 142,374,884 (GRCm38) |
D146G |
probably damaging |
Het |
| Reln |
T |
C |
5: 22,051,367 (GRCm38) |
N493S |
probably damaging |
Het |
| Rfxank |
C |
T |
8: 70,135,286 (GRCm38) |
|
probably null |
Het |
| Scn5a |
A |
T |
9: 119,486,530 (GRCm38) |
M1704K |
probably damaging |
Het |
| Slc7a7 |
G |
T |
14: 54,374,268 (GRCm38) |
A316E |
possibly damaging |
Het |
| Slco1a6 |
A |
T |
6: 142,091,068 (GRCm38) |
C538S |
probably benign |
Het |
| Spert |
A |
G |
14: 75,592,637 (GRCm38) |
S39P |
probably benign |
Het |
| Stard6 |
T |
C |
18: 70,498,647 (GRCm38) |
|
probably null |
Het |
| Strip2 |
T |
A |
6: 29,927,613 (GRCm38) |
M219K |
possibly damaging |
Het |
| Tcam1 |
T |
C |
11: 106,284,085 (GRCm38) |
V122A |
probably damaging |
Het |
| Tha1 |
A |
G |
11: 117,869,690 (GRCm38) |
V236A |
possibly damaging |
Het |
| Tmem201 |
A |
T |
4: 149,731,097 (GRCm38) |
I132N |
possibly damaging |
Het |
| Tnc |
T |
C |
4: 64,020,657 (GRCm38) |
|
probably benign |
Het |
| Vmn1r42 |
T |
C |
6: 89,845,513 (GRCm38) |
T25A |
probably benign |
Het |
| Wdfy4 |
A |
C |
14: 33,068,906 (GRCm38) |
V2188G |
|
Het |
| Zfp623 |
T |
C |
15: 75,947,398 (GRCm38) |
S68P |
probably damaging |
Het |
| Zfp950 |
A |
T |
19: 61,119,155 (GRCm38) |
C497S |
probably damaging |
Het |
| Zkscan2 |
C |
T |
7: 123,480,104 (GRCm38) |
E877K |
probably damaging |
Het |
| Zp3r |
C |
A |
1: 130,577,053 (GRCm38) |
V536L |
probably damaging |
Het |
|
| Other mutations in Vmn2r94 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01396:Vmn2r94
|
APN |
17 |
18,257,039 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01676:Vmn2r94
|
APN |
17 |
18,257,010 (GRCm38) |
missense |
probably benign |
|
|
IGL01687:Vmn2r94
|
APN |
17 |
18,253,312 (GRCm38) |
missense |
possibly damaging |
0.64 |
|
IGL02113:Vmn2r94
|
APN |
17 |
18,257,675 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02408:Vmn2r94
|
APN |
17 |
18,253,261 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02451:Vmn2r94
|
APN |
17 |
18,258,191 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL02755:Vmn2r94
|
APN |
17 |
18,244,499 (GRCm38) |
missense |
probably benign |
0.01 |
|
IGL02822:Vmn2r94
|
APN |
17 |
18,243,620 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL02868:Vmn2r94
|
APN |
17 |
18,244,054 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
IGL03008:Vmn2r94
|
APN |
17 |
18,257,646 (GRCm38) |
missense |
probably benign |
0.05 |
|
R0112:Vmn2r94
|
UTSW |
17 |
18,243,604 (GRCm38) |
missense |
probably benign |
|
|
R0371:Vmn2r94
|
UTSW |
17 |
18,257,294 (GRCm38) |
missense |
probably benign |
0.11 |
|
R0413:Vmn2r94
|
UTSW |
17 |
18,243,818 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0627:Vmn2r94
|
UTSW |
17 |
18,257,165 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0737:Vmn2r94
|
UTSW |
17 |
18,277,433 (GRCm38) |
nonsense |
probably null |
|
|
R0815:Vmn2r94
|
UTSW |
17 |
18,257,711 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0863:Vmn2r94
|
UTSW |
17 |
18,257,711 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1125:Vmn2r94
|
UTSW |
17 |
18,257,455 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1276:Vmn2r94
|
UTSW |
17 |
18,257,082 (GRCm38) |
missense |
possibly damaging |
0.47 |
|
R1491:Vmn2r94
|
UTSW |
17 |
18,257,703 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1500:Vmn2r94
|
UTSW |
17 |
18,256,980 (GRCm38) |
missense |
probably benign |
0.07 |
|
R1610:Vmn2r94
|
UTSW |
17 |
18,243,733 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1664:Vmn2r94
|
UTSW |
17 |
18,244,144 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1716:Vmn2r94
|
UTSW |
17 |
18,257,373 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1843:Vmn2r94
|
UTSW |
17 |
18,244,470 (GRCm38) |
missense |
probably benign |
0.01 |
|
R1882:Vmn2r94
|
UTSW |
17 |
18,244,214 (GRCm38) |
missense |
probably benign |
0.07 |
|
R1936:Vmn2r94
|
UTSW |
17 |
18,244,292 (GRCm38) |
nonsense |
probably null |
|
|
R2273:Vmn2r94
|
UTSW |
17 |
18,257,331 (GRCm38) |
missense |
probably benign |
0.00 |
|
R2508:Vmn2r94
|
UTSW |
17 |
18,257,474 (GRCm38) |
missense |
probably benign |
0.32 |
|
R3436:Vmn2r94
|
UTSW |
17 |
18,258,388 (GRCm38) |
splice site |
probably benign |
|
|
R3917:Vmn2r94
|
UTSW |
17 |
18,244,358 (GRCm38) |
missense |
probably benign |
|
|
R3968:Vmn2r94
|
UTSW |
17 |
18,258,385 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R3969:Vmn2r94
|
UTSW |
17 |
18,258,385 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R4257:Vmn2r94
|
UTSW |
17 |
18,244,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4271:Vmn2r94
|
UTSW |
17 |
18,243,678 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4349:Vmn2r94
|
UTSW |
17 |
18,244,343 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4436:Vmn2r94
|
UTSW |
17 |
18,258,383 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4603:Vmn2r94
|
UTSW |
17 |
18,257,385 (GRCm38) |
missense |
probably benign |
0.33 |
|
R4821:Vmn2r94
|
UTSW |
17 |
18,257,031 (GRCm38) |
missense |
probably benign |
0.02 |
|
R5288:Vmn2r94
|
UTSW |
17 |
18,244,466 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5725:Vmn2r94
|
UTSW |
17 |
18,256,227 (GRCm38) |
missense |
possibly damaging |
0.88 |
|
R5735:Vmn2r94
|
UTSW |
17 |
18,243,804 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6066:Vmn2r94
|
UTSW |
17 |
18,257,433 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6124:Vmn2r94
|
UTSW |
17 |
18,244,059 (GRCm38) |
missense |
probably benign |
0.01 |
|
R6189:Vmn2r94
|
UTSW |
17 |
18,257,734 (GRCm38) |
missense |
probably benign |
0.25 |
|
R6245:Vmn2r94
|
UTSW |
17 |
18,258,123 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6574:Vmn2r94
|
UTSW |
17 |
18,256,159 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7236:Vmn2r94
|
UTSW |
17 |
18,257,549 (GRCm38) |
missense |
possibly damaging |
0.49 |
|
R7317:Vmn2r94
|
UTSW |
17 |
18,243,620 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7398:Vmn2r94
|
UTSW |
17 |
18,257,341 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7478:Vmn2r94
|
UTSW |
17 |
18,257,505 (GRCm38) |
missense |
probably benign |
|
|
R8099:Vmn2r94
|
UTSW |
17 |
18,257,397 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8189:Vmn2r94
|
UTSW |
17 |
18,258,356 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8217:Vmn2r94
|
UTSW |
17 |
18,243,724 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8303:Vmn2r94
|
UTSW |
17 |
18,244,171 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8543:Vmn2r94
|
UTSW |
17 |
18,243,722 (GRCm38) |
missense |
possibly damaging |
0.45 |
|
R8684:Vmn2r94
|
UTSW |
17 |
18,277,650 (GRCm38) |
start gained |
probably benign |
|
|
R8889:Vmn2r94
|
UTSW |
17 |
18,244,073 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R8892:Vmn2r94
|
UTSW |
17 |
18,244,073 (GRCm38) |
missense |
possibly damaging |
0.83 |
|
R9282:Vmn2r94
|
UTSW |
17 |
18,277,489 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R9526:Vmn2r94
|
UTSW |
17 |
18,256,999 (GRCm38) |
missense |
probably benign |
|
|
R9647:Vmn2r94
|
UTSW |
17 |
18,243,622 (GRCm38) |
missense |
probably benign |
0.00 |
|
R9748:Vmn2r94
|
UTSW |
17 |
18,243,727 (GRCm38) |
missense |
probably benign |
0.21 |
|
R9789:Vmn2r94
|
UTSW |
17 |
18,243,776 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF014:Vmn2r94
|
UTSW |
17 |
18,253,287 (GRCm38) |
nonsense |
probably null |
|
|
X0011:Vmn2r94
|
UTSW |
17 |
18,244,448 (GRCm38) |
missense |
possibly damaging |
0.76 |
|
X0028:Vmn2r94
|
UTSW |
17 |
18,243,975 (GRCm38) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCTGTGTTTCACAAAGATGCC -3'
(R):5'- GTGCATACACTGGCTTTCCTG -3'
Sequencing Primer
(F):5'- CTGTGTTTCACAAAGATGCCAATAAC -3'
(R):5'- GGCTTTCCTGAATTTAATCAGTGAC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation