Incidental Mutation 'R7404:Dapk1'
| ID |
574452 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
045486-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R7404 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 60867455 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 221
(T221A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000076666
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000044083
AA Change: T221A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
AA Change: T221A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000077453
AA Change: T221A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
AA Change: T221A
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224789
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000226059
AA Change: T221A
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.7%
- 20x: 99.1%
|
| Validation Efficiency |
99% (92/93) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Ablim3 |
C |
T |
18: 61,955,099 (GRCm39) |
A297T |
probably damaging |
Het |
| Adprhl1 |
T |
A |
8: 13,275,118 (GRCm39) |
S547C |
probably damaging |
Het |
| Ankrd63 |
G |
C |
2: 118,533,793 (GRCm39) |
R43G |
unknown |
Het |
| Asah2 |
T |
C |
19: 32,035,254 (GRCm39) |
T24A |
probably benign |
Het |
| Asb17 |
G |
A |
3: 153,550,447 (GRCm39) |
|
probably null |
Het |
| Atp8b5 |
C |
T |
4: 43,342,640 (GRCm39) |
T437I |
probably benign |
Het |
| Bbs2 |
T |
C |
8: 94,808,992 (GRCm39) |
D311G |
probably damaging |
Het |
| Birc6 |
C |
T |
17: 74,946,789 (GRCm39) |
T2851I |
possibly damaging |
Het |
| Bnip5 |
G |
A |
17: 29,124,298 (GRCm39) |
R335W |
probably damaging |
Het |
| Cchcr1 |
T |
C |
17: 35,835,693 (GRCm39) |
W266R |
probably benign |
Het |
| Col14a1 |
C |
A |
15: 55,252,024 (GRCm39) |
S560* |
probably null |
Het |
| Crocc |
G |
A |
4: 140,753,497 (GRCm39) |
T1317M |
possibly damaging |
Het |
| Cxxc1 |
T |
A |
18: 74,352,278 (GRCm39) |
V334E |
possibly damaging |
Het |
| Cyp3a25 |
T |
A |
5: 145,923,635 (GRCm39) |
D336V |
probably damaging |
Het |
| Dnah11 |
G |
T |
12: 118,068,543 (GRCm39) |
T1605K |
probably benign |
Het |
| Dnah7c |
T |
C |
1: 46,705,223 (GRCm39) |
V2412A |
possibly damaging |
Het |
| Ect2l |
T |
A |
10: 18,035,529 (GRCm39) |
D524V |
probably damaging |
Het |
| Ehbp1l1 |
T |
C |
19: 5,770,872 (GRCm39) |
E223G |
possibly damaging |
Het |
| Ephb2 |
A |
T |
4: 136,498,524 (GRCm39) |
M185K |
probably damaging |
Het |
| Fcer1a |
T |
C |
1: 173,049,083 (GRCm39) |
K243E |
probably damaging |
Het |
| Fcgbp |
T |
A |
7: 27,800,932 (GRCm39) |
I1326N |
probably damaging |
Het |
| Fgfr1 |
T |
C |
8: 26,045,566 (GRCm39) |
V45A |
probably benign |
Het |
| Filip1 |
T |
A |
9: 79,727,380 (GRCm39) |
E413V |
possibly damaging |
Het |
| Frs3 |
T |
C |
17: 48,013,651 (GRCm39) |
|
probably null |
Het |
| Fstl4 |
A |
G |
11: 53,024,898 (GRCm39) |
T257A |
probably benign |
Het |
| Golga5 |
A |
T |
12: 102,450,778 (GRCm39) |
K477M |
probably damaging |
Het |
| Gpr171 |
A |
T |
3: 59,005,622 (GRCm39) |
I51K |
probably damaging |
Het |
| H1f0 |
T |
A |
15: 78,913,080 (GRCm39) |
Y53* |
probably null |
Het |
| Hephl1 |
A |
G |
9: 14,981,047 (GRCm39) |
V795A |
possibly damaging |
Het |
| Hmcn1 |
A |
T |
1: 150,596,510 (GRCm39) |
D1775E |
probably benign |
Het |
| Hs3st2 |
A |
G |
7: 121,100,168 (GRCm39) |
D338G |
possibly damaging |
Het |
| Hsd3b6 |
T |
A |
3: 98,713,534 (GRCm39) |
Y255F |
probably benign |
Het |
| Hspa9 |
T |
C |
18: 35,076,329 (GRCm39) |
N328D |
possibly damaging |
Het |
| Hvcn1 |
T |
A |
5: 122,375,748 (GRCm39) |
I100N |
probably damaging |
Het |
| Ifi207 |
C |
T |
1: 173,556,494 (GRCm39) |
S748N |
possibly damaging |
Het |
| Katnip |
A |
T |
7: 125,464,434 (GRCm39) |
N1267I |
probably damaging |
Het |
| Kcnma1 |
G |
T |
14: 24,052,902 (GRCm39) |
T180K |
unknown |
Het |
| Kctd16 |
A |
G |
18: 40,391,826 (GRCm39) |
D138G |
probably damaging |
Het |
| Kifc3 |
A |
G |
8: 95,830,092 (GRCm39) |
Y605H |
probably benign |
Het |
| Kmt2d |
T |
A |
15: 98,743,376 (GRCm39) |
Q3928L |
unknown |
Het |
| Lamb2 |
C |
T |
9: 108,364,782 (GRCm39) |
R1179C |
probably damaging |
Het |
| Layn |
T |
A |
9: 50,968,670 (GRCm39) |
I358F |
possibly damaging |
Het |
| Lrig1 |
G |
A |
6: 94,603,452 (GRCm39) |
T232M |
probably damaging |
Het |
| Lrp1 |
T |
C |
10: 127,418,577 (GRCm39) |
T38A |
|
Het |
| Map3k14 |
A |
G |
11: 103,129,918 (GRCm39) |
V333A |
probably benign |
Het |
| Med13 |
T |
C |
11: 86,177,272 (GRCm39) |
D1608G |
possibly damaging |
Het |
| Mrps31 |
T |
G |
8: 22,911,429 (GRCm39) |
S224A |
probably benign |
Het |
| Msh6 |
G |
T |
17: 88,282,548 (GRCm39) |
|
|
Het |
| Ncapd3 |
A |
G |
9: 26,978,315 (GRCm39) |
D838G |
probably benign |
Het |
| Nlrp1a |
C |
A |
11: 70,987,919 (GRCm39) |
E1184* |
probably null |
Het |
| Npat |
T |
A |
9: 53,466,233 (GRCm39) |
|
probably null |
Het |
| Nup210 |
A |
T |
6: 91,050,227 (GRCm39) |
I414N |
probably benign |
Het |
| Or1e19 |
A |
T |
11: 73,316,419 (GRCm39) |
L130H |
probably damaging |
Het |
| Or52n2 |
A |
T |
7: 104,542,181 (GRCm39) |
V218E |
possibly damaging |
Het |
| Or5b122 |
T |
A |
19: 13,562,752 (GRCm39) |
I28N |
possibly damaging |
Het |
| Or5h19 |
T |
C |
16: 58,856,603 (GRCm39) |
T166A |
possibly damaging |
Het |
| Or6z5 |
T |
C |
7: 6,477,163 (GRCm39) |
L18P |
probably damaging |
Het |
| Or8b12c |
A |
T |
9: 37,715,257 (GRCm39) |
T17S |
possibly damaging |
Het |
| Or8h7 |
A |
C |
2: 86,721,217 (GRCm39) |
L101V |
probably benign |
Het |
| Otud7b |
G |
C |
3: 96,043,936 (GRCm39) |
|
probably null |
Het |
| Phf11d |
A |
C |
14: 59,596,942 (GRCm39) |
W86G |
probably benign |
Het |
| Pik3c2b |
T |
A |
1: 133,018,444 (GRCm39) |
S964T |
probably damaging |
Het |
| Pira1 |
T |
C |
7: 3,742,344 (GRCm39) |
Y61C |
probably damaging |
Het |
| Plod3 |
G |
A |
5: 137,023,901 (GRCm39) |
V687I |
probably benign |
Het |
| Poglut1 |
T |
G |
16: 38,358,284 (GRCm39) |
Y208S |
possibly damaging |
Het |
| Pou1f1 |
T |
A |
16: 65,330,749 (GRCm39) |
L253H |
probably damaging |
Het |
| Pou2f1 |
C |
T |
1: 165,738,955 (GRCm39) |
A166T |
unknown |
Het |
| Rhbdl3 |
C |
T |
11: 80,237,659 (GRCm39) |
S297L |
probably damaging |
Het |
| Rxra |
A |
T |
2: 27,631,866 (GRCm39) |
N179I |
probably damaging |
Het |
| Ryr2 |
C |
T |
13: 11,750,506 (GRCm39) |
E1922K |
probably damaging |
Het |
| Scube1 |
T |
C |
15: 83,499,211 (GRCm39) |
Y668C |
probably damaging |
Het |
| Sec16b |
A |
G |
1: 157,358,927 (GRCm39) |
Y120C |
probably damaging |
Het |
| Sec61b |
G |
T |
4: 47,483,047 (GRCm39) |
K92N |
probably damaging |
Het |
| Skic3 |
T |
A |
13: 76,296,866 (GRCm39) |
Y1074* |
probably null |
Het |
| Slc13a3 |
T |
C |
2: 165,275,984 (GRCm39) |
N254S |
possibly damaging |
Het |
| Slc17a7 |
T |
A |
7: 44,822,354 (GRCm39) |
Y397N |
probably benign |
Het |
| Slc25a3 |
A |
G |
10: 90,952,902 (GRCm39) |
V333A |
possibly damaging |
Het |
| Slc7a8 |
A |
T |
14: 54,964,283 (GRCm39) |
V390E |
probably damaging |
Het |
| Sorbs2 |
G |
A |
8: 46,212,233 (GRCm39) |
|
probably null |
Het |
| Srgap1 |
T |
C |
10: 121,621,650 (GRCm39) |
N948D |
probably benign |
Het |
| Tacc2 |
A |
T |
7: 130,225,066 (GRCm39) |
T584S |
probably benign |
Het |
| Tec |
A |
T |
5: 72,920,961 (GRCm39) |
D471E |
probably damaging |
Het |
| Tecpr2 |
C |
T |
12: 110,898,038 (GRCm39) |
A430V |
probably benign |
Het |
| Tmcc2 |
A |
T |
1: 132,288,759 (GRCm39) |
D309E |
probably damaging |
Het |
| Tmem82 |
G |
A |
4: 141,344,742 (GRCm39) |
A67V |
possibly damaging |
Het |
| Ttc23l |
T |
C |
15: 10,551,663 (GRCm39) |
Q21R |
probably damaging |
Het |
| Ubl3 |
A |
G |
5: 148,448,764 (GRCm39) |
F26L |
probably damaging |
Het |
| Upf2 |
A |
G |
2: 6,045,014 (GRCm39) |
E1088G |
unknown |
Het |
| Usp9y |
T |
A |
Y: 1,341,780 (GRCm39) |
I1362F |
probably benign |
Het |
| Wnk4 |
T |
A |
11: 101,159,318 (GRCm39) |
|
probably null |
Het |
| Wrn |
C |
G |
8: 33,738,994 (GRCm39) |
W1278S |
probably benign |
Het |
| Zfc3h1 |
T |
A |
10: 115,251,153 (GRCm39) |
V1248D |
probably damaging |
Het |
| Zfp12 |
T |
A |
5: 143,226,099 (GRCm39) |
V56D |
probably damaging |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4790:Dapk1
|
UTSW |
13 |
60,870,919 (GRCm39) |
frame shift |
probably null |
|
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- CTCTGCAAGGACTTGATACTCTTG -3'
(R):5'- TCTGGTCTTGGCCACATGAG -3'
Sequencing Primer
(F):5'- CATAACTGTTCAGTATTCCATGGTG -3'
(R):5'- GGTGTTCCGGAAGAATTC -3'
|
| Posted On |
2019-09-13 |
Incidental Mutation