Incidental Mutation 'R7404:Tacc2'
| ID |
574423 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tacc2
|
| Ensembl Gene |
ENSMUSG00000030852 |
| Gene Name |
transforming, acidic coiled-coil containing protein 2 |
| Synonyms |
|
| MMRRC Submission |
045486-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7404 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
130179168-130366515 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 130225066 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 584
(T584S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081561
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000059145]
[ENSMUST00000084513]
[ENSMUST00000124096]
[ENSMUST00000207789]
[ENSMUST00000207918]
[ENSMUST00000208722]
[ENSMUST00000215492]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000059145
|
| SMART Domains |
Protein: ENSMUSP00000061242
Gene: ENSMUSG00000030852
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
87 |
102 |
N/A |
INTRINSIC |
|
low complexity region
|
147 |
173 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
181 |
291 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
345 |
356 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
483 |
566 |
2.03e-5 |
PROSPERO |
|
low complexity region
|
571 |
586 |
N/A |
INTRINSIC |
|
low complexity region
|
603 |
614 |
N/A |
INTRINSIC |
|
low complexity region
|
648 |
662 |
N/A |
INTRINSIC |
|
coiled coil region
|
873 |
900 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
939 |
1145 |
4e-85 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000084513
AA Change: T584S
PolyPhen 2
Score 0.221 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000081561
Gene: ENSMUSG00000030852
AA Change: T584S
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_1
|
19 |
346 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
398 |
410 |
N/A |
INTRINSIC |
|
low complexity region
|
413 |
431 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
778 |
1068 |
3.83e-6 |
PROSPERO |
|
low complexity region
|
1397 |
1415 |
N/A |
INTRINSIC |
|
low complexity region
|
1723 |
1739 |
N/A |
INTRINSIC |
|
low complexity region
|
1794 |
1809 |
N/A |
INTRINSIC |
|
low complexity region
|
1854 |
1880 |
N/A |
INTRINSIC |
|
low complexity region
|
2052 |
2063 |
N/A |
INTRINSIC |
|
low complexity region
|
2278 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2310 |
2321 |
N/A |
INTRINSIC |
|
low complexity region
|
2355 |
2369 |
N/A |
INTRINSIC |
|
coiled coil region
|
2606 |
2633 |
N/A |
INTRINSIC |
|
Pfam:TACC
|
2673 |
2873 |
6.1e-87 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207789
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000207918
AA Change: T584S
PolyPhen 2
Score 0.127 (Sensitivity: 0.93; Specificity: 0.86)
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000208722
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000215492
AA Change: T603S
PolyPhen 2
Score 0.022 (Sensitivity: 0.95; Specificity: 0.81)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (92/93) |
| MGI Phenotype |
FUNCTION: This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous null mice are healthy and fertile and do not display any increase in tumorigenesis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim3 |
C |
T |
18: 61,955,099 (GRCm39) |
A297T |
probably damaging |
Het |
| Adprhl1 |
T |
A |
8: 13,275,118 (GRCm39) |
S547C |
probably damaging |
Het |
| Ankrd63 |
G |
C |
2: 118,533,793 (GRCm39) |
R43G |
unknown |
Het |
| Asah2 |
T |
C |
19: 32,035,254 (GRCm39) |
T24A |
probably benign |
Het |
| Asb17 |
G |
A |
3: 153,550,447 (GRCm39) |
|
probably null |
Het |
| Atp8b5 |
C |
T |
4: 43,342,640 (GRCm39) |
T437I |
probably benign |
Het |
| Bbs2 |
T |
C |
8: 94,808,992 (GRCm39) |
D311G |
probably damaging |
Het |
| Birc6 |
C |
T |
17: 74,946,789 (GRCm39) |
T2851I |
possibly damaging |
Het |
| Bnip5 |
G |
A |
17: 29,124,298 (GRCm39) |
R335W |
probably damaging |
Het |
| Cchcr1 |
T |
C |
17: 35,835,693 (GRCm39) |
W266R |
probably benign |
Het |
| Col14a1 |
C |
A |
15: 55,252,024 (GRCm39) |
S560* |
probably null |
Het |
| Crocc |
G |
A |
4: 140,753,497 (GRCm39) |
T1317M |
possibly damaging |
Het |
| Cxxc1 |
T |
A |
18: 74,352,278 (GRCm39) |
V334E |
possibly damaging |
Het |
| Cyp3a25 |
T |
A |
5: 145,923,635 (GRCm39) |
D336V |
probably damaging |
Het |
| Dapk1 |
A |
G |
13: 60,867,455 (GRCm39) |
T221A |
probably benign |
Het |
| Dnah11 |
G |
T |
12: 118,068,543 (GRCm39) |
T1605K |
probably benign |
Het |
| Dnah7c |
T |
C |
1: 46,705,223 (GRCm39) |
V2412A |
possibly damaging |
Het |
| Ect2l |
T |
A |
10: 18,035,529 (GRCm39) |
D524V |
probably damaging |
Het |
| Ehbp1l1 |
T |
C |
19: 5,770,872 (GRCm39) |
E223G |
possibly damaging |
Het |
| Ephb2 |
A |
T |
4: 136,498,524 (GRCm39) |
M185K |
probably damaging |
Het |
| Fcer1a |
T |
C |
1: 173,049,083 (GRCm39) |
K243E |
probably damaging |
Het |
| Fcgbp |
T |
A |
7: 27,800,932 (GRCm39) |
I1326N |
probably damaging |
Het |
| Fgfr1 |
T |
C |
8: 26,045,566 (GRCm39) |
V45A |
probably benign |
Het |
| Filip1 |
T |
A |
9: 79,727,380 (GRCm39) |
E413V |
possibly damaging |
Het |
| Frs3 |
T |
C |
17: 48,013,651 (GRCm39) |
|
probably null |
Het |
| Fstl4 |
A |
G |
11: 53,024,898 (GRCm39) |
T257A |
probably benign |
Het |
| Golga5 |
A |
T |
12: 102,450,778 (GRCm39) |
K477M |
probably damaging |
Het |
| Gpr171 |
A |
T |
3: 59,005,622 (GRCm39) |
I51K |
probably damaging |
Het |
| H1f0 |
T |
A |
15: 78,913,080 (GRCm39) |
Y53* |
probably null |
Het |
| Hephl1 |
A |
G |
9: 14,981,047 (GRCm39) |
V795A |
possibly damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,596,510 (GRCm39) |
D1775E |
probably benign |
Het |
| Hs3st2 |
A |
G |
7: 121,100,168 (GRCm39) |
D338G |
possibly damaging |
Het |
| Hsd3b6 |
T |
A |
3: 98,713,534 (GRCm39) |
Y255F |
probably benign |
Het |
| Hspa9 |
T |
C |
18: 35,076,329 (GRCm39) |
N328D |
possibly damaging |
Het |
| Hvcn1 |
T |
A |
5: 122,375,748 (GRCm39) |
I100N |
probably damaging |
Het |
| Ifi207 |
C |
T |
1: 173,556,494 (GRCm39) |
S748N |
possibly damaging |
Het |
| Katnip |
A |
T |
7: 125,464,434 (GRCm39) |
N1267I |
probably damaging |
Het |
| Kcnma1 |
G |
T |
14: 24,052,902 (GRCm39) |
T180K |
unknown |
Het |
| Kctd16 |
A |
G |
18: 40,391,826 (GRCm39) |
D138G |
probably damaging |
Het |
| Kifc3 |
A |
G |
8: 95,830,092 (GRCm39) |
Y605H |
probably benign |
Het |
| Kmt2d |
T |
A |
15: 98,743,376 (GRCm39) |
Q3928L |
unknown |
Het |
| Lamb2 |
C |
T |
9: 108,364,782 (GRCm39) |
R1179C |
probably damaging |
Het |
| Layn |
T |
A |
9: 50,968,670 (GRCm39) |
I358F |
possibly damaging |
Het |
| Lrig1 |
G |
A |
6: 94,603,452 (GRCm39) |
T232M |
probably damaging |
Het |
| Lrp1 |
T |
C |
10: 127,418,577 (GRCm39) |
T38A |
|
Het |
| Map3k14 |
A |
G |
11: 103,129,918 (GRCm39) |
V333A |
probably benign |
Het |
| Med13 |
T |
C |
11: 86,177,272 (GRCm39) |
D1608G |
possibly damaging |
Het |
| Mrps31 |
T |
G |
8: 22,911,429 (GRCm39) |
S224A |
probably benign |
Het |
| Msh6 |
G |
T |
17: 88,282,548 (GRCm39) |
|
|
Het |
| Ncapd3 |
A |
G |
9: 26,978,315 (GRCm39) |
D838G |
probably benign |
Het |
| Nlrp1a |
C |
A |
11: 70,987,919 (GRCm39) |
E1184* |
probably null |
Het |
| Npat |
T |
A |
9: 53,466,233 (GRCm39) |
|
probably null |
Het |
| Nup210 |
A |
T |
6: 91,050,227 (GRCm39) |
I414N |
probably benign |
Het |
| Or1e19 |
A |
T |
11: 73,316,419 (GRCm39) |
L130H |
probably damaging |
Het |
| Or52n2 |
A |
T |
7: 104,542,181 (GRCm39) |
V218E |
possibly damaging |
Het |
| Or5b122 |
T |
A |
19: 13,562,752 (GRCm39) |
I28N |
possibly damaging |
Het |
| Or5h19 |
T |
C |
16: 58,856,603 (GRCm39) |
T166A |
possibly damaging |
Het |
| Or6z5 |
T |
C |
7: 6,477,163 (GRCm39) |
L18P |
probably damaging |
Het |
| Or8b12c |
A |
T |
9: 37,715,257 (GRCm39) |
T17S |
possibly damaging |
Het |
| Or8h7 |
A |
C |
2: 86,721,217 (GRCm39) |
L101V |
probably benign |
Het |
| Otud7b |
G |
C |
3: 96,043,936 (GRCm39) |
|
probably null |
Het |
| Phf11d |
A |
C |
14: 59,596,942 (GRCm39) |
W86G |
probably benign |
Het |
| Pik3c2b |
T |
A |
1: 133,018,444 (GRCm39) |
S964T |
probably damaging |
Het |
| Pira1 |
T |
C |
7: 3,742,344 (GRCm39) |
Y61C |
probably damaging |
Het |
| Plod3 |
G |
A |
5: 137,023,901 (GRCm39) |
V687I |
probably benign |
Het |
| Poglut1 |
T |
G |
16: 38,358,284 (GRCm39) |
Y208S |
possibly damaging |
Het |
| Pou1f1 |
T |
A |
16: 65,330,749 (GRCm39) |
L253H |
probably damaging |
Het |
| Pou2f1 |
C |
T |
1: 165,738,955 (GRCm39) |
A166T |
unknown |
Het |
| Rhbdl3 |
C |
T |
11: 80,237,659 (GRCm39) |
S297L |
probably damaging |
Het |
| Rxra |
A |
T |
2: 27,631,866 (GRCm39) |
N179I |
probably damaging |
Het |
| Ryr2 |
C |
T |
13: 11,750,506 (GRCm39) |
E1922K |
probably damaging |
Het |
| Scube1 |
T |
C |
15: 83,499,211 (GRCm39) |
Y668C |
probably damaging |
Het |
| Sec16b |
A |
G |
1: 157,358,927 (GRCm39) |
Y120C |
probably damaging |
Het |
| Sec61b |
G |
T |
4: 47,483,047 (GRCm39) |
K92N |
probably damaging |
Het |
| Skic3 |
T |
A |
13: 76,296,866 (GRCm39) |
Y1074* |
probably null |
Het |
| Slc13a3 |
T |
C |
2: 165,275,984 (GRCm39) |
N254S |
possibly damaging |
Het |
| Slc17a7 |
T |
A |
7: 44,822,354 (GRCm39) |
Y397N |
probably benign |
Het |
| Slc25a3 |
A |
G |
10: 90,952,902 (GRCm39) |
V333A |
possibly damaging |
Het |
| Slc7a8 |
A |
T |
14: 54,964,283 (GRCm39) |
V390E |
probably damaging |
Het |
| Sorbs2 |
G |
A |
8: 46,212,233 (GRCm39) |
|
probably null |
Het |
| Srgap1 |
T |
C |
10: 121,621,650 (GRCm39) |
N948D |
probably benign |
Het |
| Tec |
A |
T |
5: 72,920,961 (GRCm39) |
D471E |
probably damaging |
Het |
| Tecpr2 |
C |
T |
12: 110,898,038 (GRCm39) |
A430V |
probably benign |
Het |
| Tmcc2 |
A |
T |
1: 132,288,759 (GRCm39) |
D309E |
probably damaging |
Het |
| Tmem82 |
G |
A |
4: 141,344,742 (GRCm39) |
A67V |
possibly damaging |
Het |
| Ttc23l |
T |
C |
15: 10,551,663 (GRCm39) |
Q21R |
probably damaging |
Het |
| Ubl3 |
A |
G |
5: 148,448,764 (GRCm39) |
F26L |
probably damaging |
Het |
| Upf2 |
A |
G |
2: 6,045,014 (GRCm39) |
E1088G |
unknown |
Het |
| Usp9y |
T |
A |
Y: 1,341,780 (GRCm39) |
I1362F |
probably benign |
Het |
| Wnk4 |
T |
A |
11: 101,159,318 (GRCm39) |
|
probably null |
Het |
| Wrn |
C |
G |
8: 33,738,994 (GRCm39) |
W1278S |
probably benign |
Het |
| Zfc3h1 |
T |
A |
10: 115,251,153 (GRCm39) |
V1248D |
probably damaging |
Het |
| Zfp12 |
T |
A |
5: 143,226,099 (GRCm39) |
V56D |
probably damaging |
Het |
|
| Other mutations in Tacc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00836:Tacc2
|
APN |
7 |
130,360,898 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01396:Tacc2
|
APN |
7 |
130,360,919 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01621:Tacc2
|
APN |
7 |
130,331,498 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02000:Tacc2
|
APN |
7 |
130,330,898 (GRCm39) |
splice site |
probably null |
|
|
IGL02075:Tacc2
|
APN |
7 |
130,330,582 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02201:Tacc2
|
APN |
7 |
130,227,942 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
IGL02205:Tacc2
|
APN |
7 |
130,228,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02399:Tacc2
|
APN |
7 |
130,225,129 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02456:Tacc2
|
APN |
7 |
130,227,991 (GRCm39) |
missense |
probably benign |
0.35 |
|
IGL02559:Tacc2
|
APN |
7 |
130,360,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02734:Tacc2
|
APN |
7 |
130,227,829 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02800:Tacc2
|
APN |
7 |
130,225,809 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02938:Tacc2
|
APN |
7 |
130,330,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03031:Tacc2
|
APN |
7 |
130,225,585 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL03278:Tacc2
|
APN |
7 |
130,335,298 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03283:Tacc2
|
APN |
7 |
130,343,996 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
IGL03371:Tacc2
|
APN |
7 |
130,227,791 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
aces
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Jacks
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
kings
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0002:Tacc2
|
UTSW |
7 |
130,223,515 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0119:Tacc2
|
UTSW |
7 |
130,223,605 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0244:Tacc2
|
UTSW |
7 |
130,353,555 (GRCm39) |
splice site |
probably benign |
|
|
R0619:Tacc2
|
UTSW |
7 |
130,318,483 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0624:Tacc2
|
UTSW |
7 |
130,179,239 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0632:Tacc2
|
UTSW |
7 |
130,227,325 (GRCm39) |
nonsense |
probably null |
|
|
R1015:Tacc2
|
UTSW |
7 |
130,225,795 (GRCm39) |
missense |
probably benign |
|
|
R1081:Tacc2
|
UTSW |
7 |
130,330,304 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1086:Tacc2
|
UTSW |
7 |
130,228,227 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1351:Tacc2
|
UTSW |
7 |
130,264,733 (GRCm39) |
intron |
probably benign |
|
|
R1538:Tacc2
|
UTSW |
7 |
130,227,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1743:Tacc2
|
UTSW |
7 |
130,228,328 (GRCm39) |
nonsense |
probably null |
|
|
R1771:Tacc2
|
UTSW |
7 |
130,343,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1876:Tacc2
|
UTSW |
7 |
130,225,475 (GRCm39) |
missense |
probably benign |
0.38 |
|
R1893:Tacc2
|
UTSW |
7 |
130,227,055 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1899:Tacc2
|
UTSW |
7 |
130,225,932 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R2005:Tacc2
|
UTSW |
7 |
130,333,280 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Tacc2
|
UTSW |
7 |
130,223,587 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2338:Tacc2
|
UTSW |
7 |
130,335,299 (GRCm39) |
splice site |
probably null |
|
|
R2407:Tacc2
|
UTSW |
7 |
130,223,770 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R3051:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3052:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3053:Tacc2
|
UTSW |
7 |
130,227,226 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R3116:Tacc2
|
UTSW |
7 |
130,360,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3412:Tacc2
|
UTSW |
7 |
130,336,724 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3683:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3685:Tacc2
|
UTSW |
7 |
130,226,800 (GRCm39) |
missense |
probably benign |
0.40 |
|
R3872:Tacc2
|
UTSW |
7 |
130,224,152 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4063:Tacc2
|
UTSW |
7 |
130,330,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4410:Tacc2
|
UTSW |
7 |
130,343,941 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4434:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4438:Tacc2
|
UTSW |
7 |
130,225,271 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4618:Tacc2
|
UTSW |
7 |
130,227,946 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4674:Tacc2
|
UTSW |
7 |
130,226,591 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4742:Tacc2
|
UTSW |
7 |
130,227,697 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4934:Tacc2
|
UTSW |
7 |
130,330,318 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4947:Tacc2
|
UTSW |
7 |
130,227,629 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4964:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4966:Tacc2
|
UTSW |
7 |
130,330,507 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4967:Tacc2
|
UTSW |
7 |
130,225,678 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5052:Tacc2
|
UTSW |
7 |
130,336,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5276:Tacc2
|
UTSW |
7 |
130,331,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5330:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5331:Tacc2
|
UTSW |
7 |
130,335,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5372:Tacc2
|
UTSW |
7 |
130,224,990 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5556:Tacc2
|
UTSW |
7 |
130,276,336 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5645:Tacc2
|
UTSW |
7 |
130,225,781 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R5886:Tacc2
|
UTSW |
7 |
130,330,850 (GRCm39) |
missense |
probably benign |
0.18 |
|
R5996:Tacc2
|
UTSW |
7 |
130,225,213 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6074:Tacc2
|
UTSW |
7 |
130,227,165 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6127:Tacc2
|
UTSW |
7 |
130,227,845 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6156:Tacc2
|
UTSW |
7 |
130,227,494 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6298:Tacc2
|
UTSW |
7 |
130,228,255 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6444:Tacc2
|
UTSW |
7 |
130,225,142 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6533:Tacc2
|
UTSW |
7 |
130,224,567 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6724:Tacc2
|
UTSW |
7 |
130,330,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7111:Tacc2
|
UTSW |
7 |
130,330,618 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7150:Tacc2
|
UTSW |
7 |
130,330,807 (GRCm39) |
missense |
probably benign |
|
|
R7290:Tacc2
|
UTSW |
7 |
130,331,103 (GRCm39) |
missense |
probably benign |
0.07 |
|
R7460:Tacc2
|
UTSW |
7 |
130,226,363 (GRCm39) |
missense |
probably benign |
0.39 |
|
R7651:Tacc2
|
UTSW |
7 |
130,224,884 (GRCm39) |
missense |
probably benign |
0.25 |
|
R7666:Tacc2
|
UTSW |
7 |
130,318,544 (GRCm39) |
start gained |
probably benign |
|
|
R7695:Tacc2
|
UTSW |
7 |
130,330,633 (GRCm39) |
missense |
probably benign |
0.08 |
|
R7766:Tacc2
|
UTSW |
7 |
130,345,328 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7793:Tacc2
|
UTSW |
7 |
130,224,843 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7861:Tacc2
|
UTSW |
7 |
130,227,161 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8204:Tacc2
|
UTSW |
7 |
130,226,159 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8244:Tacc2
|
UTSW |
7 |
130,330,406 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8245:Tacc2
|
UTSW |
7 |
130,331,303 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8283:Tacc2
|
UTSW |
7 |
130,227,034 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8348:Tacc2
|
UTSW |
7 |
130,225,019 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8369:Tacc2
|
UTSW |
7 |
130,223,888 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8381:Tacc2
|
UTSW |
7 |
130,225,972 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8804:Tacc2
|
UTSW |
7 |
130,294,693 (GRCm39) |
missense |
probably benign |
|
|
R8809:Tacc2
|
UTSW |
7 |
130,276,421 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8835:Tacc2
|
UTSW |
7 |
130,228,258 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8880:Tacc2
|
UTSW |
7 |
130,318,564 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8918:Tacc2
|
UTSW |
7 |
130,227,823 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8936:Tacc2
|
UTSW |
7 |
130,228,367 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8953:Tacc2
|
UTSW |
7 |
130,227,487 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9026:Tacc2
|
UTSW |
7 |
130,225,266 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9193:Tacc2
|
UTSW |
7 |
130,228,304 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,209 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9221:Tacc2
|
UTSW |
7 |
130,226,058 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9222:Tacc2
|
UTSW |
7 |
130,227,985 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9264:Tacc2
|
UTSW |
7 |
130,228,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Tacc2
|
UTSW |
7 |
130,223,978 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9380:Tacc2
|
UTSW |
7 |
130,226,771 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9515:Tacc2
|
UTSW |
7 |
130,366,041 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9705:Tacc2
|
UTSW |
7 |
130,361,018 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0010:Tacc2
|
UTSW |
7 |
130,336,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,346,327 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,226,000 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1176:Tacc2
|
UTSW |
7 |
130,225,100 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,336,679 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,227,504 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1177:Tacc2
|
UTSW |
7 |
130,226,710 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGACAACCTTGAGGGACAGC -3'
(R):5'- GGTCTGAGATCTTGAACTTTCCC -3'
Sequencing Primer
(F):5'- CCTTGAGGGACAGCAAGAAGC -3'
(R):5'- GAGATCTTGAACTTTCCCAGATGGC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation