Incidental Mutation 'R7400:Slc15a5'
ID 574093
Institutional Source Beutler Lab
Gene Symbol Slc15a5
Ensembl Gene ENSMUSG00000044378
Gene Name solute carrier family 15, member 5
Synonyms 9830102E05Rik
MMRRC Submission 045482-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # R7400 (G1)
Quality Score 225.009
Status Validated
Chromosome 6
Chromosomal Location 137960584-138056914 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 138050055 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Threonine at position 120 (M120T)
Ref Sequence ENSEMBL: ENSMUSP00000129239 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000171804]
AlphaFold Q8CBB2
Predicted Effect probably benign
Transcript: ENSMUST00000171804
AA Change: M120T

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
SMART Domains Protein: ENSMUSP00000129239
Gene: ENSMUSG00000044378
AA Change: M120T

DomainStartEndE-ValueType
Pfam:PTR2 101 485 4.3e-23 PFAM
low complexity region 536 543 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 97% (69/71)
Allele List at MGI
Other mutations in this stock
Total: 71 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4932414N04Rik T C 2: 68,496,547 (GRCm39) S118P unknown Het
Ahnak T A 19: 8,991,977 (GRCm39) D4420E probably damaging Het
Atp5mc2 C T 15: 102,573,547 (GRCm39) A90T possibly damaging Het
Batf2 A G 19: 6,221,538 (GRCm39) Y116C probably damaging Het
Cd48 G A 1: 171,523,493 (GRCm39) R112H probably benign Het
Cdh8 A T 8: 100,006,192 (GRCm39) Y132N probably damaging Het
Cfap70 A C 14: 20,458,335 (GRCm39) S793A probably benign Het
Cmip A G 8: 117,984,144 (GRCm39) probably null Het
Cyp1a2 T C 9: 57,589,223 (GRCm39) N197S probably benign Het
Diaph1 T C 18: 37,987,555 (GRCm39) D1067G probably damaging Het
Disp2 T C 2: 118,622,367 (GRCm39) L1033P probably damaging Het
Dock6 G T 9: 21,713,103 (GRCm39) A1981D possibly damaging Het
Eci3 T C 13: 35,143,960 (GRCm39) D55G probably benign Het
Eea1 T A 10: 95,831,432 (GRCm39) D174E probably benign Het
Ehd2 T C 7: 15,684,581 (GRCm39) E406G possibly damaging Het
Erich3 A G 3: 154,468,214 (GRCm39) K889E Het
Fat4 C A 3: 38,942,073 (GRCm39) T322K probably damaging Het
Fitm1 A T 14: 55,814,226 (GRCm39) I241F possibly damaging Het
Fscb C A 12: 64,518,391 (GRCm39) S1025I unknown Het
Gpsm2 T A 3: 108,587,004 (GRCm39) D644V probably damaging Het
Gucy2d C A 7: 98,092,847 (GRCm39) L75M possibly damaging Het
Gvin2 T A 7: 105,551,247 (GRCm39) I602F probably benign Het
Hmcn1 T C 1: 150,550,181 (GRCm39) I2668V probably damaging Het
Hoxa7 A G 6: 52,194,033 (GRCm39) I118T possibly damaging Het
Hsp90ab1 A G 17: 45,880,210 (GRCm39) V473A probably benign Het
Ica1l T C 1: 60,081,801 (GRCm39) probably null Het
Ighv1-72 A G 12: 115,721,837 (GRCm39) S40P probably damaging Het
Inhca T A 9: 103,127,861 (GRCm39) E690V probably benign Het
Kif28 A C 1: 179,527,839 (GRCm39) W771G probably damaging Het
Klf13 G C 7: 63,587,996 (GRCm39) A100G probably benign Het
Klhl5 A G 5: 65,305,933 (GRCm39) E300G possibly damaging Het
Krt40 A G 11: 99,433,969 (GRCm39) S6P probably benign Het
Map3k13 C T 16: 21,741,072 (GRCm39) R800W probably damaging Het
Mef2d T C 3: 88,075,038 (GRCm39) L408P possibly damaging Het
Mmp10 T A 9: 7,503,301 (GRCm39) M87K probably damaging Het
Mrgprd T A 7: 144,875,643 (GRCm39) H171Q probably benign Het
Muc1 C T 3: 89,137,953 (GRCm39) T265I possibly damaging Het
Myo15b A G 11: 115,750,939 (GRCm39) N570D Het
Nfs1 T A 2: 155,968,243 (GRCm39) I408F probably damaging Het
Npdc1 G T 2: 25,296,257 (GRCm39) C48F probably damaging Het
Or2j3 A T 17: 38,616,222 (GRCm39) N43K possibly damaging Het
Or52e7 T C 7: 104,684,417 (GRCm39) I4T probably benign Het
Or52j3 T C 7: 102,836,587 (GRCm39) S260P probably damaging Het
Or9a2 A T 6: 41,748,678 (GRCm39) L185H probably damaging Het
Osbpl2 T C 2: 179,795,114 (GRCm39) M332T probably benign Het
Ostm1 T A 10: 42,574,213 (GRCm39) V302D probably damaging Het
Otof T C 5: 30,542,532 (GRCm39) D672G probably benign Het
Plekha6 A T 1: 133,201,762 (GRCm39) K392* probably null Het
Pnpla1 A T 17: 29,077,950 (GRCm39) D37V probably damaging Het
Rasgrp1 A G 2: 117,129,026 (GRCm39) S198P probably damaging Het
Reln A T 5: 22,176,932 (GRCm39) N1911K probably damaging Het
Ripply3 C A 16: 94,136,759 (GRCm39) A140E probably benign Het
Siglec1 A G 2: 130,928,015 (GRCm39) C8R possibly damaging Het
Slamf6 T C 1: 171,747,360 (GRCm39) S41P unknown Het
Slc25a20 T G 9: 108,559,172 (GRCm39) D179E possibly damaging Het
Sltm T A 9: 70,493,352 (GRCm39) V783E probably damaging Het
Smc1b C A 15: 84,953,921 (GRCm39) R1116L probably damaging Het
Smim23 A G 11: 32,774,471 (GRCm39) V16A probably benign Het
Spata20 A G 11: 94,374,226 (GRCm39) V348A probably benign Het
Spen T C 4: 141,201,052 (GRCm39) D2525G probably damaging Het
St14 A C 9: 31,019,571 (GRCm39) N83K probably benign Het
Stab1 T C 14: 30,879,341 (GRCm39) N713S probably null Het
Syne1 A T 10: 5,168,580 (GRCm39) L5267H probably benign Het
Tenm4 T C 7: 96,344,010 (GRCm39) L271P probably damaging Het
Tfap2d C T 1: 19,213,150 (GRCm39) H325Y possibly damaging Het
Trav23 A G 14: 54,215,020 (GRCm39) R78G probably benign Het
Ttc39c A T 18: 12,776,856 (GRCm39) probably benign Het
Unc79 A G 12: 103,070,889 (GRCm39) D1228G probably damaging Het
Vmn1r66 T A 7: 10,008,874 (GRCm39) H53L probably damaging Het
Vps13b A T 15: 35,379,046 (GRCm39) L53F probably damaging Het
Zfp532 C T 18: 65,771,984 (GRCm39) T834M possibly damaging Het
Other mutations in Slc15a5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00546:Slc15a5 APN 6 138,020,536 (GRCm39) missense probably damaging 1.00
IGL02090:Slc15a5 APN 6 138,020,598 (GRCm39) missense probably benign 0.00
R0288:Slc15a5 UTSW 6 137,994,914 (GRCm39) splice site probably benign
R0355:Slc15a5 UTSW 6 137,995,112 (GRCm39) splice site probably benign
R0825:Slc15a5 UTSW 6 137,995,087 (GRCm39) missense possibly damaging 0.84
R1470:Slc15a5 UTSW 6 138,049,992 (GRCm39) missense probably benign 0.01
R1470:Slc15a5 UTSW 6 138,049,992 (GRCm39) missense probably benign 0.01
R1721:Slc15a5 UTSW 6 138,049,845 (GRCm39) splice site probably benign
R1897:Slc15a5 UTSW 6 138,056,762 (GRCm39) missense possibly damaging 0.93
R4159:Slc15a5 UTSW 6 138,049,938 (GRCm39) missense possibly damaging 0.84
R4415:Slc15a5 UTSW 6 138,056,754 (GRCm39) missense probably benign 0.34
R4703:Slc15a5 UTSW 6 138,032,643 (GRCm39) missense probably benign 0.08
R4951:Slc15a5 UTSW 6 138,050,064 (GRCm39) missense probably damaging 1.00
R4996:Slc15a5 UTSW 6 138,020,583 (GRCm39) missense probably damaging 1.00
R5268:Slc15a5 UTSW 6 138,056,751 (GRCm39) missense probably damaging 1.00
R5310:Slc15a5 UTSW 6 138,050,034 (GRCm39) missense probably benign 0.28
R5321:Slc15a5 UTSW 6 137,964,436 (GRCm39) missense probably benign 0.08
R5963:Slc15a5 UTSW 6 138,056,691 (GRCm39) missense probably damaging 1.00
R5988:Slc15a5 UTSW 6 138,020,529 (GRCm39) missense probably benign 0.07
R7515:Slc15a5 UTSW 6 138,020,496 (GRCm39) missense possibly damaging 0.89
R7604:Slc15a5 UTSW 6 138,056,784 (GRCm39) missense probably damaging 1.00
R7707:Slc15a5 UTSW 6 138,056,745 (GRCm39) missense probably damaging 1.00
R8344:Slc15a5 UTSW 6 138,056,898 (GRCm39) missense probably damaging 1.00
R8410:Slc15a5 UTSW 6 137,989,153 (GRCm39) missense
R9020:Slc15a5 UTSW 6 138,032,704 (GRCm39) missense probably benign 0.00
R9157:Slc15a5 UTSW 6 137,961,456 (GRCm39) missense
R9222:Slc15a5 UTSW 6 137,961,450 (GRCm39) missense
R9526:Slc15a5 UTSW 6 138,049,954 (GRCm39) missense probably benign 0.02
R9618:Slc15a5 UTSW 6 138,032,779 (GRCm39) missense possibly damaging 0.90
Z1188:Slc15a5 UTSW 6 137,994,956 (GRCm39) missense
Predicted Primers PCR Primer
(F):5'- GACCCAATGTTGTCACTCTGTC -3'
(R):5'- AGCCATCCCTGAAATTGCAAAG -3'

Sequencing Primer
(F):5'- CCAGTTACAAAATGGCATTGGC -3'
(R):5'- TCCCTGAAATTGCAAAGATCAGC -3'
Posted On 2019-09-13