|Institutional Source||Beutler Lab|
|Gene Name||a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 3|
|Is this an essential gene?||Essential (E-score: 1.000)|
|Stock #||R7401 (G1)|
|Chromosomal Location||89677087-89883334 bp(-) (GRCm38)|
|Type of Mutation||critical splice acceptor site|
|DNA Base Change (assembly)||T to A at 89707450 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000132219 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000061427] [ENSMUST00000163159]|
|Coding Region Coverage||
|MGI Phenotype||FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease, a member of the procollagen aminopropeptidase subfamily of proteins, may play a role in the processing of type II fibrillar collagen in articular cartilage. [provided by RefSeq, Feb 2016]|
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Adamts3||
(F):5'- TGTGTAGCCTATGCAGCAGG -3'
(R):5'- ATGAGTAACTCTGTTTGGCTGAGC -3'
(F):5'- TGCAGCAGGGCATGACATG -3'
(R):5'- TACCTGTGCTGTGCCACTGATG -3'