Incidental Mutation 'R7405:Mst1r'
ID 574516
Institutional Source Beutler Lab
Gene Symbol Mst1r
Ensembl Gene ENSMUSG00000032584
Gene Name macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
Synonyms Fv2, Ron, STK, friend virus susceptibility 2, CDw136, Fv-2, PTK8
MMRRC Submission 045376-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.261) question?
Stock # R7405 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 107784072-107797582 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 107792321 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Phenylalanine at position 925 (S925F)
Ref Sequence ENSEMBL: ENSMUSP00000035203 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035203] [ENSMUST00000195617]
AlphaFold Q62190
Predicted Effect possibly damaging
Transcript: ENSMUST00000035203
AA Change: S925F

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000035203
Gene: ENSMUSG00000032584
AA Change: S925F

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Sema 57 510 9.03e-116 SMART
PSI 528 570 8.72e-4 SMART
IPT 570 684 1.63e-18 SMART
IPT 685 769 4.03e-23 SMART
IPT 771 873 8.41e-12 SMART
IPT 878 972 5.36e0 SMART
TyrKc 1059 1318 8.2e-134 SMART
low complexity region 1349 1360 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000195617
SMART Domains Protein: ENSMUSP00000142201
Gene: ENSMUSG00000032584

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
Sema 57 442 3.5e-63 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a precursor protein that is proteolytically cleaved to yield an alpha chain and a beta chain which form a membrane-spanning heterodimer. The encoded protein belongs to a family of cell-surface receptor tyrosine kinases involved in signaling from the cell surface to the intracellular environment. The binding of the encoded protein to its ligand, macrophage-stimulating protein, mediates several biological activities including wound healing, tumor immunity, macrophage activation and hematopoiesis as well as cell growth, motility, survival and adhesion. The protein encoded by this gene also functions in early development and the macrophage-mediated inflammatory response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: This locus controls susceptibility to splenomegaly or spleen focus formation induced by inoculation with Friend leukemia virus. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 73 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700010I14Rik G T 17: 9,220,649 (GRCm39) V383L probably damaging Het
4930507D05Rik C A 10: 62,285,563 (GRCm39) H96N unknown Het
5730480H06Rik T C 5: 48,545,458 (GRCm39) I235T possibly damaging Het
Abcb11 A G 2: 69,117,963 (GRCm39) Y472H probably damaging Het
Adam39 A T 8: 41,277,659 (GRCm39) I17L probably benign Het
Aire T C 10: 77,870,447 (GRCm39) H458R probably benign Het
Ap3d1 T C 10: 80,577,734 (GRCm39) D31G probably benign Het
Atad2b T A 12: 4,993,232 (GRCm39) H250Q probably benign Het
Bnip5 G A 17: 29,124,298 (GRCm39) R335W probably damaging Het
Borcs5 C A 6: 134,662,945 (GRCm39) T74N probably benign Het
Btbd16 C T 7: 130,407,586 (GRCm39) T292I probably benign Het
Catsperd G A 17: 56,939,335 (GRCm39) V55M possibly damaging Het
Cfap107 T C 4: 144,146,323 (GRCm39) N110S probably damaging Het
Ctr9 T C 7: 110,642,921 (GRCm39) F462S possibly damaging Het
Cyp4f39 A G 17: 32,700,789 (GRCm39) S153G probably benign Het
Ddo T C 10: 40,523,993 (GRCm39) C328R possibly damaging Het
Ddr1 A G 17: 36,000,992 (GRCm39) V251A probably damaging Het
Dis3l A G 9: 64,221,986 (GRCm39) F475L probably damaging Het
Dkk4 G A 8: 23,115,859 (GRCm39) V99M probably benign Het
Dync1h1 C T 12: 110,600,654 (GRCm39) A1938V probably damaging Het
Ecel1 A T 1: 87,081,238 (GRCm39) probably null Het
Fbxo7 T A 10: 85,880,445 (GRCm39) Y377N probably damaging Het
Fbxw24 T C 9: 109,436,136 (GRCm39) I299V possibly damaging Het
Fkbp10 C T 11: 100,306,707 (GRCm39) A33V probably damaging Het
Gabra1 T C 11: 42,045,850 (GRCm39) T87A probably damaging Het
Gm21886 ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG ACTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGGCCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGACCTGCAGACAGTAGGTGCTCACTGAGG 18: 80,133,040 (GRCm39) probably benign Het
Golga3 A T 5: 110,356,312 (GRCm39) I1000F probably damaging Het
Grid2ip T C 5: 143,366,199 (GRCm39) I563T probably benign Het
Gsx1 T C 5: 147,125,943 (GRCm39) S82P possibly damaging Het
Heg1 A G 16: 33,583,819 (GRCm39) K34E possibly damaging Het
Kank1 T A 19: 25,387,683 (GRCm39) L452* probably null Het
Lce1k A T 3: 92,714,181 (GRCm39) M1K probably null Het
Lcmt2 A G 2: 120,969,868 (GRCm39) I185T probably benign Het
Lrp1 T C 10: 127,417,620 (GRCm39) D1046G possibly damaging Het
Lrrc37 A T 11: 103,505,987 (GRCm39) Y1994N probably benign Het
Mast3 A T 8: 71,238,815 (GRCm39) D496E probably damaging Het
Mterf2 C T 10: 84,956,360 (GRCm39) G88D probably damaging Het
Mthfd1 T C 12: 76,358,648 (GRCm39) V783A probably damaging Het
Mybpc2 A T 7: 44,156,618 (GRCm39) W778R probably damaging Het
Nbea A G 3: 55,712,687 (GRCm39) L2130P possibly damaging Het
Ndst4 A G 3: 125,476,865 (GRCm39) N30S probably benign Het
Nphs1 T C 7: 30,162,253 (GRCm39) V299A possibly damaging Het
Nup107 T C 10: 117,606,320 (GRCm39) D474G probably benign Het
Or10ag56 A C 2: 87,139,339 (GRCm39) I89L probably benign Het
Or10w1 T C 19: 13,632,246 (GRCm39) V151A probably benign Het
Or2w25 T A 11: 59,504,899 (GRCm39) F370I possibly damaging Het
Or7a42 T C 10: 78,791,531 (GRCm39) V164A probably benign Het
Pgap2 T C 7: 101,880,595 (GRCm39) V41A probably benign Het
Plekhh1 C T 12: 79,101,821 (GRCm39) T297I probably benign Het
Plxna4 A T 6: 32,173,254 (GRCm39) Y1226N probably benign Het
Polr3b A G 10: 84,520,043 (GRCm39) D653G probably benign Het
Ppp2r2c T C 5: 37,104,486 (GRCm39) F289L possibly damaging Het
Prickle2 A G 6: 92,435,524 (GRCm39) S82P probably damaging Het
Ptger2 T A 14: 45,226,531 (GRCm39) V37D probably damaging Het
Rasa2 G A 9: 96,448,080 (GRCm39) P526S probably benign Het
Rbm47 A T 5: 66,183,838 (GRCm39) I255N probably damaging Het
Sez6 A T 11: 77,853,717 (GRCm39) T296S probably benign Het
Slc2a9 T A 5: 38,549,167 (GRCm39) I316F probably damaging Het
Slc41a1 T A 1: 131,766,884 (GRCm39) V134D probably damaging Het
Slc5a7 A T 17: 54,604,161 (GRCm39) S2T probably benign Het
Slc9a4 C T 1: 40,640,086 (GRCm39) R293C probably damaging Het
Son CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC CATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAAC 16: 91,453,579 (GRCm39) probably benign Het
Suco A G 1: 161,655,783 (GRCm39) F1039L possibly damaging Het
Sycp1 A G 3: 102,832,543 (GRCm39) Y208H possibly damaging Het
Tpr T C 1: 150,317,878 (GRCm39) S2129P probably benign Het
Trim34b T A 7: 103,985,690 (GRCm39) S442T probably damaging Het
Ttn A T 2: 76,573,690 (GRCm39) Y25734* probably null Het
Uchl5 C T 1: 143,675,752 (GRCm39) Q276* probably null Het
Wrn C G 8: 33,738,994 (GRCm39) W1278S probably benign Het
Yeats2 T A 16: 20,041,663 (GRCm39) D1184E probably damaging Het
Zfat G A 15: 68,056,334 (GRCm39) R241W probably damaging Het
Zfp646 T A 7: 127,477,968 (GRCm39) Y48* probably null Het
Zfp998 T C 13: 66,579,118 (GRCm39) Q455R unknown Het
Other mutations in Mst1r
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00429:Mst1r APN 9 107,790,449 (GRCm39) splice site probably benign
IGL01327:Mst1r APN 9 107,785,043 (GRCm39) missense probably benign 0.03
IGL01572:Mst1r APN 9 107,788,791 (GRCm39) missense probably damaging 1.00
IGL01968:Mst1r APN 9 107,794,005 (GRCm39) splice site probably null
IGL01983:Mst1r APN 9 107,794,475 (GRCm39) missense probably damaging 0.99
IGL02096:Mst1r APN 9 107,794,478 (GRCm39) missense probably damaging 0.97
IGL02203:Mst1r APN 9 107,785,068 (GRCm39) missense probably damaging 1.00
IGL02203:Mst1r APN 9 107,790,348 (GRCm39) missense possibly damaging 0.61
IGL02332:Mst1r APN 9 107,785,025 (GRCm39) nonsense probably null
IGL02402:Mst1r APN 9 107,794,026 (GRCm39) missense probably damaging 0.99
IGL02404:Mst1r APN 9 107,790,266 (GRCm39) splice site probably benign
IGL02942:Mst1r APN 9 107,790,352 (GRCm39) missense possibly damaging 0.89
IGL02951:Mst1r APN 9 107,785,403 (GRCm39) missense possibly damaging 0.88
IGL02975:Mst1r APN 9 107,790,379 (GRCm39) missense probably benign 0.20
IGL03005:Mst1r APN 9 107,791,748 (GRCm39) nonsense probably null
IGL03304:Mst1r APN 9 107,785,137 (GRCm39) missense probably damaging 1.00
R0386:Mst1r UTSW 9 107,794,003 (GRCm39) splice site probably null
R0833:Mst1r UTSW 9 107,791,975 (GRCm39) missense probably benign 0.00
R0833:Mst1r UTSW 9 107,790,366 (GRCm39) missense probably benign
R1139:Mst1r UTSW 9 107,797,168 (GRCm39) missense possibly damaging 0.93
R1371:Mst1r UTSW 9 107,794,424 (GRCm39) missense probably damaging 1.00
R1477:Mst1r UTSW 9 107,785,523 (GRCm39) missense probably benign
R1479:Mst1r UTSW 9 107,790,544 (GRCm39) splice site probably benign
R1541:Mst1r UTSW 9 107,794,562 (GRCm39) missense probably damaging 0.99
R1698:Mst1r UTSW 9 107,797,179 (GRCm39) missense probably benign 0.06
R1891:Mst1r UTSW 9 107,790,661 (GRCm39) missense probably damaging 1.00
R1971:Mst1r UTSW 9 107,790,411 (GRCm39) missense probably benign 0.06
R1974:Mst1r UTSW 9 107,793,132 (GRCm39) critical splice donor site probably null
R1974:Mst1r UTSW 9 107,791,962 (GRCm39) missense probably damaging 1.00
R2144:Mst1r UTSW 9 107,790,367 (GRCm39) missense probably benign
R2221:Mst1r UTSW 9 107,785,547 (GRCm39) missense probably damaging 1.00
R2356:Mst1r UTSW 9 107,795,069 (GRCm39) missense probably damaging 1.00
R3913:Mst1r UTSW 9 107,791,945 (GRCm39) missense probably benign
R4768:Mst1r UTSW 9 107,788,849 (GRCm39) missense probably damaging 1.00
R4793:Mst1r UTSW 9 107,797,124 (GRCm39) missense probably damaging 0.96
R5141:Mst1r UTSW 9 107,789,440 (GRCm39) missense probably damaging 0.99
R5191:Mst1r UTSW 9 107,788,750 (GRCm39) missense probably damaging 0.98
R5238:Mst1r UTSW 9 107,784,773 (GRCm39) missense probably damaging 1.00
R6024:Mst1r UTSW 9 107,785,350 (GRCm39) missense probably benign 0.00
R6220:Mst1r UTSW 9 107,784,547 (GRCm39) missense probably benign 0.11
R6256:Mst1r UTSW 9 107,794,465 (GRCm39) missense probably damaging 1.00
R6361:Mst1r UTSW 9 107,793,052 (GRCm39) missense probably benign
R6522:Mst1r UTSW 9 107,790,438 (GRCm39) missense probably benign 0.00
R6559:Mst1r UTSW 9 107,785,470 (GRCm39) missense possibly damaging 0.91
R6863:Mst1r UTSW 9 107,797,225 (GRCm39) missense probably benign
R6868:Mst1r UTSW 9 107,793,132 (GRCm39) critical splice donor site probably null
R6873:Mst1r UTSW 9 107,788,843 (GRCm39) missense possibly damaging 0.90
R6978:Mst1r UTSW 9 107,789,793 (GRCm39) missense probably benign 0.23
R7168:Mst1r UTSW 9 107,785,392 (GRCm39) missense probably benign 0.01
R7299:Mst1r UTSW 9 107,791,989 (GRCm39) missense possibly damaging 0.46
R7301:Mst1r UTSW 9 107,791,989 (GRCm39) missense possibly damaging 0.46
R7615:Mst1r UTSW 9 107,797,211 (GRCm39) missense probably benign 0.05
R7684:Mst1r UTSW 9 107,788,762 (GRCm39) missense probably benign 0.01
R7741:Mst1r UTSW 9 107,784,319 (GRCm39) start gained probably benign
R7916:Mst1r UTSW 9 107,784,777 (GRCm39) missense probably damaging 1.00
R7987:Mst1r UTSW 9 107,789,997 (GRCm39) splice site probably null
R8177:Mst1r UTSW 9 107,784,784 (GRCm39) missense probably damaging 1.00
R8356:Mst1r UTSW 9 107,794,463 (GRCm39) missense probably damaging 1.00
R8494:Mst1r UTSW 9 107,791,718 (GRCm39) missense possibly damaging 0.90
R8692:Mst1r UTSW 9 107,792,050 (GRCm39) missense possibly damaging 0.82
R8979:Mst1r UTSW 9 107,792,478 (GRCm39) missense probably damaging 0.98
R9012:Mst1r UTSW 9 107,791,960 (GRCm39) missense probably benign 0.01
X0026:Mst1r UTSW 9 107,790,402 (GRCm39) missense probably damaging 0.97
Predicted Primers PCR Primer
(F):5'- GGCCTGGTTGAGTTGAAACC -3'
(R):5'- TTAAAGATCAGGGCAACGGC -3'

Sequencing Primer
(F):5'- CCTGGTTGAGTTGAAACCTGAAG -3'
(R):5'- CCAGAAGAGCAATAAGGAGTATCC -3'
Posted On 2019-09-13