Incidental Mutation 'R7401:Cacna1b'
ID 574143
Institutional Source Beutler Lab
Gene Symbol Cacna1b
Ensembl Gene ENSMUSG00000004113
Gene Name calcium channel, voltage-dependent, N type, alpha 1B subunit
Synonyms alpha(1B), Cav2.2, Cchn1a
MMRRC Submission 045483-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R7401 (G1)
Quality Score 225.009
Status Not validated
Chromosome 2
Chromosomal Location 24493899-24653164 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 24569306 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 873 (T873S)
Ref Sequence ENSEMBL: ENSMUSP00000037416 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000041342] [ENSMUST00000070864] [ENSMUST00000100348] [ENSMUST00000102939] [ENSMUST00000114447] [ENSMUST00000124183]
AlphaFold O55017
Predicted Effect probably benign
Transcript: ENSMUST00000041342
AA Change: T873S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000037416
Gene: ENSMUSG00000004113
AA Change: T873S

DomainStartEndE-ValueType
low complexity region 9 40 N/A INTRINSIC
Pfam:Ion_trans 133 355 1.2e-57 PFAM
PDB:4DEX|B 358 467 8e-66 PDB
Pfam:Ion_trans 516 708 1.1e-47 PFAM
Pfam:PKD_channel 569 715 2.3e-7 PFAM
low complexity region 728 739 N/A INTRINSIC
low complexity region 849 858 N/A INTRINSIC
low complexity region 903 913 N/A INTRINSIC
low complexity region 916 933 N/A INTRINSIC
low complexity region 1091 1102 N/A INTRINSIC
Pfam:Ion_trans 1174 1408 2.7e-52 PFAM
Pfam:Ion_trans 1498 1698 1.2e-59 PFAM
Pfam:PKD_channel 1551 1705 8.1e-9 PFAM
Ca_chan_IQ 1837 1871 1.09e-11 SMART
low complexity region 2040 2050 N/A INTRINSIC
low complexity region 2092 2114 N/A INTRINSIC
low complexity region 2276 2292 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000070864
AA Change: T872S

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000063236
Gene: ENSMUSG00000004113
AA Change: T872S

DomainStartEndE-ValueType
low complexity region 9 40 N/A INTRINSIC
Pfam:Ion_trans 133 355 1.4e-57 PFAM
PDB:4DEX|B 358 467 8e-66 PDB
Pfam:Ion_trans 516 708 1.2e-47 PFAM
Pfam:PKD_channel 569 715 1.5e-7 PFAM
low complexity region 728 739 N/A INTRINSIC
low complexity region 848 857 N/A INTRINSIC
low complexity region 902 912 N/A INTRINSIC
low complexity region 915 932 N/A INTRINSIC
low complexity region 1090 1101 N/A INTRINSIC
Pfam:Ion_trans 1173 1403 1.8e-52 PFAM
Pfam:Ion_trans 1493 1695 5.4e-60 PFAM
Pfam:PKD_channel 1544 1702 4.9e-9 PFAM
Ca_chan_IQ 1798 1832 7.2e-12 SMART
low complexity region 2001 2011 N/A INTRINSIC
low complexity region 2053 2075 N/A INTRINSIC
low complexity region 2237 2253 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000100348
AA Change: T874S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000097920
Gene: ENSMUSG00000004113
AA Change: T874S

DomainStartEndE-ValueType
low complexity region 9 40 N/A INTRINSIC
Pfam:Ion_trans 133 355 1.4e-57 PFAM
PDB:4DEX|B 358 468 5e-68 PDB
Pfam:Ion_trans 517 709 1.2e-47 PFAM
Pfam:PKD_channel 570 716 1.6e-7 PFAM
low complexity region 729 740 N/A INTRINSIC
low complexity region 850 859 N/A INTRINSIC
low complexity region 904 914 N/A INTRINSIC
low complexity region 917 934 N/A INTRINSIC
low complexity region 1092 1103 N/A INTRINSIC
Pfam:Ion_trans 1175 1409 3.2e-52 PFAM
Pfam:Ion_trans 1499 1699 1.4e-59 PFAM
Pfam:PKD_channel 1552 1706 5.6e-9 PFAM
Ca_chan_IQ 1838 1872 1.09e-11 SMART
low complexity region 2041 2051 N/A INTRINSIC
low complexity region 2093 2115 N/A INTRINSIC
low complexity region 2277 2293 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000102939
AA Change: T873S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000100003
Gene: ENSMUSG00000004113
AA Change: T873S

DomainStartEndE-ValueType
low complexity region 9 40 N/A INTRINSIC
Pfam:Ion_trans 133 355 1.4e-57 PFAM
PDB:4DEX|B 358 467 1e-65 PDB
Pfam:Ion_trans 516 708 1.2e-47 PFAM
Pfam:PKD_channel 569 715 1.6e-7 PFAM
low complexity region 728 739 N/A INTRINSIC
low complexity region 849 858 N/A INTRINSIC
low complexity region 903 913 N/A INTRINSIC
low complexity region 916 933 N/A INTRINSIC
low complexity region 1091 1102 N/A INTRINSIC
Pfam:Ion_trans 1174 1404 1.9e-52 PFAM
Pfam:Ion_trans 1494 1696 5.5e-60 PFAM
Pfam:PKD_channel 1545 1703 5e-9 PFAM
Ca_chan_IQ 1835 1869 1.09e-11 SMART
low complexity region 2038 2048 N/A INTRINSIC
low complexity region 2090 2112 N/A INTRINSIC
low complexity region 2274 2290 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000114447
AA Change: T874S

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000110090
Gene: ENSMUSG00000004113
AA Change: T874S

DomainStartEndE-ValueType
low complexity region 9 40 N/A INTRINSIC
Pfam:Ion_trans 94 367 8.5e-69 PFAM
Pfam:Ion_trans 482 721 2.4e-57 PFAM
Pfam:PKD_channel 571 715 1e-7 PFAM
low complexity region 729 740 N/A INTRINSIC
low complexity region 850 859 N/A INTRINSIC
low complexity region 904 914 N/A INTRINSIC
low complexity region 917 934 N/A INTRINSIC
low complexity region 1092 1103 N/A INTRINSIC
Pfam:Ion_trans 1139 1421 1.3e-62 PFAM
Pfam:Ion_trans 1464 1711 3.2e-64 PFAM
Pfam:PKD_channel 1550 1706 2.7e-9 PFAM
Pfam:GPHH 1713 1783 1.9e-39 PFAM
Ca_chan_IQ 1838 1872 1.09e-11 SMART
low complexity region 2041 2051 N/A INTRINSIC
low complexity region 2093 2115 N/A INTRINSIC
low complexity region 2277 2293 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000124183
SMART Domains Protein: ENSMUSP00000114605
Gene: ENSMUSG00000004113

DomainStartEndE-ValueType
low complexity region 6 17 N/A INTRINSIC
low complexity region 44 60 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice deficient in this gene exhibit defects in nociception, memory and learning. They also exhibit hyperactive and hyperaggressive behaviors as well as defects in the the sleep-wake cycle. Deficits in the sympathetic nervous system results in defects in circulatory regulation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2610318N02Rik A T 16: 16,936,268 (GRCm39) L152Q probably benign Het
Abcg3 A T 5: 105,114,640 (GRCm39) N292K probably damaging Het
Adamts3 T A 5: 89,855,309 (GRCm39) probably null Het
Adgrg7 T C 16: 56,562,781 (GRCm39) N519D probably benign Het
Adsl A G 15: 80,846,983 (GRCm39) H263R probably damaging Het
Ak9 A T 10: 41,299,000 (GRCm39) D1567V unknown Het
Bscl2 T C 19: 8,823,914 (GRCm39) F280L possibly damaging Het
Cacna1c T C 6: 119,029,669 (GRCm39) probably null Het
Cast G T 13: 74,956,577 (GRCm39) A18E unknown Het
Cd207 A C 6: 83,654,830 (GRCm39) probably benign Het
Cd79b A G 11: 106,203,678 (GRCm39) S130P probably benign Het
Cfap52 A T 11: 67,840,459 (GRCm39) N157K probably benign Het
Cfap57 C T 4: 118,472,128 (GRCm39) V84I probably benign Het
Chaf1b G T 16: 93,681,268 (GRCm39) probably benign Het
Cntn1 A G 15: 92,215,870 (GRCm39) I968V probably benign Het
Cntn5 C T 9: 9,833,466 (GRCm39) V362I probably benign Het
Crem A G 18: 3,295,329 (GRCm39) S80P probably damaging Het
Csnk1g3 C T 18: 54,063,390 (GRCm39) T267I probably damaging Het
Cyth1 A T 11: 118,073,077 (GRCm39) N274K possibly damaging Het
Dicer1 C T 12: 104,678,537 (GRCm39) G594S probably benign Het
Enpp1 C T 10: 24,521,180 (GRCm39) C849Y probably damaging Het
Fam193a A G 5: 34,622,979 (GRCm39) E1189G possibly damaging Het
Fermt1 C A 2: 132,759,479 (GRCm39) V426L probably benign Het
Fes A G 7: 80,028,524 (GRCm39) probably null Het
Gmeb1 C A 4: 131,953,085 (GRCm39) L560F probably damaging Het
Hace1 T C 10: 45,546,722 (GRCm39) L452P probably damaging Het
Hecw2 T A 1: 53,943,502 (GRCm39) H975L probably damaging Het
Idh2 GGTCCCAG GG 7: 79,748,077 (GRCm39) probably benign Het
Il1r2 T A 1: 40,162,370 (GRCm39) C338S probably damaging Het
Iqcn T C 8: 71,169,921 (GRCm39) I1337T probably benign Het
Kcnb1 T C 2: 167,030,204 (GRCm39) S114G probably damaging Het
Lce1c A T 3: 92,587,623 (GRCm39) T17S unknown Het
Lhfpl4 C A 6: 113,153,627 (GRCm39) L141F possibly damaging Het
Ms4a14 T C 19: 11,279,594 (GRCm39) E988G possibly damaging Het
Naip5 T C 13: 100,356,204 (GRCm39) Q1137R probably benign Het
Naip5 G T 13: 100,356,205 (GRCm39) Q1137K not run Het
Neurod1 T A 2: 79,285,290 (GRCm39) D31V probably benign Het
Neurod4 A G 10: 130,106,927 (GRCm39) C116R probably damaging Het
Nisch A G 14: 30,928,537 (GRCm39) V28A probably benign Het
Odad1 A C 7: 45,592,189 (GRCm39) Q323P probably damaging Het
Or4a72 A G 2: 89,405,449 (GRCm39) V207A probably benign Het
Or5d44 T G 2: 88,141,772 (GRCm39) M123L probably benign Het
Pabpc4l T A 3: 46,401,024 (GRCm39) R207W probably damaging Het
Pabpc4l A T 3: 46,400,687 (GRCm39) I319N probably damaging Het
Pcm1 G A 8: 41,762,568 (GRCm39) D1371N probably damaging Het
Peg10 G GGTC 6: 4,756,452 (GRCm39) probably benign Het
Plxnc1 C T 10: 94,706,867 (GRCm39) A557T probably benign Het
Prkdc T A 16: 15,466,602 (GRCm39) V58D probably damaging Het
Prpf40a A G 2: 53,046,959 (GRCm39) V259A probably benign Het
Psmd3 A T 11: 98,576,466 (GRCm39) T123S probably benign Het
Ptgr2 G T 12: 84,339,103 (GRCm39) probably benign Het
Ptprr A G 10: 115,884,141 (GRCm39) H66R probably benign Het
Rftn2 A G 1: 55,233,401 (GRCm39) probably null Het
Rsph14 T A 10: 74,865,628 (GRCm39) E70V possibly damaging Het
Slc24a5 G A 2: 124,930,111 (GRCm39) V471I probably benign Het
Sorbs1 G C 19: 40,365,244 (GRCm39) R180G probably benign Het
Spag9 A T 11: 93,988,515 (GRCm39) T862S probably benign Het
Ssbp2 T A 13: 91,839,002 (GRCm39) D291E probably benign Het
Supt5 T C 7: 28,023,197 (GRCm39) K329E probably damaging Het
Syne2 G T 12: 76,014,155 (GRCm39) K3115N probably damaging Het
Tars1 A T 15: 11,392,095 (GRCm39) L239* probably null Het
Tbxa2r T C 10: 81,168,625 (GRCm39) Y105H probably benign Het
Tesk1 T A 4: 43,445,743 (GRCm39) D265E probably damaging Het
Tril T C 6: 53,795,266 (GRCm39) D652G possibly damaging Het
Tsga10 T C 1: 37,873,268 (GRCm39) R204G probably null Het
Twnk A G 19: 45,000,219 (GRCm39) D645G probably benign Het
Umodl1 A T 17: 31,217,122 (GRCm39) D1118V probably damaging Het
Unc119 T C 11: 78,238,071 (GRCm39) I83T probably benign Het
Unc80 T C 1: 66,685,574 (GRCm39) W2233R possibly damaging Het
Vmn1r45 T A 6: 89,910,416 (GRCm39) T185S possibly damaging Het
Vmn2r111 G T 17: 22,790,067 (GRCm39) T313K possibly damaging Het
Wdr4 A G 17: 31,728,806 (GRCm39) L123S probably damaging Het
Zfpm2 A G 15: 40,966,386 (GRCm39) E957G possibly damaging Het
Other mutations in Cacna1b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00502:Cacna1b APN 2 24,541,212 (GRCm39) nonsense probably null
IGL00508:Cacna1b APN 2 24,547,301 (GRCm39) critical splice donor site probably null
IGL01085:Cacna1b APN 2 24,569,006 (GRCm39) missense probably damaging 0.98
IGL01310:Cacna1b APN 2 24,575,794 (GRCm39) missense probably damaging 1.00
IGL01361:Cacna1b APN 2 24,569,107 (GRCm39) missense possibly damaging 0.49
IGL01471:Cacna1b APN 2 24,547,304 (GRCm39) missense probably damaging 1.00
IGL01537:Cacna1b APN 2 24,548,540 (GRCm39) missense probably damaging 1.00
IGL01547:Cacna1b APN 2 24,522,047 (GRCm39) unclassified probably benign
IGL01750:Cacna1b APN 2 24,544,407 (GRCm39) missense probably damaging 1.00
IGL01813:Cacna1b APN 2 24,499,902 (GRCm39) missense probably damaging 1.00
IGL01939:Cacna1b APN 2 24,551,769 (GRCm39) missense probably damaging 1.00
IGL01955:Cacna1b APN 2 24,529,149 (GRCm39) missense probably damaging 1.00
IGL01972:Cacna1b APN 2 24,525,107 (GRCm39) critical splice donor site probably null
IGL01987:Cacna1b APN 2 24,587,579 (GRCm39) splice site probably null
IGL02096:Cacna1b APN 2 24,568,927 (GRCm39) missense probably benign 0.01
IGL02111:Cacna1b APN 2 24,497,003 (GRCm39) missense probably damaging 0.96
IGL02254:Cacna1b APN 2 24,506,827 (GRCm39) splice site probably null
IGL03084:Cacna1b APN 2 24,499,944 (GRCm39) missense probably benign
IGL03184:Cacna1b APN 2 24,548,501 (GRCm39) critical splice donor site probably null
IGL03202:Cacna1b APN 2 24,541,124 (GRCm39) missense probably damaging 1.00
IGL03210:Cacna1b APN 2 24,540,584 (GRCm39) missense probably benign 0.00
IGL03402:Cacna1b APN 2 24,652,821 (GRCm39) missense probably damaging 1.00
PIT4283001:Cacna1b UTSW 2 24,521,953 (GRCm39) missense probably damaging 1.00
R0062:Cacna1b UTSW 2 24,648,343 (GRCm39) missense probably damaging 1.00
R0062:Cacna1b UTSW 2 24,648,343 (GRCm39) missense probably damaging 1.00
R0206:Cacna1b UTSW 2 24,497,492 (GRCm39) missense probably damaging 1.00
R0208:Cacna1b UTSW 2 24,497,492 (GRCm39) missense probably damaging 1.00
R0240:Cacna1b UTSW 2 24,528,669 (GRCm39) unclassified probably benign
R0265:Cacna1b UTSW 2 24,651,856 (GRCm39) missense probably damaging 1.00
R0352:Cacna1b UTSW 2 24,515,244 (GRCm39) intron probably benign
R0376:Cacna1b UTSW 2 24,549,015 (GRCm39) splice site probably benign
R0383:Cacna1b UTSW 2 24,651,856 (GRCm39) missense probably damaging 1.00
R0432:Cacna1b UTSW 2 24,577,716 (GRCm39) missense probably damaging 1.00
R0595:Cacna1b UTSW 2 24,540,001 (GRCm39) splice site probably benign
R0660:Cacna1b UTSW 2 24,544,458 (GRCm39) missense probably damaging 1.00
R0664:Cacna1b UTSW 2 24,544,458 (GRCm39) missense probably damaging 1.00
R1107:Cacna1b UTSW 2 24,587,615 (GRCm39) missense probably damaging 1.00
R1184:Cacna1b UTSW 2 24,577,757 (GRCm39) splice site probably null
R1445:Cacna1b UTSW 2 24,608,148 (GRCm39) splice site probably benign
R1446:Cacna1b UTSW 2 24,596,189 (GRCm39) missense probably benign 0.01
R1496:Cacna1b UTSW 2 24,568,047 (GRCm39) missense probably benign
R1614:Cacna1b UTSW 2 24,580,819 (GRCm39) missense possibly damaging 0.88
R1626:Cacna1b UTSW 2 24,496,721 (GRCm39) missense probably damaging 1.00
R1917:Cacna1b UTSW 2 24,506,891 (GRCm39) missense probably null 0.80
R1984:Cacna1b UTSW 2 24,538,998 (GRCm39) missense probably damaging 1.00
R1986:Cacna1b UTSW 2 24,538,998 (GRCm39) missense probably damaging 1.00
R1989:Cacna1b UTSW 2 24,611,386 (GRCm39) missense probably damaging 1.00
R1990:Cacna1b UTSW 2 24,622,318 (GRCm39) missense probably damaging 1.00
R1991:Cacna1b UTSW 2 24,622,318 (GRCm39) missense probably damaging 1.00
R1992:Cacna1b UTSW 2 24,622,318 (GRCm39) missense probably damaging 1.00
R2098:Cacna1b UTSW 2 24,540,558 (GRCm39) missense probably damaging 1.00
R2139:Cacna1b UTSW 2 24,569,485 (GRCm39) missense probably benign 0.07
R2196:Cacna1b UTSW 2 24,651,800 (GRCm39) missense probably damaging 1.00
R2229:Cacna1b UTSW 2 24,575,816 (GRCm39) missense probably damaging 1.00
R2292:Cacna1b UTSW 2 24,496,632 (GRCm39) missense probably benign 0.01
R2570:Cacna1b UTSW 2 24,496,649 (GRCm39) nonsense probably null
R2850:Cacna1b UTSW 2 24,651,800 (GRCm39) missense probably damaging 1.00
R2911:Cacna1b UTSW 2 24,497,553 (GRCm39) splice site probably null
R2937:Cacna1b UTSW 2 24,496,540 (GRCm39) missense probably benign 0.00
R2938:Cacna1b UTSW 2 24,496,540 (GRCm39) missense probably benign 0.00
R3522:Cacna1b UTSW 2 24,653,055 (GRCm39) missense possibly damaging 0.94
R3800:Cacna1b UTSW 2 24,548,971 (GRCm39) missense probably benign 0.15
R4166:Cacna1b UTSW 2 24,567,923 (GRCm39) missense probably benign 0.32
R4300:Cacna1b UTSW 2 24,525,251 (GRCm39) missense probably damaging 1.00
R4366:Cacna1b UTSW 2 24,592,632 (GRCm39) missense probably damaging 1.00
R4493:Cacna1b UTSW 2 24,542,950 (GRCm39) missense probably damaging 0.99
R4494:Cacna1b UTSW 2 24,542,950 (GRCm39) missense probably damaging 0.99
R4522:Cacna1b UTSW 2 24,544,442 (GRCm39) missense probably damaging 1.00
R4612:Cacna1b UTSW 2 24,516,864 (GRCm39) nonsense probably null
R4673:Cacna1b UTSW 2 24,521,956 (GRCm39) missense probably damaging 1.00
R4703:Cacna1b UTSW 2 24,544,475 (GRCm39) missense probably damaging 1.00
R4704:Cacna1b UTSW 2 24,544,475 (GRCm39) missense probably damaging 1.00
R4777:Cacna1b UTSW 2 24,622,337 (GRCm39) missense probably damaging 1.00
R4795:Cacna1b UTSW 2 24,527,499 (GRCm39) missense possibly damaging 0.58
R4796:Cacna1b UTSW 2 24,527,499 (GRCm39) missense possibly damaging 0.58
R4962:Cacna1b UTSW 2 24,547,378 (GRCm39) missense probably damaging 1.00
R4962:Cacna1b UTSW 2 24,508,330 (GRCm39) missense probably damaging 1.00
R4974:Cacna1b UTSW 2 24,538,535 (GRCm39) missense probably damaging 0.99
R4990:Cacna1b UTSW 2 24,568,886 (GRCm39) critical splice donor site probably null
R5109:Cacna1b UTSW 2 24,580,797 (GRCm39) missense possibly damaging 0.88
R5117:Cacna1b UTSW 2 24,622,340 (GRCm39) missense probably damaging 1.00
R5176:Cacna1b UTSW 2 24,525,143 (GRCm39) missense probably damaging 1.00
R5253:Cacna1b UTSW 2 24,609,964 (GRCm39) missense probably damaging 1.00
R5372:Cacna1b UTSW 2 24,623,971 (GRCm39) missense probably damaging 1.00
R5374:Cacna1b UTSW 2 24,596,228 (GRCm39) missense probably damaging 1.00
R5465:Cacna1b UTSW 2 24,540,438 (GRCm39) critical splice donor site probably null
R5568:Cacna1b UTSW 2 24,497,612 (GRCm39) missense probably damaging 1.00
R5580:Cacna1b UTSW 2 24,540,566 (GRCm39) missense probably damaging 1.00
R5677:Cacna1b UTSW 2 24,569,370 (GRCm39) missense possibly damaging 0.64
R6277:Cacna1b UTSW 2 24,620,808 (GRCm39) missense probably damaging 1.00
R6294:Cacna1b UTSW 2 24,609,069 (GRCm39) missense possibly damaging 0.94
R6609:Cacna1b UTSW 2 24,543,061 (GRCm39) missense probably damaging 1.00
R6929:Cacna1b UTSW 2 24,522,022 (GRCm39) missense probably damaging 1.00
R7016:Cacna1b UTSW 2 24,652,860 (GRCm39) missense possibly damaging 0.77
R7112:Cacna1b UTSW 2 24,580,773 (GRCm39) missense probably damaging 0.97
R7162:Cacna1b UTSW 2 24,590,034 (GRCm39) missense probably benign 0.06
R7402:Cacna1b UTSW 2 24,497,671 (GRCm39) missense probably benign 0.21
R7442:Cacna1b UTSW 2 24,497,513 (GRCm39) missense probably benign
R7450:Cacna1b UTSW 2 24,525,147 (GRCm39) nonsense probably null
R7481:Cacna1b UTSW 2 24,506,874 (GRCm39) missense probably damaging 0.99
R7792:Cacna1b UTSW 2 24,567,977 (GRCm39) missense probably damaging 0.99
R7999:Cacna1b UTSW 2 24,540,638 (GRCm39) missense probably damaging 1.00
R8041:Cacna1b UTSW 2 24,547,311 (GRCm39) missense probably damaging 1.00
R8084:Cacna1b UTSW 2 24,575,808 (GRCm39) missense probably benign 0.21
R8147:Cacna1b UTSW 2 24,569,188 (GRCm39) missense probably damaging 0.97
R8170:Cacna1b UTSW 2 24,568,886 (GRCm39) critical splice donor site probably null
R8371:Cacna1b UTSW 2 24,610,036 (GRCm39) missense possibly damaging 0.46
R8391:Cacna1b UTSW 2 24,596,212 (GRCm39) missense probably damaging 1.00
R8723:Cacna1b UTSW 2 24,548,510 (GRCm39) missense probably damaging 1.00
R8836:Cacna1b UTSW 2 24,542,982 (GRCm39) missense possibly damaging 0.93
R8856:Cacna1b UTSW 2 24,569,530 (GRCm39) missense probably benign 0.00
R8922:Cacna1b UTSW 2 24,622,340 (GRCm39) missense possibly damaging 0.94
R8940:Cacna1b UTSW 2 24,653,084 (GRCm39) unclassified probably benign
R9140:Cacna1b UTSW 2 24,525,224 (GRCm39) missense probably damaging 1.00
R9414:Cacna1b UTSW 2 24,538,514 (GRCm39) missense probably damaging 0.99
R9476:Cacna1b UTSW 2 24,540,058 (GRCm39) missense probably damaging 0.99
R9510:Cacna1b UTSW 2 24,540,058 (GRCm39) missense probably damaging 0.99
R9520:Cacna1b UTSW 2 24,651,799 (GRCm39) missense probably damaging 0.97
R9566:Cacna1b UTSW 2 24,498,092 (GRCm39) nonsense probably null
R9671:Cacna1b UTSW 2 24,596,282 (GRCm39) missense probably benign 0.00
R9757:Cacna1b UTSW 2 24,609,113 (GRCm39) missense probably damaging 0.99
R9784:Cacna1b UTSW 2 24,651,801 (GRCm39) missense possibly damaging 0.88
R9797:Cacna1b UTSW 2 24,508,287 (GRCm39) missense probably damaging 1.00
Z1088:Cacna1b UTSW 2 24,623,957 (GRCm39) missense probably damaging 1.00
Z1088:Cacna1b UTSW 2 24,551,856 (GRCm39) missense probably damaging 1.00
Z1176:Cacna1b UTSW 2 24,516,896 (GRCm39) nonsense probably null
Z1177:Cacna1b UTSW 2 24,569,000 (GRCm39) missense probably damaging 0.97
Z1177:Cacna1b UTSW 2 24,551,802 (GRCm39) missense probably damaging 1.00
Z1177:Cacna1b UTSW 2 24,528,689 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TGCTTGAGTCCTGTGCATGC -3'
(R):5'- CCATGTGAGGCCAGACATGAAG -3'

Sequencing Primer
(F):5'- AGTCCTGTGCATGCCGGTG -3'
(R):5'- ACATGGACCGACCCCTAGTG -3'
Posted On 2019-09-13