Incidental Mutation 'R7406:Vmn2r8'
ID 574730
Institutional Source Beutler Lab
Gene Symbol Vmn2r8
Ensembl Gene ENSMUSG00000090961
Gene Name vomeronasal 2, receptor 8
Synonyms EG627479
MMRRC Submission 045487-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # R7406 (G1)
Quality Score 225.009
Status Validated
Chromosome 5
Chromosomal Location 108945059-108956620 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 108948442 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Serine at position 482 (L482S)
Ref Sequence ENSEMBL: ENSMUSP00000126953 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172140]
AlphaFold L7N472
Predicted Effect probably benign
Transcript: ENSMUST00000172140
AA Change: L482S

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000126953
Gene: ENSMUSG00000090961
AA Change: L482S

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
Pfam:ANF_receptor 78 419 1.1e-28 PFAM
Pfam:NCD3G 507 561 8.2e-18 PFAM
Pfam:7tm_3 594 829 1.1e-54 PFAM
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 98% (60/61)
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2810459M11Rik T C 1: 85,974,231 (GRCm39) S183P possibly damaging Het
2900092C05Rik A G 7: 12,249,391 (GRCm39) T75A possibly damaging Het
Abhd8 A G 8: 71,914,406 (GRCm39) V74A probably benign Het
Agrn A C 4: 156,256,758 (GRCm39) S1282R possibly damaging Het
Atf5 T C 7: 44,462,380 (GRCm39) N248S possibly damaging Het
Atp2a3 A G 11: 72,869,576 (GRCm39) Y497C probably damaging Het
Bpifa2 T G 2: 153,851,739 (GRCm39) S58R probably benign Het
Cacna1h C T 17: 25,604,600 (GRCm39) E1238K possibly damaging Het
Ccdc71 T A 9: 108,340,523 (GRCm39) L112* probably null Het
Cd300e A T 11: 114,946,128 (GRCm39) I111N probably damaging Het
Cdkl3 A T 11: 51,924,369 (GRCm39) E552D probably benign Het
Chst5 A G 8: 112,617,245 (GRCm39) V125A probably benign Het
Clock A T 5: 76,414,692 (GRCm39) M1K probably null Het
Cops7b T A 1: 86,528,852 (GRCm39) L193Q probably benign Het
Csmd1 T C 8: 16,338,707 (GRCm39) T467A probably damaging Het
Ctr9 A G 7: 110,652,615 (GRCm39) E971G unknown Het
Dcp2 A G 18: 44,543,254 (GRCm39) T271A probably benign Het
Dsp A G 13: 38,381,172 (GRCm39) N2639S possibly damaging Het
Fhip1a T C 3: 85,637,784 (GRCm39) I172V probably benign Het
Gm11168 C G 9: 3,006,912 (GRCm39) C212W probably benign Het
Gpr179 G T 11: 97,242,420 (GRCm39) D141E probably damaging Het
H2bc4 A G 13: 23,868,342 (GRCm39) Y43C probably damaging Het
Hdhd2 C T 18: 77,031,811 (GRCm39) T89M probably benign Het
Krt6b T G 15: 101,587,513 (GRCm39) T194P probably benign Het
Lrp1b T C 2: 41,266,030 (GRCm39) probably null Het
Maneal A T 4: 124,754,161 (GRCm39) I214N possibly damaging Het
Map1lc3b T A 8: 122,317,355 (GRCm39) C11S unknown Het
Mapt G A 11: 104,213,350 (GRCm39) G296E possibly damaging Het
Mgam A G 6: 40,640,459 (GRCm39) N509S probably benign Het
Mrgprx1 T A 7: 47,671,733 (GRCm39) I5F possibly damaging Het
Mroh5 T C 15: 73,659,583 (GRCm39) D416G probably benign Het
Ncan T G 8: 70,562,749 (GRCm39) D503A probably benign Het
Nedd1 A T 10: 92,547,185 (GRCm39) probably null Het
Ogdh A G 11: 6,298,351 (GRCm39) T641A probably benign Het
Or2b6 T C 13: 21,823,316 (GRCm39) I126V probably benign Het
Or4k2 T A 14: 50,424,015 (GRCm39) I221F probably damaging Het
Or6c219 A T 10: 129,781,435 (GRCm39) D50E probably benign Het
Or8b1b T A 9: 38,375,439 (GRCm39) M34K possibly damaging Het
Pcdhga8 A C 18: 37,859,238 (GRCm39) Q98P possibly damaging Het
Pik3c2a A G 7: 115,953,242 (GRCm39) Y1218H probably damaging Het
Ppp3cc A T 14: 70,483,387 (GRCm39) S229T possibly damaging Het
Prss43 T G 9: 110,657,764 (GRCm39) I221S probably damaging Het
Rasal1 A T 5: 120,801,002 (GRCm39) T221S probably benign Het
Serpinb9f G T 13: 33,518,543 (GRCm39) E348* probably null Het
Sfxn5 A G 6: 85,244,889 (GRCm39) Y169H probably damaging Het
Skint9 T C 4: 112,246,428 (GRCm39) N228S probably benign Het
Slx4ip A T 2: 136,842,162 (GRCm39) D29V probably damaging Het
Snx29 G T 16: 11,573,180 (GRCm39) G474V probably damaging Het
Spata6 T A 4: 111,638,017 (GRCm39) D282E possibly damaging Het
Srek1 A T 13: 103,905,890 (GRCm39) V77E probably damaging Het
Timd6 A G 11: 46,468,285 (GRCm39) T120A possibly damaging Het
Tmt1a3 T C 15: 100,233,289 (GRCm39) V160A probably benign Het
Tnfrsf22 T C 7: 143,194,564 (GRCm39) D121G probably damaging Het
Ucma G A 2: 4,990,170 (GRCm39) W122* probably null Het
Vmn2r124 T C 17: 18,282,306 (GRCm39) M113T unknown Het
Vmn2r54 A T 7: 12,350,150 (GRCm39) probably null Het
Vwa3a T A 7: 120,378,138 (GRCm39) I476N probably damaging Het
Vwa8 A C 14: 79,219,674 (GRCm39) probably null Het
Wdr26 A T 1: 181,015,240 (GRCm39) S390R probably damaging Het
Zbtb40 A T 4: 136,728,205 (GRCm39) S471T probably benign Het
Other mutations in Vmn2r8
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02957:Vmn2r8 APN 5 108,950,091 (GRCm39) missense probably benign 0.01
R0324:Vmn2r8 UTSW 5 108,945,807 (GRCm39) splice site probably null
R0335:Vmn2r8 UTSW 5 108,945,317 (GRCm39) splice site probably null
R0394:Vmn2r8 UTSW 5 108,949,938 (GRCm39) missense probably benign 0.12
R0501:Vmn2r8 UTSW 5 108,951,049 (GRCm39) missense probably benign 0.03
R0615:Vmn2r8 UTSW 5 108,947,195 (GRCm39) missense probably damaging 1.00
R0678:Vmn2r8 UTSW 5 108,948,412 (GRCm39) missense probably benign 0.00
R1167:Vmn2r8 UTSW 5 108,951,042 (GRCm39) missense probably benign 0.01
R1187:Vmn2r8 UTSW 5 108,951,085 (GRCm39) nonsense probably null
R1406:Vmn2r8 UTSW 5 108,950,234 (GRCm39) missense probably benign
R1406:Vmn2r8 UTSW 5 108,950,234 (GRCm39) missense probably benign
R1451:Vmn2r8 UTSW 5 108,945,933 (GRCm39) missense probably damaging 1.00
R1535:Vmn2r8 UTSW 5 108,950,040 (GRCm39) missense probably damaging 1.00
R1795:Vmn2r8 UTSW 5 108,950,972 (GRCm39) missense probably benign
R1874:Vmn2r8 UTSW 5 108,950,284 (GRCm39) missense possibly damaging 0.74
R1908:Vmn2r8 UTSW 5 108,945,436 (GRCm39) missense probably benign 0.03
R1925:Vmn2r8 UTSW 5 108,950,019 (GRCm39) missense probably damaging 0.97
R1960:Vmn2r8 UTSW 5 108,947,152 (GRCm39) missense probably damaging 0.99
R1961:Vmn2r8 UTSW 5 108,945,961 (GRCm39) missense probably benign 0.45
R1967:Vmn2r8 UTSW 5 108,950,249 (GRCm39) missense probably benign 0.01
R2095:Vmn2r8 UTSW 5 108,956,487 (GRCm39) missense possibly damaging 0.94
R2159:Vmn2r8 UTSW 5 108,950,169 (GRCm39) missense probably benign 0.22
R4240:Vmn2r8 UTSW 5 108,945,369 (GRCm39) missense probably damaging 0.99
R4581:Vmn2r8 UTSW 5 108,949,570 (GRCm39) missense probably benign 0.03
R4744:Vmn2r8 UTSW 5 108,956,447 (GRCm39) missense probably benign 0.00
R4755:Vmn2r8 UTSW 5 108,949,566 (GRCm39) missense probably benign 0.03
R4917:Vmn2r8 UTSW 5 108,945,264 (GRCm39) missense probably damaging 1.00
R4957:Vmn2r8 UTSW 5 108,947,129 (GRCm39) missense probably benign 0.16
R5141:Vmn2r8 UTSW 5 108,956,572 (GRCm39) missense probably damaging 0.96
R5481:Vmn2r8 UTSW 5 108,949,636 (GRCm39) missense probably benign 0.09
R5571:Vmn2r8 UTSW 5 108,950,106 (GRCm39) missense probably damaging 1.00
R5624:Vmn2r8 UTSW 5 108,950,325 (GRCm39) missense probably damaging 0.99
R6003:Vmn2r8 UTSW 5 108,945,248 (GRCm39) missense probably damaging 1.00
R6243:Vmn2r8 UTSW 5 108,947,211 (GRCm39) missense probably benign 0.01
R6265:Vmn2r8 UTSW 5 108,956,463 (GRCm39) missense probably benign
R6315:Vmn2r8 UTSW 5 108,949,757 (GRCm39) missense probably benign
R6413:Vmn2r8 UTSW 5 108,949,589 (GRCm39) missense probably benign 0.09
R7120:Vmn2r8 UTSW 5 108,956,504 (GRCm39) missense possibly damaging 0.56
R7409:Vmn2r8 UTSW 5 108,956,449 (GRCm39) nonsense probably null
R7489:Vmn2r8 UTSW 5 108,945,522 (GRCm39) missense possibly damaging 0.95
R7532:Vmn2r8 UTSW 5 108,950,106 (GRCm39) missense probably benign 0.22
R7534:Vmn2r8 UTSW 5 108,950,040 (GRCm39) missense possibly damaging 0.94
R7739:Vmn2r8 UTSW 5 108,950,043 (GRCm39) missense probably damaging 1.00
R8099:Vmn2r8 UTSW 5 108,949,700 (GRCm39) missense probably benign
R8245:Vmn2r8 UTSW 5 108,945,936 (GRCm39) missense probably damaging 1.00
R8711:Vmn2r8 UTSW 5 108,945,962 (GRCm39) missense possibly damaging 0.89
R8781:Vmn2r8 UTSW 5 108,945,597 (GRCm39) missense possibly damaging 0.95
R8874:Vmn2r8 UTSW 5 108,956,617 (GRCm39) missense probably damaging 1.00
R8927:Vmn2r8 UTSW 5 108,950,131 (GRCm39) missense
R8928:Vmn2r8 UTSW 5 108,950,131 (GRCm39) missense
R9288:Vmn2r8 UTSW 5 108,950,185 (GRCm39) missense probably benign 0.39
R9596:Vmn2r8 UTSW 5 108,947,196 (GRCm39) missense possibly damaging 0.94
R9652:Vmn2r8 UTSW 5 108,951,107 (GRCm39) missense probably benign 0.18
Z1088:Vmn2r8 UTSW 5 108,949,864 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- AGATAACTGAATCTGGAGAAAGATTTC -3'
(R):5'- GATGCATCTCACTTAGGTGGC -3'

Sequencing Primer
(F):5'- TGAATCCAGAGGTCTTTGATCTC -3'
(R):5'- GTGGCTTCCATGCTGAAATCCAG -3'
Posted On 2019-10-07