Incidental Mutation 'R7403:Vldlr'
| ID |
574385 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vldlr
|
| Ensembl Gene |
ENSMUSG00000024924 |
| Gene Name |
very low density lipoprotein receptor |
| Synonyms |
|
| MMRRC Submission |
045485-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.285)
|
| Stock # |
R7403 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
27193884-27231631 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 27213674 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Stop codon
at position 120
(C120*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000127329
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025866]
[ENSMUST00000047645]
[ENSMUST00000164746]
[ENSMUST00000165761]
[ENSMUST00000167487]
[ENSMUST00000172302]
|
| AlphaFold |
P98156 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000025866
AA Change: C120*
|
| SMART Domains |
Protein: ENSMUSP00000025866
Gene: ENSMUSG00000024924
AA Change: C120*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
5.81e-15 |
SMART |
|
LDLa
|
112 |
151 |
1.96e-12 |
SMART |
|
LDLa
|
153 |
190 |
7.15e-15 |
SMART |
|
LDLa
|
192 |
231 |
1.23e-13 |
SMART |
|
LDLa
|
238 |
275 |
1.1e-15 |
SMART |
|
LDLa
|
277 |
314 |
1.13e-12 |
SMART |
|
LDLa
|
317 |
357 |
3.86e-11 |
SMART |
|
EGF_CA
|
356 |
395 |
1e-5 |
SMART |
|
EGF_CA
|
396 |
435 |
6.1e-10 |
SMART |
|
Blast:LY
|
461 |
495 |
4e-15 |
BLAST |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000047645
|
| SMART Domains |
Protein: ENSMUSP00000049145
Gene: ENSMUSG00000024924
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
1.25e-14 |
SMART |
|
LDLa
|
112 |
149 |
7.15e-15 |
SMART |
|
LDLa
|
151 |
190 |
1.23e-13 |
SMART |
|
LDLa
|
197 |
234 |
1.1e-15 |
SMART |
|
LDLa
|
236 |
273 |
1.13e-12 |
SMART |
|
LDLa
|
276 |
316 |
3.86e-11 |
SMART |
|
EGF_CA
|
315 |
354 |
1e-5 |
SMART |
|
EGF_CA
|
355 |
394 |
6.1e-10 |
SMART |
|
LY
|
420 |
462 |
2.16e-1 |
SMART |
|
LY
|
464 |
506 |
9.54e-12 |
SMART |
|
LY
|
507 |
550 |
2.22e-12 |
SMART |
|
LY
|
551 |
593 |
1.66e-11 |
SMART |
|
LY
|
594 |
637 |
5.97e-4 |
SMART |
|
EGF
|
664 |
709 |
2.16e-1 |
SMART |
|
transmembrane domain
|
728 |
750 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000164746
|
| SMART Domains |
Protein: ENSMUSP00000128193
Gene: ENSMUSG00000024924
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165761
|
| SMART Domains |
Protein: ENSMUSP00000130382
Gene: ENSMUSG00000024924
| Domain | Start | End | E-Value | Type |
|---|
|
LDLa
|
1 |
26 |
1.58e0 |
SMART |
|
EGF
|
28 |
64 |
4e-5 |
SMART |
|
LY
|
88 |
130 |
2.16e-1 |
SMART |
|
LY
|
132 |
174 |
9.54e-12 |
SMART |
|
LY
|
175 |
218 |
2.22e-12 |
SMART |
|
LY
|
219 |
258 |
3.25e-5 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000167487
AA Change: C120*
|
| SMART Domains |
Protein: ENSMUSP00000127329
Gene: ENSMUSG00000024924
AA Change: C120*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
5.81e-15 |
SMART |
|
LDLa
|
112 |
151 |
1.96e-12 |
SMART |
|
LDLa
|
153 |
190 |
7.15e-15 |
SMART |
|
LDLa
|
192 |
231 |
1.23e-13 |
SMART |
|
LDLa
|
238 |
275 |
1.1e-15 |
SMART |
|
LDLa
|
277 |
314 |
1.13e-12 |
SMART |
|
LDLa
|
317 |
357 |
3.86e-11 |
SMART |
|
EGF_CA
|
356 |
395 |
1e-5 |
SMART |
|
EGF_CA
|
396 |
435 |
6.1e-10 |
SMART |
|
LY
|
461 |
503 |
2.16e-1 |
SMART |
|
LY
|
505 |
547 |
9.54e-12 |
SMART |
|
LY
|
548 |
591 |
2.22e-12 |
SMART |
|
LY
|
592 |
634 |
1.66e-11 |
SMART |
|
LY
|
635 |
678 |
5.97e-4 |
SMART |
|
EGF
|
705 |
750 |
2.16e-1 |
SMART |
|
transmembrane domain
|
797 |
819 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000172302
AA Change: C120*
|
| SMART Domains |
Protein: ENSMUSP00000126730
Gene: ENSMUSG00000024924
AA Change: C120*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
EGF_like
|
32 |
68 |
7.38e1 |
SMART |
|
LDLa
|
32 |
69 |
1.69e-16 |
SMART |
|
LDLa
|
71 |
110 |
5.81e-15 |
SMART |
|
LDLa
|
112 |
151 |
1.96e-12 |
SMART |
|
LDLa
|
153 |
190 |
7.15e-15 |
SMART |
|
LDLa
|
192 |
231 |
1.23e-13 |
SMART |
|
LDLa
|
238 |
275 |
1.1e-15 |
SMART |
|
LDLa
|
277 |
314 |
1.13e-12 |
SMART |
|
LDLa
|
317 |
357 |
3.86e-11 |
SMART |
|
EGF_CA
|
356 |
395 |
1e-5 |
SMART |
|
EGF_CA
|
396 |
435 |
6.1e-10 |
SMART |
|
LY
|
461 |
503 |
2.16e-1 |
SMART |
|
LY
|
505 |
547 |
9.54e-12 |
SMART |
|
LY
|
548 |
591 |
2.22e-12 |
SMART |
|
LY
|
592 |
634 |
1.66e-11 |
SMART |
|
LY
|
635 |
678 |
5.97e-4 |
SMART |
|
EGF
|
705 |
750 |
2.16e-1 |
SMART |
|
transmembrane domain
|
769 |
791 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.0%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. This gene encodes a lipoprotein receptor that is a member of the LDLR family and plays important roles in VLDL-triglyceride metabolism and the reelin signaling pathway. Mutations in this gene cause VLDLR-associated cerebellar hypoplasia. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene. [provided by RefSeq, Aug 2009]
PHENOTYPE: Homozygous null mutants exhibit modest reductions in body weight and adiposity. In behavioral tests, mutants display deficits in contextual fear conditioning and long term potentiation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 75 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Appl2 |
G |
A |
10: 83,450,059 (GRCm39) |
A271V |
probably benign |
Het |
| Brpf3 |
C |
T |
17: 29,040,330 (GRCm39) |
T917I |
probably benign |
Het |
| Camta1 |
G |
A |
4: 151,537,752 (GRCm39) |
Q143* |
probably null |
Het |
| Cd3e |
C |
A |
9: 44,913,590 (GRCm39) |
E48D |
probably benign |
Het |
| Clca3b |
A |
G |
3: 144,529,259 (GRCm39) |
L805P |
probably benign |
Het |
| Crispld1 |
A |
G |
1: 17,817,820 (GRCm39) |
Y241C |
probably damaging |
Het |
| Ddx43 |
T |
G |
9: 78,321,133 (GRCm39) |
N380K |
probably damaging |
Het |
| Dtl |
A |
T |
1: 191,295,285 (GRCm39) |
V155E |
probably damaging |
Het |
| Eif1ad19 |
G |
T |
12: 87,740,314 (GRCm39) |
Q82K |
probably benign |
Het |
| Elp1 |
A |
T |
4: 56,778,994 (GRCm39) |
C608S |
probably damaging |
Het |
| Elp2 |
A |
G |
18: 24,752,542 (GRCm39) |
H365R |
probably damaging |
Het |
| Fam78a |
T |
C |
2: 31,959,627 (GRCm39) |
N161S |
probably damaging |
Het |
| Far2 |
T |
C |
6: 148,060,475 (GRCm39) |
I276T |
possibly damaging |
Het |
| Frem3 |
T |
C |
8: 81,342,774 (GRCm39) |
L1689P |
probably damaging |
Het |
| Gak |
T |
C |
5: 108,761,401 (GRCm39) |
K210R |
probably benign |
Het |
| Gna14 |
G |
T |
19: 16,576,445 (GRCm39) |
D151Y |
|
Het |
| Hdhd2 |
A |
G |
18: 77,042,736 (GRCm39) |
D55G |
probably benign |
Het |
| Hycc2 |
A |
T |
1: 58,587,861 (GRCm39) |
D117E |
possibly damaging |
Het |
| Ifna5 |
A |
G |
4: 88,754,110 (GRCm39) |
N117D |
probably benign |
Het |
| Il16 |
T |
A |
7: 83,319,343 (GRCm39) |
T383S |
probably damaging |
Het |
| Il36rn |
T |
C |
2: 24,171,214 (GRCm39) |
F101L |
probably damaging |
Het |
| Ino80d |
A |
G |
1: 63,101,378 (GRCm39) |
V416A |
possibly damaging |
Het |
| Ints6 |
T |
C |
14: 62,945,104 (GRCm39) |
R409G |
possibly damaging |
Het |
| Itgb5 |
G |
T |
16: 33,723,163 (GRCm39) |
|
probably null |
Het |
| Itprid1 |
T |
A |
6: 55,953,399 (GRCm39) |
L905* |
probably null |
Het |
| Kcnq3 |
T |
A |
15: 65,874,066 (GRCm39) |
R561W |
probably damaging |
Het |
| Lipo4 |
C |
T |
19: 33,480,679 (GRCm39) |
E230K |
possibly damaging |
Het |
| Lrrc7 |
A |
T |
3: 157,854,311 (GRCm39) |
L1299* |
probably null |
Het |
| Mcm3ap |
T |
C |
10: 76,318,657 (GRCm39) |
|
probably null |
Het |
| Mok |
A |
T |
12: 110,781,563 (GRCm39) |
|
probably null |
Het |
| Mylk2 |
T |
A |
2: 152,759,261 (GRCm39) |
V344E |
probably damaging |
Het |
| Oacyl |
T |
C |
18: 65,870,966 (GRCm39) |
V389A |
probably benign |
Het |
| Oplah |
T |
C |
15: 76,189,209 (GRCm39) |
D278G |
probably benign |
Het |
| Or1j8 |
T |
C |
2: 36,192,342 (GRCm39) |
F264L |
probably benign |
Het |
| Or8s5 |
T |
C |
15: 98,238,000 (GRCm39) |
Y290C |
probably damaging |
Het |
| Padi3 |
T |
C |
4: 140,527,430 (GRCm39) |
N124D |
probably benign |
Het |
| Parp3 |
T |
C |
9: 106,352,052 (GRCm39) |
S107G |
probably benign |
Het |
| Pcdhb18 |
G |
A |
18: 37,624,950 (GRCm39) |
G760D |
probably benign |
Het |
| Plekhh1 |
G |
A |
12: 79,087,351 (GRCm39) |
W13* |
probably null |
Het |
| Poglut3 |
T |
A |
9: 53,301,741 (GRCm39) |
V131E |
probably damaging |
Het |
| Pou2f1 |
C |
T |
1: 165,738,955 (GRCm39) |
A166T |
unknown |
Het |
| Ppp1r10 |
C |
T |
17: 36,240,326 (GRCm39) |
P539S |
probably benign |
Het |
| Prdm11 |
T |
C |
2: 92,817,036 (GRCm39) |
T310A |
probably benign |
Het |
| Rbm25 |
A |
G |
12: 83,722,908 (GRCm39) |
Y777C |
probably damaging |
Het |
| Relt |
A |
T |
7: 100,500,655 (GRCm39) |
C72S |
probably damaging |
Het |
| Rhag |
T |
A |
17: 41,145,549 (GRCm39) |
I334N |
probably damaging |
Het |
| Rhbdf2 |
A |
C |
11: 116,491,245 (GRCm39) |
L630R |
probably damaging |
Het |
| Rnps1 |
T |
C |
17: 24,644,061 (GRCm39) |
S274P |
unknown |
Het |
| Rtkn2 |
A |
G |
10: 67,841,466 (GRCm39) |
I205V |
probably benign |
Het |
| Ryr1 |
A |
T |
7: 28,713,292 (GRCm39) |
V4690E |
probably benign |
Het |
| Secisbp2l |
T |
C |
2: 125,602,199 (GRCm39) |
Y387C |
possibly damaging |
Het |
| Sema3d |
A |
T |
5: 12,547,551 (GRCm39) |
I158F |
probably damaging |
Het |
| Slc17a1 |
A |
G |
13: 24,058,690 (GRCm39) |
N48S |
probably benign |
Het |
| Slc2a1 |
G |
A |
4: 118,989,752 (GRCm39) |
G130S |
probably damaging |
Het |
| Slc6a3 |
T |
C |
13: 73,710,546 (GRCm39) |
|
probably null |
Het |
| Snx27 |
A |
T |
3: 94,436,233 (GRCm39) |
S261T |
probably damaging |
Het |
| Spag17 |
A |
T |
3: 99,846,691 (GRCm39) |
I72F |
possibly damaging |
Het |
| Spink6 |
T |
G |
18: 44,204,564 (GRCm39) |
L10R |
unknown |
Het |
| Swt1 |
G |
A |
1: 151,264,444 (GRCm39) |
T690I |
probably benign |
Het |
| Syne2 |
G |
A |
12: 75,962,020 (GRCm39) |
E729K |
not run |
Het |
| Synj2 |
C |
T |
17: 6,088,005 (GRCm39) |
T1352M |
possibly damaging |
Het |
| Taar4 |
G |
A |
10: 23,836,957 (GRCm39) |
G189D |
probably damaging |
Het |
| Thsd4 |
T |
C |
9: 59,964,170 (GRCm39) |
N441D |
probably damaging |
Het |
| Tm9sf2 |
A |
G |
14: 122,378,640 (GRCm39) |
D248G |
probably benign |
Het |
| Tmem69 |
A |
T |
4: 116,410,664 (GRCm39) |
L102Q |
probably damaging |
Het |
| Tshr |
A |
G |
12: 91,464,548 (GRCm39) |
Y98C |
probably damaging |
Het |
| Tspan1 |
A |
G |
4: 116,020,219 (GRCm39) |
V230A |
probably benign |
Het |
| Upk3a |
T |
C |
15: 84,903,709 (GRCm39) |
V136A |
possibly damaging |
Het |
| Ush2a |
T |
A |
1: 188,365,924 (GRCm39) |
N2259K |
probably damaging |
Het |
| Usp24 |
A |
G |
4: 106,264,232 (GRCm39) |
D1721G |
possibly damaging |
Het |
| Vmn2r23 |
A |
T |
6: 123,681,538 (GRCm39) |
I149L |
probably benign |
Het |
| Vps8 |
A |
T |
16: 21,253,722 (GRCm39) |
E21V |
possibly damaging |
Het |
| Wdr35 |
A |
G |
12: 9,062,685 (GRCm39) |
I635V |
probably damaging |
Het |
| Zfp955a |
T |
C |
17: 33,462,720 (GRCm39) |
D58G |
probably benign |
Het |
| Zkscan5 |
A |
G |
5: 145,155,403 (GRCm39) |
Q358R |
probably benign |
Het |
|
| Other mutations in Vldlr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01346:Vldlr
|
APN |
19 |
27,217,081 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL01575:Vldlr
|
APN |
19 |
27,224,031 (GRCm39) |
missense |
probably benign |
|
|
IGL01626:Vldlr
|
APN |
19 |
27,221,173 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02213:Vldlr
|
APN |
19 |
27,218,726 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02365:Vldlr
|
APN |
19 |
27,223,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02488:Vldlr
|
APN |
19 |
27,215,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02708:Vldlr
|
APN |
19 |
27,215,485 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02947:Vldlr
|
APN |
19 |
27,217,120 (GRCm39) |
missense |
probably benign |
0.03 |
|
disturbed
|
UTSW |
19 |
27,216,204 (GRCm39) |
nonsense |
probably null |
|
|
r26
|
UTSW |
19 |
27,223,054 (GRCm39) |
missense |
probably damaging |
0.99 |
|
spotty
|
UTSW |
19 |
27,216,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4142001:Vldlr
|
UTSW |
19 |
27,212,269 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0195:Vldlr
|
UTSW |
19 |
27,215,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0288:Vldlr
|
UTSW |
19 |
27,218,051 (GRCm39) |
splice site |
probably benign |
|
|
R0536:Vldlr
|
UTSW |
19 |
27,217,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0537:Vldlr
|
UTSW |
19 |
27,225,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0542:Vldlr
|
UTSW |
19 |
27,213,655 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0594:Vldlr
|
UTSW |
19 |
27,212,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Vldlr
|
UTSW |
19 |
27,215,663 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R0726:Vldlr
|
UTSW |
19 |
27,215,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1017:Vldlr
|
UTSW |
19 |
27,218,733 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1148:Vldlr
|
UTSW |
19 |
27,218,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1148:Vldlr
|
UTSW |
19 |
27,218,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1443:Vldlr
|
UTSW |
19 |
27,217,121 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R1493:Vldlr
|
UTSW |
19 |
27,218,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1520:Vldlr
|
UTSW |
19 |
27,224,466 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R1520:Vldlr
|
UTSW |
19 |
27,217,943 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1657:Vldlr
|
UTSW |
19 |
27,223,070 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1901:Vldlr
|
UTSW |
19 |
27,218,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2047:Vldlr
|
UTSW |
19 |
27,212,238 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2258:Vldlr
|
UTSW |
19 |
27,215,786 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2273:Vldlr
|
UTSW |
19 |
27,225,415 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2423:Vldlr
|
UTSW |
19 |
27,213,688 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R3196:Vldlr
|
UTSW |
19 |
27,220,554 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3752:Vldlr
|
UTSW |
19 |
27,215,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3801:Vldlr
|
UTSW |
19 |
27,195,021 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3835:Vldlr
|
UTSW |
19 |
27,212,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4027:Vldlr
|
UTSW |
19 |
27,215,713 (GRCm39) |
missense |
probably benign |
|
|
R4301:Vldlr
|
UTSW |
19 |
27,215,802 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4470:Vldlr
|
UTSW |
19 |
27,212,219 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4541:Vldlr
|
UTSW |
19 |
27,216,192 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4765:Vldlr
|
UTSW |
19 |
27,217,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4771:Vldlr
|
UTSW |
19 |
27,217,290 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4795:Vldlr
|
UTSW |
19 |
27,216,252 (GRCm39) |
splice site |
probably null |
|
|
R4839:Vldlr
|
UTSW |
19 |
27,215,465 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5074:Vldlr
|
UTSW |
19 |
27,215,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5134:Vldlr
|
UTSW |
19 |
27,216,212 (GRCm39) |
nonsense |
probably null |
|
|
R5281:Vldlr
|
UTSW |
19 |
27,221,631 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5466:Vldlr
|
UTSW |
19 |
27,217,243 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5514:Vldlr
|
UTSW |
19 |
27,221,624 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5886:Vldlr
|
UTSW |
19 |
27,221,171 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5889:Vldlr
|
UTSW |
19 |
27,217,064 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6110:Vldlr
|
UTSW |
19 |
27,215,477 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6343:Vldlr
|
UTSW |
19 |
27,223,049 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6833:Vldlr
|
UTSW |
19 |
27,217,974 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6838:Vldlr
|
UTSW |
19 |
27,225,370 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7169:Vldlr
|
UTSW |
19 |
27,221,728 (GRCm39) |
missense |
probably benign |
|
|
R7197:Vldlr
|
UTSW |
19 |
27,212,241 (GRCm39) |
missense |
probably benign |
0.36 |
|
R7304:Vldlr
|
UTSW |
19 |
27,216,004 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7658:Vldlr
|
UTSW |
19 |
27,220,536 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7754:Vldlr
|
UTSW |
19 |
27,195,015 (GRCm39) |
start codon destroyed |
probably benign |
0.01 |
|
R8105:Vldlr
|
UTSW |
19 |
27,216,204 (GRCm39) |
nonsense |
probably null |
|
|
R8377:Vldlr
|
UTSW |
19 |
27,212,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8529:Vldlr
|
UTSW |
19 |
27,207,656 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8777:Vldlr
|
UTSW |
19 |
27,217,946 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8777-TAIL:Vldlr
|
UTSW |
19 |
27,217,946 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Vldlr
|
UTSW |
19 |
27,216,192 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R9400:Vldlr
|
UTSW |
19 |
27,216,175 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9483:Vldlr
|
UTSW |
19 |
27,224,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9502:Vldlr
|
UTSW |
19 |
27,218,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9509:Vldlr
|
UTSW |
19 |
27,221,687 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9630:Vldlr
|
UTSW |
19 |
27,207,623 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9767:Vldlr
|
UTSW |
19 |
27,212,274 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9768:Vldlr
|
UTSW |
19 |
27,218,720 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGGTTCTCAGGTACGCTGC -3'
(R):5'- TTCAGGCTTAAGTTAGCATCCC -3'
Sequencing Primer
(F):5'- CGTAGCTTCTAAGGACGGAGCTG -3'
(R):5'- CTTGCCTGCCTTTCTTTAGGAAAAGG -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation